Sphingoid base synthesis requirement for endocytosis in Saccharomyces cerevisiae

Extraction of Cholesterol with Methyl-β-Cyclodextrin Perturbs Formation of Clathrin-coated Endocytic Vesicles

1999 • 970 citations

PCR-synthesis of marker cassettes with long flanking homology regions for gene disruptions in S. cerevisiae

1996 • 852 citations

Structural rearrangements of tubulin and actin during the cell cycle of the yeast Saccharomyces.

1984 • 827 citations

Ubiquitination of a Yeast Plasma Membrane Receptor Signals Its Ligand-Stimulated Endocytosis

1996 • 789 citations

Caveolae, DIGs, and the dynamics of sphingolipid—cholesterol microdomains

1997 • 783 citations

The diversity of Rab proteins in vesicle transport

1997 • 762 citations

Phosphoinositides as Regulators in Membrane Traffic

1996 • 717 citations

On the Origin of Sphingolipid/Cholesterol-Rich Detergent-Insoluble Cell Membranes: Physiological Concentrations of Cholesterol and Sphingolipid Induce Formation of a Detergent-Insoluble, Liquid-Ordered Lipid Phase in Model Membranes

1997 • 661 citations

Cholesterol binds to synaptophysin and is required for biogenesis of synaptic vesicles

1999 • 562 citations

Endophilin I mediates synaptic vesicle formation by transfer of arachidonate to lysophosphatidic acid

1999 • 536 citations

The Actin-Binding Protein Profilin Binds to PIP ₂ and Inhibits Its Hydrolysis by Phospholipase C

1990 • 472 citations

Gettin’ down with ubiquitin: turning off cell-surface receptors, transporters and channels

1999 • 461 citations

SIGNALING TO THE ACTIN CYTOSKELETON

1998 • 450 citations

Linking cargo to vesicle formation: receptor tail interactions with coat proteins

1997 • 408 citations

The Actin Cytoskeleton Is Required for Receptor-mediated Endocytosis in Mammalian Cells

1997 • 394 citations

end3 and end4: two mutants defective in receptor-mediated and fluid-phase endocytosis in Saccharomyces cerevisiae.

1993 • 380 citations

Actin and fimbrin are required for the internalization step of endocytosis in yeast.

1993 • 346 citations

Acidic Sphingomyelinase Mediates Entry of N. gonorrhoeae into Nonphagocytic Cells

1997 • 319 citations

Ubiquitination Mediated by the Npi1p/Rsp5p Ubiquitin-protein Ligase Is Required for Endocytosis of the Yeast Uracil Permease

1996 • 316 citations

The role of ceramide in cell signaling

1998 • 312 citations

end5, end6, and end7: mutations that cause actin delocalization and block the internalization step of endocytosis in Saccharomyces cerevisiae.

1995 • 305 citations

Involvement of Yeast Sphingolipids in the Heat Stress Response of Saccharomyces cerevisiae

1997 • 294 citations

Synthetic-lethal interactions identify two novel genes, SLA1 and SLA2, that control membrane cytoskeleton assembly in Saccharomyces cerevisiae

1993 • 289 citations

Cytoplasmic Tail Phosphorylation of the α-Factor Receptor Is Required for Its Ubiquitination and Internalization

1998 • 276 citations

Endocytosis and degradation of the yeast uracil permease under adverse conditions

1994 • 266 citations

Sphingosine-1-phosphate inhibits PDGF-induced chemotaxis of human arterial smooth muscle cells: spatial and temporal modulation of PDGF chemotactic signal transduction.

1995 • 264 citations

Hydroxylation of Saccharomyces cerevisiae Ceramides Requires Sur2p and Scs7p

1997 • 260 citations

The END3 gene encodes a protein that is required for the internalization step of endocytosis and for actin cytoskeleton organization in yeast.

1994 • 260 citations

Endocytosis is required for the growth of vacuolar H(+)-ATPase-defective yeast: identification of six new END genes.

1994 • 258 citations

Essential role for diacylglycerol in protein transport from the yeast Golgi complex

1997 • 257 citations

Sphingoid base 1-phosphate phosphatase: A key regulator of sphingolipid metabolism and stress response

1998 • 244 citations

Invasion of T-lymphoma cells: cooperation between Rho family GTPases and lysophospholipid receptor signaling

1998 • 223 citations

Sphingosine 1-phosphate, a specific endogenous signaling molecule controlling cell motility and tumor cell invasiveness.

1992 • 223 citations

Regulatory interactions in the recognition of endocytic sorting signals by AP-2 complexes

1997 • 218 citations

A novel fluorescence-activated cell sorter-based screen for yeast endocytosis mutants identifies a yeast homologue of mammalian eps15.

1996 • 217 citations

Ceramide synthesis enhances transport of GPI-anchored proteins to the Golgi apparatus in yeast.

1994 • 210 citations

A ceramide-activated protein phosphatase mediates ceramide-induced G1 arrest of Saccharomyces cerevisiae.

