TSC2 regulates VEGF through mTOR-dependent and -independent pathways

Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O ₂ -Regulated Prolyl Hydroxylation

2001 • 5,255 citations

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

1999 • 4,973 citations

HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O ₂ Sensing

2001 • 4,537 citations

C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation

2001 • 3,215 citations

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

2002 • 2,945 citations

Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

1998 • 2,427 citations

Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor

2002 • 1,717 citations

Identification and characterization of the tuberous sclerosis gene on chromosome 16

1993 • 1,617 citations

Regulation of translation initiation by FRAP/mTOR

2001 • 1,532 citations

Identification of the Tuberous Sclerosis Complex-2 Tumor Suppressor Gene Product Tuberin as a Target of the Phosphoinositide 3-Kinase/Akt Pathway

2002 • 1,518 citations

VEGF and the quest for tumour angiogenesis factors

2002 • 1,467 citations

Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics.

2000 • 1,430 citations

Definition of Two Angiogenic Pathways by Distinct α _v Integrins

1995 • 1,333 citations

HER2 (neu) Signaling Increases the Rate of Hypoxia-Inducible Factor 1α (HIF-1α) Synthesis: Novel Mechanism for HIF-1-Mediated Vascular Endothelial Growth Factor Expression

2001 • 1,230 citations

Regulation of Hypoxia-Inducible Factor 1α Expression and Function by the Mammalian Target of Rapamycin

2002 • 1,147 citations

Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha.

2000 • 1,087 citations

Insulin Activation of Rheb, a Mediator of mTOR/S6K/4E-BP Signaling, Is Inhibited by TSC1 and 2

2003 • 1,015 citations

Independent function of two destruction domains in hypoxia-inducible factor-α chains activated by prolyl hydroxylation

2001 • 994 citations

Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR

2001 • 981 citations

The splice variants of vascular endothelial growth factor (VEGF) and their receptors

2001 • 943 citations

Akt regulates growth by directly phosphorylating Tsc2

2002 • 932 citations

Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1α

2000 • 893 citations

Molecular basis of the VHL hereditary cancer syndrome

2002 • 826 citations

Loss of PTEN facilitates HIF-1-mediated gene expression

2000 • 824 citations

Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling

2002 • 812 citations

p42/p44 Mitogen-activated Protein Kinases Phosphorylate Hypoxia-inducible Factor 1α (HIF-1α) and Enhance the Transcriptional Activity of HIF-1

1999 • 777 citations

Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein

2002 • 754 citations

HIF-1α binding to VHL is regulated by stimulus-sensitive proline hydroxylation

2001 • 748 citations

Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes

2001 • 729 citations

A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells

2002 • 652 citations

Rheb promotes cell growth as a component of the insulin/TOR signalling network

2003 • 648 citations

Transcription Factor HIF-1 Is a Necessary Mediator of the Pasteur Effect in Mammalian Cells

2001 • 602 citations

An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity inPten^+/−mice

2001 • 574 citations

Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1alpha /ARNT

1998 • 561 citations

Phosphatidylinositol 3-kinase signaling controls levels of hypoxia-inducible factor 1.

2001 • 550 citations

Insulin Stimulates Hypoxia-inducible Factor 1 through a Phosphatidylinositol 3-Kinase/Target of Rapamycin-dependent Signaling Pathway

2002 • 527 citations

V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: involvement of HIF-1 in tumor progression.

1997 • 526 citations

Rheb is an essential regulator of S6K in controlling cell growth in Drosophila

2003 • 510 citations

von Hippel-Lindau Disease

1997 • 506 citations

Identification of a Conserved Motif Required for mTOR Signaling

2002 • 472 citations

TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth

2001 • 449 citations

The contribution of VHL substrate binding and HIF1-α to the phenotype of VHL loss in renal cell carcinoma

2002 • 438 citations

Tuberin Regulates p70 S6 Kinase Activation and Ribosomal Protein S6 Phosphorylation

2002 • 422 citations

Vascular tumors in livers with targeted inactivation of the von Hippel–Lindau tumor suppressor

2001 • 402 citations

Tsc2+/– mice develop tumors in multiple sites that express gelsolin and are influenced by genetic background

1999 • 380 citations

Phosphatidylinositol 3-Kinase/Akt Pathway Regulates Tuberous Sclerosis Tumor Suppressor Complex by Phosphorylation of Tuberin

2002 • 373 citations

Molecular genetic advances in tuberous sclerosis

2000 • 354 citations

p42/p44 MAP Kinase Module Plays a Key Role in the Transcriptional Regulation of the Vascular Endothelial Growth Factor Gene in Fibroblasts

1998 • 321 citations

Constitutive activation of hypoxia-inducible genes related to overexpression of hypoxia-inducible factor-1alpha in clear cell renal carcinomas.

2001 • 315 citations

Predisposition to renal carcinoma in the Eker rat is determined by germ-line mutation of the tuberous sclerosis 2 (TSC2) gene.

1994 • 305 citations

Epidermal growth factor receptor transcriptionally up-regulates vascular endothelial growth factor expression in human glioblastoma cells via a pathway involving phosphatidylinositol 3'-kinase and distinct from that induced by hypoxia.

