Structure of the APPL1 BAR-PH domain and characterization of its interaction with Rab5

BAR Domains as Sensors of Membrane Curvature: The Amphiphysin BAR Structure

2003 • 1,660 citations

APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function

2006 • 636 citations

Generation of high curvature membranes mediated by direct endophilin bilayer interactions

2001 • 589 citations

Mechanism of endophilin N-BAR domain-mediated membrane curvature

2006 • 582 citations

APPL Proteins Link Rab5 to Nuclear Signal Transduction via an Endosomal Compartment

2004 • 536 citations

The mammalian Rab family of small GTPases: definition of family and subfamily sequence motifs suggests a mechanism for functional specificity in the Ras superfamily 1 1Edited by M. Yaniv

2000 • 446 citations

Sorting Nexin-1 Mediates Tubular Endosome-to-TGN Transport through Coincidence Sensing of High- Curvature Membranes and 3-Phosphoinositides

2004 • 446 citations

BIN1 is a novel MYC–interacting protein with features of a tumour suppressor

1996 • 358 citations

Structural Basis of Rab Effector Specificity

1999 • 347 citations

PLECKSTRIN HOMOLOGY DOMAINS: A Common Fold with Diverse Functions

1998 • 289 citations

The BAR‐domain family of proteins: a case of bending and binding?

2004 • 280 citations

The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways

2001 • 251 citations

Structural basis of family-wide Rab GTPase recognition by rabenosyn-5

2005 • 236 citations

Pleckstrin homology domains: not just for phosphoinositides

2004 • 224 citations

A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange

2002 • 221 citations

Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2

1999 • 204 citations

The small GTPase Rab22 interacts with EEA1 and controls endosomal membrane trafficking

2002 • 148 citations

Membrane and juxtamembrane targeting by PH and PTB domains

2006 • 148 citations

Exo84 and Sec5 are competitive regulatory Sec6/8 effectors to the RalA GTPase

2005 • 143 citations

Structural basis for recruitment of RILP by small GTPase Rab7

2005 • 143 citations

APPL1 Associates with TrkA and GIPC1 and Is Required for Nerve Growth Factor-Mediated Signal Transduction

2006 • 137 citations

GIPC Is Recruited by APPL to Peripheral TrkA Endosomes and Regulates TrkA Trafficking and Signaling

2006 • 132 citations

PH domain of ELMO functions in trans to regulate Rac activation via Dock180

2004 • 130 citations

Structural basis of Rab5-Rabaptin5 interaction in endocytosis

2004 • 125 citations

Mediation of the DCC Apoptotic Signal by DIP13α

2002 • 114 citations

Structural Plasticity of an Invariant Hydrophobic Triad in the Switch Regions of Rab GTPases Is a Determinant of Effector Recognition

2001 • 102 citations

APPL1, APPL2, Akt2 and FOXO1a interact with FSHR in a potential signaling complex

2006 • 89 citations

Multifunctional Roles for the PH Domain of Dbs in Regulating Rho GTPase Activation

2003 • 84 citations

High Resolution Crystal Structures of Human Rab5a and Five Mutants with Substitutions in the Catalytically Important Phosphate-binding Loop

2003 • 61 citations

The Interaction of the Human GGA1 GAT Domain with Rabaptin-5 Is Mediated by Residues on Its Three-Helix Bundle

2003 • 22 citations

Molecular Dissection of Rab11 Binding from Coiled-Coil Formation in the Rab11-FIP2 C-Terminal Domain

2006 • 20 citations

Rab5 GTPase and endocytosis.

1996 • 16 citations