APPL1: role in adiponectin signaling and beyond

Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor

1999 • 6,443 citations

AKT/PKB Signaling: Navigating Downstream

2007 • 5,728 citations

The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

2001 • 4,874 citations

Paradoxical Decrease of an Adipose-Specific Protein, Adiponectin, in Obesity

1999 • 4,825 citations

Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase

2002 • 4,335 citations

Hypoadiponectinemia in Obesity and Type 2 Diabetes: Close Association with Insulin Resistance and Hyperinsulinemia

2001 • 3,408 citations

Anorexigenic and Orexigenic Hormone Modulation of Mammalian Target of Rapamycin Complex 1 Activity and the Regulation of Hypothalamic Agouti-Related Protein mRNA Expression

2012 • 3,329 citations

Rab proteins as membrane organizers

2001 • 3,320 citations

A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes

1995 • 3,159 citations

Plasma Concentrations of a Novel, Adipose-Specific Protein, Adiponectin, in Type 2 Diabetic Patients

2000 • 3,142 citations

Cloning of adiponectin receptors that mediate antidiabetic metabolic effects

2003 • 3,114 citations

Obesity and insulin resistance

2000 • 3,076 citations

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα

1997 • 2,747 citations

Cellular mechanisms of insulin resistance

2000 • 2,692 citations

Adiponectin and Adiponectin Receptors

2005 • 2,543 citations

The development of androgen-independent prostate cancer

2001 • 2,285 citations

AdipoQ Is a Novel Adipose-specific Gene Dysregulated in Obesity

1996 • 2,229 citations

Novel Modulator for Endothelial Adhesion Molecules

1999 • 2,168 citations

AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy

2007 • 2,144 citations

Neurotrophin signal transduction in the nervous system

2000 • 1,910 citations

Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice

2001 • 1,903 citations

Plasma Adiponectin Levels and Risk of Myocardial Infarction in Men

2004 • 1,794 citations

Insulin Resistance and a Diabetes Mellitus-Like Syndrome in Mice Lacking the Protein Kinase Akt2 (PKBβ)

2001 • 1,789 citations

Identification of a Chromosome 18q Gene that Is Altered in Colorectal Cancers

1990 • 1,747 citations

Adiponectin, an Adipocyte-Derived Plasma Protein, Inhibits Endothelial NF-κB Signaling Through a cAMP-Dependent Pathway

2000 • 1,711 citations

BAR Domains as Sensors of Membrane Curvature: The Amphiphysin BAR Structure

2003 • 1,660 citations

PPARγ Ligands Increase Expression and Plasma Concentrations of Adiponectin, an Adipose-Derived Protein

2001 • 1,659 citations

AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus

2004 • 1,610 citations

The PI3K–PDK1 connection: more than just a road to PKB

2000 • 1,563 citations

The p38 signal transduction pathway Activation and function

2000 • 1,560 citations

The glamour and gloom of glycogen synthase kinase-3

2004 • 1,490 citations

Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages

2000 • 1,438 citations

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

2000 • 1,431 citations

Association of Hypoadiponectinemia With Coronary Artery Disease in Men

2003 • 1,428 citations

PHOSPHOINOSITIDE KINASES

1998 • 1,321 citations

Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions

2007 • 1,305 citations

Obesity-associated improvements in metabolic profile through expansion of adipose tissue

2007 • 1,246 citations

AMP-Activated Protein Kinase in Metabolic Control and Insulin Signaling

2007 • 1,231 citations

Weight Reduction Increases Plasma Levels of an Adipose-Derived Anti-Inflammatory Protein, Adiponectin

2001 • 1,144 citations

Adiponectin and protection against type 2 diabetes mellitus

2003 • 1,130 citations

The AMP-activated protein kinase pathway – new players upstream and downstream

2004 • 1,129 citations

The TSC1-2 tumor suppressor controls insulin–PI3K signaling via regulation of IRS proteins

2004 • 1,101 citations

Circulating Concentrations of the Adipocyte Protein Adiponectin Are Decreased in Parallel With Reduced Insulin Sensitivity During the Progression to Type 2 Diabetes in Rhesus Monkeys

2001 • 1,091 citations

Protein Kinase B Kinases That Mediate Phosphatidylinositol 3,4,5-Trisphosphate-Dependent Activation of Protein Kinase B

1998 • 1,050 citations

Phosphatidylinositol 3′-kinase is activated by association with IRS-1 during insulin stimulation.

