Regulation and Function of the Cytokine-Inducible SH-2 Domain Proteins, CIS and SOCS3, in Mammary Epithelial Cells

A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors.

1995 • 761 citations

Functional interactions between Stat5 and the glucocorticoid receptor

1996 • 681 citations

Negative Regulation of Cytokine Signaling Pathways

2000 • 607 citations

Prolactin induces phosphorylation of Tyr694 of Stat5 (MGF), a prerequisite for DNA binding and induction of transcription.

1994 • 599 citations

CIS, a Cytokine Inducible SH2 Protein, Is a Target of the JAK-STAT5 Pathway and Modulates STAT5 Activation

1997 • 538 citations

SOCS/CIS Protein Inhibition of Growth Hormone-stimulated STAT5 Signaling by Multiple Mechanisms

1999 • 364 citations

Suppression of STAT5 Functions in Liver, Mammary Glands, and T Cells in Cytokine-Inducible SH2-Containing Protein 1 Transgenic Mice

1999 • 269 citations

SOCS-3 Is Tyrosine Phosphorylated in Response to Interleukin-2 and Suppresses STAT5 Phosphorylation and Lymphocyte Proliferation

1999 • 267 citations

Cloning and Characterization of Novel CIS Family Genes

1997 • 259 citations

Prolactin, Growth Hormone, and Epidermal Growth Factor Activate Stat5 in Different Compartments of Mammary Tissue and Exert Different and Overlapping Developmental Effects

2001 • 232 citations

Activation of Stat5a and Stat5b by tyrosine phosphorylation is tightly linked to mammary gland differentiation.

1996 • 228 citations

Interleukin-10 (IL-10) Selectively Enhances CIS3/SOCS3 mRNA Expression in Human Neutrophils: Evidence for an IL-10–Induced Pathway That Is Independent of STAT Protein Activation

1999 • 212 citations

Inhibition and Restoration of Prolactin Signal Transduction by Suppressors of Cytokine Signaling

1999 • 197 citations

Proteasomes Regulate Erythropoietin Receptor and Signal Transducer and Activator of Transcription 5 (STAT5) Activation

1998 • 193 citations

Erbb4 Signaling in the Mammary Gland Is Required for Lobuloalveolar Development and Stat5 Activation during Lactation

1999 • 192 citations

Interaction of Human Suppressor of Cytokine Signaling (SOCS)-2 with the Insulin-like Growth Factor-I Receptor

1998 • 190 citations

A Cytosolic Protein-tyrosine Phosphatase PTP1B Specifically Dephosphorylates and Deactivates Prolactin-activated STAT5a and STAT5b

2000 • 183 citations

Cytosolic Tyrosine Dephosphorylation of STAT5

2000 • 170 citations

STAT Activation by Epidermal Growth Factor (EGF) and Amphiregulin

1996 • 165 citations

Characterization of Stat5a and Stat5b Homodimers and Heterodimers and Their Association with the Glucocortiocoid Receptor in Mammary Cells

1998 • 164 citations

Stat5 as a Target for Regulation by Extracellular Matrix

1995 • 154 citations

Epidermal growth factor induces the tyrosine phosphorylation and nuclear translocation of Stat 5 in mouse liver.

1995 • 139 citations

Efficient control of tetracycline-responsive gene expression from an autoregulated bi-directional expression vector

1999 • 135 citations

Role of the Cytokine-inducible SH2 Protein CIS in Desensitization of STAT5b Signaling by Continuous Growth Hormone

2000 • 123 citations

Glucocorticoid Receptor/Signal Transducer and Activator of Transcription 5 (STAT5) Interactions Enhance STAT5 Activation by Prolonging STAT5 DNA Binding and Tyrosine Phosphorylation

1999 • 123 citations

Promoter-dependent Synergy between Glucocorticoid Receptor and Stat5 in the Activation of β-Casein Gene Transcription

1997 • 123 citations

SOCS1 deficiency results in accelerated mammary gland development and rescues lactation in prolactin receptor–deficient mice

2001 • 98 citations

Regulation of Mammary Differentiation by Extracellular Matrix Involves Protein-tyrosine Phosphatases

1998 • 97 citations

Tyrosine Docking Sites of the Rat Prolactin Receptor Required for Association and Activation of Stat5

1997 • 95 citations

Prolactin and Glucocorticoid Hormones Control Transcription of the β-Casein Gene by Kinetically Distinct Mechanisms

1990 • 92 citations

Stat transcription factors in mammary gland development and tumorigenesis.

2001 • 90 citations

Cytokine‐inducible SH2 protein (CIS3) and JAK2 binding protein (JAB) abolish prolactin receptor‐mediated STAT5 signaling

1998 • 87 citations

Growth Hormone, but Not Prolactin, Maintains Low-Level Activation of STAT5a and STAT5b in Female Rat Liver

1999 • 84 citations

Prolactin-dependent activation of a tyrosine phosphorylated DNA binding factor in mouse mammary epithelial cells.

1994 • 82 citations

Regulation of expression of the rat SOCS‐3 gene in hepatocytes by growth hormone, interleukin‐6 and glucocorticoids

2000 • 72 citations

Platelet-derived growth factor (PDGF)-induced activation of signal transducer and activator of transcription (Stat) 5 is mediated by PDGF beta-receptor and is not dependent on c-src, fyn, jak1 or jak2 kinases.

2000 • 52 citations

A distal enhancer region in the human β-casein gene mediates the response to prolactin and glucocorticoid hormones

1998 • 49 citations

Nucleotide sequence of a cDNA encoding mouse beta casein

1986 • 48 citations

Platelet-derived growth factor (PDGF)-induced activation of signal transducer and activator of transcription (Stat) 5 is mediated by PDGF β-receptor and is not dependent on c-Src, Fyn, Jak1 or Jak2 kinases

2000 • 35 citations

Involvement of Ets‐related proteins in hormone‐independent mammary cell‐specific gene expression

1994 • 34 citations

Selective coupling of STAT factors to the mouse prolactin receptor

1998 • 27 citations

The Protein Tyrosine Phosphatase-PEST Is Implicated in the Negative Regulation of Epidermal Growth Factor on PRL Signaling in Mammary Epithelial Cells

2001 • 13 citations

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