Multiple mutations of the human cytochrome P450IID6 gene (CYP2D6) in poor metabolizers of debrisoquine. Study of the functional significance of individual mutations by expression of chimeric genes.
Data up to Jan 2025
Total Citations Per Year
Abstract
References (27)
DNA sequencing with chain-terminating inhibitors
1977 • 69,181 citations
Molecular Cloning. A Laboratory Manual
1983 • 27,328 citations
A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity
1983 • 26,063 citations
A catalogue of splice junction sequences
1982 • 3,861 citations
SV40-transformed simian cells support the replication of early SV40 mutants
1981 • 2,564 citations
Dideoxy sequencing method using denatured plasmid templates
1986 • 1,537 citations
Cloning, structure, and expression of the mitochondrial cytochrome P-450 sterol 26-hydroxylase, a bile acid biosynthetic enzyme
1989 • 1,244 citations
Characterization of the common genetic defect in humans deficient in debrisoquine metabolism
1988 • 717 citations
Efficient infection of monkey cells with DNA of simian virus 40.
1981 • 419 citations
The human debrisoquine 4-hydroxylase (CYP2D) locus: sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene.
1989 • 407 citations
Expression of Bovine 17α-Hydroxylase Cytochrome P-450 cDNA in Nonsteroidogenic (COS 1) Cells
1986 • 389 citations
Sequence requirements for splicing of higher eukaryotic nuclear pre-mRNA
1986 • 389 citations
Promoter-regulatory region of the major immediate early gene of human cytomegalovirus.
1984 • 296 citations
Signals for the selection of a splice site in pre-mRNA
1987 • 247 citations
Aberrant splicing and missense mutations cause steroid 21-hydroxylase [P-450(C21)] deficiency in humans: possible gene conversion products.
1988 • 241 citations
Antibodies against human cytochrome P-450db1 in autoimmune hepatitis type II.
1988 • 237 citations
Rapid insertional mutagenesis of DNA by polymerase chain reaction (PCR)
1989 • 218 citations
Two mutant alleles of the human cytochrome P-450db1 gene (P450C2D1) associated with genetically deficient metabolism of debrisoquine and other drugs.
1988 • 199 citations
Human debrisoquine 4-hydroxylase (P450IID1): cDNA and deduced amino acid sequence and assignment of the CYP2D locus to chromosome 22
1988 • 157 citations
Ethnic Differences in Reactions to Drugs and Xenobiotics
1987 • 156 citations
Structural Characterization of Normal and Mutant Human Steroid 17α- Hydroxylase Genes: Molecular Basis of One Example of Combined 17α- Hydroxylase/17,20 Lyase Deficiency
1988 • 154 citations
Absence of hepatic cytochrome P450bufI causes genetically deficient debrisoquine oxidation in man
1988 • 152 citations
The genetic polymorphism of debrisoquine/sparteine metabolism—molecular mechanisms
1990 • 129 citations
Hepatic monooxygenase activities in subjects with a genetic defect in drug oxidation
1983 • 123 citations
RNA isolation: a mini-prep method
1988 • 93 citations
The genetic polymorphism of sparteine metabolism
1986 • 75 citations
Alternative splicing mechanism in a cytochrome P-450 (P-450PB-1) gene generates the two mRNAs coding for proteins of different functions
1989 • 28 citations