mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways

PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

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High Frequency of Mutations of the PIK3CA Gene in Human Cancers

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The Tumor Suppressor, PTEN/MMAC1, Dephosphorylates the Lipid Second Messenger, Phosphatidylinositol 3,4,5-Trisphosphate

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Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt

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Identification of the Tuberous Sclerosis Complex-2 Tumor Suppressor Gene Product Tuberin as a Target of the Phosphoinositide 3-Kinase/Akt Pathway

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Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics.

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PIK3CA is implicated as an oncogene in ovarian cancer

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Tuberous Sclerosis Complex Gene Products, Tuberin and Hamartin, Control mTOR Signaling by Acting as a GTPase-Activating Protein Complex toward Rheb

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Regulation of Hypoxia-Inducible Factor 1α Expression and Function by the Mammalian Target of Rapamycin

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Expression of the protooncogene bcl-2 in the prostate and its association with emergence of androgen-independent prostate cancer.

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Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR

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The Role of Apoptosis in Creating and Maintaining Luminal Space within Normal and Oncogene-Expressing Mammary Acini

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Tsc tumour suppressor proteins antagonize amino-acid–TOR signalling

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Akt Maintains Cell Size and Survival by Increasing mTOR-dependent Nutrient Uptake

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An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity inPten^+/−mice

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Forkhead Transcription Factors Are Critical Effectors of Cell Death and Cell Cycle Arrest Downstream of PTEN

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Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway

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A role of the kinase mTOR in cellular transformation induced by the oncoproteins P3k and Akt

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A phase I dose-finding study of combined treatment with an antisense Bcl-2 oligonucleotide (Genasense) and mitoxantrone in patients with metastatic hormone-refractory prostate cancer.

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Inhibitors of mammalian target of rapamycin as novel antitumor agents: from bench to clinic.

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PTEN Induces Chemosensitivity in PTEN-mutated Prostate Cancer Cells by Suppression of Bcl-2 Expression

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Phase I trial of BCL-2 antisense oligonucleotide (G3139) administered by continuous intravenous infusion in patients with advanced cancer.

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Akt activation disrupts mammary acinar architecture and enhances proliferation in an mTOR-dependent manner

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Mammalian Target of Rapamycin: A New Molecular Target for Breast Cancer

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mTOR as a Positive Regulator of Tumor Cell Responses to Hypoxia

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Early Clinical Experience With a Novel Rapamycin Derivative

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Phase I Clinical and Pharmacologic Study of 13-cis-Retinoic Acid, Interferon Alfa, and Paclitaxel in Patients With Prostate Cancer and Other Advanced Malignancies

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