Genetic Polymorphisms in the Base Excision Repair Pathway and Cancer Risk: A HuGE Review

Bias in meta-analysis detected by a simple, graphical test

1997 • 47,526 citations

Meta-analysis in clinical trials

1986 • 36,193 citations

Tobacco smoke and involuntary smoking

2004 • 1,743 citations

Quality Control by DNA Repair

1999 • 1,469 citations

Polymorphisms in DNA repair genes and associations with cancer risk.

2002 • 1,199 citations

Repair and Genetic Consequences of Endogenous DNA Base Damage in Mammalian Cells

2004 • 722 citations

XRCC1 polymorphisms: effects on aflatoxin B1-DNA adducts and glycophorin A variant frequency.

1999 • 575 citations

XRCC1, XRCC3, XPD gene polymorphisms, smoking and 32P-DNA adducts in a sample of healthy subjects

2001 • 490 citations

A comprehensive model for familial breast cancer incorporating BRCA1, BRCA2 and other genes

2002 • 483 citations

Genetic polymorphisms and alternative splicing of the hOGG1 gene, that is involved in the repair of 8-hydroxyguanine in damaged DNA

1998 • 441 citations

Base excision repair of DNA in mammalian cells

2000 • 364 citations

Amino acid substitution variants of APE1 and XRCC1 genes associated with ionizing radiation sensitivity

2001 • 345 citations

Polymorphisms in DNA repair and metabolic genes in bladder cancer

2003 • 345 citations

Genetic susceptibility to lung cancer: the role of DNA damage and repair.

2003 • 344 citations

Involvement of XRCC1 and DNA Ligase III Gene Products in DNA Base Excision Repair

1997 • 328 citations

Polymorphisms of DNA repair gene XRCC1 in squamous cell carcinoma of the head and neck

1999 • 317 citations

A variant within the DNA repair gene XRCC3 is associated with the development of melanoma skin cancer.

2000 • 306 citations

DNA repair gene polymorphisms, bulky DNA adducts in white blood cells and bladder cancer in a case-control study

2001 • 299 citations

Evidence for further breast cancer susceptibility genes in addition to BRCA1 and BRCA2 in a population‐based study

2001 • 287 citations

Repair of Oxidative DNA Damage: Mechanisms and Functions

2001 • 261 citations

Excision of oxidatively damaged DNA bases by the human alpha-hOgg1 protein and the polymorphic alpha-hOgg1(Ser326Cys) protein which is frequently found in human populations

1999 • 254 citations

Polymorphic variation inhOGG1 and risk of cancer: A review of the functional and epidemiologic literature

2004 • 253 citations

DNA repair gene XRCC1 polymorphisms, smoking, and bladder cancer risk.

2001 • 236 citations

Association of the hOGG1 Ser326Cys polymorphism with lung cancer risk.

2002 • 235 citations

Polymorphisms In The DNA Repair Gene Xrcc1 And Breast Cancer

2001 • 235 citations

hOGG1 Ser326Cys polymorphism and lung cancer susceptibility.

1999 • 233 citations

The XRCC1 399 glutamine allele is a risk factor for adenocarcinoma of the lung

2001 • 225 citations

Identification of Genetic Variants in Base Excision Repair Pathway and Their Associations with Risk of Esophageal Squamous Cell Carcinoma

2004 • 220 citations

Specific combinations of DNA repair gene variants and increased risk for non-small cell lung cancer

2004 • 208 citations

Polymorphisms of the DNA repair geneXRCC1 and risk of gastric cancer in a Chinese population

2000 • 207 citations

XRCC1 co-localizes and physically interacts with PCNA

2004 • 199 citations

From genotype to phenotype: correlating XRCC1 polymorphisms with mutagen sensitivity

2003 • 197 citations

Inheritance of the 194Trp and the 399Gln variant alleles of the DNA repair gene XRCC1 are associated with increased risk of early-onset colorectal carcinoma in Egypt

2000 • 195 citations

Polymorphisms in the DNA repair genes XRCC1 and ERCC2, smoking, and lung cancer risk.

2003 • 189 citations

Repair of abasic sites in DNA

2003 • 189 citations

Polymorphisms of the DNA repair gene XRCC1 and lung cancer risk.

