Intraepithelial Effector (CD3+)/Regulatory (FoxP3+) T-Cell Ratio Predicts a Clinical Outcome of Human Colon Carcinoma

PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer

2016 • 29,943 citations

Control of Regulatory T Cell Development by the Transcription Factor Foxp3

2003 • 7,902 citations

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

2003 • 7,470 citations

Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome

2006 • 5,923 citations

Cancer Statistics, 2006

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Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

2004 • 4,872 citations

The Role of Tumoral FOXP3 on Cell Proliferation, Migration, and Invasion in Gastric Cancer

2017 • 4,003 citations

Intratumoral T Cells, Recurrence, and Survival in Epithelial Ovarian Cancer

2003 • 3,194 citations

Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis

1993 • 2,711 citations

Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

2001 • 2,503 citations

Intraepithelial CD8⁺tumor-infiltrating lymphocytes and a high CD8⁺/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer

2005 • 2,226 citations

Regulatory T cells, tumour immunity and immunotherapy

2006 • 2,009 citations

CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer

2006 • 1,883 citations

Systematic Review of Microsatellite Instability and Colorectal Cancer Prognosis

2005 • 1,761 citations

Colon Cancer Survival Rates With the New American Joint Committee on Cancer Sixth Edition Staging

2004 • 1,556 citations

Induction of Tumor Immunity by Removing CD25+CD4+ T Cells: A Common Basis Between Tumor Immunity and Autoimmunity

1999 • 1,475 citations

Prevalence of Regulatory T Cells Is Increased in Peripheral Blood and Tumor Microenvironment of Patients with Pancreas or Breast Adenocarcinoma

2002 • 1,454 citations

Natural versus adaptive regulatory T cells

2003 • 1,363 citations

CD8+ T cells infiltrated within cancer cell nests as a prognostic factor in human colorectal cancer.

1998 • 1,175 citations

Incidence of Hereditary Nonpolyposis Colorectal Cancer and the Feasibility of Molecular Screening for the Disease

1998 • 1,173 citations

Quantification of Regulatory T Cells Enables the Identification of High-Risk Breast Cancer Patients and Those at Risk of Late Relapse

2006 • 1,118 citations

Intratumoral Balance of Regulatory and Cytotoxic T Cells Is Associated With Prognosis of Hepatocellular Carcinoma After Resection

2007 • 1,060 citations

Pillars Article: Control of Regulatory T Cell Development by the Transcription Factor Foxp3. Science 2003. 299: 1057-1061.

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A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3

2005 • 957 citations

FOXP3: Of Mice and Men

2005 • 929 citations

Granzyme B and Perforin Are Important for Regulatory T Cell-Mediated Suppression of Tumor Clearance

2007 • 871 citations

Increased Regulatory T Cells Correlate With CD8 T-Cell Impairment and Poor Survival in Hepatocellular Carcinoma Patients

2007 • 830 citations

Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells

2004 • 805 citations

Foxp3 Expressing CD4+CD25high Regulatory T Cells Are Overrepresented in Human Metastatic Melanoma Lymph Nodes and Inhibit the Function of Infiltrating T Cells

2004 • 680 citations

CTLA4 blockade and GM-CSF combination immunotherapy alters the intratumor balance of effector and regulatory T cells

2006 • 677 citations

Prognostic value of indoleamine 2,3-dioxygenase expression in colorectal cancer: effect on tumor-infiltrating T cells.

2006 • 587 citations

Concomitant Tumor Immunity to a Poorly Immunogenic Melanoma Is Prevented by Regulatory T Cells

2004 • 541 citations

Microsatellite instability in colorectal cancer: different mutator phenotypes and the principal involvement of hMLH1.

