Phosphatidyldmositol hydrolysis: A multifunctional transducing mechanism

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

1980 • 12,033 citations

Inositol phospholipids and cell surface receptor function

1975 • 2,458 citations

The role of hormone receptors and GTP-regulatory proteins in membrane transduction

1980 • 1,750 citations

Activation of calcium and phospholipid-dependent protein kinase by diacylglycerol, its possible relation to phosphatidylinositol turnover.

1980 • 1,317 citations

The effects of lithium ion and other agents on the activity of myo-inositol-1-phosphatase from bovine brain.

1980 • 1,099 citations

Leukotrienes are potent constrictors of human bronchi

1980 • 984 citations

ENZYME SECRETION AND THE INCORPORATION OF P32 INTO PHOSPHOLIPIDES OF PANCREAS SLICES

1953 • 757 citations

Unsaturated diacylglycerol as a possible messenger for the activation of calcium-activated, phospholipid-dependent protein kinase system

1979 • 727 citations

Production of diglyceride from phosphatidylinositol in activated human platelets.

1979 • 727 citations

Local regulation of adrenergic neurotransmission.

1977 • 645 citations

Prostaglandins released by the Spleen

1968 • 542 citations

Metabolism of [14C]arachidonic acid by human platelets

1976 • 453 citations

UNSTABLE METABOLITES OF ARACHIDONIC ACID AND THEIR ROLE IN HAEMOSTASIS AND THROMBOSIS

1978 • 447 citations

Sodium nitroprusside and other smooth muscle-relaxants increase cyclic GMP levels in rat ductus deferens

1977 • 422 citations

Local modulation of adrenergic neuroeffector interaction in the blood vessel well.

1981 • 417 citations

Phospholipid exchange reactions within the liver cell

1969 • 394 citations

Phospholipase A2 activity specific for phosphatidic acid. A possible mechanism for the production of arachidonic acid in platelets.

1981 • 368 citations

Phospholipid Metabolism in Stimulated Human Platelets

1980 • 367 citations

The role of lipids in platelet function: with particular reference to the arachidonic acid pathway.

1978 • 364 citations

Phospholipid precursors of prostaglandins

1968 • 333 citations

Is phosphatidic acid a calcium ionophore under neurohumoral control?

1980 • 331 citations

Role of phosphatidylinositol turnover in alpha1 and of adenylate cyclase inhibition in alpha2 effects of catecholamines

1980 • 298 citations

Corticotropin-(1–24)-tetracosapeptide affects protein phosphorylation and polyphosphoinositide metabolism in rat brain

1981 • 287 citations

Phospholipase A2 and phospholipase C activities of platelets. Differential substrate specificity, Ca2+ requirement, pH dependence, and cellular localization.

1980 • 287 citations

SIGNIFICANCE OF PHOSPHOLIPASE A FOR PROSTAGLANDIN FORMATION

1971 • 282 citations

Inositol phospholipids in membrane function

1979 • 272 citations

THE DISTRIBUTION AND METABOLISM OF ARACHIDONIC ACID IN RABBIT PLATELETS DURING AGGREGATION AND ITS MODIFICATION BY DRUGS

1977 • 264 citations

Proposed mechanism of cholinergic action in smooth muscle

1980 • 256 citations

Nitroglycerin Stimulates Synthesis of Prostacyclin by Cultured Human Endothelial Cells

1981 • 252 citations

ELEVATION OF CYCLIC GMP LEVELS IN CENTRAL NERVOUS SYSTEM BY EXCITATORY AND INHIBITORY AMINO ACIDS

1974 • 247 citations

PHOSPHOLIPIDS IN SYNAPTIC FUNCTION

1979 • 235 citations

The requirement for endothelial cells in the relaxation of arteries by acetylcholine and some other vasodilators

1981 • 231 citations

The initial action of thrombin on platelets. Conversion of phosphatidylinositol to phosphatidic acid preceding the production of arachidonic acid.

1981 • 228 citations

Studies on alpha-adrenergic activation of hepatic glucose output. The role of mitochondrial calcium release in alpha-adrenergic activation of phosphorylase in perfused rat liver.

1979 • 201 citations

Muscarinic, alpha‐adrenergic and peptide receptors regulate the same calcium influx sites in the parotid gland.

1977 • 197 citations

Relationship between hormonal activation of phosphatidylinositol hydrolysis, fluid secretion and calcium flux in the blowfly salivary gland

1979 • 193 citations

Stimulation by vasopressin and alpha-catecholamines of phosphatidylinositol formation in isolated rat liver parenchymal cells.

