Effector/Memory but Not Naive Regulatory T Cells Are Responsible for the Loss of Concomitant Tumor Immunity

Cancer-related inflammation

2008 • 10,288 citations

Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

2004 • 4,872 citations

Vaccination of melanoma patients with peptide- or tumorlysate-pulsed dendritic cells

1998 • 2,916 citations

Intraepithelial CD8⁺tumor-infiltrating lymphocytes and a high CD8⁺/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer

2005 • 2,226 citations

CD4+CD25+ suppressor T cells: more questions than answers

2002 • 2,202 citations

Use of Tumor-Infiltrating Lymphocytes and Interleukin-2 in the Immunotherapy of Patients with Metastatic Melanoma

1988 • 2,196 citations

Immunosuppressive networks in the tumour environment and their therapeutic relevance

2005 • 1,990 citations

A New Approach to the Adoptive Immunotherapy of Cancer with Tumor-Infiltrating Lymphocytes

1986 • 1,787 citations

CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity

2002 • 1,733 citations

Induction of Tumor Immunity by Removing CD25+CD4+ T Cells: A Common Basis Between Tumor Immunity and Autoimmunity

1999 • 1,475 citations

Prevalence of Regulatory T Cells Is Increased in Peripheral Blood and Tumor Microenvironment of Patients with Pancreas or Breast Adenocarcinoma

2002 • 1,454 citations

Quantification of Regulatory T Cells Enables the Identification of High-Risk Breast Cancer Patients and Those at Risk of Late Relapse

2006 • 1,118 citations

Synergism of Cytotoxic T Lymphocyte–Associated Antigen 4 Blockade and Depletion of Cd25+ Regulatory T Cells in Antitumor Therapy Reveals Alternative Pathways for Suppression of Autoreactive Cytotoxic T Lymphocyte Responses

2001 • 1,033 citations

The Foxp3+ regulatory T cell: a jack of all trades, master of regulation

2008 • 999 citations

Granzyme B and Perforin Are Important for Regulatory T Cell-Mediated Suppression of Tumor Clearance

2007 • 871 citations

Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-β signalsin vivo

2004 • 761 citations

Developmental Stage, Phenotype, and Migration Distinguish Naive- and Effector/Memory-like CD4+ Regulatory T Cells

2004 • 618 citations

Concomitant Tumor Immunity to a Poorly Immunogenic Melanoma Is Prevented by Regulatory T Cells

2004 • 541 citations

Tregs and rethinking cancer immunotherapy

2007 • 532 citations

Tumour immunity: effector response to tumour and role of the microenvironment

2008 • 511 citations

Essential role for CD103 in the T cell–mediated regulation of experimental colitis

2005 • 474 citations

A monoclonal antibody (HML‐1) defining a novel membrane molecule present on human intestinal lymphocytes

1987 • 461 citations

Intratumor depletion of CD4+ cells unmasks tumor immunogenicity leading to the rejection of late-stage tumors

2005 • 423 citations

Cancer vaccines

1998 • 422 citations

FOXP3+ Regulatory T Cells Affect the Development and Progression of Hepatocarcinogenesis

2007 • 412 citations

Altering the distribution of Foxp3+ regulatory T cells results in tissue-specific inflammatory disease

2007 • 388 citations

Recruitment of Foxp3+ T regulatory cells mediating allograft tolerance depends on the CCR4 chemokine receptor

2005 • 371 citations

Induction of a proinflammatory program in normal human thyrocytes by the RET/PTC1 oncogene

2005 • 319 citations

A Role for CD103 in the Retention of CD4+CD25+ Treg and Control of Leishmania major Infection

2005 • 313 citations

Elucidating the Autoimmune and Antitumor Effector Mechanisms of a Treatment Based on Cytotoxic T Lymphocyte Antigen-4 Blockade in Combination with a B16 Melanoma Vaccine

2001 • 307 citations

Generation and decay of the immune response to a progressive fibrosarcoma. I. Ly-1+2- suppressor T cells down-regulate the generation of Ly-1-2+ effector T cells.

1984 • 249 citations

Critical role for CCR5 in the function of donor CD4+CD25+ regulatory T cells during acute graft-versus-host disease

2005 • 243 citations

CCR5-dependent homing of naturally occurring CD4+ regulatory T cells to sites of Leishmania major infection favors pathogen persistence

2006 • 224 citations

Depletion of CD25(+) CD4(+) T cells and treatment with tyrosinase-related protein 2-transduced dendritic cells enhance the interferon alpha-induced, CD8(+) T-cell-dependent immune defense of B16 melanoma.

2001 • 223 citations

Depletion of CD4+CD25+ Regulatory Cells Augments the Generation of Specific Immune T Cells in Tumor-Draining Lymph Nodes

2002 • 206 citations

Collected Studies on Immunity.

1906 • 184 citations

CD4+ CD25+ regulatory T cells control the induction of antigen-specific CD4+ helper T cell responses in cancer patients

2005 • 169 citations

CD8+ Tumor-Infiltrating T Cells Are Deficient in Perforin-Mediated Cytolytic Activity Due to Defective Microtubule-Organizing Center Mobilization and Lytic Granule Exocytosis

2001 • 153 citations

Systemic and Local Characterization of Regulatory T Cells in a Chronic Fungal Infection in Humans

2006 • 150 citations

In vivo–activated CD103+CD4+ regulatory T cells ameliorate ongoing chronic graft-versus-host disease

2008 • 139 citations

Distinct Subsets of FoxP3+ Regulatory T Cells Participate in the Control of Immune Responses

2007 • 92 citations

The immunological basis of endotoxin-induced tumor regression. Requirement for a pre-existing state of concomitant anti-tumor immunity.

1978 • 83 citations

Adenovirus-transduced dendritic cells stimulate cellular immunity to melanoma via a CD4+ T cell-dependent mechanism

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Effector-phase tolerance: another mechanism of how cancer escapes antitumor immune response

2006 • 73 citations

Defects in cell‐mediated immunity during growth of a syngeneic simian virus‐induced tumor

1975 • 62 citations

CD8+ Tumor-Infiltrating Lymphocytes Are Primed for Fas-Mediated Activation-Induced Cell Death But Are Not Apoptotic In Situ

2001 • 58 citations

T cell suppressors of antitumor immunity. The production of Ly-1-,2+ suppressors of delayed sensitivity precedes the production of suppressors of protective immunity.

1986 • 42 citations

Liver injury is associated with enhanced regulatory T‐cell activity in patients with chronic hepatitis B

2007 • 28 citations

FOURTH SCIENTIFIC REPORT OF THE INVESTIGATIONS OF THE IMPERIAL CANCER RESEARCH FUND

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The adoptive transfer of concomitant immunity to murine tumor isografts with spleen cells from tumor-bearing animals.

1971 • 27 citations