Glutamate-induced apoptosis results in a loss of striatal neurons in the parkinsonian rat

Cell Death During Development of the Nervous System

1991 • 3,033 citations

Excitotoxic cell death

1992 • 2,307 citations

Reversal of Experimental Parkinsonism by Lesions of the Subthalamic Nucleus

1990 • 1,875 citations

Developmental cell death: morphological diversity and multiple mechanisms

1990 • 1,695 citations

Chromatin cleavage in apoptosis: Association with condensed chromatin morphology and dependence on macromolecular synthesis

1984 • 1,586 citations

Programmed Cell Death and the Control of Cell Survival: Lessons from the Nervous System

1993 • 1,470 citations

3,4-Dihydroxyphenylalanine and 5-Hydroxytryptophan as Reserpine Antagonists

1957 • 1,233 citations

Apoptotic death in epithelial cells: cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation.

1993 • 1,144 citations

Interactions between glutamatergic and monoaminergic systems within the basal ganglia-implications for schizophrenia and Parkinson's disease

1990 • 1,102 citations

The neural network of the basal ganglia as revealed by the study of synaptic connections of identified neurones

1990 • 1,021 citations

NMDA Antagonist Neurotoxicity: Mechanism and Prevention

1991 • 837 citations

Compensations after lesions of central dopaminergic neurons: some clinical and basic implications

1990 • 597 citations

Role for Excitatory Amino Acids in Methamphetamine-Induced Nigrostriatal Dopaminergic Toxicity

1989 • 495 citations

THE BRAIN-STEM LESIONS IN PARKINSONISM

1953 • 485 citations

Global ischemia can cause DNA fragmentation indicative of apoptosis in rat brain

1993 • 481 citations

An N-methylaspartate receptor-mediated synapse in rat cerebral cortex: a site of action of ketamine?

1985 • 457 citations

Neural mechanisms underlying parkinsonian symptoms based upon regional uptake of 2-deoxyglucose in monkeys exposed to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

1989 • 455 citations

Effect of Reserpine on the Storage of Catechol Amines in Brain and Other Tissues

1961 • 300 citations

Glutamate triggers internucleosomal DNA cleavage in neuronal cells

1991 • 276 citations

Ultrastructural changes in the hippocampal CA1 region following transient cerebral ischemia: evidence against programmed cell death

1992 • 270 citations

The AMPA receptor antagonist NBQX has antiparkinsonian effects in monoamine‐depleted rats and MPTP‐treated monkeys

1991 • 258 citations

Alleviation of parkinsonism by antagonism of excitatory amino acid transmission in the medial segment of the globus pallidus in rat and primate

1991 • 201 citations

Neurotoxin-induced cell death in neuronal PC12 cells is mediated by induction of apoptosis

1994 • 200 citations

Glutamate‐Induced Neuronal Death Is Not a Programmed Cell Death in Cerebellar Culture

1993 • 160 citations

Immunocytochemical studies on the basal ganglia and substantia nigra in Parkinson's disease and Huntington's chorea

1988 • 123 citations

NMDA antagonists partially protect against MPTP induced neurotoxicity in mice

1993 • 90 citations

Microtopography of methionine-enkephalin, dopamine and noradrenaline in the ventral mesencephalon of human control and Parkinsonian brains

1982 • 63 citations

Effects of reserpine and a tyrosine hydroxylase inhibitor on the monoamine levels in different regions of the rat central nervous system

1967 • 55 citations

Death of neurons in the neonatal rodent and primate globus pallidus occurs by a mechanism of apoptosis

1994 • 43 citations

Nerve cell death induced in vivo by kainic acid and quinolinic acid does not involve apoptosis

1991 • 41 citations

In vivo protection of striatum from MPP+ neurotoxicity by N-methyl-d-aspartate antagonists

1992 • 40 citations