Oxidative stress and role of antioxidant and ω-3 essential fatty acid supplementation in schizophrenia

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Oxidative Stress, Glutamate, and Neurodegenerative Disorders

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Comorbidity of Mental Disorders With Alcohol and Other Drug Abuse

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Reactive Oxygen Species and the Central Nervous System

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Dopamine Receptor Binding Predicts Clinical and Pharmacological Potencies of Antischizophrenic Drugs

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Omega-3 fatty acids in health and disease and in growth and development

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Schizophrenia: manifestations, incidence and course in different cultures A World Health Organization Ten-Country Study

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Glutamate Receptor Dysfunction and Schizophrenia

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Schizophrenia: Caused by a fault in programmed synaptic elimination during adolescence?

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Increase in Circulating Products of Lipid Peroxidation (F₂-Isoprostanes) in Smokers — Smoking as a Cause of Oxidative Damage

1995 • 1,343 citations

Oxidative Stress in Neurodegenerative Diseases

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Prostaglandins and Thromboxanes

1978 • 1,310 citations

CEREBRAL VENTRICULAR SIZE AND COGNITIVE IMPAIRMENT IN CHRONIC SCHIZOPHRENIA

1976 • 1,235 citations

Oxidants in Cigarette Smoke Radicals, Hydrogen Peroxide, Peroxynitrate, and Peroxynitritea

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Interactions between glutamatergic and monoaminergic systems within the basal ganglia-implications for schizophrenia and Parkinson's disease

1990 • 1,102 citations

Anatomical Abnormalities in the Brains of Monozygotic Twins Discordant for Schizophrenia

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Prenatal developmental disturbances in the limbic allocortex in schizophrenics

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Abnormally High Neuronal Density in the Schizophrenic Cortex

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Brain abnormality in schizophrenia

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Omega 3 Fatty Acids in Bipolar Disorder

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Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse

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Lipid composition of the normal human brain: gray matter, white matter, and myelin

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Postmortem Evidence of Structural Brain Changes in Schizophrenia

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Tardive Dyskinesia

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The prostaglandins: a family of biologically active lipids.

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A study of the reactivity of HO2/O2- with unsaturated fatty acids.

1983 • 519 citations

Brain Morphology and Schizophrenia

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Is Schizophrenia due to excessive synaptic pruning in the prefrontal cortex? The Feinberg hypothesis revisited

1994 • 507 citations

Age-related losses of cognitive function and motor skills in mice are associated with oxidative protein damage in the brain.

1996 • 493 citations

Alterations in Brain High-Energy Phosphate and Membrane Phospholipid Metabolism in First-Episode, Drug-Naive Schizophrenics

1991 • 481 citations

Prenatal exposure to maternal stress and subsequent schizophrenia

1998 • 480 citations

Glutamate uptake inhibition by oxygen free radicals in rat cortical astrocytes

1994 • 462 citations

Distorted Distribution of Nicotinamide-Adenine Dinucleotide Phosphate—Diaphorase Neurons in Temporal Lobe of Schizophrenics Implies Anomalous Cortical Development

1993 • 449 citations

Schizophrenia : manifestations, incidence and course in different cultures

1992 • 448 citations

Current status of antioxidant therapy

1993 • 429 citations

Excitotoxic Amino Acids and Neuropsychiatric Disorders

1990 • 407 citations

Maternal Smoking During Pregnancy and Psychiatric Adjustment in Late Adolescence

1998 • 404 citations

Arachidonic acid induces a prolonged inhibition of glutamate uptake into glial cells

1989 • 375 citations

Brain morphology in first-episode schizophrenic-like psychotic patients: A quantitative magnetic resonance imaging study

1991 • 365 citations

Infants at Risk for Schizophrenia: Sequelae of a Genetic Neurointegrative Defect

1992 • 358 citations

Mental Illness in Adults With Fetal Alcohol Syndrome or Fetal Alcohol Effects

1998 • 357 citations

Smoking and schizophrenia

1992 • 346 citations

Schizophrenia – a Brain Disease? a Critical Review of Structural and Functional Cerebral Abnormality in the Disorder

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Phosphatidyldmositol hydrolysis: A multifunctional transducing mechanism

1981 • 341 citations

Premorbid Social Functioning in Schizophrenia and Bipolar Disorder: Similarities and Differences

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CRC Handbook of free radicals and antioxidants in biomedicine

1989 • 337 citations

Neurologic Soft Signs in Schizophrenia and Character Disorders

1976 • 335 citations

Free radical pathology and antioxidant defense in schizophrenia: a review

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Essential fatty acids, lipid membrane abnormalities, and the diagnosis and treatment of schizophrenia

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The membrane hypothesis of schizophrenia

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Excitatory amino acids and neuropsychiatrie disorders

1989 • 327 citations

Lipid and phospholipid fatty acid composition of plasma, red blood cells, and platelets and how they are affected by dietary lipids: a study of normal subjects from Italy, Finland, and the USA

1987 • 311 citations

Docosahexaenoic acid status of preterm infants at birth and following feeding with human milk or formula

1986 • 292 citations

Neurotrophins: a family of proteins supporting the survival of neurons.

