Conservation and divergence of axon guidance mechanisms

Mutations affecting segment number and polarity in Drosophila

1980 • 4,280 citations

The Molecular Biology of Axon Guidance

1996 • 3,246 citations

Neuropilin-1 Is Expressed by Endothelial and Tumor Cells as an Isoform-Specific Receptor for Vascular Endothelial Growth Factor

1998 • 2,440 citations

Histologie du système nerveux de l'homme & des vertébrés

1909 • 2,282 citations

Netrin-1 Is Required for Commissural Axon Guidance in the Developing Vertebrate Nervous System

1996 • 1,253 citations

Slit Proteins Bind Robo Receptors and Have an Evolutionarily Conserved Role in Repulsive Axon Guidance

1999 • 1,155 citations

Plexins Are a Large Family of Receptors for Transmembrane, Secreted, and GPI-Anchored Semaphorins in Vertebrates

1999 • 1,118 citations

THE EPHRINS AND EPH RECEPTORS IN NEURAL DEVELOPMENT

1998 • 1,082 citations

Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis

1999 • 1,019 citations

Slit Is the Midline Repellent for the Robo Receptor in Drosophila

1999 • 930 citations

The unc-5, unc-6, and unc-40 genes guide circumferential migrations of pioneer axons and mesodermal cells on the epidermis in C. elegans

1990 • 909 citations

Roundabout Controls Axon Crossing of the CNS Midline and Defines a Novel Subfamily of Evolutionarily Conserved Guidance Receptors

1998 • 882 citations

In vitro guidance of retinal ganglion cell axons by RAGS, a 25 kDa tectal protein related to ligands for Eph receptor tyrosine kinases

1995 • 849 citations

Plexin-Neuropilin-1 Complexes Form Functional Semaphorin-3A Receptors

1999 • 803 citations

Early Animal Evolution: Emerging Views from Comparative Biology and Geology

1999 • 803 citations

Phenotype of mice lacking functional Deleted in colorectal cancer (Dec) gene

1997 • 764 citations

RETRACTED: A Ligand-Gated Association between Cytoplasmic Domains of UNC5 and DCC Family Receptors Converts Netrin-Induced Growth Cone Attraction to Repulsion

1999 • 686 citations

Mutations affecting growth cone guidance in drosophila: Genes necessary for guidance toward or away from the midline

1993 • 677 citations

Neuropilin-2, a Novel Member of the Neuropilin Family, Is a High Affinity Receptor for the Semaphorins Sema E and Sema IV but Not Sema III

1997 • 650 citations

Directional guidance of neuronal migration in the olfactory system by the protein Slit

1999 • 517 citations

Disruption of Semaphorin III/D Gene Causes Severe Abnormality in Peripheral Nerve Projection

1997 • 517 citations

Vertebrate homologues of C. elegans UNC-5 are candidate netrin receptors

1997 • 511 citations

slit: an extracellular protein necessary for development of midline glia and commissural axon pathways contains both EGF and LRR domains.

1990 • 499 citations

NEURAL CELL ADHESION MOLECULES OF THE IMMUNOGLOBULIN SUPERFAMILY: Role in Axon Growth and Guidance

1997 • 473 citations

Neuropilin-1 Mediates Collapsin-1/Semaphorin III Inhibition of Endothelial Cell Motility

1999 • 469 citations

Biochemical Purification of a Mammalian Slit Protein as a Positive Regulator of Sensory Axon Elongation and Branching

1999 • 464 citations

Genetic Analysis of Netrin Genes in Drosophila: Netrins Guide CNS Commissural Axons and Peripheral Motor Axons

1996 • 459 citations

Plexin A Is a Neuronal Semaphorin Receptor that Controls Axon Guidance

1998 • 456 citations

PDZ Proteins Bind, Cluster, and Synaptically Colocalize with Eph Receptors and Their Ephrin Ligands

1998 • 455 citations

The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains.

