Trafficking of High Avidity HER-2/neu-Specific T Cells into HER-2/neu-Expressing Tumors after Depletion of Effector/Memory-Like Regulatory T Cells

Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

2004 • 4,872 citations

Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity.

1993 • 2,828 citations

An essential role for Scurfin in CD4+CD25+ T regulatory cells

2003 • 2,825 citations

The tumor microenvironment and its role in promoting tumor growth

2008 • 2,152 citations

Lineage relationship and protective immunity of memory CD8 T cell subsets

2003 • 1,833 citations

Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease.

1992 • 1,496 citations

The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation

2009 • 1,171 citations

Natural and Adaptive Foxp3+ Regulatory T Cells: More of the Same or a Division of Labor?

2009 • 1,026 citations

Chemokine Expression in Melanoma Metastases Associated with CD8+ T-Cell Recruitment

2009 • 1,000 citations

Tumor Regression and Autoimmunity after Reversal of a Functionally Tolerant State of Self-reactive CD8+ T Cells

2003 • 919 citations

Adoptive immunotherapy for cancer: building on success

2006 • 848 citations

SPICE: Exploration and analysis of post‐cytometric complex multivariate datasets

2011 • 801 citations

Does the Immune System See Tumors as Foreign or Self?

2003 • 746 citations

CD8+ T Cell Immunity Against a Tumor/Self-Antigen Is Augmented by CD4+ T Helper Cells and Hindered by Naturally Occurring T Regulatory Cells

2005 • 741 citations

Developmental Stage, Phenotype, and Migration Distinguish Naive- and Effector/Memory-like CD4+ Regulatory T Cells

2004 • 618 citations

Two Functional Subsets of FOXP3+ Regulatory T Cells in Human Thymus and Periphery

2008 • 503 citations

CD8⁺ T‐cell memory in tumor immunology and immunotherapy

2006 • 472 citations

Initial T cell frequency dictates memory CD8+ T cell lineage commitment

2005 • 458 citations

Cyclophosphamide, doxorubicin, and paclitaxel enhance the antitumor immune response of granulocyte/macrophage-colony stimulating factor-secreting whole-cell vaccines in HER-2/neu tolerized mice.

2001 • 454 citations

Endogenous Naive CD8+ T Cell Precursor Frequency Regulates Primary and Memory Responses to Infection

2008 • 434 citations

Immune resistance orchestrated by the tumor microenvironment

2006 • 422 citations

Low avidity recognition of self-antigen by T cells permits escape from central tolerance

1995 • 415 citations

Recruitment of latent pools of high-avidity CD8+ T cells to the antitumor immune response

2005 • 403 citations

Inhibition of LFA‐1/ICAM‐1 and VLA‐4/VCAM‐1 as a therapeutic approach to inflammation and autoimmune diseases

2002 • 378 citations

Inflammatory signals regulate hematopoietic stem cells

2011 • 314 citations

T-cell integrins: more than just sticking points

2003 • 312 citations

Intraepithelial Effector (CD3+)/Regulatory (FoxP3+) T-Cell Ratio Predicts a Clinical Outcome of Human Colon Carcinoma

2009 • 304 citations

The promise of cancer vaccines

2004 • 266 citations

Principles of adoptive T cell cancer therapy

2007 • 260 citations

Foxp3⁺CD25^–CD4 T cells constitute a reservoir of committed regulatory cells that regain CD25 expression upon homeostatic expansion

2005 • 228 citations

Timed Sequential Treatment With Cyclophosphamide, Doxorubicin, and an Allogeneic Granulocyte-Macrophage Colony-Stimulating Factor–Secreting Breast Tumor Vaccine: A Chemotherapy Dose-Ranging Factorial Study of Safety and Immune Activation

2009 • 225 citations

HER-2/neu is a tumor rejection target in tolerized HER-2/neu transgenic mice.

2000 • 219 citations

Intrathymic and extrathymic clonal deletion of T cells

1995 • 201 citations

A Vascular Endothelial Growth Factor Receptor-2 Inhibitor Enhances Antitumor Immunity through an Immune-Based Mechanism

2007 • 198 citations

Cyclophosphamide induces type I interferon and augments the number of CD44hi T lymphocytes in mice: implications for strategies of chemoimmunotherapy of cancer

2000 • 196 citations

HER-2/neu Protein: A Target for Antigen-Specific Immunotherapy of Human Cancer

1997 • 173 citations

Cassette vectors directing expression of T cell receptor genes in transgenic mice

1995 • 159 citations

Cyclophosphamide Induces Differentiation of Th17 Cells in Cancer Patients

2010 • 159 citations

Expression of ICOS on Human Melanoma-Infiltrating CD4+CD25highFoxp3+ T Regulatory Cells: Implications and Impact on Tumor-Mediated Immune Suppression

2008 • 153 citations

Memory CD8⁺ T cell differentiation

2010 • 143 citations

The phenotypic characterization of naturally occurring regulatory CD4+CD25+ T cells.

