Transforming Growth Factor-β in Renal Disease

Quantitative Monitoring of Gene Expression Patterns with a Complementary DNA Microarray

1995 • 9,575 citations

The Effect of Angiotensin-Converting-Enzyme Inhibition on Diabetic Nephropathy

1993 • 5,296 citations

Transforming Growth Factor β in Tissue Fibrosis

1994 • 3,055 citations

The Transforming Growth Factor-beta Family

1990 • 3,028 citations

Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease

1992 • 2,969 citations

Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro.

1986 • 2,878 citations

The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms.

1994 • 1,950 citations

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death.

1993 • 1,941 citations

Effect of the Angiotensin-Converting–Enzyme Inhibitor Benazepril on the Progression of Chronic Renal Insufficiency

1996 • 1,759 citations

TGFβ2 knockout mice have multiple developmental defects that are non-overlapping with other TGFβ knockout phenotypes

1997 • 1,404 citations

A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye.

1995 • 1,118 citations

Angiotensin II stimulates extracellular matrix protein synthesis through induction of transforming growth factor-beta expression in rat glomerular mesangial cells.

1994 • 1,063 citations

Abnormal lung development and cleft palate in mice lacking TGF–β3 indicates defects of epithelial–mesenchymal interaction

1995 • 1,027 citations

BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning.

1995 • 1,021 citations

Defective haematopoiesis and vasculogenesis in transforming growth factor-β1 knock out mice

1995 • 1,020 citations

Adenovector-mediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lung.

1997 • 1,010 citations

Suppression of experimental glomerulonephritis by antiserum against transforming growth factor β1

1990 • 1,002 citations

TGF-β stimulation and inhibition of cell proliferation: New mechanistic insights

1990 • 992 citations

Natural inhibitor of transforming growth factor-β protects against scarring in experimental kidney disease

1992 • 984 citations

Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism.

1995 • 938 citations

Transforming growth factor–β3 is required for secondary palate fusion

1995 • 895 citations

Betaglycan presents ligand to the TGFβ signaling receptor

1993 • 887 citations

TGFβ Signaling: Receptors, Transducers, and Mad Proteins

1996 • 840 citations

Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells.

1992 • 837 citations

Cytokines in context.

1991 • 808 citations

Physiological Actions and Clinical Applications of Transforming Growth Factor-β (TGF-β)

1993 • 755 citations

Hepatic expression of mature transforming growth factor beta 1 in transgenic mice results in multiple tissue lesions.

1995 • 668 citations

Structure and expression of the membrane proteoglycan betaglycan, a component of the TGF-β receptor system

1991 • 661 citations

Neutralization of TGF-β by Anti-TGF-β Antibody Attenuates Kidney Hypertrophy and the Enhanced Extracellular Matrix Gene Expression in STZ-Induced Diabetic Mice

1996 • 658 citations

TGF-β Receptor Type II Deficiency Results in Defects of Yolk Sac Hematopoiesis and Vasculogenesis

1996 • 651 citations

Vascular smooth muscle cell hypertrophy vs. hyperplasia. Autocrine transforming growth factor-beta 1 expression determines growth response to angiotensin II.

1992 • 648 citations

Latent high molecular weight complex of transforming growth factor beta 1. Purification from human platelets and structural characterization.

1988 • 648 citations

Receptors for the TGF-β family

1992 • 638 citations

Expression cloning and characterization of the TGF-β type III receptor

1991 • 638 citations

Elevated expression of transforming growth factor-beta and proteoglycan production in experimental glomerulonephritis. Possible role in expansion of the mesangial extracellular matrix.

1990 • 555 citations

Glomerulosclerosis induced by in vivo transfection of transforming growth factor-beta or platelet-derived growth factor gene into the rat kidney.