1996 • 206 citations

MSS4, a Phosphatidylinositol-4-phosphate 5-Kinase Required for Organization of the Actin Cytoskeleton in Saccharomyces cerevisiae

1998 • 204 citations

Sphingomyelinase Treatment Induces ATP-independent Endocytosis

1998 • 204 citations

[48] Yeast endocytosis assays

1991 • 203 citations

End4p/Sla2p Interacts with Actin-associated Proteins for Endocytosis inSaccharomyces cerevisiae

1997 • 196 citations

Ceramide-binding and activation defines protein kinase c-Raf as a ceramide-activated protein kinase.

1996 • 193 citations

Cloning and characterization of LCB1, a Saccharomyces gene required for biosynthesis of the long-chain base component of sphingolipids

1991 • 185 citations

The LCB4 (YOR171c) and LCB5(YLR260w) Genes of Saccharomyces Encode Sphingoid Long Chain Base Kinases

1998 • 184 citations

The protein machinery of vesicle budding and fusion

1996 • 181 citations

Sphingosine 1-phosphate: a prototype of a new class of second messengers

1999 • 176 citations

The phosphoinositol sphingolipids of Saccharomyces cerevisiae are highly localized in the plasma membrane

1991 • 173 citations

Phosphatidylinositol-4-phosphate 5-Kinase Localized on the Plasma Membrane Is Essential for Yeast Cell Morphogenesis

1998 • 166 citations

Specific Sterols Required for the Internalization Step of Endocytosis in Yeast

1999 • 166 citations

Phosphatidylinositol 4,5-Bisphosphate Phosphatase Regulates the Rearrangement of Actin Filaments

1997 • 165 citations

Protein traffic in the yeast endocytic and vacuolar protein sorting pathways

1998 • 164 citations

The Discovery of Australifungin, a Novel Inhibitor of Sphinganine N-Acyltransferase from Sporormiella australis. Producing Organism, Fermentation, Isolation, and Biological Activity.

1995 • 161 citations

Endocytic internalization in yeast and animal cells: similar and different

1998 • 160 citations

Identification and Characterization of Saccharomyces cerevisiae Dihydrosphingosine-1-phosphate Phosphatase

1997 • 154 citations

Synaptojanin 1: localization on coated endocytic intermediates in nerve terminals and interaction of its 170 kDa isoform with Eps15

1997 • 153 citations

Metabolism and selected functions of sphingolipids in the yeast Saccharomyces cerevisiae

1999 • 147 citations

Coatomer (COPI)-coated vesicles: role in intracellular transport and protein sorting

1997 • 138 citations

COPII and secretory cargo capture into transport vesicles

1997 • 136 citations

Two different types of lipid moieties are present in glycophosphoinositol-anchored membrane proteins of Saccharomyces cerevisiae.

1992 • 135 citations

Analysis of Phosphorylated Sphingolipid Long-Chain Bases Reveals Potential Roles in Heat Stress and Growth Control in Saccharomyces

1999 • 133 citations

Heat-induced Elevation of Ceramide in Saccharomyces cerevisiae via de Novo Synthesis

1998 • 120 citations

The dihydrosphingosine-1-phosphate phosphatases of Saccharomyces cerevisiae are important regulators of cell proliferation and heat stress responses

1999 • 114 citations

Sphingosine 1-phosphate stimulates Rho-mediated tyrosine phosphorylation of focal adhesion kinase and paxillin in Swiss 3T3 fibroblasts

1997 • 112 citations

Synaptojanin family members are implicated in endocytic membrane traffic in yeast

1998 • 112 citations

Cytoskeletal changes induced by GRAF, the <u>G</u>TPase <u>r</u>egulator <u>a</u>ssociated with <u>f</u>ocal adhesion kinase, are mediated by Rho

1999 • 100 citations

Increased protein kinase or decreased PP2A activity bypasses sphingoid base requirement in endocytosis

2000 • 95 citations

Identification of a Saccharomyces Gene,LCB3, Necessary for Incorporation of Exogenous Long Chain Bases into Sphingolipids

1997 • 93 citations

Inhibition of Amino Acid Transport by Sphingoid Long Chain Bases in Saccharomyces cerevisiae

1998 • 80 citations

Docked Secretory Vesicles Undergo Ca2+-activated Exocytosis in a Cell-free System

1997 • 77 citations

Role of Phosphatidylinositol 4,5-Bisphosphate in Ras/Rac-Induced Disruption of the Cortactin-Actomyosin II Complex and Malignant Transformation

1998 • 74 citations

Phospholipid metabolism and membrane dynamics

1996 • 57 citations

Quantitation of alpha-factor internalization and response during the Saccharomyces cerevisiae cell cycle.

1991 • 33 citations

Activation of a Plasma Membrane–Associated Neutral Sphingomyelinase and Concomitant Ceramide Accumulation During IgG-Dependent Phagocytosis in Human Polymorphonuclear Leukocytes

1998 • 32 citations

[26] Yeast sphingosine-1-phosphate phosphatases: Assay, expression, deletion, purification, and cellular localization by GFP tagging

2000 • 14 citations

Quantitation of α-Factor Internalization and Response during the Saccharomyces cerevisiae Cell Cycle

1991 • 11 citations