Hepatitis B virus-X protein upregulates the expression of p21wafl/cipl and prolongs G1→S transition via a p53-independent pathway in human hepatoma cells

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

p21 is a universal inhibitor of cyclin kinases

1993 • 3,408 citations

Principles of CDK regulation

1995 • 3,267 citations

Recombinant Genomes Which Express Chloramphenicol Acetyltransferase in Mammalian Cells

1982 • 3,106 citations

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1993 • 2,969 citations

A Cell Cycle Regulator Potentially Involved in Genesis of Many Tumor Types

1994 • 2,821 citations

Association of Human Papillomavirus Types 16 and 18 E6 Proteins with p53

1990 • 2,587 citations

G ₁ Events and Regulation of Cell Proliferation

1989 • 2,203 citations

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

1991 • 2,127 citations

p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest

1994 • 1,475 citations

p21 is necessary for the p53-mediated G1 arrest in human cancer cells.

1995 • 1,193 citations

HBx gene of hepatitis B virus induces liver cancer in transgenic mice

1991 • 1,155 citations

Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism.

1995 • 938 citations

Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line.

1992 • 871 citations

Cell Growth Arrest and Induction of Cyclin-Dependent Kinase Inhibitor p21 ^WAF1/CIP1 Mediated by STAT1

1996 • 796 citations

Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3.

1994 • 666 citations

HBV X Protein Alters the DNA Binding Specificity of CREB and ATF-2 by Protein-Protein Interactions

1991 • 457 citations

Functional Analysis of the Transforming Growth Factor βResponsive Elements in the WAF1/Cip1/p21 Promoter

1995 • 440 citations

Erythroleukemia induction by Friend murine leukemia virus: insertional activation of a new member of the ets gene family, Fli-1, closely linked to c-ets-1.

1991 • 404 citations

Butyrate Activates the WAF1/Cip1 Gene Promoter through Sp1 Sites in a p53-negative Human Colon Cancer Cell Line

1997 • 399 citations

Ras-Mediated Phosphorylation of a Conserved Threonine Residue Enhances the Transactivation Activities of c-Ets1 and c-Ets2

1996 • 325 citations

Hepatitis B virus X protein and p53 tumor suppressor interactions in the modulation of apoptosis

1997 • 322 citations

Hepatitis B virus HBx protein sensitizes cells to apoptotic killing by tumor necrosis factor α

1997 • 302 citations

Hepatitis B virus HBx protein deregulates cell cycle checkpoint controls.

1995 • 286 citations

The hepatitis B virus X gene potentiates c-myc-induced liver oncogenesis in transgenic mice

1997 • 286 citations

AP2 inhibits cancer cell growth and activates p21WAF1/CIP1 expression

1997 • 285 citations

The Role of the Transcription Factor Sp1 in Regulating the Expression of the WAF1/CIP1 Gene in U937 Leukemic Cells

1996 • 215 citations

Increased sensitivity to the hepatocarcinogen diethylnitrosamine in transgenic mice carrying the hepatitis B virusX gene

1996 • 182 citations

p53-independent apoptotic effects of the hepatitis B virus HBx protein in vivo and in vitro

1998 • 173 citations

Hepatitis B Virus Transgenic Mice: Models of Viral Immunobiology and Pathogenesis

1996 • 134 citations

The Hepatitis B Virus HBx Protein Inhibits Caspase 3 Activity

1998 • 130 citations

The ets gene family

1992 • 107 citations

Regulation of the GnT-V Promoter by Transcription Factor Ets-1 in Various Cancer Cell Lines

1999 • 104 citations

Cytoplasmic retention of the p53 tumor suppressor gene product is observed in the hepatitis B virus X gene-transfected cells

1997 • 83 citations

The human hepatitis B virus transactivator X gene product regulates Sp1 mediated transcription of an insulin-like growth factor II promoter 4

1998 • 81 citations

c-ets-2 protooncogene has mitogenic and oncogenic activity.

1989 • 79 citations

Functional Analysis of Hepatitis B Virus Transactivator X: Implication of the Leucine Zipper-like Region and C-Terminal Seven Conserved Amino Acids in Functional Regions

1993 • 24 citations

Establishment and characterization of cell lines constitutively expressing hepatitis B virus X-protein

1998 • 20 citations

Malignant Hyperthermia Syndrome

1984 • 3 citations

Hemoglobinuria during General Anesthesia

1984 • 2 citations