Semaphorins command cells to move

Integrin signalling during tumour progression

2004 • 1,430 citations

Neuropilin Is a Semaphorin III Receptor

1997 • 1,166 citations

Neuropilin Is a Receptor for the Axonal Chemorepellent Semaphorin III

1997 • 1,131 citations

Plexins Are a Large Family of Receptors for Transmembrane, Secreted, and GPI-Anchored Semaphorins in Vertebrates

1999 • 1,118 citations

Activation of molecular oxygen by flavins and flavoproteins.

1994 • 785 citations

Conversion of Neuronal Growth Cone Responses from Repulsion to Attraction by Cyclic Nucleotides

1998 • 784 citations

Neuropilin-1 Conveys Semaphorin and VEGF Signaling during Neural and Cardiovascular Development

2003 • 707 citations

S<scp>IGNALING AT THE</scp> G<scp>ROWTH</scp> C<scp>ONE</scp>: Ligand-Receptor Complexes and the Control of Axon Growth and Guidance

2003 • 707 citations

Semaphorin 3A is a chemoattractant for cortical apical dendrites

2000 • 678 citations

Semaphorin III is needed for normal patterning and growth of nerves, bones and heart

1996 • 570 citations

Class 3 semaphorins control vascular morphogenesis by inhibiting integrin function

2003 • 559 citations

Semaphorin 3E and Plexin-D1 Control Vascular Pattern Independently of Neuropilins

2004 • 518 citations

Semaphorin 7A promotes axon outgrowth through integrins and MAPKs

2003 • 491 citations

Blood vessels and nerves: common signals, pathways and diseases

2003 • 491 citations

Plexin A Is a Neuronal Semaphorin Receptor that Controls Axon Guidance

1998 • 456 citations

The Semaphorin 4D receptor controls invasive growth by coupling with Met

2002 • 428 citations

Rac1 Mediates Collapsin-1-Induced Growth Cone Collapse

1997 • 384 citations

Tumor suppressor genes on chromosome 3p involved in the pathogenesis of lung and other cancers

2002 • 382 citations

The Semaphorin 4D Receptor Plexin-B1 Is a GTPase Activating Protein for R-Ras

2004 • 371 citations

Semaphorin-Plexin Signaling Guides Patterning of the Developing Vasculature

2004 • 371 citations

PlexinD1 and Semaphorin Signaling Are Required in Endothelial Cells for Cardiovascular Development

2004 • 358 citations

Plexin-B1 Directly Interacts with PDZ-RhoGEF/LARG to Regulate RhoA and Growth Cone Morphology

2002 • 357 citations

MICALs, a Family of Conserved Flavoprotein Oxidoreductases, Function in Plexin-Mediated Axonal Repulsion

2002 • 351 citations

Identification of CD72 as a Lymphocyte Receptor for the Class IV Semaphorin CD100

2000 • 343 citations

Semaphorins act as attractive and repulsive guidance signals during the development of cortical projections

1998 • 340 citations

Fyn and Cdk5 Mediate Semaphorin-3A Signaling, Which Is Involved in Regulation of Dendrite Orientation in Cerebral Cortex

2002 • 331 citations

Targeted disruption of semaphorin 3C leads to persistent truncus arteriosus and aortic arch interruption

2001 • 312 citations

Stereotyped Pruning of Long Hippocampal Axon Branches Triggered by Retraction Inducers of the Semaphorin Family

2003 • 307 citations

Class IV semaphorin Sema4A enhances T-cell activation and interacts with Tim-2

2002 • 306 citations

Semaphorin junction: making tracks toward neural connectivity

2003 • 304 citations

Apoptotic Pathway and MAPKs Differentially Regulate Chemotropic Responses of Retinal Growth Cones

2003 • 289 citations

Signalling mechanisms mediating neuronal responses to guidance cues

2003 • 288 citations

Netrin-1 and Semaphorin 3A Promote or Inhibit Cortical Axon Branching, Respectively, by Reorganization of the Cytoskeleton

2004 • 281 citations

Central Roles of α ₅ β ₁ Integrin and Fibronectin in Vascular Development in Mouse Embryos and Embryoid Bodies

