Lymphoid organ dendritic cells: beyond the Langerhans cells paradigm

Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.

1994 • 5,204 citations

The Dendritic Cell System and its Role in Immunogenicity

1991 • 4,733 citations

Toll-like receptors and innate immunity

2001 • 4,138 citations

Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor.

1992 • 3,751 citations

Tolerogenic Dendritic Cells

2003 • 3,131 citations

Mouse and human dendritic cell subtypes

2002 • 2,311 citations

Antigen Presentation and T Cell Stimulation by Dendritic Cells

2002 • 1,860 citations

Dendritic Cells Induce Peripheral T Cell Unresponsiveness under Steady State Conditions in Vivo

2001 • 1,845 citations

The B7–CD28 superfamily

2002 • 1,646 citations

Positive and Negative Selection of T Cells

2003 • 1,547 citations

Efficient Targeting of Protein Antigen to the Dendritic Cell Receptor DEC-205 in the Steady State Leads to Antigen Presentation on Major Histocompatibility Complex Class I Products and Peripheral CD8+ T Cell Tolerance

2002 • 1,296 citations

Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells

1997 • 1,143 citations

Murine epidermal Langerhans cells mature into potent immunostimulatory dendritic cells in vitro.

1985 • 1,141 citations

Mouse type I IFN-producing cells are immature APCs with plasmacytoid morphology

2001 • 1,017 citations

A Discrete Subpopulation of Dendritic Cells Transports Apoptotic Intestinal Epithelial Cells to T Cell Areas of Mesenteric Lymph Nodes

2000 • 908 citations

Maturation Stages of Mouse Dendritic Cells in Growth Factor–dependent Long-Term Cultures

1997 • 860 citations

CD4 and CD8 Expression by Dendritic Cell Subtypes in Mouse Thymus and Spleen

2000 • 812 citations

Plasmacytoid dendritic cells activated by influenza virus and CD40L drive a potent TH1 polarization

2000 • 804 citations

Regulation of dendritic cell numbers and maturation by lipopolysaccharide in vivo.

1996 • 800 citations

Developmental regulation of MHC class II transport in mouse dendritic cells

1997 • 754 citations

Cd11c+B220+Gr-1+ Cells in Mouse Lymph Nodes and Spleen Display Characteristics of Plasmacytoid Dendritic Cells

2001 • 717 citations

Distinct Dendritic Cell Populations Sequentially Present Antigen to CD4 T Cells and Stimulate Different Aspects of Cell-Mediated Immunity

2003 • 702 citations

Migration and maturation of Langerhans cells in skin transplants and explants.

1990 • 663 citations

Efficient Presentation of Phagocytosed Cellular Fragments on the Major Histocompatibility Complex Class II Products of Dendritic Cells

1998 • 649 citations

The surface phenotype of dendritic cells purified from mouse thymus and spleen: investigation of the CD8 expression by a subpopulation of dendritic cells.

1992 • 642 citations

The use of dendritic cells in cancer immunotherapy

2003 • 641 citations

The tissue distribution of the B7-2 costimulator in mice: abundant expression on dendritic cells in situ and during maturation in vitro.

1994 • 607 citations

Localization of antigen on lymph node dendritic cells after exposure to the contact sensitizer fluorescein isothiocyanate. Functional and morphological studies.

1987 • 592 citations

Epidermal Viral Immunity Induced by CD8α ⁺ Dendritic Cells But Not by Langerhans Cells

2003 • 580 citations

Dendritic cells in the T‐cell areas of lymphoid organs

1997 • 572 citations

CD40 Triggering of Heterodimeric IL-12 p70 Production by Dendritic Cells In Vivo Requires a Microbial Priming Signal

2000 • 558 citations

Specific Migratory Dendritic Cells Rapidly Transport Antigen from the Airways to the Thoracic Lymph Nodes

2000 • 554 citations

Toll‐like receptor expression in murine DC subsets: lack of TLR7 expression by CD8α⁺ DC correlates with unresponsiveness to imidazoquinolines

2003 • 544 citations

Presentation of exogenous protein antigens by dendritic cells to T cell clones. Intact protein is presented best by immature, epidermal Langerhans cells.

1989 • 542 citations

Dendritic cell subtypes in mouse lymphoid organs: cross-correlation of surface markers, changes with incubation, and differences among thymus, spleen, and lymph nodes.

1997 • 524 citations

Negative selection — clearing out the bad apples from the T-cell repertoire

2003 • 494 citations

The CD8α+ Dendritic Cell Is Responsible for Inducing Peripheral Self-Tolerance to Tissue-associated Antigens

2002 • 468 citations

Antigen presentation to naive CD4 T cells in the lymph node

2003 • 467 citations

The Dendritic Cell Populations of Mouse Lymph Nodes

2001 • 461 citations

Targeted Expression of Major Histocompatibility Complex (MHC) Class II Molecules Demonstrates that Dendritic Cells Can Induce Negative but Not Positive Selection of Thymocytes In Vivo

1997 • 459 citations

Developmental kinetics and lifespan of dendritic cells in mouse lymphoid organs

2002 • 443 citations

The Development, Maturation, and Turnover Rate of Mouse Spleen Dendritic Cell Populations

2000 • 418 citations

Dendritic cell maturation is required for the cross-tolerization of CD8+ T cells

2001 • 407 citations

Cords, channels, corridors and conduits: critical architectural elements facilitating cell interactions in the lymph node cortex

