Regulation of B-Raf Kinase Activity by Tuberin and Rheb Is Mammalian Target of Rapamycin (mTOR)-independent

Mutations of the BRAF gene in human cancer

2002 • 10,249 citations

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

2002 • 2,945 citations

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

2003 • 1,803 citations

Identification and characterization of the tuberous sclerosis gene on chromosome 16

1993 • 1,617 citations

Identification of the Tuberous Sclerosis Gene TSC1 on Chromosome 9q34

1997 • 1,613 citations

Tuberous Sclerosis Complex Gene Products, Tuberin and Hamartin, Control mTOR Signaling by Acting as a GTPase-Activating Protein Complex toward Rheb

2003 • 1,160 citations

Insulin Activation of Rheb, a Mediator of mTOR/S6K/4E-BP Signaling, Is Inhibited by TSC1 and 2

2003 • 1,015 citations

Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

2003 • 909 citations

Tsc tumour suppressor proteins antagonize amino-acid–TOR signalling

2002 • 654 citations

A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells

2002 • 652 citations

Rheb promotes cell growth as a component of the insulin/TOR signalling network

2003 • 648 citations

Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products

1998 • 566 citations

The Drosophila Tuberous Sclerosis Complex Gene Homologs Restrict Cell Growth and Cell Proliferation

2001 • 542 citations

TSC2 regulates VEGF through mTOR-dependent and -independent pathways

2003 • 521 citations

Drosophila Tsc1 Functions with Tsc2 to Antagonize Insulin Signaling in Regulating Cell Growth, Cell Proliferation, and Organ Size

2001 • 511 citations

Rheb is an essential regulator of S6K in controlling cell growth in Drosophila

2003 • 510 citations

Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR

2003 • 491 citations

Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR

2003 • 460 citations

Tuberin Regulates p70 S6 Kinase Activation and Ribosomal Protein S6 Phosphorylation

2002 • 422 citations

Rheb Binds Tuberous Sclerosis Complex 2 (TSC2) and Promotes S6 Kinase Activation in a Rapamycin- and Farnesylation-dependent Manner

2003 • 380 citations

Identification of Tuberin, the Tuberous Sclerosis-2 Product. TUBERIN POSSESSES SPECIFIC Rap1GAP ACTIVITY

1995 • 361 citations

The Tuberous Sclerosis 2 Gene Product, Tuberin, Functions as a Rab5 GTPase Activating Protein (GAP) in Modulating Endocytosis

1997 • 353 citations

The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho

2000 • 325 citations

MEK kinase activity is not necessary for Raf-1 function

2001 • 308 citations

rheb, a growth factor- and synaptic activity-regulated gene, encodes a novel Ras-related protein.

1994 • 294 citations

Endothelial apoptosis in Braf-deficient mice

1997 • 291 citations

Activated mammalian target of rapamycin pathway in the pathogenesis of tuberous sclerosis complex renal tumors.

2002 • 275 citations

gigas, a Drosophila Homolog of Tuberous Sclerosis Gene Product-2, Regulates the Cell Cycle

1999 • 257 citations

Hamartin, the product of the tuberous sclerosis 1 (TSC1) gene, interacts with tuberin and appears to be localized to cytoplasmic vesicles.

1998 • 247 citations

Activation of B-Raf kinase requires phosphorylation of the conserved residues Thr598 and Ser601

2000 • 239 citations

Survey of Somatic Mutations in Tuberous Sclerosis Complex (TSC) Hamartomas Suggests Different Genetic Mechanisms for Pathogenesis of TSC Lesions

2001 • 201 citations

Mutation in TSC2 and activation of mammalian target of rapamycin signalling pathway in renal angiomyolipoma

2003 • 195 citations

Role of the Tuberous Sclerosis Gene-2 Product in Cell Cycle Control

1997 • 195 citations

Lethality of Drosophila lacking TSC tumor suppressor function rescued by reducing dS6K signaling

2002 • 180 citations

The Ras-related Protein Rheb Is Farnesylated and Antagonizes Ras Signaling and Transformation

1997 • 178 citations

Rodent model of reproductive tract leiomyomata. Establishment and characterization of tumor-derived cell lines.

1995 • 169 citations

Dominant inhibitory Ras mutants selectively inhibit the activity of either cellular or oncogenic Ras.

1991 • 164 citations

Tuberin, the tuberous sclerosis complex 2 tumor suppressor gene product, regulates Rho activation, cell adhesion and migration

2002 • 152 citations

Tuber and subependymal giant cell astrocytoma associated with tuberous sclerosis: an immunohistochemical, ultrastructural, and immunoelectron microscopic study

1995 • 133 citations

The Saccharomyces cerevisiae Rheb G-protein Is Involved in Regulating Canavanine Resistance and Arginine Uptake

2000 • 130 citations

Rheb is in a high activation state and inhibits B-Raf kinase in mammalian cells

2002 • 128 citations

Tuberous Sclerosis Gene 2 Product Modulates Transcription Mediated by Steroid Hormone Receptor Family Members

1998 • 127 citations

The TSC1 gene product, hamartin, negatively regulates cell proliferation

2000 • 123 citations

Renal Angiomyolipomas from Patients with Sporadic Lymphangiomyomatosis Contain Both Neoplastic and Non-Neoplastic Vascular Structures

2003 • 112 citations

Determination of absolute amounts of GDP and GTP bound to Ras in mammalian cells: comparison of parental and Ras-overproducing NIH 3T3 fibroblasts.

1995 • 97 citations

14-3-3 interacts with the tumor suppressor tuberin at Akt phosphorylation site(s).

2002 • 89 citations

Rheb Interacts with Raf-1 Kinase and May Function To Integrate Growth Factor- and Protein Kinase A-Dependent Signals

1997 • 87 citations

ERK signalling and oncogene transformation are not impaired in cells lacking A-Raf

2002 • 61 citations