TSC1-2 tumour suppressor and regulation of mTOR signalling: linking cell growth and proliferation?

Upstream and downstream of mTOR

2004 • 4,085 citations

TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival

2003 • 3,731 citations

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

2002 • 2,945 citations

mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery

2002 • 2,904 citations

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

2003 • 1,803 citations

Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor

2002 • 1,717 citations

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

2004 • 1,710 citations

Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade

2003 • 1,604 citations

LKB1 Is the Upstream Kinase in the AMP-Activated Protein Kinase Cascade

2003 • 1,599 citations

Identification of the Tuberous Sclerosis Complex-2 Tumor Suppressor Gene Product Tuberin as a Target of the Phosphoinositide 3-Kinase/Akt Pathway

2002 • 1,518 citations

The tor pathway: a target for cancer therapy

2004 • 1,308 citations

Tuberous Sclerosis Complex Gene Products, Tuberin and Hamartin, Control mTOR Signaling by Acting as a GTPase-Activating Protein Complex toward Rheb

2003 • 1,160 citations

The AMP-activated protein kinase cascade – a unifying system for energy control

2003 • 1,115 citations

The TSC1-2 tumor suppressor controls insulin–PI3K signaling via regulation of IRS proteins

2004 • 1,101 citations

The LKB1 tumor suppressor negatively regulates mTOR signaling

2004 • 1,056 citations

Insulin Activation of Rheb, a Mediator of mTOR/S6K/4E-BP Signaling, Is Inhibited by TSC1 and 2

2003 • 1,015 citations

mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways

2004 • 951 citations

Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy

2004 • 945 citations

Akt regulates growth by directly phosphorylating Tsc2

2002 • 932 citations

Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

2003 • 909 citations

mTOR Controls Cell Cycle Progression through Its Cell Growth Effectors S6K1 and 4E-BP1/Eukaryotic Translation Initiation Factor 4E

2003 • 850 citations

Ehd1, a B-type response regulator in rice, confers short-day promotion of flowering and controls FT-like gene expression independently of Hd1

2004 • 788 citations

Inappropriate Activation of the TSC/Rheb/mTOR/S6K Cassette Induces IRS1/2 Depletion, Insulin Resistance, and Cell Survival Deficiencies

2004 • 773 citations

S6K1^−/−/S6K2^−/− Mice Exhibit Perinatal Lethality and Rapamycin-Sensitive 5′-Terminal Oligopyrimidine mRNA Translation and Reveal a Mitogen-Activated Protein Kinase-Dependent S6 Kinase Pathway

2004 • 726 citations

Drosophila S6 Kinase: A Regulator of Cell Size

1999 • 710 citations

eIF-4E expression and its role in malignancies and metastases

2004 • 702 citations

Ribosomal S6 Kinase Signaling and the Control of Translation

1999 • 679 citations

A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells

2002 • 652 citations

Rheb promotes cell growth as a component of the insulin/TOR signalling network

2003 • 648 citations

Drosophila myc Regulates Cellular Growth during Development

1999 • 637 citations

Disruption of the p70s6k/p85s6k gene reveals a small mouse phenotype and a new functional S6 kinase

1998 • 636 citations

Regulation of cellular growth by the Drosophila target of rapamycin dTOR

2000 • 615 citations

An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity inPten^+/−mice

2001 • 574 citations

The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis

2004 • 573 citations

Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products

1998 • 566 citations

Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome

2004 • 562 citations

The Drosophila Tuberous Sclerosis Complex Gene Homologs Restrict Cell Growth and Cell Proliferation

2001 • 542 citations

TSC2 regulates VEGF through mTOR-dependent and -independent pathways

2003 • 521 citations

Drosophila Tsc1 Functions with Tsc2 to Antagonize Insulin Signaling in Regulating Cell Growth, Cell Proliferation, and Organ Size

2001 • 511 citations

Rheb is an essential regulator of S6K in controlling cell growth in Drosophila

2003 • 510 citations

TOS Motif-Mediated Raptor Binding Regulates 4E-BP1 Multisite Phosphorylation and Function

2003 • 501 citations

Identification of a Conserved Motif Required for mTOR Signaling

2002 • 472 citations

Rheb fills a GAP between TSC and TOR

2003 • 467 citations

Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases

2004 • 455 citations

TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth

2001 • 449 citations

Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin

2000 • 431 citations

Proliferation, But Not Growth, Blocked by Conditional Deletion of 40 S Ribosomal Protein S6

2000 • 366 citations

p70s6k function is essential for G1 progression

1993 • 348 citations

Activated mammalian target of rapamycin pathway in the pathogenesis of tuberous sclerosis complex renal tumors.

2002 • 275 citations

gigas, a Drosophila Homolog of Tuberous Sclerosis Gene Product-2, Regulates the Cell Cycle

1999 • 257 citations

Drosophila PTEN Regulates Cell Growth and Proliferation through PI3K-Dependent and -Independent Pathways

2000 • 255 citations

Tuberous sclerosis complex tumor suppressor–mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent

2002 • 207 citations

SKAR Is a Specific Target of S6 Kinase 1 in Cell Growth Control

2004 • 192 citations

The Ras-related Protein Rheb Is Farnesylated and Antagonizes Ras Signaling and Transformation

1997 • 178 citations

The mRNA 5' cap-binding protein, eIF-4E, cooperates with v-myc or E1A in the transformation of primary rodent fibroblasts.

1992 • 172 citations

Loss of Tsc1 or Tsc2 induces vascular endothelial growth factor production through mammalian target of rapamycin.

2003 • 153 citations

Expression of Antisense RNA against Initiation Factor eIF-4E mRNA in HeLa Cells Results in Lengthened Cell Division Times, Diminished Translation Rates, and Reduced Levels of Both eIF-4E and the p220 Component of eIF-4F

1991 • 151 citations

DrosophilaRheb GTPase is required for cell cycle progression and cell growth

2003 • 148 citations

Pathological mutations in TSC1 and TSC2 disrupt the interaction between hamartin and tuberin

2001 • 126 citations

Negative Regulation of dE2F1 by Cyclin-Dependent Kinases Controls Cell Cycle Timing

2004 • 124 citations

Deletion of Ribosomal S6 Kinases Does Not Attenuate Pathological, Physiological, or Insulin-Like Growth Factor 1 Receptor-Phosphoinositide 3-Kinase-Induced Cardiac Hypertrophy

2004 • 123 citations

Tsc2 is not a critical target of Akt during normal Drosophila development

2004 • 102 citations

Regulation of B-Raf Kinase Activity by Tuberin and Rheb Is Mammalian Target of Rapamycin (mTOR)-independent

2004 • 99 citations

Expression of antisense RNA against initiation factor eIF-4E mRNA in HeLa cells results in lengthened cell division times, diminished translation rates, and reduced levels of both eIF-4E and the p220 component of eIF-4F.

1991 • 93 citations

The coupling of cell growth to the cell cycle

2001 • 76 citations

Cdc42 Promotes G1 Progression through p70 S6 Kinase-mediated Induction of Cyclin E Expression

2003 • 51 citations

Critical Role of T-Loop and H-Motif Phosphorylation in the Regulation of S6 Kinase 1 by the Tuberous Sclerosis Complex

2004 • 23 citations