2001 • 188 citations

Polymorphism of the DNA repair gene XRCC1 and risk of primary lung cancer.

2002 • 185 citations

Polymorphisms of XRCC1 and XRCC3 genes and susceptibility to breast cancer

2003 • 185 citations

Large-Scale Investigation of Base Excision Repair Genetic Polymorphisms and Lung Cancer Risk in a Multicenter Study

2005 • 185 citations

Polymorphisms in the DNA repair genes XPD, XRCC1, XRCC3, and APE/ref-1, and the risk of lung cancer amongmale smokers in Finland

2003 • 183 citations

Polymorphisms in the DNA repair gene XRCC1, breast cancer risk, and response to radiotherapy.

2003 • 183 citations

Requirement for human AP endonuclease 1 for repair of 3′-blocking damage at DNA single-strand breaks induced by reactive oxygen species

2000 • 183 citations

The human OGG1 DNA repair enzyme and its association with orolaryngeal cancer risk

2002 • 182 citations

DNA repair gene XRCC1 and XPD polymorphisms and risk of lung cancer in a Chinese population

2002 • 179 citations

Single nucleotide polymorphisms in breast cancer

2004 • 178 citations

The genotype distribution of the XRCC1gene indicates a role for base excision repair in the development of therapy-related acute myeloblastic leukemia

2002 • 175 citations

Associations between hOGG1 sequence variants and prostate cancer susceptibility.

2002 • 172 citations

Polymorphisms in DNA Base Excision Repair Genes ADPRT and XRCC1 and Risk of Lung Cancer

2005 • 171 citations

hOGG1 polymorphism and loss of heterozygosity (LOH): Significance for lung cancer susceptibility in a caucasian population

2000 • 163 citations

Polymorphisms of the DNA repair genes XRCC1, XRCC3, XPD, interaction with environmental exposures, and bladder cancer risk in a case-control study in northern Italy.

2003 • 163 citations

Oxidative damage-related genes AKR1C3 and OGG1 modulate risks for lung cancer due to exposure to PAH-rich coal combustion emissions

2004 • 158 citations

Requirement for human AP endonuclease 1 for repair of 3′-blocking damage at DNA single-strand breaks induced by reactive oxygen species

2000 • 157 citations

The XRCC1 Arg399Gln polymorphism, sunburn, and non-melanoma skin cancer: evidence of gene-environment interaction.

2002 • 156 citations

Ser326Cys polymorphism inhOGG1 gene and risk of esophageal cancer in a Chinese population

2001 • 153 citations

Nasopharyngeal carcinoma and genetic polymorphisms of DNA repair enzymes XRCC1 and hOGG1.

2003 • 153 citations

DNA-repair genetic polymorphisms and breast cancer risk.

2003 • 151 citations

Gene-environment interactions between the smoking habit and polymorphisms in the DNA repair genes, APE1 Asp148Glu and XRCC1 Arg399Gln, in Japanese lung cancer risk

2004 • 151 citations

A population-based study of the Arg399Gln polymorphism in X-ray repair cross- complementing group 1 (XRCC1) and risk of pancreatic adenocarcinoma.

2002 • 141 citations

Genetic polymorphisms of DNA repair and xenobiotic-metabolizing enzymes: role in mutagen sensitivity

2002 • 139 citations

TheOGG1Gene Encodes a Repair Enzyme for Oxidatively Damaged DNA and Is Involved in Human Carcinogenesis

2001 • 136 citations

Genetic polymorphism of XRCC1 and lung cancer risk among African–Americans and Caucasians

2001 • 135 citations

DNA adduct levels and DNA repair polymorphisms in traffic-exposed workers and a general population sample

2001 • 134 citations

Human DNA Glycosylases Involved in the Repair of Oxidatively Damaged DNA

2004 • 128 citations

DNA Repair Gene XRCC1 and XPD Polymorphisms and Risk of Prostate Cancer

2004 • 128 citations

Polymorphisms in DNA repair gene XRCC1 and increased genetic susceptibility to breast cancer

2005 • 127 citations

Genetic polymorphisms ofXRCC1 and risk of the esophageal cancer

2001 • 127 citations

Contribution of the NQO1 and GSTT1 polymorphisms to lung adenocarcinoma susceptibility.