1993 • 525 citations

Maternal Rescue of Transforming Growth Factor-β 1 Null Mice

1994 • 494 citations

Expression of a Truncated, Kinase-Defective TGF-β Type II Receptor in Mouse Skeletal Tissue Promotes Terminal Chondrocyte Differentiation and Osteoarthritis

1997 • 466 citations

Latent transforming growth factor-beta 1 associates to fibroblast extracellular matrix via latent TGF-beta binding protein

1994 • 450 citations

Crystal Structure of Transforming Growth Factor-β2: an Unusual Fold for the Superfamily

1992 • 446 citations

Plasminogen deficiency causes severe thrombosis but is compatible with development and reproduction.

1995 • 440 citations

Latent transforming growth factor-beta in serum. A specific complex with alpha 2-macroglobulin.

1987 • 434 citations

Loss of Fibrinogen Rescues Mice from the Pleiotropic Effects of Plasminogen Deficiency

1996 • 428 citations

Expression of transforming growth factor-β isoforms in human glomerular diseases

1996 • 424 citations

Regulation of Transforming Growth Factor-β Activation by Discrete Sequences of Thrombospondin 1

1995 • 413 citations

Sustained expression of TGF-β1 underlies development of progressive kidney fibrosis

1994 • 413 citations

Tumor suppressor activity of the TGF-β pathway in human cancers

1996 • 412 citations

Protective effect of transforming growth factor beta 1 on experimental autoimmune diseases in mice.

1991 • 400 citations

Latent Transforming Growth Factor-β Binding Protein Domains Involved in Activation and Transglutaminase-dependent Cross-Linking of Latent Transforming Growth Factor-β

1997 • 397 citations

The serum concentration of active transforming growth factor-β is severely depressed in advanced atherosclerosis

1995 • 386 citations

Angiotensin II-induced hypertrophy of cultured murine proximal tubular cells is mediated by endogenous transforming growth factor-beta.

1993 • 381 citations

Betaglycan can act as a dual modulator of TGF-beta access to signaling receptors: mapping of ligand binding and GAG attachment sites

1994 • 379 citations

Activation of transforming growth factor-β is inhibited in transgenic apolipoprotein(a) mice

1994 • 363 citations

Gene targeting in mice reveals a requirement for angiotensin in the development and maintenance of kidney morphology and growth factor regulation.

1995 • 340 citations

Angiotensin II receptor antagonist ameliorates renal tubulointerstitial fibrosis caused by unilateral ureteral obstruction

1995 • 332 citations

Transforming Growth Factor β as a Predictor of Liver and Lung Fibrosis after Autologous Bone Marrow Transplantation for Advanced Breast Cancer

1993 • 318 citations

Transforming growth factor β: a matter of life and death

1994 • 306 citations

Endoglin modulates cellular responses to TGF-beta 1.

1996 • 306 citations

Early-onset multifocal inflammation in the transforming growth factor beta 1-null mouse is lymphocyte mediated.

1995 • 275 citations

Increased Renal Production of Transforming Growth Factor-β1 in Patients with Type II Diabetes

1997 • 275 citations

TGF-β-receptor-mediated signaling

1994 • 274 citations

Thrombospondin binds and activates the small and large forms of latent transforming growth factor-beta in a chemically defined system.

1994 • 274 citations

Expression of a dominant-negative mutant TGF-beta type II receptor in transgenic mice reveals essential roles for TGF-beta in regulation of growth and differentiation in the exocrine pancreas

1997 • 257 citations

Transforming growth factor-beta protein and mRNA in glomeruli in normal and diseased human kidneys.

1993 • 249 citations

Expression of transforming growth factor-β1 during diabetic renal hypertrophy

1994 • 237 citations

Autoimmunity associated with TGF-beta1-deficiency in mice is dependent on MHC class II antigen expression.

1996 • 236 citations

Association of the small latent transforming growth factor-beta with an eight cysteine repeat of its binding protein LTBP-1.

1996 • 236 citations

Adriamycin-induced nephropathy as a model of chronic progressive glomerular disease

1986 • 221 citations

Transforming growth factor-beta inhibits E-selectin expression on human endothelial cells.

