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Small anti-viral compounds activate immune cells via the TLR7 MyD88–dependent signaling pathway

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Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs

1998 • 2,378 citations

Mouse and human dendritic cell subtypes

2002 • 2,311 citations

Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell derived exosomes

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Subsets of Human Dendritic Cell Precursors Express Different Toll-like Receptors and Respond to Different Microbial Antigens

2001 • 1,989 citations

Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon

1999 • 1,754 citations

In Vivo Depletion of CD11c+ Dendritic Cells Abrogates Priming of CD8+ T Cells by Exogenous Cell-Associated Antigens

2002 • 1,734 citations

Molecular identification of a danger signal that alerts the immune system to dying cells

2003 • 1,649 citations

Cutting Edge: Heat Shock Protein 60 Is a Putative Endogenous Ligand of the Toll-Like Receptor-4 Complex

2000 • 1,632 citations

Natural adjuvants: Endogenous activators of dendritic cells

1999 • 1,611 citations

Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming

2001 • 1,538 citations

Cd8+ but Not Cd8− Dendritic Cells Cross-Prime Cytotoxic T Cells in Vivo

2000 • 1,286 citations

Immature Dendritic Cells Phagocytose Apoptotic Cells via αvβ5 and CD36, and Cross-present Antigens to Cytotoxic T Lymphocytes

1998 • 1,226 citations

The Enigmatic Plasmacytoid T Cells Develop into Dendritic Cells with Interleukin (IL)-3 and CD40-Ligand

1997 • 1,224 citations

Ablation of “tolerance” and induction of diabetes by virus infection in viral antigen transgenic mice

1991 • 1,187 citations

Role of Bone Marrow-Derived Cells in Presenting MHC Class I-Restricted Tumor Antigens

1994 • 1,185 citations

Sec6l-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction

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Immunostimulatory DNA Sequences Necessary for Effective Intradermal Gene Immunization

1996 • 1,078 citations

Roles of heat-shock proteins in innate and adaptive immunity

2002 • 1,037 citations

Mouse type I IFN-producing cells are immature APCs with plasmacytoid morphology

2001 • 1,017 citations

Distinct dendritic cell subsets differentially regulate the class of immune responseinvivo

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Cross-priming for a secondary cytotoxic response to minor H antigens with H-2 congenic cells which do not cross-react in the cytotoxic assay.

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Langerhans cells renew in the skin throughout life under steady-state conditions

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Langerin, a Novel C-Type Lectin Specific to Langerhans Cells, Is an Endocytic Receptor that Induces the Formation of Birbeck Granules

2000 • 934 citations

Fcγ Receptor–mediated Induction of Dendritic Cell Maturation and Major Histocompatibility Complex Class I–restricted Antigen Presentation after Immune Complex Internalization

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DNA–based immunization by in vivo transfection of dendritic cells

1996 • 849 citations

Viral Subversion of the Immune System

2000 • 833 citations

The Biogenesis and Functions of Exosomes

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CD4 and CD8 Expression by Dendritic Cell Subtypes in Mouse Thymus and Spleen

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Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells

1998 • 809 citations

Regulation of dendritic cell numbers and maturation by lipopolysaccharide in vivo.

1996 • 800 citations

Viral Strategies of Immune Evasion

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Cross-priming of CD8+ T cells stimulated by virus-induced type I interferon

2003 • 787 citations

ER–phagosome fusion defines an MHC class I cross-presentation compartment in dendritic cells

2003 • 737 citations

Induction of a CD8+ Cytotoxic T Lymphocyte Response by Cross-priming Requires Cognate CD4+ T Cell Help

1997 • 729 citations

Efficient presentation of exogenous antigen by liver endothelial cells to CD8+ T cells results in antigen-specific T-cell tolerance

2000 • 723 citations

Class I–restricted Cross-Presentation of Exogenous Self-Antigens Leads to Deletion of Autoreactive CD8+ T Cells

1997 • 719 citations

Cd11c+B220+Gr-1+ Cells in Mouse Lymph Nodes and Spleen Display Characteristics of Plasmacytoid Dendritic Cells

2001 • 717 citations

Distinct Dendritic Cell Populations Sequentially Present Antigen to CD4 T Cells and Stimulate Different Aspects of Cell-Mediated Immunity

2003 • 702 citations

Phagosomes are competent organelles for antigen cross-presentation

2003 • 701 citations

The surface phenotype of dendritic cells purified from mouse thymus and spleen: investigation of the CD8 expression by a subpopulation of dendritic cells.

