Protein kinase C translocates from cytosol to membrane upon hormone activation: Effects of thyrotropin-releasing hormone in GH3 cells

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

1982 • 4,786 citations

Inositol trisphosphate and diacylglycerol as second messengers

1984 • 3,535 citations

Turnover of Inositol Phospholipids and Signal Transduction

1984 • 1,629 citations

Activation of calcium and phospholipid-dependent protein kinase by diacylglycerol, its possible relation to phosphatidylinositol turnover.

1980 • 1,317 citations

Phorbol esters increase the amount of Ca2+, phospholipid-dependent protein kinase associated with plasma membrane

1983 • 1,304 citations

Calcium-dependent activation of a multifunctional protein kinase by membrane phospholipids.

1979 • 1,139 citations

Calcium-activated, phospholipid-dependent protein kinase from rat brain. Subcellular distribution, purification, and properties.

1982 • 1,008 citations

Protein kinase C as a possible receptor protein of tumor-promoting phorbol esters.

1983 • 890 citations

Decrease in cytosolic calcium/phospholipid-dependent protein kinase activity following phorbol ester treatment of EL4 thymoma cells.

1982 • 417 citations

Thyrotropin-releasing hormone rapidly activates the phosphodiester hydrolysis of polyphosphoinositides in GH3 pituitary cells. Evidence for the role of a polyphosphoinositide-specific phospholipase C in hormone action.

1983 • 292 citations

Mechanism of action of the phorbol ester tumor promoters: Specific receptors for lipophilic ligands

1984 • 209 citations

Evidence for the role of phosphorylase kinase, protein kinase C, and other Ca2+-sensitive protein kinases in the response of hepatocytes to angiotensin II and vasopressin.

1984 • 192 citations

Thyrotropin-releasing hormone-induced spike and plateau in cytosolic free Ca2+ concentrations in pituitary cells. Relation to prolactin release.

1984 • 192 citations

Thyrotropin-releasing hormone stimulates rapid loss of phosphatidylinositol and its conversion to 1,2-diacylglycerol and phosphatidic acid in rat mammotropic pituitary cells. Association with calcium mobilization and prolactin secretion.

1983 • 181 citations

CALCIUM INFLUX IS NOT REQUIRED FOR TRH TO ELEVATE FREE CYTOPLASMIC CALCIUM IN GH₃CELLS

1983 • 133 citations

Evidence for the Role of Calcium and Diacylglycerol as Dual Second Messengers in Thyrotropin-Releasing Hormone Action: Involvement of Diacylglycerol*

1984 • 132 citations

Thyrotropin-releasing hormone rapidly activates protein phosphorylation in GH3 pituitary cells by a lipid-linked, protein kinase C-mediated pathway.

1984 • 115 citations

Thyrotropin-releasing hormone rapidly and transiently stimulates cytosolic calcium-dependent protein phosphorylation in GH3 pituitary cells.

1982 • 102 citations

A new possible regulatory system for protein phosphorylation in human peripheral lymphocytes. I. Characterization of a calcium-activated, phospholipid-dependent protein kinase.

1981 • 82 citations

Thyrotropin-releasing hormone stimulates rapid breakdown of phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 4-phosphate in GH3 pituitary tumor cells.

1984 • 78 citations

Evidence for the Role of Calcium and Diacylglycerol as Dual Second Messengers in Thyrotropin-Releasing Hormone Action: Involvement of Ca⁺²*

1984 • 76 citations

Platelet Ca2+-activated, phospholipid-dependent protein kinase: Evidence for proteolytic activation of the enzyme in cells treated with phospholipase C

1984 • 74 citations

Thyrotropin-releasing hormone and cyclic AMP activate distinctive pathways of protein phosphorylation in GH pituitary cells.

1982 • 64 citations

Subcellular distribution of phospholipid-sensitive calcium-dependent protein kinase in guinea pig heart, spleen and cerebral cortex, and inhibition of the enzyme by Triton X-100

1982 • 50 citations

Hormone action at membranes

1984 • 15 citations