Role of Reactive Oxygen Species in Skin Carcinogenesis

Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly

1996 • 5,498 citations

Dietary Carcinogens and Anticarcinogens

1983 • 3,028 citations

Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG

1991 • 2,172 citations

Mutations of the Human Homolog of Drosophila patched in the Nevoid Basal Cell Carcinoma Syndrome

1996 • 2,021 citations

A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma.

1991 • 1,946 citations

Human Homolog of patched , a Candidate Gene for the Basal Cell Nevus Syndrome

1996 • 1,850 citations

Radical causes of cancer

2003 • 1,611 citations

Mitogenic Signaling Mediated by Oxidants in Ras-Transformed Fibroblasts

1997 • 1,582 citations

Persistent oxidative stress in cancer

1995 • 1,218 citations

REDOX REGULATION OF CELLULAR ACTIVATION

1997 • 1,121 citations

The Genetic Basis of Human Cancer

1997 • 1,113 citations

Analysis of a form of oxidative DNA damage, 8-hydroxy-2′-deoxyguanosine, as a marker of cellular oxidative stress during carcinogenesis

1997 • 1,108 citations

Hydroxylation of deoxyguanosine at the C-8 position by ascorbic acid and other reducing agents

1984 • 941 citations

Nevoid Basal-Cell Carcinoma Syndrome

1987 • 886 citations

Role of oxygen free radicals in carcinogenesis and brain ischemia

1990 • 885 citations

Mice deficient in tumor necrosis factor-α are resistant to skin carcinogenesis

1999 • 833 citations

Functional food science and defence against reactive oxidative species

1998 • 819 citations

Inflammation and cancer: role of phagocyte-generated oxidants in carcinogenesis

1990 • 741 citations

Wavelengths effective in induction of malignant melanoma.

1993 • 739 citations

Protein kinase C signaling and oxidative stress

2000 • 691 citations

Redox regulation of transcriptional activators

1996 • 690 citations

Childhood sun exposure as a risk factor for melanoma: a systematic review of epidemiologic studies.

2001 • 621 citations

Iron-induced carcinogenesis: The role of redox regulation

1996 • 556 citations

Reactive oxygen species‐induced molecular damage and its application in pathology

1999 • 549 citations

Oxidative damage to DNA in mammalian chromatin

1992 • 546 citations

Oxidative mechanisms in carcinogenesis

1993 • 484 citations

Ultraviolet and ionizing radiation enhance the growth of BCCs and trichoblastomas in patched heterozygous knockout mice

1999 • 415 citations

Endogenous UVA-photosensitizers: mediators of skin photodamage and novel targets for skin photoprotection

2005 • 389 citations

MOLECULAR MECHANISMS OF ULTRAVIOLET RADIATION CARCINOGENESIS

1990 • 385 citations

Neonatal sunburn and melanoma in mice

2001 • 383 citations

DNA repair protects against cutaneous and internal neoplasia: evidence from xeroderma pigmentosum

1984 • 382 citations

Melanocortin‐1 receptor structure and functional regulation

2005 • 370 citations

In vitro repair of oxidative DNA damage by human nucleotide excision repair system: Possible explanation for neurodegeneration in Xeroderma pigmentosum patients

1997 • 358 citations

Induction of oxidative DNA base damage in human skin cells by UV and near visible radiation

1997 • 347 citations

Removal of oxygen free-radical-induced 5′,8-purine cyclodeoxynucleosides from DNA by the nucleotide excision-repair pathway in human cells

2000 • 344 citations

Formation of 8-hydroxy(deoxy)guanosine and generation of strand breaks at guanine residues in DNA by singlet oxygen

1991 • 304 citations

The glutathione S-transferases: influence of polymorphism on cancer susceptibility.

1999 • 302 citations

8-Hydroxydeoxyguanosine formation at the 5' site of 5'-GG-3' sequences in double-stranded DNA by UV radiation with riboflavin

1993 • 298 citations

Photosensitized formation of 7,8-dihydro-8-oxo-2'-deoxyguanosine (8-hydroxy-2'-deoxyguanosine) in DNA by riboflavin: a nonsinglet oxygen-mediated reaction

1992 • 295 citations

The Oxidative DNA Lesion 8,5′-(S)-Cyclo-2′-deoxyadenosine Is Repaired by the Nucleotide Excision Repair Pathway and Blocks Gene Expression in Mammalian Cells

2000 • 295 citations

Mutagenic specificity of ultraviolet light

1985 • 282 citations

Specific UV-induced mutation spectrum in the p53 gene of skin tumors from DNA-repair-deficient xeroderma pigmentosum patients.