2000 • 298 citations

Normoxic induction of the hypoxia‐inducible factor 1α by insulin and interleukin‐1β involves the phosphatidylinositol 3‐kinase pathway

2002 • 282 citations

Renal carcinogenesis, hepatic hemangiomatosis, and embryonic lethality caused by a germ-line Tsc2 mutation in mice.

1999 • 277 citations

BCR/ABL induces expression of vascular endothelial growth factor and its transcriptional activator, hypoxia inducible factor-1α, through a pathway involving phosphoinositide 3-kinase and the mammalian target of rapamycin

2002 • 276 citations

Activated mammalian target of rapamycin pathway in the pathogenesis of tuberous sclerosis complex renal tumors.

2002 • 275 citations

A germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice

2001 • 240 citations

Extracellular Signal-regulated Protein Kinase/Jun Kinase Cross-talk Underlies Vascular Endothelial Cell Growth Factor-induced Endothelial Cell Proliferation

1998 • 216 citations

Tuberous sclerosis complex tumor suppressor–mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent

2002 • 207 citations

The von Hippel–Lindau tumor suppressor, hypoxia-inducible factor-1 (HIF-1) degradation, and cancer pathogenesis

2002 • 202 citations

Norepinephrine Induces Vascular Endothelial Growth Factor Gene Expression in Brown Adipocytes through a β-Adrenoreceptor/cAMP/Protein Kinase A Pathway Involving Src but Independently of Erk1/2

2000 • 184 citations

Stress-activated Protein Kinases (JNK and p38/HOG) Are Essential for Vascular Endothelial Growth Factor mRNA Stability

2000 • 183 citations

Lethality of Drosophila lacking TSC tumor suppressor function rescued by reducing dS6K signaling

2002 • 180 citations

Phosphatidylinositol 3-Kinase/Akt Signaling Is Neither Required for Hypoxic Stabilization of HIF-1α nor Sufficient for HIF-1-dependent Target Gene Transcription

2002 • 171 citations

Hypoxia-Induced Gene Expression Occurs Solely through the Action of Hypoxia-Inducible Factor 1α (HIF-1α): Role of Cytoplasmic Trapping of HIF-2α

2003 • 170 citations

Induction of vascular endothelial growth factor by nitric oxide in human glioblastoma and hepatocellular carcinoma cells

1997 • 167 citations

PTEN mutation and epidermal growth factor receptor activation regulate vascular endothelial growth factor (VEGF) mRNA expression in human glioblastoma cells by transactivating the proximal VEGF promoter.

2003 • 145 citations

Ionizing radiation modulates vascular endothelial growth factor (VEGF) expression through multiple mitogen activated protein kinase dependent pathways

2001 • 134 citations

Tuberous Sclerosis Gene 2 Product Modulates Transcription Mediated by Steroid Hormone Receptor Family Members

1998 • 127 citations

Mechanical stretch induces vascular permeability factor in human mesangial cells: Mechanisms of signal transduction

1997 • 125 citations

Lack of Evidence for the Involvement of the Phosphoinositide 3-Kinase/Akt Pathway in the Activation of Hypoxia-inducible Factors by Low Oxygen Tension

2002 • 116 citations

Co-localization of the TSC2 product tuberin with its target Rap1 in the Golgi apparatus.

1996 • 109 citations

Loss of function of the tuberous sclerosis 2 tumor suppressor gene results in embryonic lethality characterized by disrupted neuroepithelial growth and development

1998 • 102 citations

Hereditary renal adenomas and adenocarcinomas in rats.

1981 • 101 citations

Nitric oxide synthase inhibition attenuates the skeletal muscle VEGF mRNA response to exercise

2000 • 96 citations

Growth Signaling: TSC Takes Its Place

2002 • 93 citations

Stretch-induced Retinal Vascular Endothelial Growth Factor Expression Is Mediated by Phosphatidylinositol 3-Kinase and Protein Kinase C (PKC)-ζ but Not by Stretch-induced ERK1/2, Akt, Ras, or Classical/Novel PKC Pathways

2002 • 79 citations

Up-regulation of hypoxia-inducible factor 2alpha in renal cell carcinoma associated with loss of Tsc-2 tumor suppressor gene.

2003 • 74 citations

Enhancement by histamine of vascular endothelial growth factor production in granulation tissue via H₂ receptors

2001 • 62 citations

Involvement of p38 MAP kinase in TGF‐β‐stimulated VEGF synthesis in aortic smooth muscle cells

2001 • 55 citations

Genetic and clinical aspects of familial renal neoplasms.

2000 • 53 citations

Analysis of the TSC1and TSC2genes in sporadic renal cell carcinomas

2001 • 48 citations

Loss of tuberin, the tuberous‐sclerosis‐complex‐2 gene product is associated with angiogenesis

2001 • 37 citations

Identification of the coding sequences responsible for Tsc2-mediated tumor suppression using a transgenic rat system

2002 • 34 citations

Molecular Genetics of Renal Carcinogenesis

1998 • 33 citations

Von Hippel–Lindau Disease

2013 • 24 citations

Stress‐activated protein kinase/c‐Jun N‐terminal kinase (JNK) plays a part in endothelin‐1‐induced vascular endothelial growth factor synthesis in osteoblasts

2002 • 17 citations

Atypical Protein Kinase Cs Are the Ras Effectors That Mediate Repression of Myogenic Satellite Cell Differentiation

2002 • 17 citations

Deleted Work

1955 • 0 citations