1994 • 290 citations

Neurobiologic Antecedents of Schizophrenia in Children

1977 • 283 citations

Dopamine activation of the arachidonic acid cascade as a basis for D1D2 receptor synergism

1991 • 262 citations

Superoxide-dependent and ascorbate-dependent formation of hydroxyl radicals from hydrogen peroxide in the presence of iron. Are lactoferrin and transferrin promoters of hydroxyl-radical generation?

1987 • 253 citations

A red cell membrane abnormality in a subgroup of schizophrenic patients: evidence for two diseases

1994 • 250 citations

Fatty acid levels in the brains of schizophrenics and normal controls

1991 • 250 citations

Protein oxidation associated with aging is reduced by dietary restriction of protein or calories.

1992 • 248 citations

Markers of Glutamatergic Neurotransmission and Oxidative Stress Associated With Tardive Dyskinesia

1998 • 247 citations

On the Plausibility of “The Neurodevelopmental Hypothesis” of Schizophrenia

1996 • 240 citations

Neurodevelopmental Schizophrenia: The Rediscovery of Dementia Praecox

1994 • 229 citations

Volumes of Ventricular System Subdivisions Measured From Magnetic Resonance Images in First-Episode Schizophrenic Patients

1992 • 225 citations

Neurological soft signs in neuroleptic-naive and neuroleptic-treated schizophrenic patients and in normal comparison subjects

1995 • 213 citations

Free radical pathology in schizophrenia: a review

1996 • 205 citations

Ventricular Enlargement in Poor-Outcome Schizophrenia

1998 • 203 citations

Advancing a Neurodevelopmental Origin for Schizophrenia

1993 • 202 citations

Docosahexaenoic Acid Is the Preferred Dietary n-3 Fatty Acid for the Development of the Brain and Retina

1990 • 201 citations

Absence of Neurodegeneration and Neural Injury in the Cerebral Cortex in a Sample of Elderly Patients With Schizophrenia

1998 • 200 citations

Metabolism of Oxygen Derivatives in Down's Syndrome*

1982 • 199 citations

The anthropometric assessment of dysmorphic features in schizophrenia as an index of its developmental origins

1997 • 197 citations

Increased serum phospholipase A2 activity in schizophrenia: a replication study.

1990 • 191 citations

Para-amino-salicylic acid in pulmonary tuberculosis.

1949 • 187 citations

Postmortem Studies in Schizophrenia

1998 • 187 citations

SCHIZOPHRENIA AS A PROSTAGLANDIN DEFICIENCY DISEASE

1977 • 182 citations

Increased Phospholipid Breakdown in Schizophrenia

1997 • 181 citations

Increased indices of free radical activity in the cerebrospinal fluid of patients with tardive dyskinesia

1990 • 177 citations

Size, shape, and orientation of neurons in the left and right hippocampus: investigation of normal asymmetries and alterations in schizophrenia

1997 • 176 citations

Essential fatty acid deficiency in erythrocyte membranes from chronic schizophrenic patients, and the clinical effects of dietary supplementation

1996 • 172 citations

Neuropathology of Schizophrenia: Cortex, Thalamus, Basal Ganglia, and Neurotransmitter-specific Projection Systems

1997 • 172 citations

Do essential fatty acids play a role in brain and behavioral development?