1997 • 401 citations

Constitutive Presentation of a Natural Tissue Autoantigen Exclusively by Dendritic Cells in the Draining Lymph Node

2002 • 387 citations

Mouse Plasmacytoid Cells

2002 • 377 citations

Functionally distinct dendritic cell (DC) populations induced by physiologic stimuli: prostaglandin E2 regulates the migratory capacity of specific DC subsets

2002 • 369 citations

Most lymphoid organ dendritic cell types are phenotypically and functionally immature

2003 • 362 citations

Isolation and characterization of plasmacytoid dendritic cells from Flt3 ligand and granulocyte-macrophage colony-stimulating factor–treated mice

2001 • 354 citations

Activation of influenza virus–specific CD4+ and CD8+ T cells: a new role for plasmacytoid dendritic cells in adaptive immunity

2003 • 346 citations

Origin, precursors and differentiation of mouse dendritic cells

2003 • 292 citations

Human and murine dermis contain dendritic cells. Isolation by means of a novel method and phenotypical and functional characterization.

1993 • 279 citations

Accumulation of Immature Langerhans Cells in Human Lymph Nodes Draining Chronically Inflamed Skin

2002 • 274 citations

A life stage of particle-laden rat dendritic cells in vivo: their terminal division, active phagocytosis, and translocation from the liver to the draining lymph.

1996 • 261 citations

Characterization of a new subpopulation of mouse CD8α+ B220+ dendritic cells endowed with type 1 interferon production capacity and tolerogenic potential

2002 • 254 citations

Definition of Dendritic Cell Subpopulations Present in the Spleen, Peyer’s Patches, Lymph Nodes, and Skin of the Mouse

1999 • 244 citations

Interferon-producing cells: on the front line in immune responses against pathogens

2002 • 242 citations

Antigen processing by epidermal Langerhans cells correlates with the level of biosynthesis of major histocompatibility complex class II molecules and expression of invariant chain.

1990 • 214 citations

Anatomical Origin of Dendritic Cells Determines Their Life Span in Peripheral Lymph Nodes

2000 • 208 citations

Human thymus contains IFN-α–producing CD11c–, myeloid CD11c+, and mature interdigitating dendritic cells

2001 • 203 citations

Dendritic cells constitutively present self antigens in their immature state in vivo and regulate antigen presentation by controlling the rates of MHC class II synthesis and endocytosis

2003 • 203 citations

Characterization of sheep afferent lymph dendritic cells and their role in antigen carriage.

1989 • 196 citations

Bidirectional Interactions between Antigen-bearing Respiratory Tract Dendritic Cells (DCs) and T Cells Precede the Late Phase Reaction in Experimental Asthma

2003 • 192 citations

Phenotypic Characterization of Five Dendritic Cell Subsets in Human Tonsils

2001 • 189 citations

Visualization and Characterization of Migratory Langerhans Cells in Murine Skin and Lymph Nodes by Antibodies Against Langerin/CD207

2003 • 177 citations

Dendritic cell precursor populations of mouse blood: identification of the murine homologues of human blood plasmacytoid pre-DC2 and CD11c+ DC1 precursors

2003 • 171 citations

Interferon-producing Cells Fail to Induce Proliferation of Naive T Cells but Can Promote Expansion and T Helper 1 Differentiation of Antigen-experienced Unpolarized T Cells

2003 • 170 citations

Enhanced antigen-presenting capacity of cultured Langerhans' cells is associated with markedly increased expression of Ia antigen.

1987 • 154 citations

Human thymus contains 2 distinct dendritic cell populations

2001 • 143 citations

Three populations of mouse lymph node dendritic cells with different origins and dynamics

1997 • 133 citations

Human and mouse plasmacytoid dendritic cells

2002 • 118 citations

Human Cutaneous Dendritic Cells Migrate Through Dermal Lymphatic Vessels in a Skin Organ Culture Model

1996 • 114 citations

Quantitation of Surface Antigens on Cultured Murine Epidermal Langerhans Cells: Rapid and Selective Increase in the Level of Surface MHC Products

1988 • 103 citations

Three Populations of Mouse Lymph Node Dendritic Cells with Different Origins and Dynamics

1998 • 99 citations

Investigation of human spleen dendritic cell phenotype and distribution reveals evidence of in vivo activation in a subset of organ donors

2001 • 87 citations

The Protease Inhibitor Cystatin C Is Differentially Expressed among Dendritic Cell Populations, but Does Not Control Antigen Presentation

2003 • 77 citations

Heterogeneity of Dendritic Cells in Human Superficial Lymph Node

1998 • 62 citations

CD8α+ mouse spleen dendritic cells do not originate from the CD8α- dendritic cell subset

2003 • 61 citations

In Vivo-Matured Langerhans Cells Continue to Take Up and Process Native Proteins Unlike In Vitro-Matured Counterparts

2001 • 47 citations

Is Maturation Required for Langerhans Cell Migration?

2002 • 45 citations

Identification of mature and immature human thymic dendritic cells that differentially express HLA-DR and interleukin-3 receptor in vivo

2000 • 32 citations

Afferent lymph veiled cells stimulate proliferative responses in allogeneic CD4⁺ and CD8⁺ T cells but not γδ TCR⁺ T cells

1996 • 31 citations

Current issues in dendritic cell cancer immunotherapy.

2002 • 30 citations

Phenotype of Langerhans cells in human afferent skin lymph derived from allergic contact dermatitis

1993 • 11 citations

Cited By (0)

Loading...