2002 • 275 citations

Dual roles of Sema6D in cardiac morphogenesis through region-specific association of its receptor, Plexin-A1, with off-track and vascular endothelial growth factor receptor type 2

2004 • 274 citations

Semaphorin 3F, a chemorepulsant for endothelial cells, induces a poorly vascularized, encapsulated, nonmetastatic tumor phenotype

2004 • 269 citations

The GTPase Rap1 controls functional activation of macrophage integrin αMβ2 by LPS and other inflammatory mediators

2000 • 259 citations

Human semaphorins A(V) and IV reside in the 3p21.3 small cell lung cancer deletion region and demonstrate distinct expression patterns.

1996 • 238 citations

Rnd Proteins Function as RhoA Antagonists by Activating p190 RhoGAP

2003 • 237 citations

A Poxvirus-Encoded Semaphorin Induces Cytokine Production from Monocytes and Binds to a Novel Cellular Semaphorin Receptor, VESPR

1998 • 234 citations

Integrins and T Cell–Mediated Immunity

2004 • 232 citations

Ras GTPases: integrins' friends or foes?

2003 • 227 citations

The A5 antigen, a candidate for the neuronal recognition molecule, has homologies to complement components and coagulation factors

1991 • 224 citations

Differential Requirement for Plexin-A3 and -A4 in Mediating Responses of Sensory and Sympathetic Neurons to Distinct Class 3 Semaphorins

2005 • 219 citations

PlexinA2 and semaphorin signaling during cardiac neural crest development

2001 • 217 citations

Structure of the human and murine R-ras genes, novel genes closely related to ras proto-oncogenes

1987 • 216 citations

Plexin B Regulates Rho through the Guanine Nucleotide Exchange Factors Leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF

2002 • 213 citations

The integrin family of cell adhesion molecules has multiple functions within the CNS

2002 • 212 citations

Inhibition of lung cancer cell growth and induction of apoptosis after reexpression of 3p21.3 candidate tumor suppressor gene SEMA3B

2001 • 212 citations

Semaphorin3a Enhances Endocytosis at Sites of Receptor–F-Actin Colocalization during Growth Cone Collapse

2000 • 207 citations

PlexinA1 Autoinhibition by the Plexin Sema Domain

2001 • 203 citations

Plexin B Mediates Axon Guidance in Drosophila by Simultaneously Inhibiting Active Rac and Enhancing RhoA Signaling

2001 • 201 citations

Semaphorin 3F Is Critical for Development of Limbic System Circuitry and Is Required in Neurons for Selective CNS Axon Guidance Events

2003 • 197 citations

An Eph receptor regulates integrin activity through R-Ras

1999 • 195 citations

Guidance of myocardial patterning in cardiac development by Sema6D reverse signalling

2004 • 195 citations

An Oligodendrocyte Lineage-Specific Semaphorin, Sema5A, Inhibits Axon Growth by Retinal Ganglion Cells

2004 • 191 citations

Plexin-B semaphorin receptors interact directly with active Rac and regulate the actin cytoskeleton by activating Rho

2001 • 187 citations

Myelin and Collapsin-1 Induce Motor Neuron Growth Cone Collapse through Different Pathways: Inhibition of Collapse by Opposing Mutants of Rac1

1999 • 184 citations

Semaphorins in interactions between T cells and antigen-presenting cells

2003 • 180 citations

Neuronal cdc2-like kinase

1995 • 179 citations

Semaphorin 3B (SEMA3B) induces apoptosis in lung and breast cancer, whereas VEGF ₁₆₅ antagonizes this effect

2004 • 179 citations

The semaphorin 3A receptor may directly regulate the activity of small GTPases

2000 • 177 citations

The semaphorin receptor plexin-B1 specifically interacts with active Rac in a ligand-dependent manner

2000 • 173 citations

The Versatile Roles of “Axon Guidance” Cues in Tissue Morphogenesis

2004 • 171 citations

The Transmembrane Protein Off-Track Associates with Plexins and Functions Downstream of Semaphorin Signaling during Axon Guidance

2001 • 168 citations

Evidence That Collapsin Response Mediator Protein-2 Is Involved in the Dynamics of Microtubules