1980 • 188 citations

Inhibition of phosphatidylinositol synthesis and the inactivation of calcium entry after prolonged exposure of the blowfly salivary gland to 5-hydroxytryptamine

1979 • 181 citations

Biosynthesis of lipids in golgi complex and other subcellular fractions from rat liver

1974 • 179 citations

Initiation of phospholipase A2 activity in human platelets by the calcium ion ionophore A23187

1977 • 178 citations

Modulation of brain polyphosphoinositide metabolism by ACTH-sensitive protein phosphorylation

1980 • 178 citations

The action of prostaglandin synthetase on 2-arachidonyl-lecithin

1968 • 160 citations

Phosphatidylinositol metabolism in rat hepatocytes stimulated by vasopressin

1981 • 152 citations

Activation and inhibition of calcium‐dependent histamine secretion by ATP ions applied to rat mast cells.

1979 • 151 citations

Modulation of purified phospholipase A2 activity from human platelets by calcium and indomethacin

1979 • 150 citations

Activation of soluble splenic cell guanylate cyclase by prostaglandin endoperoxides and fatty acid hydroperoxides

1978 • 150 citations

Function and Biosynthesis of Lipids

1977 • 148 citations

Isoproterenol-induced desensitization of adenylate cyclase in human astrocytoma cells. Relation of loss of hormonal responsiveness and decrement in beta-adrenergic receptors.

1979 • 142 citations

Regulation of Pancreatic Exocrine Function In Vitro: Initial Steps in the Actions of Secretagogues

1979 • 141 citations

Phosphoinositides. 3. Enzymic hydrolysis of inositol-containing phospholipids

1961 • 137 citations

Relationship between phosphatidylinositol synthesis and recovery of 5-hydroxytryptamine-responsive Ca2+ flux in blowfly salivary glands

1979 • 135 citations

Why is phosphatidylinositol degraded in response to stimulation of certain receptors?

1981 • 135 citations

Phosphatidylinositol metabolism in rat hepatocytes stimulated by glycogenolytic hormones. Effects of angiotensin, vasopressin, adrenaline, ionophore A23187 and calcium-ion deprivation

1979 • 133 citations

The fatty acid composition of phosphatidylinositol from thrombin-stimulated human platelets.

1981 • 125 citations

Indomethacin-induced accumulation of diglyceride in activated human platelets. The role of diglyceride lipase.

1980 • 122 citations

EFFECTS OF ACETYLCHOLINE ON PHOSPHOLIPIDES IN THE PANCREAS

1954 • 122 citations

Requirement for calcium ions in acetylcholine-stimulated phosphodiesteratic cleavage of phosphatidyl-myo-inositol 4,5-bisphosphate in rabbit iris smooth muscle

1980 • 122 citations

Transfer of arachidonic acid between phospholipids in rat liver microsomes

1979 • 121 citations

Release of renal prostaglandin by catecholamines: relationship to renal endocrine function.

1974 • 117 citations

SEPARATE 5‐HYDROXYTRYPTAMINE RECEPTORS ON THE SALIVARY GLAND OF THE BLOWFLY ARE LINKED TO THE GENERATION OF EITHER CYCLIC ADENOSINE 3‘,5’‐MONOPHOSPHATE OR CALCIUM SIGNALS

1981 • 111 citations

Acetylcholine causes a net decrease in phosphatidylinositol and a net increase in phosphatidic acid in mouse pancreas

1974 • 108 citations

Control by TSH of a phospholipase A₂ activity, a limiting factor in the biosynthesis of prostaglandins in the thyroid

1973 • 108 citations

Evidence for a role of phosphatidylinositol turnover in stimulus–secretion coupling. Studies with rat peritoneal mast cells

1979 • 107 citations

Hormonal stimulation of arachidonic release from isolated perfused organs relationship to prostaglandin biosynthesis

1977 • 106 citations

The protein-mediated net transfer of phosphatidylinositol in model systems

1977 • 103 citations

Studies on the enzymic hydrolysis of monophosphoinositide by phospholipase preparations from P. notatum and ox pancreas

1959 • 102 citations

Ca²⁺, K⁺ Redistributions and α‐Adrenergic Activation of Glycogenolysis in Perfused Rat Livers

