Apoptotic triggers initiate translocations within the MLL gene involving the nonhomologous end joining repair system.

Genetic applications of an inverse polymerase chain reaction.

1988 • 1,867 citations

Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis

1998 • 1,651 citations

Apoptotic DNA Fragmentation

2000 • 885 citations

The CD95 (APO-1/Fas) and the TRAIL (APO-2L) Apoptosis Systems

2000 • 625 citations

DNA end-joining: from yeast to man

1998 • 586 citations

DNA Transposition by the RAG1 and RAG2 Proteins

1998 • 532 citations

Molecular mechanisms of DNA double-strand break repair

1998 • 515 citations

Frequent chromosomal translocations induced by DNA double-strand breaks

2000 • 498 citations

Nonhomologous recombination in mammalian cells: role for short sequence homologies in the joining reaction.

1986 • 465 citations

Early Activation of Caspases during T Lymphocyte Stimulation Results in Selective Substrate Cleavage in Nonapoptotic Cells

1999 • 387 citations

The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations

2000 • 351 citations

Review: Nuclear Events in Apoptosis

2000 • 283 citations

c-Myc target gene specificity is determined by a post-DNAbinding mechanism

1998 • 280 citations

Double Strand Break Repair

1997 • 268 citations

DNA-dependent protein kinase stimulates an independently active, nonhomologous, end-joining apparatus.

2000 • 249 citations

Distribution of 11q23 breakpoints within the MLL breakpoint cluster region in de novo acute leukemia and in treatment-related acute myeloid leukemia: correlation with scaffold attachment regions and topoisomerase II consensus binding sites

1996 • 242 citations

What to do at an end: DNA double-strand-break repair

1995 • 195 citations

Annexin V Staining Due to Loss of Membrane Asymmetry Can Be Reversible and Precede Commitment to Apoptotic Death

1999 • 194 citations

DNA Cleavage within the MLL Breakpoint Cluster Region Is a Specific Event Which Occurs as Part of Higher-Order Chromatin Fragmentation during the Initial Stages of Apoptosis

1997 • 182 citations

Site-specific DNA cleavage within the MLL breakpoint cluster region induced by topoisomerase II inhibitors [see comments]

1996 • 171 citations

Sequence analysis of the breakpoint cluster region in the ALL-1 gene involved in acute leukemia.

1994 • 149 citations

CBFA2(AML1) Translocations With Novel Partner Chromosomes in Myeloid Leukemias: Association With Prior Therapy

1998 • 126 citations

Wortmannin is a potent inhibitor of DNA double strand break but not single strand break repair in Chinese hamster ovary cells

1996 • 118 citations

The (4;11)(q21;q23) chromosome translocations in acute leukemias involve the VDJ recombinase.

1992 • 109 citations

Fine structure of translocation breakpoints in leukemic blasts with chromosomal translocation t(4;11): the DNA damage-repair model of translocation

1998 • 107 citations

Double‐strand break repair mediated by DNA end‐joining

1998 • 99 citations

DNA structural properties of AF9 are similar to MLL and could act as recombination hot spots resulting in MLL/AF9 translocations and leukemogenesis

2000 • 93 citations

Wortmannin Inhibits Repair of DNA Double-Strand Breaks in Irradiated Normal Human Cells

1998 • 74 citations

The relative radiosensitivity of TK6 and WI-L2-NS lymphoblastoid cells derived from a common source is primarily determined by their p53 mutational status

1995 • 65 citations

DNA repair is activated in early stages of p53-induced apoptosis

2000 • 65 citations

MLL self fusion mediated by Alu repeat homologous recombination and prognosis of AML-M4/M5 subtypes.

1997 • 65 citations

Molecular analysis of the chromosomal breakpoint and fusion transcripts in the acute lymphoblastic SEM cell line with chromosomal translocation t(4;ll)

1995 • 28 citations

LINE L1 retrotransposable element is targeted during the initial stages of apoptotic DNA fragmentation

2000 • 23 citations