Human and Murine Serine‐Palmitoyl‐CoA Transferase

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Antibodies, a laboratory manual

1989 • 12,929 citations

Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

1988 • 6,107 citations

Tmbase-A database of membrane spanning protein segments

1993 • 2,294 citations

A new collection method for the evaluation of nasal mucus proteins

1998 • 1,297 citations

The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling

1994 • 934 citations

Serine Palmitoyltransferase Is the Primary Target of a Sphingosine-like Immunosuppressant, ISP-1/Myriocin

1995 • 537 citations

Methods for methanolysis of sphingolipids and direct determination of long‐chain bases by gas chromatography

1965 • 533 citations

Subcellular localization and membrane topology of serine palmitoyltransferase, 3-dehydrosphinganine reductase, and sphinganine N-acyltransferase in mouse liver.

1992 • 343 citations

Inhibition of phorbol ester-dependent differentiation of human promyelocytic leukemic (HL-60) cells by sphinganine and other long-chain bases.

1986 • 307 citations

The LCB2 gene of Saccharomyces and the related LCB1 gene encode subunits of serine palmitoyltransferase, the initial enzyme in sphingolipid synthesis.

1994 • 228 citations

Cloning and characterization of LCB1, a Saccharomyces gene required for biosynthesis of the long-chain base component of sphingolipids

1991 • 185 citations

Enzymology of long-chain base synthesis by liver: Characterization of serine palmitoyltransferase in rat liver microsomes

1984 • 182 citations

Biosynthesis of long-chain (sphingoid) bases from serine by LM cells. Evidence for introduction of the 4-trans-double bond after de novo biosynthesis of N-acylsphinganine(s).

1986 • 145 citations

Biosynthesis of sphingolipids: Dihydroceramide and not sphinganine is desaturated by cultured cells

1992 • 144 citations

Ceramide: a novel second messenger

1992 • 137 citations

Sphingofungins F and F: Novel serinepalmitoyl transferase inhibitors from Paecilomyces variotii.

1992 • 119 citations

Inhibition of Sphingolipid Synthesis by Cycloserine In Vitro and In Vivo

1984 • 110 citations

Activities of serine palmitoyltransferase (3-ketosphinganine synthase) in microsomes from different rat tissues.

1985 • 101 citations

Sphingolipid long-chain-base auxotrophs of Saccharomyces cerevisiae: genetics, physiology, and a method for their selection

1992 • 100 citations

Signal transduction through the sphingomyelin pathway

1994 • 93 citations

Inhibition of serine palmitoyltransferase in vitro and long-chain base biosynthesis in intact Chinese hamster ovary cells by .beta.-chloroalanine

1988 • 78 citations

Introduction: sphingolipids and their metabolites in cell regulation.

1993 • 77 citations

Sphingolipid biosynthesis in cultured neurons

1991 • 77 citations

Metabolism of Sphingosine Bases, V. Biosynthesis of Dihydrosphingosinein vitro

1968 • 74 citations

Heme biosynthesis in mammalian systems: Evidence of a schiff base linkage between the pyridoxal 5′‐phosphate cofactor and a lysine residue in 5‐aminolevulinate synthase

1993 • 74 citations

Sphingolipid synthesis: Identification and characterization of mammalian cDNAs encoding the Lcb2 subunit of serine palmitoyltransferase

1996 • 73 citations

Ceramide: a novel second messenger.

1993 • 65 citations

Inhibition of serine palmitoyl-transferase activity by lipoxamycin.

1994 • 64 citations

Metabolism of Sphingosine Bases, VIII. Distribution, Isolation and Properties of D-3-Oxosphinganine Reductase. Stereospecificity of the NADPH-dependent Reduction Reaction of 3-Oxodihydrosphingosine(2-Amino-1-hydroxyoctadecane-3-one)

1968 • 60 citations

In Vivo Studies on the Introduction of the 4-t-Double Bond of the Sphingenine Moiety of Rat Brain Ceramides

1973 • 52 citations

The sphingomyelin cycle: a prototypic sphingolipid signaling pathway.

1993 • 47 citations

The biosynthesis of dihydrosphingosine in cell-free preparations of Hansenula ciferri.

1967 • 45 citations

Aminolevulinate synthase: Lysine 313 is not essential for binding the pyridoxal phosphate cofactor but is essential for catalysis

1995 • 39 citations

2-Amino-3-ketobutyrate CoA ligase of Escherichia coli: stoichiometry of pyridoxal phosphate binding and location of the pyridoxyllysine peptide in the primary structure of the enzyme

1990 • 34 citations

Studies on the Desaturation of Sphinganine. Ceramide and Sphingomyelin Metabolism in the Rat and in BHK 21 Cells in Tissue Culture

1974 • 33 citations

Metabolism of Sphingosine Bases, IV. 2-Amino-1-hydroxyoctadecane-3-one (3-oxodihydrosphingosine), the Common Intermediate in the Biosynthesis of Dihydrosphingosine and Sphingosine and in the Degradation of Dihydrosphingosine

1967 • 33 citations

Inhibition of cerebroside synthesis in the brains of mice treated with L-cycloserine.

1985 • 25 citations

Inhibition of serine palmitoyltransferase activity in rabbit aorta by L-cycloserine.

1987 • 25 citations

Network of Signal Transduction Pathways Involving Lipids: Protein Kinase C-Dependent and -Independent Pathways

1992 • 14 citations

Characterization of a Saccharomyces cerevisiae mutant defective in inositol sphingolipid synthesis

1986 • 5 citations