Oncogene N-ras mediates selective inhibition of c-fos induction by nerve growth factor and basic fibroblast growth factor in a PC12 cell line.

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS

1987 • 6,374 citations

INOSITOL TRISPHOSPHATE AND DIACYLGLYCEROL: TWO INTERACTING SECOND MESSENGERS

1987 • 3,302 citations

Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene

1984 • 3,150 citations

Mapping Patterns of c- fos Expression in the Central Nervous System After Seizure

1987 • 1,771 citations

Nerve growth factor and epidermal growth factor induce rapid transient changes in proto-oncogene transcription in PC12 cells.

1985 • 888 citations

Identification of a protein-binding site that mediates transcriptional response of the c-fos gene to serum factors

1986 • 883 citations

Transient accumulation of c-fos RNA following serum stimulation requires a conserved 5′ element and c-fos 3′ sequences

1985 • 871 citations

Fibroblast growth factor promotes survival of dissociated hippocampal neurons and enhances neurite extension.

1986 • 741 citations

Microinjection of the ras oncogene protein into PC12 cells induces morphological differentiation

1985 • 738 citations

The Nerve Growth Factor: Biochemistry, Synthesis, and Mechanism of Action

1980 • 733 citations

FBJ murine osteosarcoma virus: identification and molecular cloning of biologically active proviral DNA

1982 • 668 citations

Transcriptional autoregulation of the proto-oncogene fos

1988 • 630 citations

ras GTPase activating protein: Signal transmitter and signal terminator

1989 • 621 citations

Intrinsic GTPase activity distinguishes normal and oncogenic ras p21 molecules.

1984 • 607 citations

The product of ras is a GTPase and the T24 oncogenic mutant is deficient in this activity

1984 • 539 citations

Multiple protein-binding sites in the 5'-flanking region regulate c-fos expression.

1986 • 516 citations

Homologies Between Signal Transducing G Proteins and ras Gene Products

1984 • 500 citations

Hormone-mediated repression: a negative glucocorticoid response element from the bovine prolactin gene.

1988 • 485 citations

Superinduction of c- fos by Nerve Growth Factor in the Presence of Peripherally Active Benzodiazepines

1985 • 478 citations

Expression and regulation of Escherichia coli lacZ gene fusions in mammalian cells.

1983 • 471 citations

Nerve growth factor-induced fiber outgrowth from isolated rat adrenal chromaffin cells: impairment by glucocorticoids.

1978 • 468 citations

Sarcoma viruses carrying ras oncogenes induce differentiation-associated properties in a neuronal cell line

1985 • 458 citations

Ras -Transformed Cells: Altered Levels of Phosphatidylinositol-4,5-Bisphosphate and Catabolites

1986 • 450 citations

Inhibition of growth factor-induced differentiation of PC12 cells by microinjection of antibody to ras p21

1986 • 421 citations

Induction of the proto-oncogene fos by nerve growth factor.

1985 • 359 citations

A bipotential neuroendocrine precursor whose choice of cell fate is determined by NGF and glucocorticoids

1986 • 337 citations

Novel source of 1,2-diacylglycerol elevated in cells transformed by Ha-ras oncogene

1987 • 303 citations

Primary structure of the α-subunit of transducin and its relationship to ras proteins

1985 • 291 citations

PC12 cell mutants that possess low- but not high-affinity nerve growth factor receptors neither respond to nor internalize nerve growth factor.

1986 • 282 citations

Sequence of the Alpha Subunit of Photoreceptor G Protein: Homologies Between Transducin, ras , and Elongation Factors

1985 • 276 citations

The effect of fibroblast growth factor on PC12 cells

1985 • 270 citations

Identification and characterization of mRNAs regulated by nerve growth factor in PC12 cells.

1987 • 267 citations

The c-fos serum response element responds to protein kinase C-dependent and -independent signals but not to cyclic AMP.

