Insulin release: The fuel hypothesis

Calcium transport in contraction and secretion

1975 • 567 citations

Regulation of insulin secretion studied with pieces of rabbit pancreas incubated in vitro

1964 • 540 citations

Oscillatory Phenomena in Biochemistry

1971 • 486 citations

The stimulus-secretion coupling of glucose-induced insulin release

1979 • 420 citations

A Possible Role for the Adenylcyclase System in Insulin Secretion*

1967 • 320 citations

Metabolism of Glucose in the Islets of Langerhans

1968 • 307 citations

Interrelationship of islet metabolism, adenosine triphosphate content and insulin release

1973 • 307 citations

Stimulus-Secretion Coupling of Glucose-Induced Insulin Release. III. Uptake of⁴⁵Calcium by Isolated Islets of Langerhans1

1971 • 287 citations

The Stimulus-Secretion Coupling of Glucose-Induced Insulin Release. VII. A PROPOSED SITE OF ACTION FOR ADENOSINE-3′,5′-CYCLIC MONOPHOSPHATE

1972 • 209 citations

D-Glucose inhibits potassium efflux from pancreatic islet cells

1978 • 208 citations

Interrelationship of Glucagon, Insulin and Glucose: The Insulinogenic Effect of Glucagon

1966 • 190 citations

Electrophysiological evidence for coupling between β cells of pancreatic islets

1976 • 170 citations

Effects of Carbohydrates on the Oxygen Consumption of Isolated Pancreatic Islets of Mice

1967 • 169 citations

Adenosine 3′,5′-Monophosphate in Pancreatic Islets: Glucose-Induced Insulin Release

1973 • 166 citations

Pancreatic polypeptide: A possible role in the regulation of food intake in the mouse. Hypothesis

1977 • 154 citations

Structural coupling between pancreatic islet cells

1973 • 145 citations

The Stimulus-Secretion Coupling of Glucose-Induced Insulin Release. Metoabolic Effects of Menadione in Isolated Islets

1978 • 141 citations

The stimulus-secretion coupling of glucose-induced insulin release. Effect of exogenous pyruvate on islet function

1978 • 140 citations

Stimulus-secretion coupling of glucose-induced insulin release. X. Effect of glucose on 45 Ca efflux from perifused islets

1973 • 139 citations

Immediate and Time-Dependent Effects of Glucose on Insulin Release from Rat Pancreatic Tissue

1978 • 138 citations

Evidence for mediated transport of glucose in mammalian pancreatic β-cells

1971 • 131 citations

Calcium-antagonists and islet function

1976 • 128 citations

ROLE OF MICROTUBULES IN THE PHASIC PATTERN OF INSULIN RELEASE*

1975 • 127 citations

The stimulus secretion coupling of glucose-induced insulin release

1978 • 126 citations

REGULATION OF CALCIUM FLUXES AND THEIR REGULATORY ROLES IN PANCREATIC ISLETS*

1978 • 123 citations

On the Biological Role of Cyclic AMP

1970 • 122 citations

The electron microscopic localization of cations to pancreatic islets of langerhans and their possible role in insulin secretion

1973 • 121 citations

[Further studies on the dynamic aspects of insulin release in vitro with evidence for a two-compartmental storage system].

1969 • 116 citations

The Pancreatic β-Cell Recognition of Insulin Secretagogues: Does Cyclic AMP Mediate the Effect of Glucose?

1974 • 112 citations

Regulation of calcium fluxes in pancreatic islets: dissociation between calcium and insulin release.

1978 • 108 citations

Pentitols and insulin release by isolated rat islets of Langerhans

1968 • 108 citations

Effects of glucose on 45Ca2+ uptake by pancreatic islets as studied with the lanthanum method.

1976 • 108 citations

Stimulation by d-Glucose of Cyclic Adenosine 3′ : 5′-Monophosphate Accumulation and Insulin Release in Isolated Pancreatic Islets of the Rat

1974 • 103 citations

The stimulus-secretion coupling of glucose-induced insulin release. Fasting-induced adaptation of key glycolytic enzymes in isolated islets.

1976 • 103 citations

The Kinetics of Electrical Activity of Beta Cells in Response to a "Square Wave" Stimulation with Glucose or Glibenclamide

1976 • 101 citations

Similarities in the Stimulus-Secretion Coupling Mechanisms of Glucose- and 2-Keto Acid-Induced Insulin Release*

1980 • 99 citations

Stimulus-secretion coupling of glucose-induced insulin release. Metabolism of alpha- and beta-D-glucose in isolated islets.