2002 • 126 citations

DNA repair activity of 8-oxoguanine DNA glycosylase 1 (OGG1) in human lymphocytes is not dependent on genetic polymorphism Ser326/Cys326

2001 • 125 citations

Polymorphisms of DNA repair genes XRCC1 and XPD and their associations with risk of esophageal squamous cell carcinoma in a Chinese population

2002 • 122 citations

XRCC1 polymorphisms and head and neck cancer

2002 • 117 citations

Characterization of the hOGG1 promoter and its expression during the cell cycle

2000 • 113 citations

HOGG1 Ser³²⁶Cys polymorphism and modification by environmental factors of stomach cancer risk in Chinese

2002 • 107 citations

The human 8-oxoguanine DNA N-glycosylase 1 (hOGG1) DNA repair enzyme and its association with lung cancer risk

2004 • 104 citations

Polymorphisms in XRCC1 and Glutathione S-Transferase Genes and Hepatitis B-Related Hepatocellular Carcinoma

2003 • 103 citations

Polymorphisms of the XRCC1, XRCC3, & XPDgenes, and colorectal cancer risk: a case-control study in Taiwan

2005 • 100 citations

8-Hydroxydeoxyguanosine in DNA from leukocytes of healthy adults: relationship with cigarette smoking, environmental tobacco smoke, alcohol and coffee consumption

1999 • 99 citations

hOGG1 Ser326Cys polymorphism modifies the significance of the environmental risk factor for colon cancer

2003 • 99 citations

Genetic polymorphisms of XRCC1 and risk of gastric cancer

2002 • 99 citations

Differences in base excision repair capacity may modulate the effect of dietary antioxidant intake on prostate cancer risk: an example of polymorphisms in the XRCC1 gene.

2002 • 97 citations

XRCC1 genetic polymorphism and breast cancer risk

2002 • 95 citations

Polymorphisms in DNA repair genes, chromosome aberrations, and lung cancer

2004 • 92 citations

A prospective study of XRCC1 haplotypes and their interaction with plasma carotenoids on breast cancer risk.

2003 • 84 citations

A multi-biomarker approach to study the effects of smoking on oxidative DNA damage and repair and antioxidative defense mechanisms

2001 • 80 citations

A population-based case-control study of the Arg399Gln polymorphism in DNA repair gene XRCC1 and risk of breast cancer.

2003 • 80 citations

A Limited Association of OGG1 Ser326Cys Polymorphism for Adenocarcinoma of the Lung.

2002 • 80 citations

No association between OGG1 Ser326Cys polymorphism and breast cancer risk.

2003 • 71 citations

hOGG1 exon7 polymorphism and gastric cancer in case–control studies of Japanese Brazilians and non-Japanese Brazilians

2001 • 63 citations

Multiple single nucleotide polymorphisms on human chromosome 19q13.2-3 associate with risk of Basal cell carcinoma.

2002 • 61 citations

hOGG1 Ser 326 Cys Polymorphism and Breast Cancer Risk among Asian Women

2003 • 57 citations

DNA repair gene XRCC1 polymorphisms, smoking, and esophageal cancer risk

2004 • 56 citations

Association of the XRCC1 gene polymorphisms with cancer risk in Turkish breast cancer patients

2004 • 54 citations

A Population-Based Case-Control Study of the XRCC1 Arg399Gln Polymorphism and Susceptibility to Bladder Cancer

2004 • 54 citations

CYP1A1 and XRCC1 gene polymorphisms in SCC of the larynx

2003 • 48 citations

Complex segregation analysis reveals a multigene model for lung cancer

2004 • 39 citations

Lack of association between DNA base excision repair gene XRCC1 Gln399Arg polymorphism and risk of malignant lymphoma in Japan

2004 • 37 citations

No Association between hOGG1 Ser326Cys Polymorphism and Risk of Squamous Cell Carcinoma of the Head and Neck

2004 • 33 citations

No Association between OGG1 Ser326Cys and Risk of Basal Cell Carcinoma

2004 • 26 citations

A prospective study of XRCC1 haplotypes and their interaction with plasma carotenoids on breast cancer risk

2004 • 17 citations