Cyclophosphamide resets dendritic cell homeostasis and enhances antitumor immunity through effects that extend beyond regulatory T cell elimination

Calreticulin exposure dictates the immunogenicity of cancer cell death

2006 • 2,789 citations

Mouse and human dendritic cell subtypes

2002 • 2,311 citations

Adoptive Cell Therapy for Patients With Metastatic Melanoma: Evaluation of Intensive Myeloablative Chemoradiation Preparative Regimens

2008 • 1,304 citations

Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor alpha) monoclonal antibody.

1999 • 1,066 citations

Abnormalities in Monocyte Recruitment and Cytokine Expression in Monocyte Chemoattractant Protein 1–deficient Mice

1998 • 1,022 citations

Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8+ T cells

2005 • 1,000 citations

Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells

2005 • 998 citations

Mechanisms and functional significance of tumour-induced dendritic-cell defects

2004 • 995 citations

In Vivo Analysis of Dendritic Cell Development and Homeostasis

2009 • 904 citations

Inhibition of CD4+25+ T regulatory cell function implicated in enhanced immune response by low-dose cyclophosphamide

2005 • 878 citations

CD4⁺CD25⁺ regulatory T cells suppress tumor immunity but are sensitive to cyclophosphamide which allows immunotherapy of established tumors to be curative

2004 • 854 citations

Tumor cells convert immature myeloid dendritic cells into TGF-β–secreting cells inducing CD4+CD25+ regulatory T cell proliferation

2005 • 716 citations

Central Role of Defective Interleukin-2 Production in the Triggering of Islet Autoimmune Destruction

2008 • 705 citations

Lipopolysaccharide-Induced Inflammation Exacerbates Tau Pathology by a Cyclin-Dependent Kinase 5-Mediated Pathway in a Transgenic Model of Alzheimer's Disease

2005 • 654 citations

Identification of clonogenic common Flt3+M-CSFR+ plasmacytoid and conventional dendritic cell progenitors in mouse bone marrow

2007 • 654 citations

Cyclophosphamide-facilitated adoptive immunotherapy of an established tumor depends on elimination of tumor-induced suppressor T cells.

1982 • 640 citations

Immunotherapy and chemotherapy — a practical partnership

2005 • 639 citations

The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues

2008 • 612 citations

Monocytes give rise to mucosal, but not splenic, conventional dendritic cells

2006 • 591 citations

The anticancer immune response: indispensable for therapeutic success?

2008 • 556 citations

Microbial translocation augments the function of adoptively transferred self/tumor-specific CD8+ T cells via TLR4 signaling

2007 • 510 citations

Rapid and Accurate Large-Scale Coestimation of Sequence Alignments and Phylogenetic Trees

2009 • 492 citations

Cyclophosphamide, doxorubicin, and paclitaxel enhance the antitumor immune response of granulocyte/macrophage-colony stimulating factor-secreting whole-cell vaccines in HER-2/neu tolerized mice.

2001 • 454 citations

Recruitment of latent pools of high-avidity CD8+ T cells to the antitumor immune response

2005 • 403 citations

CX3CR1+ CD115+ CD135+ common macrophage/DC precursors and the role of CX3CR1 in their response to inflammation

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The immunodominant major histocompatibility complex class I-restricted antigen of a murine colon tumor derives from an endogenous retroviral gene product.

1996 • 386 citations

The use of real-time reverse transcriptase PCR for the quantification of cytokine gene expression.

2003 • 353 citations

Induced sensitization of tumor stroma leads to eradication of established cancer by T cells

2007 • 353 citations

Reversal of Tumor-induced Dendritic Cell Paralysis by CpG Immunostimulatory Oligonucleotide and Anti–Interleukin 10 Receptor Antibody

2002 • 340 citations

Assessment of aldehyde dehydrogenase in viable cells

1995 • 322 citations

T cell homeostatic proliferation elicits effective antitumor autoimmunity

2002 • 312 citations

Immature monocytes acquire antigens from other cells in the bone marrow and present them to T cells after maturing in the periphery

2006 • 279 citations

T cell homeostatic proliferation elicits effective antitumor autoimmunity

2002 • 262 citations

Characterization of a common precursor population for dendritic cells

2002 • 223 citations

Liver Dendritic Cells Are Less Immunogenic Than Spleen Dendritic Cells because of Differences in Subtype Composition