1976 • 98 citations

PROGRESS IN ENDOCRINOLOGY

1953 • 94 citations

Electrical characteristics of the beta-cells in pancreatic islets.

1976 • 89 citations

Dynamics of insulin release and microtubular-microfilamentous system

1974 • 85 citations

The stimulus-secretion coupling of glucose-induced insulin release. XI. Effects of Theophylline and epinephrine on 45Ca efflux from perifused islets

1973 • 83 citations

The Stimulus-Secretion Coupling of Glucose-Induced Insulin Release. XIV. Glucose Regulation of Insular Biosynthetic Activity1

1973 • 81 citations

The role of Ca-2+ and cyclic adenosine 3':5'-monophosphate in insulin release induced in vitro by the divalent cation ionophore A23187.

1975 • 80 citations

The stimulus secretion coupling of glucose-induced insulin release

1979 • 79 citations

Mechanisms of glucose stimulated insulin secretion in health and in diabetes: Some re-evaluations and proposals

1975 • 77 citations

Patterns of calcium localization in pancreatic endocrine cells

1976 • 74 citations

Transport of rubidium and sodium in pancreatic islets

1974 • 74 citations

Rapid Transient Efflux of Phosphate Ions from Pancreatic Islets as an Early Action of Insulin Secretagogues

1974 • 73 citations

The stimulus-secretion coupling of glucose-induced insulin release

1978 • 72 citations

The Stimulus‐Secretion Coupling of Glucose‐Induced Insulin Release

1974 • 70 citations

The stimulus-secretion coupling of glucose-induced insulin release

1976 • 70 citations

Motile Events in Pancreatic Endocrine Cells*

1979 • 70 citations

The stimulus-secretion coupling of glucose-induced insulin release. Metabolic and functional effects of NH4+ in rat islets.

1978 • 68 citations

Polypeptide Hormones: Molecular and Cellular Aspects.

1977 • 68 citations

Concentration of adenosine 3′:5′-cyclic monophosphate in mouse pancreatic islets measured by a protein-binding radioassay

1973 • 67 citations

Stimulus-Secretion Coupling in the Gastrointestinal Tract

1977 • 67 citations

The Purine Nucleotide Cycle

1973 • 63 citations

Ca-activated ATPase activity in subcellular fractions of mouse pancreatic islets

1976 • 59 citations

The stimulus-secretion coupling of glucose-induced insulin release. Does glycolysis control calcium transport in the B-cell?

1976 • 58 citations

The stimulus-secretion coupling of glucose-induced insulin release. Insulin release due to glycogenolysis in glucose-deprived islets

1977 • 58 citations

Insulin Biosynthesis and Secretion — A Still Unsettled Topic

1970 • 58 citations

Effect of glucose on K⁺ handling by pancreatic islets

1977 • 58 citations

Inhibition of Glucose-Induced Release of Insulin by Aldose Reductase Inhibitors

1972 • 55 citations

The significance of calcium in insulin secretion

1974 • 54 citations

Calcium antagonists and islet function: VII. Effect of calcium deprivation

1978 • 52 citations

Regulatory Mechanisms of Carbohydrate Metabolism

1978 • 50 citations

Hormonal and environmental modification of islet activity

1972 • 50 citations

The stimulus -secretion coupling of glucose-induced insulin release. XIX. The insulinotropic effect of glyceraldehyde

1976 • 49 citations

Interrelationships Between α and β Anomers of Glucose Affecting both Insulin and Glucagon Secretion in the Perfused Rat Pancreas. II.

1975 • 48 citations

The effect of mannoheptulose on glucose- and pyruvate-stimulated oxygen uptake in normal mouse pancreatic islets

1972 • 47 citations

[Factors influencing different rates of insulin release in vitro].