1993 • 217 citations

Enalapril reduces collagen type IV synthesis and expansion of the interstitium in the obstructed rat kidney

1994 • 214 citations

Transforming growth factor beta enhances integrin expression and type IV collagenase secretion in human monocytes.

1993 • 211 citations

Angiotensin II blockade decreases TGF-β1 and matrix proteins in cyclosporine nephropathy

1997 • 207 citations

Loss of expression of transforming growth factor beta in skin and skin tumors is associated with hyperproliferation and a high risk for malignant conversion.

1993 • 207 citations

Transforming growth factor β1 and renal injury following subtotal nephrectomy in the rat: Role of the renin-angiotensin system

1997 • 206 citations

Inhibition of TGF-β1 expression by antisense oligonucleotides suppressed extracellular matrix accumulation in experimental glomerulonephritis

1996 • 205 citations

The types II and III transforming growth factor-beta receptors form homo-oligomers.

1994 • 199 citations

Macrophages, monocyte chemoattractant peptide-1, and TGF-beta 1 in experimental hydronephrosis

1994 • 197 citations

Transgenic mice overexpressing a dominant-negative mutant type II transforming growth factor beta receptor show enhanced tumorigenesis in the mammary gland and lung in response to the carcinogen 7,12-dimethylbenz-[a]-anthracene.

1997 • 195 citations

Early determination of a mouse somatosensory cortex marker

1994 • 193 citations

Renal hypertrophy is associated with upregulation of TGF-beta 1 gene expression in diabetic BB rat and NOD mouse

1994 • 186 citations

SLE-like autoantibodies and Sjögren's syndrome-like lymphoproliferation in TGF-beta knockout mice.

1995 • 184 citations

Murine osteogenic protein (OP-1): High levels of mRNA in kidney

1991 • 184 citations

Transforming growth factor beta 1 (TGF-beta 1) controls expression of major histocompatibility genes in the postnatal mouse: aberrant histocompatibility antigen expression in the pathogenesis of the TGF-beta 1 null mouse phenotype.

1993 • 181 citations

Mapping of a major genetic modifier of embryonic lethality in TGFβ1 knockout mice

1997 • 166 citations

Transforming growth factor-beta1 circulates in normal human plasma and is unchanged in advanced metastatic breast cancer.

1995 • 159 citations

Gene knockouts of c-src, transforming growth factor beta 1, and tenascin suggest superfluous, nonfunctional expression of proteins.

1993 • 157 citations

Accumulation of extracellular matrix and developmental dysregulation in the pancreas by transgenic production of transforming growth factor-beta 1.

1995 • 156 citations

Differential inhibition of transforming growth factor beta 1 and beta 2 activity by alpha 2-macroglobulin.

1990 • 148 citations

Identification and Characterization of an Eight-cysteine Repeat of the Latent Transforming Growth Factor-β Binding Protein-1 that Mediates Bonding to the Latent Transforming Growth Factor-β1

1996 • 143 citations

Expression of a dominant-negative type II transforming growth factor β (TGF-β) receptor in the epidermis of transgenic mice blocks TGF-β-mediated growth inhibition

1997 • 134 citations

Role of angiotensin II in the expression and regulation of transforming growth factor-β in obstructive nephropathy

1995 • 131 citations

Transforming growth factor-beta production in anti-glomerular basement membrane disease in the rabbit.

1991 • 123 citations

Angiotensin II in renal fibrosis: should TGF-beta rather than blood pressure be the therapeutic target?

1997 • 122 citations

Mechanism of the cardioprotective effect of transforming growth factor beta 1 in feline myocardial ischemia and reperfusion.

1993 • 122 citations

Latency and activation in the control of TGF-β

1996 • 121 citations

Activation of Latent Transforming Growth Factor ß

1993 • 118 citations

Spontaneously increased production of nitric oxide and aberrant expression of the inducible nitric oxide synthase in vivo in the transforming growth factor beta 1 null mouse.