1988 • 245 citations

Ras p21 as a Potential Mediator of Insulin Action in Xenopus Oocytes

1987 • 224 citations

The oncogenic forms of N-ras or H-ras prevent skeletal myoblast differentiation.

1987 • 221 citations

Autoregulation of fos: the dyad symmetry element as the major target of repression.

1989 • 211 citations

Amino acid sequence of the alpha subunit of transducin deduced from the cDNA sequence.

1985 • 202 citations

Insulin induction of Xenopus laevis oocyte maturation is inhibited by monoclonal antibody against p21 ras proteins.

1987 • 183 citations

Repression of c-fos transcription is mediated through p67SRF bound to the SRE.

1989 • 182 citations

Tumor promoter phorbol 12-myristate, 13-acetate inhibits phosphoinositide hydrolysis and cytosolic Ca2+ rise induced by the activation of muscarinic receptors in PC12 cells

1985 • 176 citations

A single Mr approximately 103,000 125I-beta-nerve growth factor-affinity-labeled species represents both the low and high affinity forms of the nerve growth factor receptor.

1986 • 159 citations

Activated N‐ras gene induces neuronal differentiation of PC12 rat pheochromocytoma cells

1986 • 149 citations

The induction of a neural-specific gene, SCG10, by nerve growth factor in PC12 cells is transcriptional, protein synthesis dependent, and glucocorticoid inhibitable

1988 • 148 citations

Deregulation of hamster fibroblast proliferation by mutated ras oncogenes is not mediated by constitutive activation of phosphoinositide-specific phospholipase C.

1988 • 143 citations

ras-induced neuronal differentiation of PC12 cells: possible involvement of fos and jun.

1989 • 140 citations

Involvement of functional protein kinase C in the mitogenic response to the H-ras oncogene product.

1987 • 131 citations

Microinjection of Transforming ras protein induces c-fos Expression

1987 • 123 citations

Introduction of v-Ha-ras oncogene induces differentiation of cultured human medullary thyroid carcinoma cells.

1987 • 116 citations

The v-mos and H-ras oncogene expression represses glucocorticoid hormone-dependent transcription from the mouse mammary tumor virus LTR.

1986 • 115 citations

Nerve growth factor has both mitogenic and antimitogenic activity

1982 • 103 citations

Malignant transformation by ras and other oncogenes produces common alterations in inositol phospholipid signaling pathways.

1988 • 99 citations

Transformation and Plasmacytoid Differentiation of EBV-Infected Human B Lymphoblasts byrasOncogenes

1989 • 94 citations

p21ras-induced responsiveness of phosphatidylinositol turnover to bradykinin is a receptor number effect.

1988 • 74 citations

Dissociation of c-fos from ODC expression and neuronal differentiation in a PC12 subline stably transfected with an inducible N-ras oncogene

1988 • 70 citations

Loss of platelet-derived growth factor-stimulated phospholipase activity in NIH-3T3 cells expressing the EJ-ras oncogene.

1987 • 63 citations

Poly-L-ornithine-mediated transformation of mammalian cells.

1987 • 62 citations

Transformer and transducer

1987 • 55 citations

Possible involvement of two signaling pathways in induction of neuron-associated properties by v-Ha-ras gene in PC12 cells.

1988 • 39 citations

Platelet-Derived Growth Factor Does Not Induce c-fos in NIH 3T3 Cells Expressing the EJ-ras Oncogene

1988 • 28 citations

Desensitization of the Ca2+-mobilizing system to serum growth factors by Ha-ras and v-mos.

1988 • 25 citations

Forskolin and a tumor promoter are able to induce c-fos and c-myc expression in normal, but not in a v-ras-transformed rat thyroid cell line.

1987 • 19 citations

The lack of PDGF-stimulated PGE2 release from ras-transformed NIH-3T3 cells results from reduced phospholipase C but not phospholipase A2 activity

1987 • 18 citations