2006 • 141 citations

Tumor-Specific CD4+ T Cells Render the Tumor Environment Permissive for Infiltration by Low-Avidity CD8+ T Cells

2008 • 137 citations

Heterogeneous T-cell response to MAGE-A10(254-262): high avidity-specific cytolytic T lymphocytes show superior antitumor activity.

2001 • 134 citations

The Shaping of the T Cell Repertoire

2001 • 134 citations

T Cell Costimulation via the Integrin VLA-4 Inhibits the Actin-Dependent Centralization of Signaling Microclusters Containing the Adaptor SLP-76

2008 • 128 citations

Cyclophosphamide enhances immunity by modulating the balance of dendritic cell subsets in lymphoid organs

2010 • 118 citations

Abundant expression of CXCL9 (MIG) by stromal cells that include dendritic cells and accumulation of CXCR3⁺ T cells in lymphocyte‐rich gastric carcinoma

2008 • 107 citations

OX40 Costimulation Synergizes with GM-CSF Whole-Cell Vaccination to Overcome Established CD8+ T Cell Tolerance to an Endogenous Tumor Antigen

2006 • 105 citations

Cyclophosphamide resets dendritic cell homeostasis and enhances antitumor immunity through effects that extend beyond regulatory T cell elimination

2009 • 104 citations

Identification and Characterization of the Immunodominant Rat HER-2/neu MHC Class I Epitope Presented by Spontaneous Mammary Tumors from HER-2/neu-Transgenic Mice

2003 • 100 citations

IL-7 Promotes CXCR3 Ligand-Dependent T Cell Antitumor Reactivity in Lung Cancer

2009 • 97 citations

GM-CSF Gene-Modifed Cancer Cell Immunotherapies: Of Mice and Men

2006 • 97 citations

Marked Differences in Human Melanoma Antigen-Specific T Cell Responsiveness after Vaccination Using a Functional Microarray

2005 • 91 citations

Antibody association with HER-2/neu–targeted vaccine enhances CD8+ T cell responses in mice through Fc-mediated activation of DCs

2008 • 79 citations

Loss of CTL Function among High-Avidity Tumor-Specific CD8+ T Cells following Tumor Infiltration

2008 • 71 citations

Immunologic considerations for generating memory CD8 T cells through vaccination

2011 • 70 citations

A rapid, single vessel method for preparation of clinical grade ligand conjugated monoclonal antibodies

1995 • 70 citations

Upregulation of Integrin 6/β1 and Chemokine Receptor CCR1 by Interleukin-12 Promotes the Migration of Human Type 1 Helper T Cells

1999 • 66 citations

Major histocompatibility complex binding and T cell recognition of a viral nonapeptide containing a minimal tetrapeptide

1991 • 64 citations

Immunity to Murine Prostatic Tumors: Continuous Provision of T-Cell Help Prevents CD8 T-Cell Tolerance and Activates Tumor-Infiltrating Dendritic Cells

2009 • 62 citations

The role of ErbB-2 tyrosine kinase receptor in cellular intrinsic chemoresistance: mechanisms and implications

1997 • 57 citations

Skin Melanoma Development in ret Transgenic Mice Despite the Depletion of CD25+Foxp3+ Regulatory T Cells in Lymphoid Organs

2009 • 54 citations

The Fate of Low Affinity Tumor-Specific CD8+ T Cells in Tumor-Bearing Mice

2005 • 54 citations

An effective chelating agent for labelling of monoclonal antibody with²¹²Bi for α-particle mediated radioimmunotherapy

1991 • 51 citations

Mobilizing the low-avidity T cell repertoire to kill tumors

2007 • 51 citations

Effector/Memory but Not Naive Regulatory T Cells Are Responsible for the Loss of Concomitant Tumor Immunity

2009 • 47 citations

Primer: mechanisms of immunologic tolerance

2006 • 44 citations

The Tumoricidal Activity of Memory CD8+ T Cells Is Hampered by Persistent Systemic Antigen, but Full Functional Capacity Is Regained in an Antigen-Free Environment

2004 • 40 citations

Type I IFN regulate DC turnover in vivo

2009 • 35 citations

Stat6 Signaling Suppresses VLA-4 Expression by CD8+ T Cells and Limits Their Ability to Infiltrate Tumor Lesions In Vivo

2008 • 29 citations

Mechanisms of T-cell inhibition: implications for cancer immunotherapy

2009 • 27 citations

A role for the integrin 6 1 in the differential distribution of CD4 and CD8 T-cell subsets within the rheumatoid synovium

2008 • 13 citations

Alpha tumor necrosis factor contributes to CD8+ T cell survival in the transition phase

2007 • 8 citations