Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system

A statistical method for evaluating systematic relationships

1958 • 4,429 citations

Rapid and Sensitive Protein Similarity Searches

1985 • 4,091 citations

DEVELOPMENT IN DROSOPHILA MELANOGASTER

1927 • 2,909 citations

2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans

1994 • 1,472 citations

Notch Signaling

1995 • 1,282 citations

Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1

1997 • 1,239 citations

The I.M.A.G.E. Consortium: An Integrated Molecular Analysis of Genomes and Their Expression

1996 • 1,132 citations

The Discoidin Domain Receptor Tyrosine Kinases Are Activated by Collagen

1997 • 956 citations

Nested expression domains of four homeobox genes in developing rostral brain

1992 • 794 citations

A structural basis of the interactions between leucine-rich repeats and protein ligands

1995 • 726 citations

The Drosophila single-minded gene encodes a helix-loop-helix protein that acts as a master regulator of CNS midline development

1991 • 501 citations

slit: an extracellular protein necessary for development of midline glia and commissural axon pathways contains both EGF and LRR domains.

1990 • 499 citations

The midline of the drosophila central nervous system: A model for the genetic analysis of cell fate, cell migration, and growth cone guidance

1991 • 497 citations

The Family of the Small Leucine-Rich Proteoglycans: Key Regulators of Matrix Assembly and Cellular Growth

1997 • 491 citations

A strategy for the rapid multiple alignment of protein sequences

1987 • 482 citations

The structure of a Ca2+-binding epidermal growth factor-like domain: Its role in protein-protein interactions

1995 • 340 citations

Structural and functional diversity in the leucine-rich repeat family of proteins

1996 • 311 citations

Otx1 and Otx2 define layers and regions in developing cerebral cortex and cerebellum

1994 • 310 citations

Epilepsy and brain abnormalities in mice lacking the Otx1 gene

1996 • 285 citations

slit: An EGF-homologous locus of D. melanogaster involved in the development of the embryonic central nervous system

1988 • 281 citations

Turning of Retinal Growth Cones in a Netrin-1 Gradient Mediated by the Netrin Receptor DCC

1997 • 280 citations

Developmental defects in brain segmentation caused by mutations of the homeobox genes orthodenticle and empty spiracles in Drosophila

1995 • 205 citations

A novel modular mosaic of cell adhesion motifs in the extracellular domains of the neurogenic trk and trkB tyrosine kinase receptors.

1991 • 193 citations

Two New Members of the Murine Sim Gene Family Are Transcriptional Repressors and Show Different Expression Patterns during Mouse Embryogenesis

1996 • 160 citations

Determination of residues important in hormone binding to the extracellular domain of the luteinizing hormone/chorionic gonadotropin receptor by site-directed mutagenesis and modeling.

1996 • 132 citations

Characterization of Star and its interactions with sevenless and EGF receptor during photoreceptor cell development in Drosophila

1994 • 123 citations

Sequential activation of the EGF receptor pathway during Drosophila oogenesis establishes the dorsoventral axis

1998 • 112 citations

Mutations that affect the length, fasciculation, or ventral orientation of specific sensory axons in the Drosophila embryo

1995 • 96 citations

Down syndrome-critical region contains a gene homologous to Drosophila sim expressed during rat and human central nervous system development.

1995 • 92 citations

Porcine Submaxillary Mucin Forms Disulfide-bonded Dimers between Its Carboxyl-terminal Domains

1996 • 74 citations

Modularity of the slit protein

1992 • 70 citations

Mesectodermal cell fate analysis in Drosophila midline mutants

1994 • 70 citations

Argos and Spitz group genes function to regulate midline glial cell number in Drosophila embryos

1997 • 64 citations

Determination of residues important in hormone binding to the extracellular domain of the luteinizing hormone/chorionic gonadotropin receptor by site-directed mutagenesis and modeling

1996 • 52 citations

Testing the Agrin Hypothesis

1996 • 48 citations

CNS midline to mesoderm signaling in Drosophila

1997 • 27 citations

Why Does the Growth Cone Cross the Road?

1998 • 11 citations

CNS midline development in Drosophila.

1997 • 9 citations

Deleted Work

1955 • 0 citations