1980 • 100 citations

Stimulus–secretion coupling in rabbit neutrophils is not mediated by phosphatidylinositol breakdown

1980 • 97 citations

The metabolism of phosphatidylinositol in the thyroid gland of the pig

1971 • 96 citations

Receptor occupancy dose—response curve suggests that phosphatidyl‐inositol breakdown may be intrinsic to the mechanism of the muscarinic cholinergic receptor

1976 • 92 citations

Cyclitols and Phosphoinositides

1978 • 92 citations

Pituitary hormones influence polyphosphoinositide metabolism in rat brain

1979 • 89 citations

The relationship of calcium to receptor-controlled stimulation of phosphatidylinositol turnover. Effects of acetylcholine, adrenaline, calcium ions, cinchocaine and a bivalent cation ionophore on rat parotid-gland fragments

1975 • 89 citations

On the mechanism whereby ACTH and cyclic AMP increase adrenal polyphosphoinositides. Rapid stimulation of the synthesis of phosphatidic acid and derivatives of CDP - diacylglycerol.

1980 • 87 citations

Arachidonate metabolite(s) increase the permeability of the plasma membrane of the neutrophils to calcium

1980 • 78 citations

Acute effect of thyrotropin on phosphatidylinositol degradation and transient accumulation of diacylglycerol in isolated thyroid follicles

1980 • 74 citations

Calcium ion requirement for acetylcholine-stimulated breakdown of triphosphoinositide in rabbit iris smooth muscle.

1978 • 73 citations

Receptors and calcium signalling

1980 • 73 citations

Histamine-Induced release of arachidonic acid and of prostaglandins in the peripheral vascular bed

1980 • 71 citations

Intestinal mucosal cyclic GMP: regulation and relation to ion transport

1976 • 70 citations

Direct demonstration of the formation of prostaglandin E2 due to phosphatidylinositol breakdown associated with stimulation of enzyme secretion in the pancreas.

1981 • 65 citations

Receptor control of calcium influx in parotid acinar cells.

1978 • 63 citations

Phosphatidylinositol turnover in mitogen-activated lymphocytes. Suppression by low-density lipoproteins

1980 • 62 citations

ACETYLCHOLINE STIMULATES GROWTH HORMONE SECRETION, PHOSPHATIDYL INOSITOL LABELLING, 45Ca2+ EFFLUX AND CYCLIC GMP ACCUMULATION IN BOVINE ANTERIOR PITUITARY GLANDS

1979 • 62 citations

Metabolism and Role of Phosphatidylinositol in Acetylcholinestimulated Membrane Function

1977 • 61 citations

The relationship of phosphatidylinositol turnover to receptors and calcium-ion channels in rat parotid acinar cells

1981 • 59 citations

Incorporation of inorganic [32P] phosphate into rat parotid phosphatidylinositol. Induction through activation of alpha adrenergic and cholinergic receptors and relation to K+ release.

1975 • 58 citations

Inotropic responses of the frog ventricle to adenosine triphosphate and related changes in endogenous cyclic nucleotides.

1980 • 57 citations

f‐MetLeuPhe‐induced phosphatidylinositol turnover in rabbit neutrophils is dependent on extracellular calcium

1980 • 57 citations

Intracellular messenger role of cyclic GMP in exocrine pancreas

1976 • 56 citations

Rapid acylation and deacylation of arachidonic acid into phosphatidic acid of horse neutrophils.

1980 • 56 citations

Stimulation of Renal Prostaglandin Synthesis by the Pressor Activity of Vasopressin*

1981 • 56 citations

Cyclitols and phosphoinositides

1978 • 53 citations

Ca2+-dependent and Ca2+-independent degradation of phosphatidylinositol in rabbit vas deferens

1981 • 52 citations

THE ROLE OF HISTAMINE H_r AND H₂‐RECEPTORS IN THE GENERATION OF THROMBOXANE A₂ IN PERFUSED GUINEA‐PIG LUNGS

1979 • 51 citations

EFFECTS OF NERVE STIMULATION AND OF ADMINISTRATION OF NORADRENALINE OR POTASSIUM CHLORIDE UPON THE RELEASE OF PROSTAGLANDINS I₂, E₂ AND F_2α FROM THE PERFUSED MESENTERIC ARTERIAL BED OF THE RABBIT

1981 • 51 citations

Adrenergic stimulation of phosphatidylinositol labelling in rat vas deferens

1974 • 50 citations

The distribution of phosphatidylinositol in microsomal membranes from rat liver after biosynthesis de novo. Evidence for the existence of different pools of microsomal phosphatidylinositol by the use of phosphatidylinositol-exchange protein