1992 • 1,030 citations

Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate

1988 • 1,027 citations

Deleted in Colorectal Cancer (DCC) Encodes a Netrin Receptor

1996 • 982 citations

Adiponectin Stimulates Production of Nitric Oxide in Vascular Endothelial Cells

2003 • 980 citations

Globular Adiponectin Protected ob/ob Mice from Diabetes and ApoE-deficient Mice from Atherosclerosis

2003 • 922 citations

Molecular Cloning of Human and Rat Complementary DNA Encoding Androgen Receptors

1988 • 908 citations

Advances in protein kinase B signalling: AKTion on multiple fronts

2004 • 828 citations

Role of Adiponectin in Preventing Vascular Stenosis

2002 • 811 citations

Adiponectin Stimulates AMP-Activated Protein Kinase in the Hypothalamus and Increases Food Intake

2007 • 794 citations

Phenotype of mice lacking functional Deleted in colorectal cancer (Dec) gene

1997 • 764 citations

Adiponectin Stimulates Angiogenesis by Promoting Cross-talk between AMP-activated Protein Kinase and Akt Signaling in Endothelial Cells

2004 • 744 citations

Trichostatin A and trapoxin: Novel chemical probes for the role of histone acetylation in chromatin structure and function

1995 • 719 citations

Cytokine Stimulation of Energy Expenditure through p38 MAP Kinase Activation of PPARγ Coactivator-1

2001 • 700 citations

Selective Suppression of Endothelial Cell Apoptosis by the High Molecular Weight Form of Adiponectin

2004 • 652 citations

APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function

2006 • 636 citations

Adiponectin promotes adipocyte differentiation, insulin sensitivity, and lipid accumulation

2005 • 626 citations

Phosphatidylinositol-3-OH kinases are Rab5 effectors

1999 • 625 citations

Adiponectin regulates albuminuria and podocyte function in mice

2008 • 597 citations

Association of Hypoadiponectinemia With Impaired Vasoreactivity

2003 • 590 citations

Mechanism of endophilin N-BAR domain-mediated membrane curvature

2006 • 582 citations

APPL Proteins Link Rab5 to Nuclear Signal Transduction via an Endosomal Compartment

2004 • 536 citations

Adiponectin Increases Fatty Acid Oxidation in Skeletal Muscle Cells by Sequential Activation of AMP-Activated Protein Kinase, p38 Mitogen-Activated Protein Kinase, and Peroxisome Proliferator–Activated Receptor α

2006 • 507 citations

Adiponectin and its receptors are expressed in bone-forming cells

2004 • 491 citations

IRS-1 activates phosphatidylinositol 3'-kinase by associating with src homology 2 domains of p85.

1992 • 471 citations

Adiponectin and cancer: a systematic review

2006 • 471 citations

The Lowe's oculocerebrorenal syndrome gene encodes a protein highly homologous to inositol polyphosphate-5-phosphatase

1992 • 464 citations

NGF Signaling in Sensory Neurons

2003 • 463 citations

Adipocytokines: leptin—the classical, resistin—the controversical, adiponectin—the promising, and more to come

2005 • 462 citations

Activation of the AMP-Activated Kinase by Antidiabetes Drug Metformin Stimulates Nitric Oxide Synthesis In Vivo by Promoting the Association of Heat Shock Protein 90 and Endothelial Nitric Oxide Synthase

2006 • 455 citations

Involvement of AMP-Activated Protein Kinase in Glucose Uptake Stimulated by the Globular Domain of Adiponectin in Primary Rat Adipocytes

2003 • 446 citations

Follicle-Stimulating Hormone (FSH) Stimulates Phosphorylation and Activation of Protein Kinase B (PKB/Akt) and Serum and Glucocorticoid-Induced Kinase (Sgk): Evidence for A Kinase-Independent Signaling by FSH in Granulosa Cells

2000 • 419 citations

The DCC gene product induces apoptosis by a mechanism requiring receptor proteolysis

1998 • 415 citations

Oocyte Apoptosis: Like Sand through an Hourglass

1999 • 397 citations

Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor

2001 • 397 citations

Nutrients Suppress Phosphatidylinositol 3-Kinase/Akt Signaling via Raptor-Dependent mTOR-Mediated Insulin Receptor Substrate 1 Phosphorylation

2005 • 395 citations

Decreased plasma adiponectin concentration in patients with essential hypertension

2003 • 394 citations

Adiponectin Replenishment Ameliorates Obesity-Related Hypertension

2006 • 389 citations

Adiponectin increases bone mass by suppressing osteoclast and activating osteoblast

