Establishment and characterization of cell lines constitutively expressing hepatitis B virus X-protein

HBx gene of hepatitis B virus induces liver cancer in transgenic mice

1991 • 1,155 citations

HBV X Protein Alters the DNA Binding Specificity of CREB and ATF-2 by Protein-Protein Interactions

1991 • 457 citations

Hepatitis B virus HBx protein activates Ras-GTP complex formation and establishes a Ras, Raf, MAP kinase signaling cascade.

1994 • 418 citations

Hepatitis B virus transactivator HBx uses a tumour promoter signalling pathway

1993 • 371 citations

The hepatitis B virus HBx protein is a dual specificity cytoplasmic activator of Ras and nuclear activator of transcription factors.

1995 • 311 citations

Human RPB5, a subunit shared by eukaryotic nuclear RNA polymerases, binds human hepatitis B virus X protein and may play a role in X transactivation.

1995 • 263 citations

Trans-activation of the human immunodeficiency virus long terminal repeat by the hepatitis B virus X protein.

1988 • 212 citations

Hepatitis B virus transactivator protein X interacts with the TATA-binding protein.

1995 • 190 citations

Regulation of transforming growth factor-beta 1 expression by the hepatitis B virus (HBV) X transactivator. Role in HBV pathogenesis.

1996 • 167 citations

The hepatitis B virus X-gene product trans-activates both RNA polymerase II and III promoters.

1990 • 159 citations

Expression of the hepatitis B virus X gene in mammalian cells.

1987 • 131 citations

Induction of the DNA-Binding Activity of c-Jun/c-Fos Heterodimers by the Hepatitis B Virus Transactivator pX

1994 • 127 citations

Activation of Protooncogene C-jun by the X Protein of Hepatitis B Virus

1993 • 123 citations

Induction of the DNA-binding activity of c-jun/c-fos heterodimers by the hepatitis B virus transactivator pX.

1994 • 80 citations

Hepatitis B virus X protein transactivates the long terminal repeats of human immunodeficiency virus types 1 and 2

1990 • 77 citations

Trans-activation of HLA-DR gene by hepatitis B virus X gene product.

1990 • 69 citations

The hepatitis B virus (HBV) pX transactivates the c-fos promoter through multiple cis-acting elements.

1993 • 69 citations

Interaction of hepatitis B virus X protein with a serine protease, tryptase TL2 as an inhibitor.

1994 • 52 citations

Expression of oncogenes and tumor suppressor genes in human hepatocellular carcinoma and hepatoblastoma cell lines

1992 • 32 citations

Characterization of the P4 promoter region of the human insulin‐like growth factor II gene

1993 • 16 citations