1996 • 115 citations

Synthetic fibronectin peptides interrupt inflammatory cell infiltration in transforming growth factor beta 1 knockout mice.

1994 • 96 citations

Mesangial cell proliferation mediated by PDGF and bFGF is determined by levels of the cyclin kinase inhibitor p27Kip1

1997 • 95 citations

Differential expression of transforming growth factor-β isoforms and receptors in experimental membranous nephropathy

1996 • 95 citations

Contribution of renal angiotensin II type I receptor to gene expressions in hypertension-induced renal injury

1994 • 86 citations

Type 1 receptor tyrosine kinases are differentially phosphorylated in mammary carcinoma and differentially associated with steroid receptors.

1996 • 86 citations

Biosynthesis of the Type I and Type II TGF-β Receptors

1997 • 83 citations

Increased renal tubular expression of transforming growth factor beta in human allografts correlates with cyclosporine toxicity

1996 • 80 citations

Protein restriction reduces transforming growth factor-beta and interstitial fibrosis in nephrotic syndrome

1994 • 77 citations

The renoprotective properties of angiotensin-converting enzyme inhibitors in a chronic model of membranous nephropathy are solely due to the inhibition of angiotensin II: Evidence based on comparative studies with a receptor antagonist

1997 • 76 citations

Long-term treatment of chronic relapsing experimental allergic encephalomyelitis by transforming growth factor-β2

1993 • 74 citations

Control of transforming growth factor-β activity: Latency vs. activation

1992 • 73 citations

Extracellular Matrix/Growth Factor Interactions

1992 • 70 citations

A first or dominant immunization. II. Induced immunoglobulin carries transforming growth factor beta and suppresses cytolytic T cell responses to unrelated alloantigens.

1993 • 68 citations

Latent forms of TGF‐β: Molecular Structure and Mechanisms of Activation

2007 • 67 citations

Immunohistochemical detection of active transforming growth factor-beta in situ using engineered tissue.

1995 • 66 citations

Refined Crystal Structure of Human Transforming Growth Factor β2 at 1·5 Å Resolution

1993 • 62 citations

Induction of plasminogen activator inhibitor type 1 in murine lupus-like glomerulonephritis

1995 • 55 citations

Progressive renal lesions induced by administration of monoclonal antibody 1-22-3 to unilaterally nephrectomized rats

1995 • 54 citations

TGF-β1-induced cell cycle arrest in renal mesangial cells involves inhibition of cyclin E-cdk 2 activation and retinoblastoma protein phosphorylation

1997 • 54 citations

Analysis of limb patterning in BMP-7-deficient mice

1996 • 51 citations

Transforming Growth Factor-β1 Expression and Phenotypic Modulation in the Kidney of Hypertensive Rats

1995 • 48 citations

Specific binding of endocrine transforming growth factor-beta 1 to vascular endothelium.

1995 • 43 citations

Growth factors and diabetic nephrology: an overview.

1997 • 40 citations

Involvement of transforming growth factor-beta and its receptors in the pathogenesis of diabetic nephrology.

1997 • 39 citations

Characterization of distinct functional domains of transforming growth factor beta.

1993 • 36 citations

The role of TGF‐βs in mammalian development and neoplasia

1992 • 31 citations

In vivo transfer of engineered macrophages into the glomerulus: endogenous TGF-beta-mediated defense against macrophage-induced glomerular cell activation.

1997 • 29 citations

Role of thrombospondin in mesangial cell growth: Possible existence of an autocrine feedback growth circuit

1994 • 29 citations

Glomerulosclerosis: intrinsic and extrinsic pathways

1996 • 27 citations

Autoantibodies produced spontaneously by young 1pr mice carry transforming growth factor beta and suppress cytotoxic T lymphocyte responses.

1995 • 24 citations

Short- or long-term effects of a low-protein diet on fibronectin and transforming growth factor-β synthesis in adriamycin-induced nephropathy

1996 • 18 citations

Analysis of limb patterning in BMP‐7‐deficient mice

1996 • 4 citations