In VitroKinetics of Two HumanCYP1A1Variant Enzymes Suggested to Be Associated with Interindividual Differences in Cancer Susceptibility

Genetic Linkage of Lung Cancer-Associated MspI Polymorphisms with Amino Acid Replacement in the Heme Binding Region of the Human Cytochrome P450IA1 Gene1

1991 • 449 citations

Polymorphisms of the CYP1A1 and glutathione S-transferase genes associated with susceptibility to lung cancer in relation to cigarette dose in a Japanese population

1994 • 440 citations

Expression of CYP1A1 Gene in Patients With Lung Cancer: Evidence for Cigarette Smoke-Induced Gene Expression in Normal Lung Tissue and for Altered Gene Regulation in Primary Pulmonary Carcinomas

1990 • 330 citations

[1] High-efficiency cloning of full-length cDNA; Construction and screening of cDNA expression libraries for mammalian cells

1987 • 329 citations

High Susceptibility to Lung Cancer Analyzed in Terms of Combined Genotypes of P450IA1 and Mu‐class Glutathione S‐Transferase Genes

1992 • 284 citations

Genetic susceptibility to squamous cell carcinoma of the lung in relation to cigarette smoking dose

1992 • 282 citations

Association between CYP1A1 genotype, mRNA expression and enzymatic activity in humans

1994 • 211 citations

The CYP1A1 gene and cancer susceptibility

1993 • 210 citations

Cytochrome P4501A1 and glutathione S-transferase (M1) genetic polymorphisms and postmenopausal breast cancer risk.

1995 • 207 citations

Germ line polymorphisms of p53 and CYP1A1 genes involved in human lung cancer

1993 • 199 citations

A CYP1A1 restriction fragment length polymorphism is associated with breast cancer in African-American women.

1995 • 187 citations

Point-mutational MspI and Ile-Val polymorphisms closely linked in the CYP1A1 gene: lack of association with susceptibility to lung cancer in a Finnish study population.

1992 • 185 citations

Human CYP1A1 gene: cosegregation of the enzyme inducibility phenotype and an RFLP.

1991 • 176 citations

Genetic susceptibility to lung cancer with special emphasis on CYP1A1 and GSTM1: A study on host factors in relation to age at onset, gender and histological cancer types

1995 • 162 citations

Enhanced in vivo monooxygenase activities of mammalian P450s in engineered yeast cells producing high levels of NADPH-P450 reductase and human cytochrome b5

1993 • 160 citations

CYP1A1 genetic polymorphisms and in situ colorectal cancer.

1994 • 152 citations

Characterization of purified human recombinant cytochrome P4501A1-Ile462 and -Val462: assessment of a role for the rare allele in carcinogenesis.

1996 • 146 citations

Risk of smoking for squamous and small cell carcinomas of the lung modulated by combinations of CYP1A1 and GSTM1 gene polymorphisms in a Japanese population

1995 • 144 citations

Association of CYP1A1 germ line polymorphisms with mutations of the p53 gene in lung cancer.

1996 • 139 citations

Synthesis of functional mouse cytochromes P-450 P1 and chimeric P-450 P3-1 in the yeast Saccharomyces cerevisiae

1988 • 132 citations

The Relationship between Aryl Hydrocarbon Hydroxylase and Polymorphisms of the CYP1A1 Gene

1996 • 128 citations

Polymorphisms in the human CYP1A1 gene as susceptibility factors for lung cancer: exon-7 mutation (4889 A to G), and a T to C mutation in the 3?-flanking region

1994 • 124 citations

PCR detection of an A/G polymorphism within exon 7 of the CYP1A1 gene

1991 • 117 citations

Maximizing the expression of mammalian cytochrome P-450 monooxygenase activities in yeast cells

1990 • 110 citations

Long-lasting effects of tobacco smoking on pulmonary drug-metabolizing enzymes: A case-control study on lung cancer patients

1989 • 103 citations

CYP1A1 and CYP2E1 polymorphism and lung cancer, case-control study in Rio de Janeiro, Brazil

1995 • 65 citations

Immunohistochemical detection of pulmonary cytochrome P450IA and metabolic activities associated with P450IA1 and P450IA2 isozymes in lung cancer patients.

1992 • 59 citations

Expression of pulmonary cytochrome P4501 A1 and carcinogen DNA adduct formation in high risk subjects for tobacco-related lung cancer

1992 • 50 citations

Association of cigarette smoking and CYP1A1 polymorphisms with adenocarcinoma of the lung by grades of differentiation

1995 • 49 citations

Assciation between a cytochrome P450 CYPIA1 genotype and incidence of lung cancer

1994 • 48 citations

Individual differences in lung cancer susceptibility in relation to polymorphisms of P-450IA1 gene and cigarette dose.

1990 • 30 citations

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