A role for the architectural transcription factors HMGI(Y) in cytokine gene transcription in T cells

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

1989 • 7,558 citations

Functional diversity of helper T lymphocytes

1996 • 4,512 citations

Development of T _H 1 CD4 ⁺ T Cells Through IL-12 Produced by Listeria -Induced Macrophages

1993 • 3,140 citations

TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and Function

1997 • 2,571 citations

The Transcription Factor GATA-3 Is Necessary and Sufficient for Th2 Cytokine Gene Expression in CD4 T Cells

1997 • 2,317 citations

Signal transduction by lymphocyte antigen receptors

1994 • 2,145 citations

Stat6 Is Required for Mediating Responses to IL-4 and for the Development of Th2 Cells

1996 • 1,618 citations

Cytokines Induce the Development of Functionally Heterogeneous T Helper Cell Subsets

1998 • 1,569 citations

Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene

1996 • 1,304 citations

Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice

1996 • 1,277 citations

Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells

1996 • 1,182 citations

Virus induction of human IFNβ gene expression requires the assembly of an enhanceosome

1995 • 994 citations

High-Mobility-Group Chromosomal Proteins: Architectural Components That Facilitate Chromatin Function

1996 • 752 citations

The Proto-Oncogene c-maf Is Responsible for Tissue-Specific Expression of Interleukin-4

1996 • 677 citations

Transcriptional regulation of the IL-2 gene

1995 • 579 citations

Interaction of NF-κB and NFAT with the Interferon-γ Promoter

1997 • 427 citations

Multistage Regulation of Th1-Type Immune Responses by the Transcription Factor IRF-1

1997 • 354 citations

The Transcription Factor NF-ATc1 Regulates Lymphocyte Proliferation and Th2 Cytokine Production

1998 • 340 citations

Delayed Lymphoid Repopulation with Defects in IL-4–Driven Responses Produced by Inactivation of NF-ATc

1998 • 298 citations

Interferon Regulatory Factor-1 Is Required for a T Helper 1 Immune Response In Vivo

1997 • 286 citations

Regulation of Cell-Type-Specific Interleukin-2 Receptor α-Chain Gene Expression: Potential Role of Physical Interactions between Elf-1, HMG-I(Y), and NF-κ B Family Proteins

1995 • 244 citations

The architecture of the interleukin-2 promoter: a reflection of T lymphocyte activation

1995 • 229 citations

A dynamic assembly of diverse transcription factors integrates activation and cell-type information for interleukin 2 gene regulation.

1996 • 182 citations

How the MHC selects Th1/Th2 immunity

1998 • 178 citations

Down-Regulation of IL-4 Gene Transcription and Control of Th2 Cell Differentiation by a Mechanism Involving NFAT1

1997 • 176 citations

Neoplastic transformation of rat thyroid cells requires the junB and fra-1 gene induction which is dependent on the HMGI-C gene product

1997 • 142 citations

Intra- and Intermolecular Cooperative Binding of High-Mobility-Group Protein I(Y) to the Beta-Interferon Promoter

1997 • 120 citations

Transcription Mediated by NFAT Is Highly Inducible in Effector CD4⁺ T Helper 2 (Th2) Cells but Not in Th1 Cells

1997 • 115 citations

High Mobility Group Protein I(Y) Is Required for Function and for c-Rel Binding to CD28 Response Elements within the GM-CSF and IL-2 Promoters

1996 • 109 citations

Evidence for the stochastic acquisition of cytokine profile by CD4⁺ T cells activated in a T helper type 2‐like response in vivo

1995 • 98 citations

Regulation of Allergic Inflammation and Eosinophil Recruitment in Mice Lacking the Transcription Factor NFAT1: Role of Interleukin-4 (IL-4) and IL-5

1998 • 80 citations

HMG I(Y) interferes with the DNA binding of NF-AT factors and the induction of the interleukin 4 promoter in T cells

1996 • 67 citations

Interleukin 4-inducible Phosphorylation of HMG-I(Y) Is Inhibited by Rapamycin

1995 • 60 citations

One base pair change abolishes the T cell-restricted activity of a kB-like proto-enhancer element from the interleukin 2 promoter

1991 • 50 citations

Cell cycle regulation and functions of HMG-I(Y)

1995 • 30 citations

HMG-I(Y) Phosphorylation Status as a Nuclear Target Regulated through Insulin Receptor Substrate-1 and the I4R Motif of the Interleukin-4 Receptor

1997 • 26 citations