1993 • 278 citations

Ras gene mutation and amplification in human nonmelanoma skin cancers

1991 • 276 citations

A role for ultraviolet A in solar mutagenesis.

1995 • 259 citations

Mutagenic spectrum resulting from DNA damage by oxygen radicals

1991 • 237 citations

Influence of sun exposures during childhood and during adulthood on melanoma risk

1998 • 235 citations

Methylene blue plus light mediates 8-hydroxyguanine formation in DNA

1989 • 229 citations

Induction of DNA damage by dimethylarsine, a metabolite of inorganic arsenics, is for the major part likely due to its peroxyl radical

1990 • 219 citations

The specificity of UV-induced mutations at an endogenous locus in mammalian cells.

1987 • 216 citations

8-Hydroxy-2'-Deoxyguanosine Is Increased in Epidermal Cells of Hairless Mice after Chronic Ultraviolet B Exposure

1996 • 207 citations

Mutations in the human homologue of Drosophila patched (PTCH) in basal cell carcinomas and the Gorlin syndrome: different in vivo mechanisms of PTCH inactivation.

1996 • 203 citations

The Role of Oxidative DNA Damage in Human Arsenic Carcinogenesis: Detection of 8-Hydroxy-2′-Deoxyguanosine in Arsenic-Related Bowen's Disease

1999 • 194 citations

Diet and Cancer — An Overview

1984 • 185 citations

DNA excision-repair defect of xeroderma pigmentosum prevents removal of a class of oxygen free radical-induced base lesions.

1993 • 183 citations

Possible cause of G·C→C·G transversion mutation by guanine oxidation product, imidazolone

2001 • 180 citations

Ras Oncogene Mutations in Basal Cell Carcinomas and Squamous Cell Carcinomas of Human Skin

1990 • 178 citations

Tumour necrosis factor-α mediates tumour promotion via a PKCα- and AP-1-dependent pathway

2002 • 164 citations

Nucleotide excision repair and the link with transcription

1995 • 153 citations

Dimethylated arsenics induce DNA strand breaks in lung via the production of active oxygen in mice

1989 • 149 citations

Potent intracellular oxidative stress exerted by the carcinogen 4-nitroquinoline-N-oxide.

1993 • 147 citations

Tandem double CC-->TT mutations are produced by reactive oxygen species.

1993 • 141 citations

Non-steroidal anti-inflammatory drugs and molecular carcinogenesis of colorectal carcinomas

2003 • 139 citations

Mutations in the human homologue of the Drosophila patched gene in Caucasian and African-American nevoid basal cell carcinoma syndrome patients.

1996 • 134 citations

Yeast Lacking Superoxide Dismutase(s) Show Elevated Levels of “Free Iron” as Measured by Whole Cell Electron Paramagnetic Resonance

2000 • 134 citations

Nonsteroidal anti-inflammatory drugs in colorectal cancer: from prevention to therapy

2003 • 126 citations

Proteins of the Extracellular Matrix Are Sensitizers of Photo-oxidative Stress in Human Skin Cells

2003 • 110 citations

UV-A induces persistent genomic instability in human keratinocytes through an oxidative stress mechanism

2002 • 107 citations

UVA, Pheomelanin and the Carcinogenesis of Melanoma

2000 • 99 citations

Ultraviolet-specific mutations in p53 gene in skin tumors in xeroderma pigmentosum patients.

1993 • 99 citations

The lacI shuttle: rapid analysis of the mutagenic specificity of ultraviolet light in human cells.

1985 • 98 citations

Modification of DNA bases in chromatin of intact target human cells by activated human polymorphonuclear leukocytes.

1993 • 96 citations

Gene Alterations and Clinical Characteristics of Xeroderma Pigmentosum Group A Patients in Japan

1994 • 90 citations

Association between DNA repair-deficiency and high level of p53 mutations in melanoma of Xeroderma pigmentosum.

