Modulation of insulin secretion by cyclic AMP and prostaglandin E: The effects of theophylline, sodium salicylate and tolbutamide

Amino Acid Metabolism in Mammalian Cell Cultures

1959 • 4,025 citations

A simple ultrasensitive method for the assay of cyclic AMP and cyclic GMP in tissues

1976 • 328 citations

THE ROLE OF CYCLIC AMP IN THE INTERACTION OF GLUCAGON AND INSULIN IN THE CONTROL OF LIVER METABOLISM*

1971 • 205 citations

Adenylate Cyclase in Islets of Langerhans

1973 • 178 citations

Tolbutamide stimulation and inhibition of insulin release: Studies of the underlying ionic mechanisms in isolated rat islets

1980 • 161 citations

Stimulation of insulin secretion by noncarbohydrate metabolites.

1968 • 160 citations

A Role for Prostaglandin E in Defective Insulin Secretion and Carbohydrate Intolerance in Diabetes Mellitus

1977 • 144 citations

Studies of a Simplified Plasma Insulin Immunoassay Using Cellulose Powder

1968 • 123 citations

Monolayer Cell Culture of Neonatal Rat Pancreas: Light Microscopy and Evidence for Immunoreactive Insulin Synthesis and Release

1972 • 109 citations

Methyl xanthine phosphodiesterase inhibitors behave as prostaglandin antagonists in a perfused rat mesenteric artery preparation

1977 • 109 citations

Pancreatic action of the sulfonylureas.

1977 • 107 citations

Stimulation by d-Glucose of Cyclic Adenosine 3′ : 5′-Monophosphate Accumulation and Insulin Release in Isolated Pancreatic Islets of the Rat

1974 • 103 citations

The Kinetics of Electrical Activity of Beta Cells in Response to a "Square Wave" Stimulation with Glucose or Glibenclamide

1976 • 101 citations

Adenylate cyclase activity in isolated rat islets of Langerhans Effects of agents which alter rates of insulin secretion

1973 • 86 citations

The stimulus-secretion coupling of glucose-induced insulin release. XI. Effects of Theophylline and epinephrine on 45Ca efflux from perifused islets

1973 • 83 citations

ENHANCEMENT BY CAFFEINE OF GLUCAGON-INDUCED AND TOLBUTAMIDE-INDUCED INSULIN RELEASE FROM ISOLATED FŒTAL PANCREATIC TISSUE

1967 • 83 citations

Inhibition of Prostaglandin E Synthesis Augments Glucose-induced Insulin Secretion in Cultured Pancreas

1981 • 72 citations

Insulin and Glucagon Release from Monolayer Cell Cultures of Pancreas from Newborn Rats

1973 • 69 citations

Inhibition of Cyclic 3′,5′-AMP Phosphodiesterase in Islet Cells and Other Tissues by Tolbutamide

1971 • 61 citations

Serum tolbutamide and chlorpropamide concentrations in patients with diabetes mellitus

1978 • 60 citations

The pancreatic β-cell recognition of insulin secretagogues. II. Site of action of tolbutamide

1971 • 59 citations

Prostaglandins as Modulators of Pancreatic Islet Function

1979 • 59 citations

Cyclic nucleotide phosphodiesterase activity in normal mouse pancreatic islets

1972 • 59 citations

Cyclic Adenosine-3′,5′ -monophosphate Stimulates Islet B Cell Replication in Neonatal Rat Pancreatic Monolayer Cultures

1980 • 55 citations

Effects of hormones on cyclic AMP release in perfused rat livers

1973 • 55 citations

Insulin release and cyclic AMP accumulation in response to glucose in pancreatic islets of fed and starved rats.

1976 • 48 citations

Inhibition of vasopressin-stimulated prostaglandin E biosynthesis by chlorpropamide in the toad urinary bladder. Mechanism of enhancement of vasopressin-stimulated water flow.

1977 • 47 citations

Differential in vivo pulmonary degradation of prostaglandins E1, B1, and A1

1975 • 38 citations

Insulinotropic effects of hypoglycaemic and hyperglycaemic sulphonamides: The ionophoretic hypothesis

1980 • 34 citations

Cyclic Nucleotides in Pancreatic Islets: Tolbutamide- and Arginine-induced Insulin Release

1976 • 32 citations

Effects of glucose, glucose metabolites and calcium ions on adenylate cyclase activity in homogenates of mouse pancreatic islets

1977 • 32 citations

On the Possible Role of Thiol Groups in the Insulin-Releasing Action of Mercurials, Organic Disulfides, Alkylating Agents, and Sulfonylureas

1976 • 29 citations

Activation of adenyl cyclase in a pancreatic islet cell adenoma by glucagon and tolbutamide

1972 • 28 citations

Effects of sulfonylureas upon insulin secretion by the rat's pancreas

1967 • 26 citations

Interacting Effects of Sulfonylureas and Glucose on Cyclic AMP Metabolism and Insulin Release in Pancreatic Islets of the Rat

1978 • 25 citations

Inhibition of prostaglandin E synthesis augments glucose-induced insulin secretion is cultured pancreas

1981 • 23 citations

Glucose-mediated Insulin Release: 3′,5′ cAMP Phosphodiesterase

1973 • 21 citations

Effect of hexoses and mannoheptulose on cyclic AMP accumulation and insulin secretion in rat pancreatic islets

1976 • 21 citations

Effect of methylene blue and thiol oxidants on pancreatic islet GSH/GSSG ratios and tolbutamide mediated insulin release in vitro

1979 • 19 citations

Effect of tolbutamide on aminophylline-, 3,5-AMP-dibutyrate-or glucagon-induced insulin release from pancreatic islets after impairment of pyridine nucleotide metabolism caused by 6-aminonicotinamide (6-AN)

1975 • 17 citations

[Insulin secretion by isolated islets of Langerhans. Effects of pancreatic and intestinal hormones].

1968 • 15 citations

A hypothesis for the molecular mechanism of action of chlorpropamide in the treatment of diabetes mellitus and diabetes insipidus.

1977 • 13 citations

The Positive Inotropic Action of Sulfonylureas: A Mechanism Independent of Cyclic Adenosine 3',5'-Monophosphate

1978 • 11 citations

Cyclic nucleotides in pancreatic islets. Tolbutamide- and arginine-induced insulin release

1976 • 8 citations

Monolayer Culture of Human Fetal and Adult Pancreas. Static and Dynamic Studies of Insulin Release In Vitro

1980 • 7 citations