Redox regulation in the lens

Oxidants, oxidative stress and the biology of ageing

2000 • 8,990 citations

AP-1 function and regulation

1997 • 2,833 citations

Physiological functions of thioredoxin and thioredoxin reductase

2000 • 2,440 citations

THIOREDOXIN

1985 • 1,885 citations

Thioredoxin and Glutaredoxin Systems

1989 • 1,778 citations

Identification of three classes of cytosolic glutathione transferase common to several mammalian species: correlation between structural data and enzymatic properties.

1985 • 1,081 citations

Oxidative stress‐induced cataract: mechanism of action

1995 • 891 citations

Theory of Transparency of the Eye

1971 • 876 citations

AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1

1997 • 836 citations

Glutathione : chemical, biochemical, and medical aspects

1989 • 746 citations

Short-range order of crystallin proteins accounts for eye lens transparency

1983 • 735 citations

The redox couple between glutathione and ascorbic acid: A chemical and physiological perspective

1994 • 487 citations

Recent Trends in Glutathione Biochemistry—Glutathione–Protein Interactions: A Molecular Link between Oxidative Stress and Cell Proliferation?

1998 • 482 citations

Identification of redox/repair protein Ref-1 as a potent activator of p53.

1997 • 479 citations

Hydrogen donor system for Escherichia coli ribonucleoside-diphosphate reductase dependent upon glutathione.

1976 • 474 citations

Mammalian thioltransferase (glutaredoxin) and protein disulfide isomerase have dehydroascorbate reductase activity.

1990 • 461 citations

Properties and Biological Activities of Thioredoxins

2001 • 437 citations

The molecular structure and stability of the eye lens: X-ray analysis of γ-crystallin II

1981 • 432 citations

Glutathione: A Vital Lens Antioxidant

2000 • 391 citations

Determination of low-molecular-weight thiols using monobromobimane fluorescent labeling and high-performance liquid chromatography

1987 • 375 citations

Roles of Superoxide Radical Anion in Signal Transduction Mediated by Reversible Regulation of Protein-tyrosine Phosphatase 1B

1999 • 353 citations

Glutathionylation of human thioredoxin: A possible crosstalk between the glutathione and thioredoxin systems

2002 • 346 citations

The Lens: Development, Proteins, Metabolism and Cataract

1984 • 342 citations

Acute Cadmium Exposure Inactivates Thioltransferase (Glutaredoxin), Inhibits Intracellular Reduction of Protein-glutathionyl-mixed Disulfides, and Initiates Apoptosis

2000 • 329 citations

Cloning and Expression of a Novel Human Glutaredoxin (Grx2) with Mitochondrial and Nuclear Isoforms

2001 • 326 citations

Thioltransferase is a specific glutathionyl mixed-disulfide oxidoreductase

1993 • 305 citations

Regulation of the fission yeast transcription factor Pap1 by oxidative stress: requirement for the nuclear export factor Crm1 (Exportin) and the stress-activated MAP kinase Sty1/Spc1

1998 • 304 citations

Free and protein-bound glutathione in normal and cataractous human lenses

1970 • 288 citations

The search for a solution to senile cataracts. Proctor lecture.

1984 • 268 citations

High correlation between pentosidine protein crosslinks and pigmentation implicates ascorbate oxidation in human lens senescence and cataractogenesis.

1991 • 250 citations

Glutathione and its function in the lens—An overview

1990 • 246 citations

The Major in vivo Modifications of the Human Water-insoluble Lens Crystallins are Disulfide Bonds, Deamidation, Methionine Oxidation and Backbone Cleavage

2000 • 244 citations

Mechanisms of Cataract Formation in the Human Lens

1981 • 239 citations

S-Thiolation of Individual Human Neutrophil Proteins Including Actin by Stimulation of the Respiratory Burst: Evidence against a Role for Glutathione Disulfide

1994 • 228 citations

The UV response involving the ras signaling pathway and AP-1 transcription factors is conserved between yeast and mammals

1994 • 225 citations

Identification and Characterization of a New Mammalian Glutaredoxin (Thioltransferase), Grx2

2001 • 223 citations

The effect of H2O2 upon thioredoxin-enriched lens epithelial cells.

