Preferential killing of multidrug-resistant KB cells by inhibitors of glucosylceramide synthase

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

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Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl.

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Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis.

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Functions of Sphingolipids and Sphingolipid Breakdown Products in Cellular Regulation

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Protein kinase C zeta isoform is critical for kappa B-dependent promoter activation by sphingomyelinase.

1994 • 473 citations

Ceramide stimulates a cytosolic protein phosphatase.

1992 • 406 citations

Characterization of a ceramide-activated protein kinase: stimulation by tumor necrosis factor alpha.

1991 • 376 citations

Accumulation of Glucosylceramides in Multidrug-resistant Cancer Cells

1996 • 347 citations

Sphingomyelin Synthase, a Potential Regulator of Intracellular Levels of Ceramide and Diacylglycerol during SV40 Transformation

1998 • 290 citations

Ceramide in apoptosis—does it really matter?

1998 • 189 citations

P-glycoprotein and resistance to anticancer drugs

1992 • 182 citations

Glucosylceramide: a marker for multiple-drug resistant cancers.

1998 • 172 citations

Cell Cycle Arrest Induced by an Inhibitor of Glucosylceramide Synthase

1995 • 165 citations

Multidrug resistance and its reversal.

1998 • 149 citations

Structural and stereochemical studies of potent inhibitors of glucosylceramide synthase and tumor cell growth.

1995 • 148 citations

Ceramide and the induction of apoptosis.

1996 • 128 citations

Treatment of Gaucher disease with an enzyme inhibitor

1996 • 120 citations

Metabolic effects of inhibiting glucosylceramide synthesis with PDMP and other substances.

1993 • 97 citations

Glucosylceramides stimulate murine epidermal hyperproliferation.

1995 • 70 citations

2-Deoxy-D-glucose preferentially kills multidrug-resistant human KB carcinoma cell lines by apoptosis

1998 • 49 citations

The human KB multidrug-resistant cell line KB-C1 is hypersensitive to inhibitors of glycosylation

1997 • 37 citations

Rationales for cancer chemotherapy with PDMP, a specific inhibitor of glucosylceramide synthase

1994 • 30 citations

Multinuclear NMR Study of the Metabolism of Drug‐Sensitive and Drug‐Resistant Human Breast Cancer Cells

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2-deoxy-D-glucose toxicity and transport in human multidrug-resistant KB carcinoma cell lines.

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