1998 • 523 citations

The Expression of the Regulatory T Cell–Specific Forkhead Box Transcription Factor FoxP3 Is Associated with Poor Prognosis in Ovarian Cancer

2005 • 494 citations

CD4⁺CD25⁺ regulatory T cells in patients with gastrointestinal malignancies

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Morphology of sporadic colorectal cancer with DNA replication errors

1998 • 465 citations

Intratumor depletion of CD4+ cells unmasks tumor immunogenicity leading to the rejection of late-stage tumors

2005 • 423 citations

Tumor infiltrating Foxp3⁺ regulatory T‐cells are associated with recurrence in pathologic stage I NSCLC patients

2006 • 410 citations

Microsatellite Instability and 8p Allelic Imbalance in Stage B2 and C Colorectal Cancers

1999 • 375 citations

Immune Response Against Frameshift-Induced Neopeptides in HNPCC Patients and Healthy HNPCC Mutation Carriers

2008 • 356 citations

Microsatellite Instability and High Content of Activated Cytotoxic Lymphocytes Identify Colon Cancer Patients with a Favorable Prognosis

2001 • 316 citations

Distinct IL-2 Receptor Signaling Pattern in CD4+CD25+ Regulatory T Cells

2004 • 279 citations

Prognostic Impact of Microsatellite Instability and DNA Ploidy in Human Colon Carcinoma Patients

2006 • 223 citations

CD4+CD25+FOXP3+ Regulatory T Cells Suppress Anti-Tumor Immune Responses in Patients with Colorectal Cancer

2006 • 213 citations

Tumor-Infiltrating Foxp3−CD4+CD25+ T Cells Predict Poor Survival in Renal Cell Carcinoma

2007 • 198 citations

Intraepithelial CD8+ T-cell-count becomes a prognostic factor after a longer follow-up period in human colorectal carcinoma: possible association with suppression of micrometastasis

2004 • 195 citations

Tumour infiltrating lymphocytes and apoptosis are independent features in colorectal cancer stratified according to microsatellite instability status

2001 • 190 citations

Tumor immunoediting and immunosculpting pathways to cancer progression

2007 • 187 citations

Prognostic significance of CD3+ tumor-infiltrating lymphocytes in ovarian carcinoma

2007 • 183 citations

Investigation of the Prognostic and Predictive Value of Thymidylate Synthase, p53, and Ki-67 in Patients With Locally Advanced Colon Cancer

2002 • 177 citations

Attenuation of CD8+ T-Cell Function by CD4+CD25+ Regulatory T Cells in B-Cell Non-Hodgkin's Lymphoma

2006 • 173 citations

Increased frequency of regulatory T cells in peripheral blood and tumour infiltrating lymphocytes in colorectal cancer patients.

2007 • 171 citations

Accelerated chemically induced tumor development mediated by CD4 ⁺ CD25 ⁺ regulatory T cells in wild-type hosts

2005 • 111 citations

CD103+ intraepithelial lymphocytes—a unique population in microsatellite unstable sporadic colorectal cancer

2003 • 72 citations

Differential significance of tumour infiltrating lymphocytes in sporadic mismatch repair deficient versus proficient colorectal cancers: A potential role for dysregulation of the transforming growth factor-β pathway

2007 • 62 citations

Infiltrating regulatory T cell numbers is not a factor to predict patient's survival in oesophageal squamous cell carcinoma

2008 • 61 citations

Testing tumors for microsatellite instability

1999 • 57 citations

The Correlation of Microsatellite Instability and Tumor-infiltrating Lymphocytes in Hereditary Non-polyposis Colorectal Cancer (HNPCC) and Sporadic Colorectal Cancers: the Significance of Different Types of Lymphocyte Infiltration

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Randomized Clinical Trial of High-Dose Levamisole Combined with 5-Fluorouracil and Leucovorin as Surgical Adjuvant Therapy for High-Risk Colon Cancer

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Alterations in cell proliferation and apoptosis in colon cancers with microsatellite instability

2006 • 30 citations

Lymphokine-Activated Killing by Human Intestinal Lymphocytes

1993 • 26 citations

Proliferation of T-cell subsets that contact tumour cells in colorectal cancer

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MSI-H colorectal cancers preferentially retain and expand intraepithelial lymphocytes rather than peripherally derived CD8+ T cells

2008 • 13 citations

Changes of blood T cell subsets in patients receiving postoperative adjuvant chemotherapy for breast cancer

1984 • 5 citations