2000 • 167 citations

Rac1-Mediated Endocytosis during Ephrin-A2- and Semaphorin 3A-Induced Growth Cone Collapse

2002 • 165 citations

The semaphorin receptor plexin-B1 signals through a direct interaction with the Rho-specific nucleotide exchange factor, LARG

2002 • 164 citations

Structure of the Semaphorin-3A Receptor Binding Module

2003 • 164 citations

The ligand-binding face of the semaphorins revealed by the high-resolution crystal structure of SEMA4D

2003 • 163 citations

Biological Activity of Soluble CD100. II. Soluble CD100, Similarly to H-SemaIII, Inhibits Immune Cell Migration

2001 • 160 citations

Plexin-B1/RhoGEF–mediated RhoA activation involves the receptor tyrosine kinase ErbB-2

2004 • 160 citations

Antagonistic Effects of Rnd1 and RhoD GTPases Regulate Receptor Activity in Semaphorin 3A-Induced Cytoskeletal Collapse

2002 • 158 citations

Neurovascular congruence results from a shared patterning mechanism that utilizes Semaphorin3A and Neuropilin-1

2003 • 158 citations

Endocytosis-dependent desensitization and protein synthesis–dependent resensitization in retinal growth cone adaptation

2005 • 157 citations

R-Ras Signals through Specific Integrin α Cytoplasmic Domains to Promote Migration and Invasion of Breast Epithelial Cells

1999 • 156 citations

Plexin‐B3 is a functional receptor for semaphorin 5A

2004 • 151 citations

Regulation of Neurite Outgrowth by Integrin Activation

2000 • 149 citations

Transcription of a novel mouse semaphorin gene, M-semaH, correlates with the metastatic ability of mouse tumor cell lines.

1998 • 145 citations

Human Semaphorin 3B (SEMA3B) located at chromosome 3p21.3 suppresses tumor formation in an adenocarcinoma cell line.

2002 • 144 citations

Plexin: A novel neuronal cell surface molecule that mediates cell adhesion via a homophilic binding mechanism in the presence of calcium ions

1995 • 142 citations

Requirement for the Lymphocyte Semaphorin, CD100, in the Induction of Antigen-Specific T Cells and the Maturation of Dendritic Cells

2002 • 140 citations

MICAL, a Novel CasL Interacting Molecule, Associates with Vimentin

2002 • 137 citations

CIITA-regulated plexin-A1 affects T-cell–dendritic cell interactions

2003 • 136 citations

Semaphorin 3F gene from human 3p21.3 suppresses tumor formation in nude mice.

2002 • 134 citations

Semaphorin SEMA3F Localization in Malignant Human Lung and Cell Lines

2000 • 122 citations

Molecular Dissection of the Semaphorin 4D Receptor Plexin-B1-Stimulated R-Ras GTPase-Activating Protein Activity and Neurite Remodeling in Hippocampal Neurons

2004 • 122 citations

Direct Interaction of Rnd1 with Plexin-B1 Regulates PDZ-RhoGEF-mediated Rho Activation by Plexin-B1 and Induces Cell Contraction in COS-7 Cells

2003 • 120 citations

Bi-directional signaling by Semaphorin 1a during central synapse formation in Drosophila

2002 • 120 citations

Oxidized Phospholipid-Induced Endothelial Cell/Monocyte Interaction Is Mediated by a cAMP-Dependent R-Ras/PI3-Kinase Pathway

2003 • 119 citations

Functional soluble CD100/Sema4D released from activated lymphocytes: possible role in normal and pathologic immune responses

2001 • 119 citations

The Plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding

2002 • 116 citations

Plexin signaling hampers integrin‐based adhesion, leading to Rho‐kinase independent cell rounding, and inhibiting lamellipodia extension and cell motility

2004 • 116 citations

Involvement of Fes/Fps tyrosine kinase in semaphorin3A signaling

2002 • 115 citations

The function of semaphorins during nervous system development

2003 • 115 citations

Semaphorin3A-induced receptor endocytosis during axon guidance responses is mediated by L1 CAM

2004 • 114 citations

R-Ras induces malignant, but not morphologic, transformation of NIH3T3 cells.