1992 • 171 citations

Free Radicals in the Genesis of Alzheimer's Diseasea

1993 • 171 citations

Neuronal Apoptosis: Current Understanding of Molecular Mechanisms and Potential Role in Ischemic Brain Injury

1995 • 168 citations

Increased platelet phospholipase A2 activity in schizophrenia

1995 • 163 citations

Elevated Plasma Lipid Peroxides at the Onset of Nonaffective Psychosis

1998 • 161 citations

Impaired antioxidant defense at the onset of psychosis

1996 • 160 citations

Enzymes of the antioxidant defense system in chronic schizophrenic patients

1991 • 159 citations

CSF Prostaglandin Levels in Depressed and Schizophrenic Patients

1983 • 156 citations

Schizophrenia as a developmental disorder of the cerebral cortex

1998 • 156 citations

Fat consumption and schizophrenia

1988 • 154 citations

Depleted red cell membrane essential fatty acids in drug-treated schizophrenic patients

1995 • 151 citations

Red blood cell membrane dynamics in schizophrenia. II. Fatty acid composition

1994 • 148 citations

CNS signal transduction in the pathophysiology and pharmacotherapy of affective disorders and schizophrenia

1993 • 147 citations

Programmed cell death: Implications for neuropsychiatric disorders

1994 • 147 citations

Smoking and Vulnerability for Schizophrenia

1996 • 146 citations

Progressive ventricular enlargement in schizophrenia: Comparison to bipolar affective disorder and correlation with clinical course

1990 • 146 citations

The ‘glucocorticoid cascade’ hypothesis in man

1997 • 138 citations

Elevated PLA2 activity in schizophrenics and other psychiatric patients

1993 • 138 citations

Deterioration of spatial and nonspatial reference and working memory in aged rats: Protective effect of life-long calorie restriction

1992 • 138 citations

Vitamin E treatment of tardive dyskinesia

1993 • 136 citations

First-Episode Studies in Schizophrenia: Criteria and Characterization

1992 • 134 citations

Oxidative injury and potential use of antioxidants in schizophrenia

1996 • 130 citations

Safety of Antioxidant Vitamins

1996 • 130 citations

Progression of cerebroventricular enlargement and the subtyping of schizophrenia

1997 • 118 citations

Vitamin E in the treatment of tardive dyskinesia

1990 • 118 citations

Vitamin E Treatment for Tardive Dyskinesia

1999 • 118 citations

Glutamate-induced apoptosis results in a loss of striatal neurons in the parkinsonian rat

1994 • 114 citations

Schizophrenia as a membrane lipid disorder which is expressed throughout the body

1996 • 113 citations

A double-blind trial of essential fatty acid supplementation in patients with tardive dyskinesia

1989 • 112 citations

Possible role of free radical formation in clozapine (clozaril)-induced agranulocytosis.

1991 • 111 citations

Lack of a bimodal distribution of ventricular size in schizophrenia: A Gaussian mixture analysis of 1056 cases and controls

1991 • 109 citations

Characterization of the potential antioxidant and pro-oxidant actions of some neuroleptic drugs

1995 • 109 citations

Premorbid adjustment as predictor of outcome in schizophrenia: results of a prospective study

1996 • 108 citations

Postmortem Studies of the Hippocampal Formation in Schizophrenia

1997 • 108 citations

THE DETECTION OF SCHIZOPHRENIA IN INFANCY A Preliminary Report1,2

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Qualitative assessment of brain morphology in acute and chronic schizophrenia

1992 • 105 citations

Is the earlier age at onset of schizophrenia in males a confounded finding?

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EVIDENCE OF ENHANCED LIPID PEROXIDATION IN THE CEREBROSPINAL FLUID OF PATIENTS TAKING PHENOTHIAZINES

1987 • 105 citations

Tardive dyskinesia, lipid peroxidation, and sustained amelioration with vitamin E treatment

1993 • 102 citations

Plasma membrane phospholipid fatty acid composition of cultured skin fibroblasts from schizophrenic patients: comparison with bipolar patients and normal subjects

1996 • 102 citations

Cerebral ventricular enlargement in schizophreniform disorder does not progress A seven year follow-up study

1994 • 101 citations

Membrane phospholipid metabolism and schizophrenia: an in vivo 31P-MR spectroscopy study

1994 • 99 citations

CHILDHOOD PATTERNS PREDICTIVE OF ADULT SCHIZOPHRENIA: A 30-YEAR FOLLOW-UP STUDY

1958 • 99 citations

Oxidants and Antioxidants in Development and Differentiation

1992 • 98 citations

Conformational changes in oxidized phospholipids and their preferential hydrolysis by phospholipase A2: A monolayer study

1993 • 98 citations

Erythrocyte membrane phospholipids in psychotic patients

1993 • 97 citations

Effect of ADP on PGE₁Formation in Blood Platelets from Patients with Depression, Mania and Schizophrenia

1975 • 96 citations

31Phosphorus magnetic resonance spectroscopy of the frontal and parietal lobes in chronic schizophrenia

1994 • 96 citations

Electrophysiological correlates of peroxide damage in guinea pig hippocampus in vitro

1986 • 92 citations

σ-Tocopherol: An Efficient Protector of Lipids Against Nitric Oxide-initiated Peroxidative Damage

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Heterogeneity of the Psychoses: Is There a Neurodegenerative Psychosis?

