Cytokine Stimulation of Energy Expenditure through p38 MAP Kinase Activation of PPARγ Coactivator-1

Mammalian MAP kinase signalling cascades

2001 • 5,041 citations

Signal Transduction by the JNK Group of MAP Kinases

2000 • 4,096 citations

Mechanisms Controlling Mitochondrial Biogenesis and Respiration through the Thermogenic Coactivator PGC-1

1999 • 3,923 citations

A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis

1998 • 3,700 citations

Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia

1987 • 2,492 citations

Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine

1995 • 2,238 citations

DNA Damage-Induced Phosphorylation of p53 Alleviates Inhibition by MDM2

1997 • 2,089 citations

MKK3- and MKK6-Regulated Gene Expression Is Mediated by the p38 Mitogen-Activated Protein Kinase Signal Transduction Pathway

1996 • 1,286 citations

Peroxisome proliferator–activated receptor γ coactivator-1 promotes cardiac mitochondrial biogenesis

2000 • 1,228 citations

A Muscle-Specific Insulin Receptor Knockout Exhibits Features of the Metabolic Syndrome of NIDDM without Altering Glucose Tolerance

1998 • 1,173 citations

How NF-κB is activated: the role of the IκB kinase (IKK) complex

1999 • 1,133 citations

The Coactivator PGC-1 Cooperates with Peroxisome Proliferator-Activated Receptor α in Transcriptional Control of Nuclear Genes Encoding Mitochondrial Fatty Acid Oxidation Enzymes

2000 • 1,125 citations

Stress-Induced Phosphorylation and Activation of the Transcription Factor CHOP (GADD153) by p38 MAP Kinase

1996 • 893 citations

NF-κB-Induced Loss of MyoD Messenger RNA: Possible Role in Muscle Decay and Cachexia

2000 • 889 citations

Tumor Necrosis Factor, Other Cytokines and Disease

1993 • 788 citations

Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation

1997 • 770 citations

Energy Metabolism in Uncoupling Protein 3 Gene Knockout Mice

2000 • 679 citations

Restoration of insulin-sensitive glucose transporter (GLUT4) gene expression in muscle cells by the transcriptional coactivator PGC-1

2001 • 642 citations

Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean

2000 • 615 citations

Activation of PPARγ Coactivator-1 Through Transcription Factor Docking

1999 • 584 citations

A motif-based profile scanning approach for genome-wide prediction of signaling pathways

2001 • 517 citations

Multiple signals converging on NF-κB

1999 • 483 citations

Requirement for p38α in Erythropoietin Expression

2000 • 343 citations

Contribution of mitochondrial proton leak to skeletal muscle respiration and to standard metabolic rate

1996 • 321 citations

MEF2: a transcriptional target for signaling pathways controlling skeletal muscle growth and differentiation

1999 • 313 citations

A Tissue-Specific Coactivator of Steroid Receptors, Identified in a Functional Genetic Screen

2000 • 293 citations

Damage-mediated Phosphorylation of Human p53 Threonine 18 through a Cascade Mediated by a Casein 1-like Kinase

2000 • 285 citations

Effect of endotoxin-induced monokines on glucose metabolism in the muscle cell line L6.

1987 • 135 citations

Seismic image of the subducted trailing fragments of the Farallon plate

1997 • 135 citations

The MEF2A Isoform Is Required for Striated Muscle-specific Expression of the Insulin-responsive GLUT4 Glucose Transporter

2000 • 115 citations

The cancer anorexia-cachexia syndrome.

2000 • 99 citations

Peroxisome proliferator-activated receptor gamma and the control of adipogenesis

1997 • 91 citations

Cachectin/TNF-mediated lactate production in cultured myocytes is linked to activation of a futile substrate cycle

1993 • 61 citations

The syndrome of anorexia-cachexia

1999 • 51 citations

Disordered Metabolic Response with Cancer and Its Management

2000 • 46 citations

Thwarting the dwindling progression of cachexia

1998 • 44 citations

Exercise and the treatment of wasting: aging and human immunodeficiency virus infection.

1998 • 39 citations

Thermogenic response to glucagon in cold-acclimated mice.

1982 • 21 citations