1988 • 214 citations

The state of sulphydryl groups in normal and cataractous human lenses

1977 • 213 citations

Thioredoxin regenerates proteins inactivated by oxidative stress in endothelial cells

1992 • 210 citations

Biothiols in Health and Disease

1995 • 199 citations

Vitamin D3-up-regulated Protein-1 Is a Stress-responsive Gene That Regulates Cardiomyocyte Viability through Interaction with Thioredoxin

2002 • 183 citations

Studies on the Oxidation of Cysteine to Cystine in Lens Proteins During Cataract Formation*

1951 • 177 citations

Thioltransferase (Glutaredoxin) Reactivates the DNA-binding Activity of Oxidation-inactivated Nuclear Factor I

1998 • 161 citations

Disulfide-linked high molecular weight protein associated with human cataract.

1978 • 156 citations

Mixed Disulfides: Biological Functions and Increase in Oxidative Stress

1985 • 149 citations

Curcumin protects against 4-hydroxy-2-trans-nonenal–induced cataract formation in rat lenses

1996 • 148 citations

Nuclear light scattering, disulfide formation and membrane damage in lenses of older guinea pigs treated with hyperbaric oxygen

1995 • 146 citations

Modifications of the Water-insoluble Human Lens α-Crystallins

1996 • 135 citations

Squid major lens polypeptides are homologous to glutathione S-transferases subunits

1988 • 129 citations

Mechanisms of cataract formation in the human lens

1981 • 127 citations

Protein-thiol mixed disulfides in human lens

1992 • 125 citations

Dehydroascorbate reduction

1994 • 123 citations

Role of site-specific, metal-catalyzed oxidation in lens aging and cataract: A hypothesis

1990 • 122 citations

Ascorbic acid-induced crosslinking of lens proteins: evidence supporting a Maillard reaction

1988 • 113 citations

Glutathione ester prevents buthionine sulfoximine-induced cataracts and lens epithelial cell damage.

1989 • 111 citations

The state of sulfhydryl groups in normal and cataractous human lens proteins. I. Nuclear region

1978 • 109 citations

Glutathione ester delays the onset of scurvy in ascorbate-deficient guinea pigs.

1993 • 105 citations

Theoretical and experimental basis for the inhibition of cataract

1999 • 94 citations

Possible Differences in the Regenerative Roles Played by Thioltransferase and Thioredoxin for Oxidatively Damaged Proteins

1994 • 92 citations

The concentration and localization of heavy molecular weight aggregates in aging normal and cataractous human lenses

1975 • 91 citations

Thiol Regulation in the Lens

2000 • 91 citations

The role of protein-thiol mixed disulfides in cataractogenesis

1990 • 85 citations

The Effect and Recovery of Long-term H2O2 Exposure on Lens Morphology and Biochemistry

1993 • 84 citations

S-Thiolation and Irreversible Oxidation of Sulfhydryls on Carbonic Anhydrase III During Oxidative Stress: A Method for Studying Protein Modification in Intact Cells and Tissues

1994 • 84 citations

Crystal structure of S‐glutathiolated carbonic anhydrase III

2000 • 81 citations

Effect of chronic near-ultraviolet radiation on the gray squirrel lens in vivo.

1991 • 80 citations

Glutaredoxin Protects Cerebellar Granule Neurons from Dopamine-induced Apoptosis by Dual Activation of the Ras-Phosphoinositide 3-Kinase and Jun N-terminal Kinase Pathways

2001 • 75 citations

UVA Light In vivo Reaches the Nucleus of the Guinea Pig Lens and Produces Deleterious, Oxidative Effects

2002 • 72 citations

Mechanism of action of enzymes catalyzing thiol—disulfide interchange. Thioltransferases rather than transhydrogenases

1974 • 68 citations

Evidence for the Presence of Thioltransferase in the Lens

1996 • 64 citations

Ubiquitin and ubiquitin conjugates in human lens

1992 • 62 citations

A protective role for glutathione-dependent reduction of dehydroascorbic acid in lens epithelium.

1995 • 60 citations

Increase in the Intramolecular Disulfide Bonding of Alpha-A Crystallin During Aging of the Human Lens

1996 • 60 citations

The possible mechanism of naphthalene cataract in rat and its prevention by an aldose reductase inhibitor (ALØ1576)

1992 • 59 citations

The Redox Active Components H202 and N-AcetyI-L-Cysteine Regulate Expression of c-jun and c-fos in Lens Systems

1994 • 54 citations

Cleavage of lens protein-GSH mixed disulfide by glutathione reductase

1973 • 53 citations

Thermodynamics of thermal and athermal denaturation of .gamma.-crystallins: changes in conformational stability upon glutathione reaction

1990 • 53 citations

The primary structure of pig liver thioltransferase.