1996 • 452 citations

Eph receptors and ephrins: effectors of morphogenesis

1999 • 445 citations

Vertebrate Slit, a Secreted Ligand for the Transmembrane Protein Roundabout, Is a Repellent for Olfactory Bulb Axons

1999 • 444 citations

Netrin-1 and DCC Mediate Axon Guidance Locally at the Optic Disc: Loss of Function Leads to Optic Nerve Hypoplasia

1997 • 434 citations

In vivo cell sorting in complementary segmental domains mediated by Eph receptors and ephrins

1999 • 431 citations

Mena Is Required for Neurulation and Commissure Formation

1999 • 415 citations

Hepatocyte Growth Factor/Scatter Factor Is an Axonal Chemoattractant and a Neurotrophic Factor for Spinal Motor Neurons

1996 • 403 citations

The mouse rostral cerebellar malformation gene encodes an UNC-5-like protein

1997 • 372 citations

Neuroglia and Pioneer Neurons Express UNC-6 to Provide Global and Local Netrin Cues for Guiding Migrations in C. elegans

1996 • 359 citations

Neuropilin-2 Is a Receptor for Semaphorin IV Insight into the Structural Basis of Receptor Function and Specificity

1998 • 352 citations

EphrinB Ligands Recruit GRIP Family PDZ Adaptor Proteins into Raft Membrane Microdomains

1999 • 345 citations

Eph receptors and ephrins in neural development

1999 • 330 citations

UNC-73 Activates the Rac GTPase and Is Required for Cell and Growth Cone Migrations in C. elegans

1998 • 319 citations

Dosage-Sensitive and Complementary Functions of Roundabout and Commissureless Control Axon Crossing of the CNS Midline

1998 • 300 citations

The Tyrosine Kinase Abl and Its Substrate Enabled Collaborate with the Receptor Phosphatase Dlar to Control Motor Axon Guidance

1999 • 296 citations

Pak Functions Downstream of Dock to Regulate Photoreceptor Axon Guidance in Drosophila

1999 • 289 citations

Slit2-Mediated Chemorepulsion and Collapse of Developing Forebrain Axons

1999 • 280 citations

The Conserved Immunoglobulin Superfamily Member SAX-3/Robo Directs Multiple Aspects of Axon Guidance in C. elegans

1998 • 280 citations

Semaphorin–Neuropilin Interactions Underlying Sympathetic Axon Responses to Class III Semaphorins

1998 • 279 citations

Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells

1997 • 276 citations

Neuropilin-1 Extracellular Domains Mediate Semaphorin D/III-Induced Growth Cone Collapse

1998 • 269 citations

Genetic Analysis of the Mechanisms Controlling Target Selection: Complementary and Combinatorial Functions of Netrins, Semaphorins, and IgCAMs

1998 • 256 citations

Comparison of early nerve cord development in insects and vertebrates

1999 • 254 citations

The VAB-1 Eph Receptor Tyrosine Kinase Functions in Neural and Epithelial Morphogenesis in C. elegans

1998 • 254 citations

Chemorepulsion of Neuronal Migration by Slit2 in the Developing Mammalian Forebrain

1999 • 250 citations

Drosophila Photoreceptor Axon Guidance and Targeting Requires the Dreadlocks SH2/SH3 Adapter Protein

1996 • 248 citations

The Carboxyl Terminus of B Class Ephrins Constitutes a PDZ Domain Binding Motif

1999 • 244 citations

Cellular and Molecular Guidance of GABAergic Neuronal Migration from an Extracortical Origin to the Neocortex

1999 • 243 citations

Hepatocyte growth factor, a versatile signal for developing neurons

1999 • 235 citations

A Poxvirus-Encoded Semaphorin Induces Cytokine Production from Monocytes and Binds to a Novel Cellular Semaphorin Receptor, VESPR

1998 • 234 citations

Semaphorins A and E act as antagonists of neuropilin-1 and agonists of neuropilin-2 receptors

1998 • 232 citations

Surface densities of ephrin-B1 determine EphB1-coupled activation of cell attachment through alpha vbeta 3 and alpha 5beta 1 integrins

1999 • 202 citations

Profilin and the Abl Tyrosine Kinase Are Required for Motor Axon Outgrowth in the Drosophila Embryo

1999 • 199 citations

Chimeric Axon Guidance Receptors

1999 • 190 citations

An FGF receptor signaling pathway is required for the normal cell migrations of the sex myoblasts in C. elegans hermaphrodites

1995 • 183 citations

Floor Plate and Netrin-1 Are Involved in the Migration and Survival of Inferior Olivary Neurons

1999 • 182 citations

Control of neuronal pathway selection by a Drosophila receptor protein-tyrosine kinase family member

1995 • 179 citations

The Transmembrane Semaphorin Sema I Is Required in Drosophila for Embryonic Motor and CNS Axon Guidance

1998 • 176 citations

Suppressors of Ectopic UNC-5 Growth Cone Steering Identify Eight Genes Involved in Axon Guidance inCaenorhabditis elegans

1998 • 175 citations

Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system

1998 • 174 citations

Identification of High-Molecular-Weight Proteins with Multiple EGF-like Motifs by Motif-Trap Screening

1998 • 172 citations

Genes required for axon pathfinding and extension in the C. elegans nerve ring

1999 • 166 citations

Eukaryote genome duplication - where's the evidence?