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Apoptosis and Free Radicals

1994 • 87 citations

Vitamin E in the treatment of tardive dyskinesia: a double-blind placebo-controlled study

1992 • 85 citations

Ventricle-to-brain ratio in schizophrenia: a controlled follow-up study

1989 • 83 citations

Plasma membrane phospholipid and cholesterol distribution of skin fibroblasts from drug-naive patients at the onset of psychosis

1994 • 83 citations

The Nithsdale Schizophrenia Surveys. XIV: Plasma Lipid Peroxide and Serum Vitamin E Levels in Patients with and Without Tardive Dyskinesia, and in Normal Subjects

1995 • 80 citations

Neurological Syndromes Associated With Antipsychotic Drug Use

1973 • 80 citations

MRI brain abnormalities in chronic schizophrenia: One process or more?

1996 • 77 citations

Prostaglandins and schizophrenia: further discussion of the evidence

1978 • 77 citations

Haloperidol alters rat CNS cholinergic system: Enzymatic and morphological analyses

1988 • 77 citations

Regulation of γ‐Aminobutyric Acid/Barbiturate Receptor‐Gated Chloride Ion Flux in Brain Vesicles by Phospholipase A₂: Possible Role of Oxygen Radicals

1988 • 75 citations

Correlations of phosphomonoesters measured by phosphorus-31 magnetic resonance spectroscopy in the frontal lobes and negative symptoms in schizophrenia

1994 • 75 citations

Breath alkanes as an index of lipid peroxidation

1989 • 73 citations

Vitamin C status in chronic schizophrenia

1990 • 72 citations

Peroxidation induced changes in synaptosomal transport of dopamine and γ-aminobutyric acid

1989 • 71 citations

Platelet glutathione peroxidase and monoamine oxidase activity in schizophrenics with CT scan abnormalities: Relation to psychosocial variables

1990 • 69 citations

Neurodevelopmental Pathogenesis of Schizophrenia

1993 • 66 citations

Glutathione peroxidase and CT scan abnormalities in schizophrenia

1987 • 65 citations

Stability of cerebral ventricular size from the appearance of the first psychotic symptoms to the later diagnosis of schizophrenia

1994 • 63 citations

Effects of Chlorpromazine on the Activities of Antioxidant Enzymes and Lipid Peroxidation in the Various Regions of Aging Rat Brain

1984 • 62 citations

Volatile organic compounds in the breath of patients with schizophrenia.

1995 • 62 citations

Neurobiology of schizophrenia

1996 • 61 citations

Possible association of schizophrenia with a disturbance in prostaglandin metabolism: a physiological hypothesis

1976 • 61 citations

Study of neuropathologic changes in the striatum following 4, 8 and 12 months of treatment with fluphenazine in rats

1992 • 60 citations

Elevated plasma prostaglandin E2 levels in schizophrenia

1989 • 59 citations

Differential effects of olanzapine on the gene expression of superoxide dismutase and the low affinity nerve growth factor receptor

1999 • 58 citations

The Nithsdale Schizophrenia Surveys 16. Breast-feeding and schizophrenia: Preliminary results and hypotheses

1997 • 56 citations

Prenatal growth markers in schizophrenia: a monozygotic co-twin control study

1996 • 49 citations

Chronic treatment with prolixin causes oxidative stress in rat brain

1990 • 47 citations

Increased turnover of platelet phosphatidylinositol in schizophrenia

1992 • 46 citations

Alcohol dependence and hospitalization in schizophrenia

1999 • 46 citations

Neuroleptic-induced Movement Disorders

1996 • 46 citations

Astrocytosis in the molecular layer of the dentate gyrus: A study in Alzheimer's disease and schizophrenia

1990 • 45 citations

Role of Gangliosides in Behavioral and Biochemical Actions of Alcohol: Cell Membrane Structure and Function

1993 • 45 citations

The platelet polyphosphoinositide system in Schizophrenia: The effects of neuroleptic treatment

1990 • 43 citations

Abnormal growth of skin fibroblasts from schizophrenic patients

1991 • 43 citations

Accumulation of diacylgylcerol in platelet phosphoinositide turnover in Schizophrenia: A biological marker of good prognosis?

