Mitochondrial complex I deficiency leads to increased production of superoxide radicals and induction of superoxide dismutase.

SUPEROXIDE RADICAL AND SUPEROXIDE DISMUTASES

1995 • 3,305 citations

The cellular production of hydrogen peroxide

1972 • 1,526 citations

The inactivation of Fe-S cluster containing hydro-lyases by superoxide.

1993 • 628 citations

Differential regulation of antioxidant enzymes in response to oxidants.

1991 • 411 citations

Luminol and lucigenin as detectors for O2ṡ−

1993 • 341 citations

NADH- and NADPH-dependent formation of superoxide anions by bovine heart submitochondrial particles and NADH–ubiquinone reductase preparation

1979 • 293 citations

Tumour necrosis factor-α induces superoxide anion generation in mitochondria of L929 cells

1993 • 272 citations

An analysis of the role of coenzyme Q in free radical generation and as an antioxidant

1992 • 245 citations

Benign infantile mitochondrial myopathy due to reversible cytochrome c oxidase deficiency

1983 • 231 citations

Photolabelling of a mitochondrially encoded subunit of NADH dehydrogenase with [³H]dihydrorotenone

1987 • 187 citations

Deficiency of the iron-sulfur clusters of mitochondrial reduced nicotinamide-adenine dinucleotide-ubiquinone oxidoreductase (complex I) in an infant with congenital lactic acidosis.

1984 • 138 citations

The Use of Skin Fibroblast Cultures in the Detection of Respiratory Chain Defects in Patients with Lacticacidemia

1990 • 99 citations

Identification of the dicyclohexylcarbodiimide-binding subunit of NADH-ubiquinone oxidoreductase (Complex I).

1988 • 97 citations

Investigation of mitochondrial metabolism in small human skeletal muscle biopsy specimens. Improvement of preparation procedure

1985 • 71 citations

Lacticacidemia

1993 • 69 citations

Familial Cardiomyopathy with Cataracts and Lactic Acidosis: A Defect in Complex I (NADH-Dehydrogenase) of the Mitochondria Respiratory Chain

1996 • 64 citations

Defective intramitochondrial NADH oxidation in skin fibroblasts from an infant with fatal neonatal lacticacidemia.

1985 • 61 citations

Characterization of cytochrome‐c oxidase mutants in human fibroblasts

1988 • 56 citations

Comparison of the Inhibitory Action of Natural Rotenone and its Stereoisomers with Various NADH‐ubiquinone Reductases

1994 • 50 citations

Rat lung contains a developmentally regulated manganese superoxide dismutase mRNA-binding protein.

1993 • 35 citations

[63] Assessment of oxidative stress to eye in animal model for cataract

1994 • 21 citations