1968 • 46 citations

The mode of action of adenosine 3′:5′-cyclic monophosphate in mammalian islets of Langerhans. Effects of insulin secretagogues on islet-cell protein kinase activity

1973 • 45 citations

Measurement of lactic acid in nanomolar amounts reliability of such a method as an index of glycolysis in pancreatic islets

1976 • 43 citations

Dynamics of pancreatic ?-cell responses to glucose

1973 • 42 citations

The role of the pentose phosphate shunt in glucose-induced insulin release: In vitro studies with 6-aminonicotinamide, methylene blue, NAD+, NADH, NADP+, NADPH and nicotinamide on isolated pancreatic rat islets

1973 • 41 citations

MECHANISM OF INSULIN SECRETIONxxSupported by the Swedish Medical Research Council (12X-562)

1978 • 41 citations

Relationship between efflux of ionic calcium and phosphorus during excitation of pancreatic islets with glucose

1976 • 39 citations

Phosphoenolpyruvate in rat pancreatic islets: A possible intracellular trigger of insulin release?

1977 • 38 citations

Sodium uptake by microdissected pancreatic islets: Effects of ouabain and chloromercuribenzene‐p‐sulphonic acid

1974 • 38 citations

The Stimulus-Secretion Coupling of Glucose-Induced Insulin Release. Cationic and Secretory Effects of Menadione in the Endocrine Pancreas

1978 • 38 citations

Chemical transformations of antibiotic X-537A and their effect on antibacterial activity

1973 • 38 citations

The regulation of insulin secretion

1976 • 32 citations

The role of the cytoskeleton in pancreatic B-cell function.

1979 • 32 citations

Studies on the mechanism of insulin release

1966 • 30 citations

Pyridine Nucleotide Stimulation of Insulin Release from Isolated Toadfish Insulin Secretion Granules1

1972 • 29 citations

Inhibition by verapamil of ionophore-mediated calcium translocation

1977 • 29 citations

Stimulation of Secretion of Insulin by Adenosine-triphosphate

1963 • 28 citations

The Control of Insulin Release by Sugars

1976 • 27 citations

The effect of glucose anomers upon insulin and glucagon secretion

1974 • 26 citations

NaK-ATPase in rat pancreatic islets

1977 • 25 citations

Dynamics of Insulin Release and Microtubular‐Microfilamentous System

1974 • 24 citations

Insulin secretory dynamics in response to slow-rise and square-wave stimuli

1971 • 24 citations

Dynamics of Insulin Release and Microtubular‐Microfilamentous System

1974 • 23 citations

The metabolism of glucose in pancreatic islets.

1978 • 20 citations

Glucose-stimulated 45Ca Uptake in Isolated Rat Islets

1978 • 19 citations

[³²P] Orthophosphate Efflux from Pancreatic Islets: Graded Response to Glucose Stimulation

1976 • 15 citations

Identification of the α‐stereospecific glucosensor in the pancreatic B‐cell

1976 • 14 citations

Effect of Hormones on Accumulation of Cyclic AMP-¹⁴C in Isolated Pancreatic Islets of Rats

1972 • 14 citations

Insulin release and the movements of calcium in pancreatic islets

1975 • 13 citations

Pancreatic islet cell membranes: Extraction of a possible glucoreceptor

1973 • 13 citations

The possible link between glycolysis and insulin release in isolated islets

1976 • 12 citations

Dissociated responsiveness to glucose of two distinct calcium movements in pancreatic islets

1978 • 12 citations

Calcium Ion Fluxes and Insulin Release in Pancreatic Islets

1977 • 11 citations

The Heat Production of Pancreatic β‐Cells Stimulated by Glucose

1975 • 11 citations

The role of the microtubular-microfilamentous system in insulin and glucagon release by the endocrine pancreas

1975 • 11 citations

The stimulus-secretion coupling of glucose-induced insulin release: Effects of valinomycin upon pancreatic islet function

1979 • 10 citations

[Studies of insulin secretion: radioimmunoassay of cyclic nucleotides and the role of cyclic amp].

1970 • 10 citations

[Electrical activity in islet cells and insulin secretion].

1970 • 9 citations

The insulinotropic action of D-erythrose

1977 • 9 citations

An ionophoretic model for the study of calcium-calcium exchange

1980 • 9 citations

Sequential events in the process of glucose-induced insulin release

1977 • 6 citations

The role of microtubules and microfilaments in secretion

1976 • 3 citations

The Cytoskeleton in normal and pathologic processes : cell physiopathology

1979 • 2 citations

Il ruolo biologico dell'amp ciclico

1971 • 2 citations

Influences nutritionnelles et hormonales chroniques sur la fonction insulaire

1969 • 2 citations