1989 • 42 citations

The relationship between schizophrenia and essential fatty acid and eicosanoid metabolism

1992 • 41 citations

Clinical and pharmacological studies in psychiatric disorders

1985 • 39 citations

Left ventricular enlargement associated with diagnostic outcome of schizophreniform disorder

1992 • 36 citations

Subcortical excitatory amino acid levels after acute and subchronic administration of typical and atypical neuroleptics

1993 • 35 citations

Potential Link Between Dietary Intake of Fatty Acids and Behavior: Pilot Exploration of Serum Lipids in Attention-Deficit Hyperactivity Disorder

1994 • 35 citations

Essential fatty acids modulate apomorphine activity at dopamine receptors in cat caudate slices

1988 • 34 citations

Polyunsaturated Fatty Acids, Prostaglandins, and Schizophrenia

1989 • 34 citations

Cerebrospinal fluid prostaglandin E in depression, mania, and schizophrenia compared to normals.

1983 • 34 citations

Utilization of precursor essential fatty acids in culture by skin fibroblasts from schizophrenic patients and normal controls

1996 • 33 citations

Is the main problem in free radical damage caused by radiation, oxygen and other toxins the loss of membrane essential fatty acids rather than the accumulation of toxic materials?

1991 • 31 citations

Cultured skin fibroblasts as a cell model for investigating schizophrenia

1996 • 31 citations

Dyskinesias and their treatment with essential fatty acids: a review

1996 • 31 citations

Three-dimensional cortical morphometry of the planum temporale in childhood-onset schizophrenia

1997 • 28 citations

Penicillin and essential fatty acid supplementation in schizophrenia

1979 • 28 citations

Aspects of Oxidative Metabolism in Schizophrenia

1995 • 26 citations

Decreased adhesiveness and altered cellular distribution of fibronectin in fibroblasts from schizophrenic patients

1994 • 26 citations

Double-blind placebo controlled trial of N-3 polyunsaturated fatty acids as an adjunct to neuroleptics

1998 • 25 citations

Eicosapentaenoic acid (EPA) as an adjunct in the treatment of schizophrenia

1998 • 25 citations

Staining intensity of brain iron in patients with schizophrenia: a postmortem study

1992 • 24 citations

Mitogenic response to basic fibroblast growth factor (BFGF) in cultured skin fibroblasts from first episode psychosis patients

1995 • 24 citations

The effect of ischemia and recirculation, hypoxia and recovery on anti-oxidant factors and β-adrenoceptor density

1987 • 22 citations

Plasma prostaglandin E2 metabolite—measured as 11 -deoxy-15 -keto-13,14-dihydro-11 β, 16ξ-cyclo-PGE2—in twins with schizophrenic disorder

1986 • 21 citations

Increased calcium-independent phospholipase A2 activity in vitamin E and selenium-deficient rat lung, liver, and spleen cytosol is time-dependent and reversible

1996 • 20 citations

Maintenance Treatment of Major Depression: A Review of the Literature

1996 • 19 citations

Increased manganese-superoxide dismutase activity in postmortem brain from neuroleptic-treated psychotic patients

1996 • 18 citations

Phospholipases: in search of a genetic base of schizophrenia

1996 • 18 citations

Free Radical Scavenging Enzyme Activity and Related Trace Metals in Clozapine-Induced Agranulocytosis

1995 • 17 citations

Stimulation of arachidonic-acid release from Swiss 3T3 cells by recombinant basic fibroblast growth factor: Independence from phosphoinositide turnover

1994 • 16 citations

Influence of lipid peroxidation on [3H]ketanserin binding to 5-HT2 prefrontal cortex receptors

1995 • 16 citations

No differences in phospholipase-A2 activity between acute psychiatric patients and controls

1997 • 15 citations

Low nerve growth factor (NGF) plasma levels in schizophrenic patients: a pilot study

1996 • 13 citations

The lipid membrane hypothesis of schizophrenia: implications for possible clinical breath tests

1996 • 11 citations

[Study of the processes of lipid peroxidation in patients with endogenous psychoses using gas chromatography].

1989 • 6 citations

67. Neuroprotective actions of olanzapine in rat: cholinergic function

2000 • 4 citations

376. Eicosanoid pathways and psychiatric disorders

2000 • 2 citations

Altered signal transduction in fibroblasts from first-episode schizophrenic patients

1996 • 1 citations

68. Neuroprotective actions of olanzapine in rat: mechanism

2000 • 1 citations

Deleted Work

1955 • 0 citations