1987 • 51 citations

Late onset hereditary cataract of the Emory mouse. A model for human senile cataract

1990 • 48 citations

Quantitation of lens protein mixed disulfides by ion-exchange chromatography

1986 • 46 citations

Effect of opacification and pigmentation on human lens protein thiol/disulfide and solubility.

1989 • 45 citations

Correlation of Nuclear Color and Opalescence with Protein S-thiolation in Human Lenses

1999 • 45 citations

Effect of H2O2on Human Lens Epithelial Cells and the Possible Mechanism for Oxidative Damage Repair by Thioltransferase

2002 • 45 citations

Study on Human Erythrocyte Thioltransferase: Comparative Characterization with Bovine Enzyme and Its Physiological Role under Oxidative Stress

1992 • 44 citations

Studies on the crystalline lens. IX. Quantitative analysis of free amino acids and related compounds.

1962 • 44 citations

Specific mixed disulfide formation with purified bovine cardiac glycogen synthase I and glutathione.

1983 • 37 citations

Advances in Ocular Toxicology

1997 • 36 citations

High‐level expression of fully active human glutaredoxin (thioltransferase) in E. coli and characterization of Cys⁷ to Ser mutant protein

1996 • 36 citations

Destabilization of lens protein conformation by glutathione mixed disulfide

1988 • 35 citations

Regulation of human thioltransferase (hTTase) gene by AP-1 transcription factor under oxidative stress.

2002 • 34 citations

A new mixed disulfide species in human cataractous and aged lenses

1993 • 33 citations

The human glutaredoxin gene: determination of its organization, transcription start point, and promoter analysis

1997 • 32 citations

Thiolation of the γB-Crystallins in Intact Bovine Lens Exposed to Hydrogen Peroxide

1999 • 32 citations

Possible physiological function of thioltransferase in cells

2003 • 31 citations

Human lens thioltransferase: cloning, purification, and function.

2001 • 31 citations

Lenticular glutathione synthesis: rate-limiting factors in its regulation and decline

1984 • 30 citations

Lens-Specific Regulation of the Thioredoxin-1 Gene, but Not Thioredoxin-2, upon in Vivo Photochemical Oxidative Stress in the Emory Mouse

1999 • 29 citations

Regulation of thioltransferase expression in human lens epithelial cells.

2001 • 27 citations

Thioltransferase activity of bovine lens glutathione S-transferase

1998 • 26 citations

Distribution of thioltransferase (glutaredoxin) in ocular tissues.

1998 • 26 citations

Modulation of Lens Glycolytic Pathway by Thioltransferase

2000 • 26 citations

Protein-Bound Glutathione in Mammalian Lenses and in Galactose Cataract

1976 • 24 citations

Does Glutathione-S-Transferase Dethiolate Lens Protein-Thiol Mixed Disulfides?—A Comparative Study With Thioltransferase

1999 • 23 citations

UVA Light In vivo Reaches the Nucleus of the Guinea Pig Lens and Produces Deleterious, Oxidative Effects

2002 • 20 citations

Thioltransferase is Present in the Lens Epithelial Cells as a Highly Oxidative Stress-resistant Enzyme

1998 • 20 citations

Bovine lens neutral proteinase preferentially hydrolyses oxidatively modified glutamine synthetase

1986 • 17 citations

Thioredoxin Genes in Lens: Regulation by Oxidative Stress

2002 • 16 citations

The purification and properties of human lens glutathione reductase

1984 • 16 citations

Suppression of phase separation in solutions of bovine gamma IV-crystallin by polar modification of the sulfur-containing amino acids.

1991 • 16 citations

13C NMR spectroscopic measurement of glutathione synthesis and antioxidant metabolism in the intact ocular lens

1992 • 10 citations

Regional and subcellular distribution of ascorbate free radical reductase activity in the human lens.

1991 • 8 citations

The Presence of Mitochondrial Thioltransferase (Grx2) and its Protective and Regenerative Roles of Ascorbic Acid in Human Lens Epithelial Cells

2003 • 2 citations