1992 • 642 citations

The CD8+ Dendritic Cell Subset Selectively Endocytoses Dying Cells in Culture and In Vivo

2002 • 641 citations

Constitutive class I-restricted exogenous presentation of self antigens in vivo.

1996 • 637 citations

Phagocytic processing of bacterial antigens for class I MHC presentation to T cells

1993 • 625 citations

A viral inhibitor of peptide transporters for antigen presentation

1995 • 599 citations

Localization of antigen on lymph node dendritic cells after exposure to the contact sensitizer fluorescein isothiocyanate. Functional and morphological studies.

1987 • 592 citations

Efficient major histocompatibility complex class I presentation of exogenous antigen upon phagocytosis by macrophages.

1993 • 592 citations

Cytotoxic T-cell immunity to virus-infected non-haematopoietic cells requires presentation of exogenous antigen

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Cutting Edge: Intravenous Soluble Antigen Is Presented to CD4 T Cells by CD8− Dendritic Cells, but Cross-Presented to CD8 T Cells by CD8+ Dendritic Cells

2001 • 584 citations

Viral infection switches non-plasmacytoid dendritic cells into high interferon producers

2003 • 582 citations

Epidermal Viral Immunity Induced by CD8α ⁺ Dendritic Cells But Not by Langerhans Cells

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Dendritic cells in the T‐cell areas of lymphoid organs

1997 • 572 citations

Predominant Role for Directly Transfected Dendritic Cells in Antigen Presentation to CD8+ T Cells after Gene Gun Immunization

1998 • 569 citations

Inhibition of ubiquitin/proteasome-dependent protein degradation by the Gly-Ala repeat domain of the Epstein–Barr virus nuclear antigen 1

1997 • 549 citations

Contribution of CpG motifs to the immunogenicity of DNA vaccines.

1997 • 519 citations

Roles of tumour localization, second signals and cross priming in cytotoxic T-cell induction

2001 • 500 citations

Differential Production of IL-12, IFN-α, and IFN-γ by Mouse Dendritic Cell Subsets

2001 • 496 citations

Signal 3 Determines Tolerance versus Full Activation of Naive CD8 T Cells

2003 • 494 citations

Gene vaccination with naked plasmid DNA: mechanism of CTL priming.

1996 • 494 citations

The CD8α+ Dendritic Cell Is Responsible for Inducing Peripheral Self-Tolerance to Tissue-associated Antigens

2002 • 468 citations

Antigen presentation to naive CD4 T cells in the lymph node

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The Dendritic Cell Populations of Mouse Lymph Nodes

2001 • 461 citations

Cross-presentation in viral immunity and self-tolerance

2001 • 460 citations

Developmental pathways of dendritic cells in vivo: distinct function, phenotype, and localization of dendritic cell subsets in FLT3 ligand-treated mice.

1997 • 455 citations

Developmental kinetics and lifespan of dendritic cells in mouse lymphoid organs

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The Development, Maturation, and Turnover Rate of Mouse Spleen Dendritic Cell Populations

2000 • 418 citations

Class I-restricted processing and presentation of exogenous cell-associated antigen in vivo.

1990 • 414 citations

Cutting Edge: Receptor-Mediated Endocytosis of Heat Shock Proteins by Professional Antigen-Presenting Cells

1999 • 399 citations

Vaginal Submucosal Dendritic Cells, but Not Langerhans Cells, Induce Protective Th1 Responses to Herpes Simplex Virus-2

2003 • 390 citations

Constitutive Presentation of a Natural Tissue Autoantigen Exclusively by Dendritic Cells in the Draining Lymph Node

2002 • 387 citations

Early phagosomes in dendritic cells form a cellular compartment sufficient for cross presentation of exogenous antigens

2003 • 385 citations

Human cytomegalovirus inhibits antigen presentation by a sequential multistep process.

1996 • 379 citations

Mouse Plasmacytoid Cells

2002 • 377 citations

DNA Vaccination: Transfection and Activation of Dendritic Cells as Key Events for Immunity

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Induction of cytotoxic T lymphocytes by intramuscular immunization with plasmid DNA is facilitated by bone marrow-derived cells.