1994 • 112 citations

Distorted Odor Maps in the Olfactory Bulb of Semaphorin 3A-Deficient Mice

2003 • 111 citations

Semaphorin CD100 from Activated T Lymphocytes Induces Process Extension Collapse in Oligodendrocytes and Death of Immature Neural Cells

2004 • 102 citations

Regulation of dendritic length and branching by semaphorin 3A

2004 • 101 citations

Analysis of R-Ras signalling pathways

2001 • 100 citations

Nervy Links Protein Kinase A to Plexin-Mediated Semaphorin Repulsion

2004 • 97 citations

Diverse gene expression and function of semaphorins in developing lung: positive and negative regulatory roles of semaphorins in lung branching morphogenesis

2001 • 96 citations

Nerve Growth Factor Stimulates the Accumulation of β1 Integrin at the Tips of Filopodia in the Growth Cones of Sympathetic Neurons

1997 • 92 citations

The Activity of the Plexin-A1 Receptor Is Regulated by Rac

2004 • 92 citations

Repulsion and Attraction of Axons by Semaphorin3D Are Mediated by Different NeuropilinsIn Vivo

2004 • 90 citations

Soluble CD100 functions on human monocytes and immature dendritic cells require plexin C1 and plexin B1, respectively

2005 • 90 citations

The regulation of actin remodeling during T‐cell–APC conjugate formation

2002 • 89 citations

Plexin C1 Engagement on Mouse Dendritic Cells by Viral Semaphorin A39R Induces Actin Cytoskeleton Rearrangement and Inhibits Integrin-Mediated Adhesion and Chemokine-Induced Migration

2005 • 85 citations

The Orthologous Human and Murine Semaphorin 6A-1 Proteins (SEMA6A-1/Sema6A-1) Bind to the Enabled/Vasodilator-stimulated Phosphoprotein-like Protein (EVL) via a Novel Carboxyl-terminal Zyxin-like Domain

2000 • 80 citations

Identification of semaphorin E gene expression in metastatic human lung adenocarcinoma cells by mRNA differential display

1999 • 78 citations

Molecular Cloning of a Glycosylphosphatidylinositol-Anchored Molecule CDw108

1999 • 77 citations

CD100 is associated with CD45 at the surface of human T lymphocytes. Role in T cell homotypic adhesion.

1996 • 76 citations

Functional Regulation of Semaphorin Receptors by Proprotein Convertases

2003 • 76 citations

Sema4D stimulates axonal outgrowth of embryonic DRG sensory neurones

2004 • 75 citations

Semaphorin3D Guides Retinal Axons along the Dorsoventral Axis of the Tectum

2004 • 68 citations

Sema4C, a Transmembrane Semaphorin, Interacts with a Post-synaptic Density Protein, PSD-95

2001 • 62 citations

The Human Semaphorin-like Leukocyte Cell Surface Molecule CD100 Associates with a Serine Kinase Activity

1997 • 62 citations

A Novel Transmembrane Semaphorin Can Bind c-src

1997 • 53 citations

Poxvirus semaphorin A39R inhibits phagocytosis by dendritic cells and neutrophils

2005 • 52 citations

Involvement of R-Ras and Ral GTPases in estrogen-independent proliferation of breast cancer cells

2002 • 52 citations

Semaphorin4F interacts with the synapse‐associated protein SAP90/PSD‐95

2001 • 43 citations

Transmembrane Sema4E Guides Branchiomotor Axons to Their Targets in Zebrafish

2003 • 38 citations

R‐Ras promotes tumor growth of cervical epithelial cells

2003 • 38 citations

Molecular cloning, expression, and activity of zebrafish semaphorin Z1a

1999 • 36 citations

A Novel cAMP-Dependent Pathway Activates Neuronal Integrin Function in Retinal Neurons

2004 • 35 citations

Molecular cloning of a novel member of semaphorin family genes, semaphorin Z

1997 • 24 citations

Comment on "Nervy Links Protein Kinase A to Plexin-Mediated Semaphorin Repulsion"

2005 • 7 citations