2001 • 82 citations

Formation of 8-hydroxyguanine residues in cellular DNA exposed to the carcinogen 4-nitroquinoline 1-oxide

1986 • 81 citations

Promotion of Rat Hepatocarcinogenesis by Dimethylarsinic Acid: Association with Elevated Ornithine Decarboxylase Activity and Formation of 8‐Hydroxydeoxyguanosine in the Liver

1997 • 78 citations

Formation of 8-Hydroxy-2′-deoxyguanosine in Epidermis of Hairless Mice Exposed to Near-UV

1994 • 74 citations

TP53 Tumor Suppressor Gene and Skin Carcinogenesis.

1994 • 74 citations

Polymorphisms in Glutathione S-Transferases are Associated with Altered Risk of Nonmelanoma Skin Cancer in Renal Transplant Recipients: A Preliminary Analysis

2001 • 71 citations

Evidence That in Situ Generated Reactive Oxygen Species Act as a Potent Stage I Tumor Promoter in Mouse Skin

1995 • 70 citations

Sun exposure and basal cell carcinomas in the nevoid basal cell carcinoma syndrome

1993 • 66 citations

Determination of the spectrum of mutations induced by defined-wavelength solar UVB (313-nm) radiation in mammalian cells by use of a shuttle vector.

1988 • 65 citations

Low incidence of p53 mutations in UVA (365-nm)-induced skin tumors in hairless mice.

1997 • 62 citations

The expression of genes induced in melanocytes by exposure to 365-nm UVA: study by cDNA arrays and real-time quantitative RT-PCR

2001 • 62 citations

Photoaging and oxidative stress

2003 • 61 citations

Quinolone Antibiotic Photodynamic Production of 8‐Oxo‐7,8‐dihydro‐2‘‐deoxyguanosine in Cultured Liver Epithelial Cells

1997 • 58 citations

Activation of N-ras induced by ultraviolet irradiation in vitro.

1988 • 54 citations

MALIGNANT SKIN TUMORS AMONG DERMATOLOGY PATIENTS IN UNIVERSITY HOSPITALS OF JAPAN

1984 • 52 citations

Malignant conversion of UV radiation and chemically induced mouse skin benign tumors by free-radical-generating compounds

1989 • 50 citations

Hypersensitivity of skin fibroblasts from basal cell nevus syndrome patients to killing by ultraviolet B but not by ultraviolet C radiation.

1990 • 48 citations

Benzoyl Peroxide: An Integrated Human Safety Assessment for Carcinogenicity

1995 • 46 citations

‘‘Second Hit’’ in Sebaceous Tumors from Muir–Torre Patients with Germline Mutations in MSH2: Allele Loss is Not the Preferred Mode of Inactivation

2001 • 46 citations

Prospective protective role of melatonin against arsenic-induced metabolic toxicity in Wistar rats

2004 • 41 citations

Mutations in ras genes in cells cultured from mouse skin tumors induced by ultraviolet irradiation.

1994 • 39 citations

Protective effects of EGCG on UVB-induced damage in living skin equivalents

2005 • 35 citations

Altered Patterns of Cutaneous Xenobiotic Metabolism in UVB-Induced Squamous Cell Carcinoma in SKH-1 Hairless Mice

1985 • 32 citations

Action Spectrum for Photocarcinogenesis

1995 • 31 citations

Quantitative Detection of Ultraviolet Light‐induced Photoproducts in Mouse Skin by Immunohistochemistry

1995 • 28 citations

Carcinogenic 3-nitrobenzanthrone induces oxidative damage to isolated and cellular DNA

2005 • 25 citations

Gene alterations and clinical characteristics of xeroderma pigmentosum group A patients in Japan

1994 • 25 citations

Formation of 8-hydroxyguanine residues in DNA treated with 4-hydroxyaminoquinoline 1-oxide and its related compounds in the presence of seryl-AMP

1987 • 24 citations

Assessment of oxidative DNA damage in the oxyR‐deficient sos chromotest strain escherichia coli PQ300

1992 • 18 citations

Host genes controlling the susceptibility and resistance to squamous cell carcinoma of the tongue in a rat model

2000 • 17 citations

Accelerated Appearance of Skin Tumors in Hairless Mice by Repeated UV Irradiation with Initial Intense Exposure and Characterization of the Tumors

1992 • 10 citations

Formation of a cyclic adenine adduct with a 4-nitroquinoline N-oxide metabolite model.

1986 • 2 citations