2004 • 220 citations

Limited tumor infiltration by activated T effector cells restricts the therapeutic activity of regulatory T cell depletion against established melanoma

2008 • 206 citations

The immunodominant major histocompatibility complex class I-restricted antigen of a murine colon tumor derives from an endogenous retroviral gene product

1996 • 206 citations

Hematopoietic stem cells promote the expansion and function of adoptively transferred antitumor CD8+ T cells

2007 • 201 citations

Regulation by Chemokines of Circulating Dendritic Cell Precursors, and the Formation of Portal Tract–Associated Lymphoid Tissue, in a Granulomatous Liver Disease

2000 • 200 citations

Cyclophosphamide induces type I interferon and augments the number of CD44hi T lymphocytes in mice: implications for strategies of chemoimmunotherapy of cancer

2000 • 196 citations

Demystifying the development of dendritic cell subtypes, a little

2008 • 172 citations

Administration of a CD25-Directed Immunotoxin, LMB-2, to Patients with Metastatic Melanoma Induces a Selective Partial Reduction in Regulatory T Cells In Vivo

2007 • 163 citations

Tumor Rejection by Disturbing Tumor Stroma Cell Interactions

2001 • 147 citations

Nitric oxide-producing CD11b+Ly-6G(Gr-1)+CD31(ER-MP12)+cells in the spleen of cyclophosphamide–treated mice: implications for T-cell responses in immunosuppressed mice

2000 • 139 citations

Tumor Growth Enhances Cross-Presentation Leading to Limited T Cell Activation without Tolerance

2002 • 129 citations

CD4+CD25+ T Regulatory Cells Dominate Multiple Immune Evasion Mechanisms in Early but Not Late Phases of Tumor Development in a B Cell Lymphoma Model

2007 • 122 citations

High-dose cyclophosphamide for refractory autoimmune hemolytic anemia

2002 • 122 citations

Tumor eradication after cyclophosphamide depends on concurrent depletion of regulatory T cells: a role for cycling TNFR2-expressing effector-suppressor T cells in limiting effective chemotherapy

2008 • 118 citations

Accurate and statistically verified quantification of relative mRNA abundances using SYBR Green I and real-time RT-PCR

2003 • 116 citations

Defining the Ability of Cyclophosphamide Preconditioning to Enhance the Antigen-specific CD8+ T-cell Response to Peptide Vaccination: Creation of a Beneficial Host Microenvironment Involving Type I IFNs and Myeloid Cells

2006 • 115 citations

Phenotypic and Functional Characterization of Mouse Hepatic CD8α+ Lymphoid-Related Dendritic Cells

2000 • 100 citations

Cyclophosphamide Induces the Development of Early Myeloid Cells Suppressing Tumor Cell Growth by a Nitric Oxide-Dependent Mechanism

2001 • 94 citations

Combined chemoimmunotherapy of solid tumours: Improving vaccines?

2006 • 94 citations

Mobilization of Dendritic Cell Precursors Into the Circulation by Administration of MIP-1 in Mice

2004 • 77 citations

Successful therapy of metastatic cancer using tumor vaccines in mixed allogeneic bone marrow chimeras

2003 • 67 citations

Overexpression of Macrophage Colony-stimulating Factor Receptor on Microglial Cells Induces an Inflammatory Response

2001 • 61 citations

Synergistic Effect of a Granulocyte-Macrophage Colony-Stimulating Factor?Transduced Tumor Vaccine and Systemic Interleukin-2 in the Treatment of Murine Colorectal Cancer Hepatic Metastases

2003 • 44 citations

Response of Hematopoiesis to Cyclophosphamide Follows Highly Specific Patterns in Bone Marrow and Spleen

2003 • 39 citations

Books Received

2009 • 27 citations

Chemokine and chemokine receptor expression by liver-derived dendritic cells: MIP-1α production is induced by bacterial lipopolysaccharide and interaction with allogeneic T cells

2000 • 23 citations

T Lymphocytes Potentiate Murine Dendritic Cells to Produce IL-12

2002 • 18 citations

Breaking Self-Tolerance to Tumor-Associated Antigens by In Vivo Manipulation of Dendritic Cells

2007 • 4 citations