2005 • 386 citations

NuRD and SIN3

2000 • 384 citations

Genomic structure and mutations in adipose-specific gene, adiponectin

2000 • 379 citations

Adiponectin and Future Coronary Heart Disease Events Among Men With Type 2 Diabetes

2005 • 378 citations

Endocytosis and Signaling

2001 • 377 citations

Insulin signaling through Akt/protein kinase B analyzed by small interfering RNA-mediated gene silencing

2003 • 375 citations

Structure and ligand recognition of the phosphotyrosine binding domain of Shc

1995 • 361 citations

Hypoadiponectinemia Is Associated with Impaired Endothelium-Dependent Vasodilation

2004 • 361 citations

PIE-1 is a bifunctional protein that regulates maternal and zygotic gene expression in the embryonic germ line of Caenorhabditis elegans

2001 • 360 citations

Adiponectin stimulates human osteoblasts proliferation and differentiation via the MAPK signaling pathway

2005 • 348 citations

Adiponectin is synthesized and secreted by human and murine cardiomyocytes

2005 • 342 citations

Globular adiponectin increases GLUT4 translocation and glucose uptake but reduces glycogen synthesis in rat skeletal muscle cells

2004 • 334 citations

The Endosomal Protein Appl1 Mediates Akt Substrate Specificity and Cell Survival in Vertebrate Development

2008 • 331 citations

Renal Insulin Resistance Syndrome, Adiponectin and Cardiovascular Events in Patients with Kidney Disease

2005 • 322 citations

Androgen Receptor: An Overview

1995 • 322 citations

GTPase activity of Rab5 acts as a timer for endocytic membrane fusion

1996 • 322 citations

Generation of Globular Fragment of Adiponectin by Leukocyte Elastase Secreted by Monocytic Cell Line THP-1

2004 • 318 citations

A Role for Protein Kinase Bβ/Akt2 in Insulin-Stimulated GLUT4 Translocation in Adipocytes

1999 • 316 citations

Adiponectin-Induced Endothelial Nitric Oxide Synthase Activation and Nitric Oxide Production Are Mediated by APPL1 in Endothelial Cells

2007 • 309 citations

Dent Disease with Mutations in OCRL1

2005 • 306 citations

Reduced Activation of Phosphatidylinositol-3 Kinase and Increased Serine 636 Phosphorylation of Insulin Receptor Substrate-1 in Primary Culture of Skeletal Muscle Cells From Patients With Type 2 Diabetes

2003 • 297 citations

Regulation of bone formation by adiponectin through autocrine/paracrine and endocrine pathways

2006 • 282 citations

The BAR‐domain family of proteins: a case of bending and binding?

2004 • 280 citations

Opposing Effects of Adiponectin Receptors 1 and 2 on Energy Metabolism

2007 • 273 citations

Expression of adiponectin receptors in pancreatic β cells

2003 • 266 citations

The physiological and pathophysiological role of adiponectin and adiponectin receptors in the peripheral tissues and CNS

2007 • 263 citations

A Role of the Lowe Syndrome Protein OCRL in Early Steps of the Endocytic Pathway

2007 • 262 citations

p38 Mitogen-activated Protein Kinase Activates Peroxisome Proliferator-activated Receptor α

2001 • 253 citations

Insulin Resistance Due to Phosphorylation of Insulin Receptor Substrate-1 at Serine 302

2004 • 248 citations

PTB Domain Binding to Signaling Proteins Through a Sequence Motif Containing Phosphotyrosine

1995 • 245 citations

Expression and Regulation of Adiponectin and Receptor in Human and Rat Placenta

2005 • 237 citations

Evidence in Support of Signaling Endosome-Based Retrograde Survival of Sympathetic Neurons

2003 • 233 citations

Bar domain proteins: a role in tubulation, scission and actin assembly in clathrin-mediated endocytosis

2006 • 231 citations

The DCC Gene: Structural Analysis and Mutations in Colorectal Carcinomas

1994 • 224 citations

Pleckstrin homology domains: not just for phosphoinositides

2004 • 224 citations

Signaling on the Endocytic Pathway

2001 • 215 citations

Regulation of Pituitary Cell Function by Adiponectin

2006 • 212 citations

The SH2 domain: versatile signaling module and pharmaceutical target

2004 • 212 citations

Adiponectin Sensitizes Insulin Signaling by Reducing p70 S6 Kinase-mediated Serine Phosphorylation of IRS-1

2007 • 210 citations

Globular adiponectin upregulates nitric oxide production in vascular endothelial cells

2003 • 206 citations

Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2

1999 • 204 citations

The dependence receptor DCC (deleted in colorectal cancer) defines an alternative mechanism for caspase activation