1996 • 353 citations

Cross-Presentation of Glycoprotein 96–Associated Antigens on Major Histocompatibility Complex Class I Molecules Requires Receptor-Mediated Endocytosis

1999 • 352 citations

Physiological β Cell Death Triggers Priming of Self-reactive T Cells by Dendritic Cells in a Type-1 Diabetes Model

2003 • 345 citations

Visualizing priming of virus-specific CD8+ T cells by infected dendritic cells in vivo

2002 • 345 citations

The nature of the MHC class I peptide loading complex

1999 • 332 citations

Intracellular signalling cascades regulating innate immune responses to Mycobacteria: branching out from Toll-like receptors

2007 • 330 citations

Antigen Presentation by Dendritic Cells after Immunization with DNA Encoding a Major Histocompatibility Complex Class II–restricted Viral Epitope

1997 • 326 citations

Major Histocompatibility Complex Class I–restricted Cross-presentation Is Biased towards High Dose Antigens and Those Released during Cellular Destruction

1998 • 323 citations

Internalization of circulating apoptotic cells by splenic marginal zone dendritic cells: dependence on complement receptors and effect on cytokine production

2002 • 321 citations

Dendritic Cells Acquire Antigens from Live Cells for Cross-Presentation to CTL

2001 • 318 citations

Constitutive versus Activation-dependent Cross-Presentation of Immune Complexes by CD8+ and CD8− Dendritic Cells In Vivo

2002 • 317 citations

Protein Translocation: Tunnel Vision

1998 • 312 citations

Fibroblasts as Efficient Antigen-Presenting Cells in Lymphoid Organs

1995 • 308 citations

CD8+ T Cells Are Required for Primary Immunity in C57BL/6 Mice Following Low-Dose, Intradermal Challenge withLeishmania major

2002 • 304 citations

Cutting Edge: Conventional CD8α+ Dendritic Cells Are Generally Involved in Priming CTL Immunity to Viruses

2004 • 298 citations

A Subset of Toll-Like Receptor Ligands Induces Cross-presentation by Bone Marrow-Derived Dendritic Cells

2003 • 292 citations

Cell-Associated Ovalbumin Is Cross-Presented Much More Efficiently than Soluble Ovalbumin In Vivo

2001 • 260 citations

Langerhans cells – dendritic cells of the epidermis

2003 • 257 citations

The dominant role of bone marrow-derived cells in CTL induction following plasmid DNA immunization at different sites.

1997 • 257 citations

Minor H Antigens Introduced on H-2 Different Stimulating Cells Cross-React at the Cytotoxic T Cell Level during in Vivo Priming

1976 • 253 citations

CD8 T cell ignorance or tolerance to islet antigens depends on antigen dose

1999 • 245 citations

Presentation of Exogenous Antigens on Major Histocompatibility Complex (MHC) Class I and MHC Class II Molecules Is Differentially Regulated during Dendritic Cell Maturation

2003 • 245 citations

In Vivo Cross-Priming of MHC Class I–Restricted Antigens Requires the TAP Transporter

1996 • 225 citations

Cross‐presentation of cell‐associated antigens by CD8α⁺ dendritic cells is attributable to their ability to internalize dead cells

2002 • 214 citations

Class discrimination in the world of immunology

1987 • 214 citations

Vaccination with Plasmid DNA Activates Dendritic Cells via Toll-Like Receptor 9 (TLR9) but Functions in TLR9-Deficient Mice

2003 • 206 citations

Characterization of antigen-presenting cells that present exogenous antigens in association with class I MHC molecules.

1993 • 206 citations

Presentation of Antigen by Endothelial Cells and Chemoattraction Are Required for Homing of Insulin-specific CD8+ T Cells

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Control of dendritic cell cross-presentation by the major histocompatibility complex class I cytoplasmic domain

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Uptake of Apoptotic Antigen-Coupled Cells by Lymphoid Dendritic Cells and Cross-Priming of CD8+ T Cells Produce Active Immune Unresponsiveness

2002 • 193 citations

A Role for Class A Scavenger Receptor in Dendritic Cell Nibbling from Live Cells

2003 • 185 citations

Cutting Edge: Conventional CD8α+ Dendritic Cells Are Preferentially Involved in CTL Priming After Footpad Infection with Herpes Simplex Virus-1

2003 • 183 citations

In Vivo Priming by DNA Injection Occurs Predominantly by Antigen Transfer

1999 • 180 citations

Cytotoxic T lymphocytes against a soluble protein

1987 • 178 citations

Peripheral Deletion of Autoreactive CD8 T Cells by Cross Presentation of Self-Antigen Occurs by a Bcl-2–inhibitable Pathway Mediated by Bim

2002 • 160 citations

Enhancing DNA vaccine potency by coadministration of DNA encoding antiapoptotic proteins

2003 • 153 citations

Interleukin 1α Promotes Th1 Differentiation and Inhibits Disease Progression in Leishmania major–susceptible BALB/c Mice

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Tolerance to Islet Antigens and Prevention from Diabetes Induced by Limited Apoptosis of Pancreatic β Cells

2002 • 151 citations

Macrophages as accessory cells for class I MHC-restricted immune responses.