1978 • 48 citations

Cyclitols and Phosphoinositides

1979 • 46 citations

Stimulation of inorganic-phosphate incorporation into phosphatidylinositol in rat thoracic aorta mediated through V1-vasopressin receptors

1981 • 45 citations

Stimulation of phosphatidylinositol turnover by histamine, 5-hydroxytryptamine and adrenaline in the longitudinal smooth muscle of guinea pig ileum

1976 • 45 citations

Increased intracellular cyclic GMP does not correlate with protein discharge from pancreatic acinar cells

1979 • 44 citations

Phospholipid Metabolism in Embryonic Rat Fibroblasts following Stimulation by a Combination of the Serum Proteins S1 and S2

1974 • 42 citations

Studies on the properties of a soluble phosphatidylinositol-phosphodiesterase of rabbit iris smooth muscle

1980 • 42 citations

Phosphatidate releases calcium from cardiac sarcoplasmic reticulum

1980 • 40 citations

Temperature Dependence of Muscarinic Acetylcholine Receptor Activation, Desensitization, and Resensitization

1980 • 39 citations

Phosphatidylinositol exchange protein effects of membrane structure on activity and evidence for a ping-pong mechanism

1976 • 39 citations

Hormonal Systems and Renal Hemodynamics

1980 • 38 citations

On the relationship between formylmethionyl-leucyl-phenylalanine stimulation of arachidonyl phosphatidylinositol turnover and lysosomal enzyme secretion by rabbit neutrophils.

1981 • 38 citations

The effect of Ca++ omission on the secretion of catecholamines and the incorporation of orthophosphate-32P into nucleotides and phospholipids of bovine adrenal medulla during acetylcholine stimulation.

1969 • 37 citations

Activation of (arachidonyl) phosphatidylinositol turnover in rabbit neutrophils by the calcium ionophore A23187

1981 • 37 citations

Role of calcium in the fade of the potassium release response in the rat parotid gland.

1978 • 34 citations

Adrenergic and cholinergic stimulation of 32P-labeling of phospholipids in rabbit iris muscle

1976 • 32 citations

Proposed mechanisms of stimulation and inhibition of guanylate cyclase with reference to the actions of chlorpromazine, phospholipases and triton X-100

1975 • 29 citations

Role of Inositol Cyclic Phosphate in Stimulated Tissues

1973 • 28 citations

A proposal for the mechanism by which α-adrenergic agonists, vasopressin, angiotensin and cyclic AMP induce calcium release from intracellular stores in the liver cell: A possible role for metabolites of arachidonic acid

1981 • 26 citations

Lanthanum as a Tool to Study the Role of Phosphatidylinositol in the Calcium Transport in Rat Parotid Glands upon Cholinergic Stimulation

1978 • 23 citations

“Phospholipid effect” and secretion in the rat pancreas

1972 • 21 citations

Arachidonic acid activation of guinea pig lung guanylate cyclase by two independent mechanisms

1979 • 20 citations

Guanylate cyclase from bovine adrenal medulla: Subcellular distribution and studies on the effect of lysolecithin on enzyme activity

1978 • 19 citations

Acetylcholine promotes the synthesis of prostaglandin E in mouse pancreas

1980 • 18 citations

The importance of Ca2+-mediated phospholipase A2 activation for stimulus-evoked PGE2-release from rabbit splenic capsular strips

1979 • 15 citations

Calcium and O2-dependent control of inner medullary cGMP: Possible role for Ca2+-dependent arachidonate release and prostaglandin synthesis in expression of the action of osmolality on renal inner medullary guanosine 3′5′ monophosphate

1980 • 13 citations

Thyrotropin‐stimulated phosphatidylinositol‐specific phospholipase A₂ in pig thyroid, a re‐examination

1980 • 13 citations

Calcium Ions and Inositol Phospholipid Metabolism in Nervous Tissue

1979 • 10 citations

Membrane protein mediation of thromboxane A2 induced platelet aggregation

1980 • 9 citations

Alpha-adrenergic regulation of cholinergic responses in rat parotid acinar cells.

1980 • 8 citations

Ca2+-DEPENDENT POLYPHOSPHOINOSITIDE (PPI) BREAKDOWN IN STIMULATED RAT HEPATOCYTES

1981 • 3 citations