The genotype distribution of the XRCC1gene indicates a role for base excision repair in the development of therapy-related acute myeloblastic leukemia

XRCC1 Is Specifically Associated with Poly(ADP-Ribose) Polymerase and Negatively Regulates Its Activity following DNA Damage

1998 • 900 citations

Nonconservative amino acid substitution variants exist at polymorphic frequency in DNA repair genes in healthy humans.

1998 • 775 citations

Reconstitution of DNA base excision-repair with purified human proteins: interaction between DNA polymerase beta and the XRCC1 protein.

1996 • 775 citations

XRCC1 Polypeptide Interacts with DNA Polymerase and Possibly Poly (ADP-Ribose) Polymerase, and DNA Ligase III Is a Novel Molecular 'Nick-Sensor' In Vitro

1996 • 607 citations

XRCC1 polymorphisms: effects on aflatoxin B1-DNA adducts and glycophorin A variant frequency.

1999 • 575 citations

XRCC1, XRCC3, XPD gene polymorphisms, smoking and 32P-DNA adducts in a sample of healthy subjects

2001 • 490 citations

An interaction between the mammalian DNA repair protein XRCC1 and DNA ligase III.

1994 • 477 citations

Polymorphisms in the DNA repair genes XRCC1 and ERCC2 and biomarkers of DNA damage in human blood mononuclear cells

2000 • 461 citations

XPD polymorphisms: effects on DNA repair proficiency

2000 • 436 citations

Polymorphisms of DNA repair gene XRCC1 in squamous cell carcinoma of the head and neck

1999 • 317 citations

A variant within the DNA repair gene XRCC3 is associated with the development of melanoma skin cancer.

2000 • 306 citations

DNA repair gene polymorphisms, bulky DNA adducts in white blood cells and bladder cancer in a case-control study

2001 • 299 citations

Prevalence of the Inactivating 609C→T Polymorphism in the NAD(P)H:Quinone Oxidoreductase (NQO1) Gene in Patients With Primary and Therapy-Related Myeloid Leukemia

1999 • 299 citations

Genetic pathways in therapy-related myelodysplasia and acute myeloid leukemia

2002 • 254 citations

Xrcc3 Is Required for Assembly of Rad51 Complexes in Vivo

1998 • 251 citations

Genotype-phenotype relationships in studies of a polymorphism in NAD(P)H

1999 • 238 citations

DNA repair gene XRCC1 polymorphisms, smoking, and bladder cancer risk.

2001 • 236 citations

Polymorphisms In The DNA Repair Gene Xrcc1 And Breast Cancer

2001 • 235 citations

Variation in DNA repair is a factor in cancer susceptibility: a paradigm for the promises and perils of individual and population risk estimation?

1998 • 232 citations

The XRCC1 399 glutamine allele is a risk factor for adenocarcinoma of the lung

2001 • 225 citations

The 399Gln polymorphism in the DNA repair gene XRCC1 modulates the genotoxic response induced in human lymphocytes by the tobacco-specific nitrosamine NNK

2000 • 207 citations

Microsatellite instability and p53 mutations in therapy-related leukemia suggest mutator phenotype

1996 • 196 citations

Inheritance of the 194Trp and the 399Gln variant alleles of the DNA repair gene XRCC1 are associated with increased risk of early-onset colorectal carcinoma in Egypt

2000 • 195 citations

The XRCC1 Arg399Gln polymorphism, sunburn, and non-melanoma skin cancer: evidence of gene-environment interaction.

2002 • 156 citations

Low NAD(P)H:quinone oxidoreductase 1 activity is associated with increased risk of acute leukemia in adults

2001 • 150 citations

Identification of an NAD(P)H:quinone oxidoreductase polymorphism and its association with lung cancer and smoking

1995 • 130 citations

Mutations in hamster single-strand break repair gene XRCC1 causing defective DNA repair

1998 • 127 citations

Microsatellite Instability and p53 Mutations Are Associated With Abnormal Expression of the MSH2 Gene in Adult Acute Leukemia

1999 • 115 citations

Genomic sequence comparison of the human and mouse XRCC1 DNA repair gene regions

1995 • 102 citations

Five polymorphisms in the coding sequence of the xeroderma pigmentosum group D gene

1996 • 62 citations

Microsatellite instability occurs in defined subsets of patients with acute myeloblastic leukaemia

2001 • 50 citations

Microsatellite instability and p53 mutations in therapy-related leukemia suggest mutator phenotype

1996 • 21 citations