Prostaglandins and Thromboxanes

An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation

1976 • 3,613 citations

Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides.

1975 • 3,075 citations

Prostaglandin Endoperoxides. Novel Transformations of Arachidonic Acid in Human Platelets

1974 • 1,410 citations

Arterial walls are protected against deposition of platelet thrombi by a substance (prostaglandin X) which they make from prostaglandin endoperoxides

1976 • 1,012 citations

Isolation and Structure of Two Prostaglandin Endoperoxides That Cause Platelet Aggregation

1974 • 1,004 citations

Arterial walls generate from prostaglandin endoperoxides a substance (prostaglandin X) which relaxes strips of mesenteric and coeliac arteries and inhibits platelet aggregation

1976 • 956 citations

Release of Additional Factors in Anaphylaxis and its Antagonism by Anti-inflammatory Drugs

1969 • 886 citations

Isolation and properties of intermediates in prostaglandin biosynthesis

1973 • 796 citations

The chemical structure of prostaglandin X (prostacyclin)

1976 • 729 citations

Purification of prostaglandin endoperoxide synthetase from bovine vesicular gland microsomes.

1976 • 668 citations

Modulation of human platelet adenylate cyclase by prostacyclin (PGX)

1977 • 659 citations

Detection and Isolation of an Endoperoxide Intermediate in Prostaglandin Biosynthesis

1973 • 640 citations

Arachidonate lipoxygenase in blood platelets

1975 • 613 citations

A lipid peroxide inhibits the enzyme in blood vessel microsomes that generates from prostaglandin endoperoxides the substance (prostaglandin X) which prevents platelet aggregation

1976 • 606 citations

Effects of prostacyclin (PGX) on cyclic AMP concentrations in human platelets

1977 • 601 citations

Prostaglandin Endoperoxides. A New Concept Concerning the Mode of Action and Release of Prostaglandins

1974 • 495 citations

Purification of the cyclooxygenase that forms prostaglandins. Demonstration of two forms of iron in the holoenzyme.

1976 • 435 citations

Prostacyclin (PGX) is the endogeneous metabolite responsible for relaxation of coronary arteries induced by arachidonic acid

1977 • 412 citations

Physiological role of an endoperoxide in human platelets: hemostatic defect due to platelet cyclo-oxygenase deficiency.

1975 • 312 citations

Arachidonic acid-induced human platelet aggregation and prostaglandin formation

1973 • 279 citations

On the Incorporation of Oxygen in the Conversion of 8,11,14-Eicosatrienoic Acid to Prostaglandin E₁

1965 • 231 citations

Platelet Aggregation induced by Arachidonic Acid is accompanied by Release of Potential Inflammatory Mediators distinct from PGE2 and PGF2

1973 • 227 citations

Prostaglandin endoperoxides VII. Novel transformations of arachidonic acid in guinea pig lung

1974 • 226 citations

Formation of an Intermediate in Prostaglandin Biosynthesis and Its Association with the Platelet Release Reaction

1974 • 203 citations

Prostaglandin endoperoxides IV. Effects on smooth muscle

1975 • 193 citations

Radioimmunoassay for Thromboxane B₂

1976 • 190 citations

Prostaglandin Endoperoxides IX. Characterization of Rabbit Aorta Contracting Substance (RCS) from Guinea Pig Lung and Human Platelets

1975 • 179 citations

An endoperoxide aggregator (LASS), formed in platelets in response to thrombotic stimuli-purification, identification and unique biological significance

1974 • 178 citations

Novel prostaglandin derivative formed from arachidonic acid by rat stomach homogenates

1971 • 163 citations

Localization of platelet prostaglandin production in the platelet dense tubular system.

1976 • 145 citations

Distribution of prostaglandin biosynthetic pathways in several rat tissues. Formation of 6-ketoprostaglandin F1α

1977 • 127 citations

Isolation, structure, and biosynthesis of 6-ketoprostaglandin F1.alpha. in the rat stomach

1976 • 124 citations

Endogenous formation of the prostaglandin endoperoxine metabolite, thromboxane B2, by brain tissue

1976 • 122 citations

The release of prostaglandins and rabbit aorta contracting substance (RCS) from rabbit spleen and its antagonism by anti‐inflammatory drugs

1972 • 113 citations

PRODUCTION OF PROSTAGLANDINS BY THE PSEUDOPREGNANT RAT UTERUS, in vitro, AND THE EFFECT OF TAMOXIFEN WITH THE IDENTIFICATION OF 6‐KETO‐PROSTAGLANDIN F_1α AS A MAJOR PRODUCT

1977 • 108 citations

An Enzymatic Mechanism for the Antithrombotic and Antihemostatic Actions of Aspirin

1974 • 107 citations

Isolation of a chemical trigger for thrombosis

1974 • 103 citations

A novel prostaglandin is the major product of arachidonic acid metabolism in rabbit heart.

1977 • 91 citations

Formation and Action of Prostaglandin Endoperoxides in the Isolated Human Umbilical Artery

1976 • 84 citations

A new prostaglandin transformed from arachidonic acid in carrageenin-induced granuloma

1976 • 79 citations

The 6-ketoprostaglandin F1α pathway in the lamb ductus arteriosus

1977 • 71 citations

Thromboxane Synthesis and the Platelet Release Reaction in Bernard‐Soulier Syndrome, Thrombasthenia Glanzmann and Hermansky‐Pudlak Syndrome

1977 • 70 citations

Release of prostaglandins, a prostaglandin metabolite, slow-reacting substance and histamine from anaphylactic lungs, and its modification by catecholamines

1974 • 68 citations

The role of prostaglandin endoperoxides and thromboxanes in platelet aggregation.

1976 • 65 citations

Synthesis of 13,14-dehydroprostacyclin methyl ester: a potent inhibitor of platelet aggregation.

1977 • 53 citations

A method for measuring the unstable thromboxane A2: Radioimmunoassay of the derived mono-o-methyl-thromboxane B2

1976 • 50 citations

On the Interrelationship of Prostaglandin Endoperoxide G₂ and Cyclic Nucleotides in Platelet Function

1977 • 48 citations

A new prostaglandin metabolite of arachidonic acid. Formation of 6-keto-PGF1α by the rat stomach

1976 • 48 citations

Mechanism of hormonally induced refractoriness of ovarian adenylate cyclase to luteinizing hormone and prostaglandin E.

1977 • 47 citations

Formation of 6-oxoprostaglandin F1α by arteries of the fetal calf

1977 • 44 citations

The involvement of prostaglandin endoperoxide formation in the elevation of cyclic GMP levels during platelet aggregation.

1977 • 44 citations

Identification of 6-ketoprostaglandin f1α formed from arachidonic acid in bovine seminal vesicles

1977 • 40 citations

Total synthesis of thromboxane B21

1976 • 38 citations

Introduction: new trends in prostaglandin research.

1976 • 36 citations

Prostaglandins and platelet function.

1976 • 35 citations

Mechanistic studies on the biosynthesis of 6-ketoprostaglandin F1α

1977 • 30 citations

Synthesis of thromboxane B2

1976 • 25 citations

Effect of hormones on cyclic AMP levels in cultured human cells

1976 • 15 citations