1991 • 148 citations

Surfing the Sec61 channel: bidirectional protein translocation across the ER membrane

1999 • 147 citations

Bone Marrow–Derived Antigen-Presenting Cells Are Required for the Generation of Cytotoxic T Lymphocyte Responses to Viruses and Use Transporter Associated with Antigen Presentation (Tap)-Dependent and -Independent Pathways of Antigen Presentation

2000 • 138 citations

Genetic tagging shows increased frequency and longevity of antigen-presenting, skin-derived dendritic cells in vivo

2003 • 128 citations

CD8α2 CD11b+ Dendritic Cells Present Exogenous Virus-like Particles to CD8+ T Cells and Subsequently Express CD8α and CD205 Molecules

2002 • 128 citations

Apoptosis-mediated enhancement of DNA-raised immune responses by mutant caspases

2001 • 125 citations

Enhancement of antigen-presenting cell surface molecules involved in cognate interactions by immunostimulatory DNA sequences

1999 • 112 citations

Cross-Priming as a Predominant Mechanism for Inducing CD8+ T Cell Responses in Gene Gun DNA Immunization

2001 • 112 citations

Exogenous antigens gain access to the major histocompatibility complex class I processing pathway in B cells by receptor-mediated uptake.

1996 • 111 citations

Macrophages and Dendritic Cells Use the Cytosolic Pathway to Rapidly Cross-Present Antigen from Live, Vaccinia-Infected Cells

2002 • 110 citations

Presentation of exogenous antigens by macrophages: analysis of major histocompatibility complex class I and II presentation and regulation by cytokines

1994 • 107 citations

Ontogeny of T cell tolerance to peripherally expressed antigens

1999 • 107 citations

Lymphoid organ dendritic cells: beyond the Langerhans cells paradigm

2004 • 102 citations

The Murine Cytomegalovirus Immunomodulatory Gene m152 Prevents Recognition of Infected Cells by M45-Specific CTL But Does Not Alter the Immunodominance of the M45-Specific CD8 T Cell Response In Vivo

2002 • 102 citations

Requirements for Bone Marrow–Derived Antigen-Presenting Cells in Priming Cytotoxic T Cell Responses to Intracellular Pathogens

2000 • 99 citations

Efficiency of cross presentation of vaccinia virus-derived antigens by human dendritic cells

2001 • 98 citations

Incoming Human Cytomegalovirus pp65 (UL83) Contained in Apoptotic Infected Fibroblasts Is Cross-Presented to CD8⁺T Cells by Dendritic Cells

2000 • 97 citations

CD4+ T Cell Polarization in Mice Is Modulated by Strain-specific Major Histocompatibility Complex–independent Differences within Dendritic Cells

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Protein Dislocation from the Endoplasmic Reticulum – Pulling Out the Suspect

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H-2 antigen requirements in the in vitro induction of SV40-specific cytotoxic T lymphocytes.

1980 • 86 citations

Major Histocompatibility Complex Class II Presentation of Cell-associated Antigen Is Mediated by CD8α+ Dendritic Cells In Vivo

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Helper Requirements for Generation of Effector CTL to Islet β Cell Antigens

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Inhibitory Effects of Cytomegalovirus Proteins US2 and US11 Point to Contributions from Direct Priming and Cross-Priming in Induction of Vaccinia Virus-Specific CD8+ T Cells

2002 • 56 citations

Cutting Edge: Recombinant Adenoviruses Induce CD8 T Cell Responses to an Inserted Protein Whose Expression Is Limited to Nonimmune Cells

2001 • 55 citations

Induction of MHC Class I Presentation of Exogenous Antigen by Dendritic Cells Is Controlled by CD4+ T Cells Engaging Class II Molecules in Cholesterol-Rich Domains

2002 • 51 citations

Immunomodulation by apoptosis-inducing caspases for an influenza DNA vaccine delivered by gene gun

2002 • 28 citations

The Cross-Priming APC Requires a Rel-Dependent Signal to Induce CTL

2002 • 15 citations