2001 • 202 citations

The BAR Domain Proteins: Molding Membranes in Fission, Fusion, and Phagy

2006 • 201 citations

AMP-activated protein kinase: balancing the scales

2004 • 197 citations

Myo6 Facilitates the Translocation of Endocytic Vesicles from Cell Peripheries

2003 • 191 citations

Signaling endosome hypothesis: A cellular mechanism for long distance communication

2003 • 188 citations

Membrane Curvature: How BAR Domains Bend Bilayers

2004 • 188 citations

Polymorphisms in the gene encoding adiponectin receptor 1 are associated with insulin resistance and high liver fat

2005 • 187 citations

Comparison of Circulating Adiponectin and Proinflammatory Markers Regarding Their Association With Metabolic Syndrome in Japanese Men

2006 • 175 citations

NGF and Neurotrophin-3 Both Activate TrkA on Sympathetic Neurons but Differentially Regulate Survival and Neuritogenesis

1997 • 173 citations

Lowe Syndrome Protein OCRL1 Interacts with Clathrin and Regulates Protein Trafficking between Endosomes and the Trans-Golgi Network

2005 • 173 citations

Adiponectin and AMP kinase activator stimulate proliferation, differentiation, and mineralization of osteoblastic MC3T3-E1 cells

2007 • 168 citations

Adiponectin is expressed by skeletal muscle fibers and influences muscle phenotype and function

2008 • 158 citations

AdipoR1 mediates the anorexigenic and insulin/leptin‐like actions of adiponectin in the hypothalamus

2008 • 157 citations

PDK2: the missing piece in the receptor tyrosine kinase signaling pathway puzzle

2005 • 157 citations

GIPC and GAIP Form a Complex with TrkA: A Putative Link between G Protein and Receptor Tyrosine Kinase Pathways

2001 • 153 citations

BAR domains and membrane curvature: bringing your curves to the BAR.

2005 • 153 citations

Membrane targeting and activation of the Lowe syndrome protein OCRL1 by rab GTPases

2006 • 149 citations

Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages

2000 • 147 citations

Increased plasma concentrations of interleukin-18 in acute coronary syndromes

2002 • 146 citations

Pincher-Mediated Macroendocytosis Underlies Retrograde Signaling by Neurotrophin Receptors

2005 • 145 citations

Improved Glucose Tolerance Restores Insulin-Stimulated Akt Kinase Activity and Glucose Transport in Skeletal Muscle From Diabetic Goto-Kakizaki Rats

1997 • 138 citations

APPL1 Associates with TrkA and GIPC1 and Is Required for Nerve Growth Factor-Mediated Signal Transduction

2006 • 137 citations

Effect of Phosphoinositide-Dependent Kinase 1 on Protein Kinase B Translocation and Its Subsequent Activation

2000 • 137 citations

Adiponectin Blocks Interleukin-18-mediated Endothelial Cell Death via APPL1-dependent AMP-activated Protein Kinase (AMPK) Activation and IKK/NF-κB/PTEN Suppression

2008 • 133 citations

GIPC Is Recruited by APPL to Peripheral TrkA Endosomes and Regulates TrkA Trafficking and Signaling

2006 • 132 citations

Organization of the gene for gelatin-binding protein (GBP28)

1999 • 128 citations

The inositol polyphosphate 5-phosphatase Ocrl associates with endosomes that are partially coated with clathrin

2004 • 127 citations

The Interaction of Akt with APPL1 Is Required for Insulin-stimulated Glut4 Translocation

2007 • 125 citations

Structure of the APPL1 BAR-PH domain and characterization of its interaction with Rab5

2007 • 125 citations

Association of adiponectin with adverse outcome in coronary artery disease patients: results from the AtheroGene study

2008 • 123 citations

Molecular recognition by SH2 domains

2002 • 122 citations

Insulin can regulate GLUT4 internalization by signaling to Rab5 and the motor protein dynein

2001 • 121 citations

Mediation of the DCC Apoptotic Signal by DIP13α

2002 • 114 citations

Stimulated HSP90 binding to eNOS and activation of the PI3–Akt pathway contribute to globular adiponectin-induced NO production: Vasorelaxation in response to globular adiponectin

2005 • 114 citations

Deficiency of Adiponectin Receptor 2 Reduces Diet-Induced Insulin Resistance but Promotes Type 2 Diabetes

2006 • 110 citations

Endothelial nitric oxide synthase and endothelial dysfunction

2003 • 109 citations

Human Follicle-Stimulating Hormone (FSH) Receptor Interacts with the Adaptor Protein APPL1 in HEK 293 Cells: Potential Involvement of the PI3K Pathway in FSH Signaling1

