Deletion of Stat3 Blocks Mammary Gland Involution and Extends Functional Competence of the Secretory Epithelium in the Absence of Lactogenic Stimuli

Matrix metalloproteinases: effectors of development and normal physiology

2000 • 1,236 citations

Stat5a is mandatory for adult mammary gland development and lactogenesis.

1997 • 1,106 citations

Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation

1999 • 744 citations

Stat3 Activation Is Responsible for IL-6-Dependent T Cell Proliferation Through Preventing Apoptosis: Generation and Characterization of T Cell-Specific Stat3-Deficient Mice

1998 • 571 citations

Two distinct phases of apoptosis in mammary gland involution: proteinase-independent and -dependent pathways

1996 • 538 citations

Cre-mediated gene deletion in the mammary gland

1997 • 504 citations

Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3

1999 • 481 citations

Extracellular matrix-dependent tissue-specific gene expression in mammary epithelial cells requires both physical and biochemical signal transduction.

1994 • 466 citations

Coordinated expression of extracellular matrix-degrading proteinases and their inhibitors regulates mammary epithelial function during involution.

1992 • 445 citations

Targeted expression of stromelysin-1 in mammary gland provides evidence for a role of proteinases in branching morphogenesis and the requirement for an intact basement membrane for tissue-specific gene expression [published erratum appears in J Cell Biol 1996 Feb;132(4):following 752]

1994 • 405 citations

Essential role of STAT3 for embryonic stem cell pluripotency

1999 • 404 citations

Mammary-derived signals activate programmed cell death during the first stage of mammary gland involution

1997 • 371 citations

Clusterin is a secreted mammalian chaperone

2000 • 365 citations

Signal transducer and activator of transcription (Stat) 5 controls the proliferation and differentiation of mammary alveolar epithelium

2001 • 268 citations

Prolactin, Growth Hormone, and Epidermal Growth Factor Activate Stat5 in Different Compartments of Mammary Tissue and Exert Different and Overlapping Developmental Effects

2001 • 232 citations

Activation of Stat5a and Stat5b by tyrosine phosphorylation is tightly linked to mammary gland differentiation.

1996 • 228 citations

Prevention of cell death induced by tumor necrosis factor alpha in LNCaP cells by overexpression of sulfated glycoprotein-2 (clusterin).

1995 • 224 citations

Stromelysin-1 Regulates Adipogenesis during Mammary Gland Involution

2001 • 199 citations

Matrix metalloproteinases are expressed during ductal and alveolar mammary morphogenesis, and misregulation of stromelysin-1 in transgenic mice induces unscheduled alveolar development.

1995 • 194 citations

Clusterin Gene Expression Mediates Resistance to Apoptotic Cell Death Induced by Heat Shock and Oxidative Stress

1999 • 181 citations

Mammary Gland Involution Is Delayed by Activated Akt in Transgenic Mice

2001 • 165 citations

Accelerated apoptosis in the Timp-3–deficient mammary gland

2001 • 164 citations

Oncostatin M-Induced Matrix Metalloproteinase and Tissue Inhibitor of Metalloproteinase-3 Genes Expression in Chondrocytes Requires Janus Kinase/STAT Signaling Pathway

2001 • 162 citations

Accelerated apoptosis in the Timp-3–deficient mammary gland

2001 • 144 citations

NF-κB Inhibits Apoptosis in Murine Mammary Epithelia

2000 • 112 citations

Identification of the interleukin-6/oncostation M response element in the rat tissue inhibitor of metalloproteinases-1 (TIMP-1)Promoter

1995 • 109 citations

Signal transducer and activator of transcription 5a influences mammary epithelial cell survival and tumorigenesis.

1999 • 103 citations

Conditional deletion of the bcl-x gene from mouse mammary epithelium results in accelerated apoptosis during involution but does not compromise cell function during lactation

2001 • 83 citations

Apoptosis in normal and neoplastic mammary gland development

2001 • 69 citations

Insulin-like Growth Factor Binding Protein-5 (IGFBP-5) Potentially Regulates Programmed Cell Death and Plasminogen Activation in the Mammary Gland

2005 • 56 citations

Introduction: mammary gland involution and apoptosis of mammary epithelial cells.

1999 • 53 citations

Matrix metalloproteinases and their expression in mammary gland

1998 • 49 citations

A novel role for IRF-1 as a suppressor of apoptosis

2000 • 47 citations

Insulin-like growth factor-I and insulin-like growth factor binding protein-3 inhibit involution of the mammary gland following lactation: Studies in transgenic mice

1995 • 39 citations

Functional role of matrix metalloproteinases (MMPs) in mammary epithelial cell development

2001 • 34 citations

Inability of Overexpressed des(1–3)Human Insulin-Like Growth Factor I (IGF-I) to Inhibit Forced Mammary Gland Involution Is Associated with Decreased Expression of IGF Signaling Molecules*

2001 • 32 citations

Apoptotic Cell Debris and Phosphatidylserine-Containing Lipid Vesicles Induce Apolipoprotein J (Clusterin) Gene Expression in Vital Fibroblasts

2001 • 31 citations