1998 • 163 citations

Neuroendocrine dysplasia in mice lacking protein tyrosine phosphatase σ

1999 • 158 citations

Nck Recruitment to Eph Receptor, EphB1/ELK, Couples Ligand Activation to c-Jun Kinase

1998 • 151 citations

Distinct but overlapping expression patterns of two vertebrate slit homologs implies functional roles in CNS development and organogenesis

1998 • 149 citations

Competition and cooperation among receptor tyrosine phosphatases control motoneuron growth cone guidance in Drosophila

1997 • 147 citations

Signaling by Eph receptors and their ephrin ligands

1998 • 147 citations

Genetic analysis of protein tyrosine phosphatases

1998 • 145 citations

Multiple Roles for Hepatocyte Growth Factor in Sympathetic Neuron Development

1998 • 143 citations

Netrin-3, a Mouse Homolog of Human NTN2L, Is Highly Expressed in Sensory Ganglia and Shows Differential Binding to Netrin Receptors

1999 • 140 citations

Axon guidance at choice points

1998 • 136 citations

Neuronal defects and posterior pituitary hypoplasia in mice lacking the receptor tyrosine phosphatase PTPσ

1999 • 135 citations

The Laminin–Nidogen Complex is a Ligand for a Specific Splice Isoform of the Transmembrane Protein Tyrosine Phosphatase LAR

1998 • 134 citations

The Drosophila beaten path Gene Encodes a Novel Secreted Protein That Regulates Defasciculation at Motor Axon Choice Points

1996 • 134 citations

Axon repulsion from the midline of the Drosophila CNS requires slit function

1999 • 132 citations

Embryonic phenotype of Unc5h3 mutant mice suggests chemorepulsion during the formation of the rostral cerebellar boundary

1998 • 124 citations

Cloning and Functional Studies of a Novel Gene Aberrantly Expressed in RB-Deficient Embryos

1999 • 120 citations

Deficient LAR expression decreases basal forebrain cholinergic neuronal size and hippocampal cholinergic innervation

1997 • 114 citations

clr-1 encodes a receptor tyrosine phosphatase that negatively regulates an FGF receptor signaling pathway in Caenorhabditis elegans

1998 • 104 citations

Extensive Gene Duplication in the Early Evolution of Animals Before the Parazoan–Eumetazoan Split Demonstrated by G Proteins and Protein Tyrosine Kinases from Sponge and Hydra

1999 • 99 citations

Functions of netrins and semaphorins in axon guidance

1996 • 98 citations

Netrin-1: interaction with deleted in colorectal cancer (DCC) and alterations in brain tumors and neuroblastomas.

1999 • 90 citations

Protein tyrosine phosphatases and neural development

1998 • 83 citations

Surround Repulsion of Spinal Sensory Axons in Higher Vertebrate Embryos

1997 • 82 citations

Autocrine Hepatocyte Growth Factor Provides a Local Mechanism for Promoting Axonal Growth

1998 • 81 citations

vab-8 Is a Key Regulator of Posteriorly Directed Migrations in C. elegans and Encodes a Novel Protein with Kinesin Motor Similarity

1998 • 76 citations

Tyrosine phosphorylation and axon guidance: of mice and flies

1997 • 73 citations

The C. elegans gene vab-8 guides posteriorly directed axon outgrowth and cell migration

1996 • 72 citations

Mesectodermal cell fate analysis in Drosophila midline mutants

1994 • 70 citations

Neuronal growth cone collapse triggers lateral extensions along trailing axons

1999 • 69 citations

Isolation and Characterization of Dek, a Drosophila Eph Receptor Protein Tyrosine Kinase

1999 • 60 citations

TheNTN2LGene Encoding a Novel Human Netrin Maps to the Autosomal Dominant Polycystic Kidney Disease Region on Chromosome 16p13.3

1997 • 54 citations

Multiple Protein Tyrosine Phosphatases in Sponges and Explosive Gene Duplication in the Early Evolution of Animals Before the Parazoan–Eumetazoan Split

1999 • 44 citations

Divergent properties of mouse netrins

1999 • 35 citations

The Netrin receptor Frazzled is required in the target for establishment of retinal projections in the Drosophila visual system

1999 • 28 citations