2004 • 100 citations

Genetic Variation in Adiponectin Receptor 1 and Adiponectin Receptor 2 Is Associated With Type 2 Diabetes in the Old Order Amish

2005 • 98 citations

Adiponectin: Protection of the endothelium

2005 • 91 citations

APPL1, APPL2, Akt2 and FOXO1a interact with FSHR in a potential signaling complex

2006 • 89 citations

Activating AMP-Activated Protein Kinase without AMP

2005 • 87 citations

Induction of adiponectin in skeletal muscle of type 2 diabetic mice: in vivo and in vitro studies

2006 • 85 citations

Adiponectin inhibits induction of TNF‐α/RANKL‐stimulated NFATc1 via the AMPK signaling

2008 • 83 citations

GAIP, GIPC and Gαi3 are Concentrated in Endocytic Compartments of Proximal Tubule Cells

2002 • 77 citations

The Crystal Structure of the BAR Domain from Human Bin1/Amphiphysin II and Its Implications for Molecular Recognition

2006 • 74 citations

Genetic Analysis of ADIPOR1 and ADIPOR2 Candidate Polymorphisms for Type 2 Diabetes in the Caucasian Population

2006 • 74 citations

Follicle-Stimulating Hormone Activates Mitogen-Activated Protein Kinase in Preneoplastic and Neoplastic Ovarian Surface Epithelial Cells

2002 • 72 citations

Induction of apoptosis and G2/M cell cycle arrest by DCC

1999 • 72 citations

Chromosomal Localization, Expression Pattern, and Promoter Analysis of the Mouse Gene Encoding Adipocyte-Specific Secretory Protein Acrp30

2001 • 71 citations

Biomolecular motors: the F1-ATPase paradigm

2004 • 69 citations

Crystal Structures of the BAR-PH and PTB Domains of Human APPL1

2007 • 67 citations

Angiotensin II‐induced apoptosis in human endothelial cells is inhibited by adiponectin through restoration of the association between endothelial nitric oxide synthase and heat shock protein 90

2004 • 66 citations

Insulin-stimulated Interaction between Insulin Receptor Substrate 1 and p85α and Activation of Protein Kinase B/Akt Require Rab5

2006 • 66 citations

OCRL1 mutation analysis in French Lowe syndrome patients: Implications for molecular diagnosis strategy and genetic counseling

2000 • 65 citations

Serum leptin and adiponectin are positively associated with bone mineral density at the distal radius in patients with type 2 diabetes mellitus

2007 • 63 citations

ADIPOCYTOKINES: LEPTIN-THE CLASSICAL, RESISTIN-THE CONTROVERSIAL, ADIPONECTIN- THE PROMISING, AND MORE TO COME

2005 • 59 citations

APPL Suppresses Androgen Receptor Transactivation via Potentiating Akt Activity

2003 • 58 citations

Adiponectin and Adiponectin Receptors in Obesity‐Linked Insulin Resistance

2007 • 52 citations

Expression of the adiponectin receptors AdipoR1 and AdipoR2 in lean rats and in obese Zucker rats

2006 • 51 citations

Functional consequences of progressive cone dystrophy-associated mutations in the human cone photoreceptor cyclic nucleotide-gated channel CNGA3 subunit

2005 • 50 citations

Membrane Targeting by APPL1 and APPL2: Dynamic Scaffolds that Oligomerize and Bind Phosphoinositides

2007 • 50 citations

A Polymorphism in the AMPKα2 Subunit Gene Is Associated With Insulin Resistance and Type 2 Diabetes in the Japanese Population

2006 • 49 citations

Interleukin-18 and Macrophage Migration Inhibitory Factor Are Associated With Increased Carotid Intima–Media Thickening

2005 • 43 citations

Differential regulation of testosterone vs. 5alpha-dihydrotestosterone by selective androgen response elements.

2000 • 34 citations

Translocation and activation of AKT2 in response to stimulation by insulin.

1998 • 28 citations

Translocation and activation of AKT2 in response to stimulation by insulin

1998 • 26 citations

Glucose and lipid metabolism in relation to novel polymorphisms in the 5′-AMP-activated protein kinase γ2 gene in Chinese

2005 • 13 citations

[Association of variants in APPL1 gene with body fat and its distribution in Chinese patients with type 2 diabetic mellitus].

2008 • 10 citations

Genetic variation within the APPL locus is not associated with metabolic or inflammatory traits in a healthy White population

2007 • 4 citations