The complexity of p53 stabilization and activation

In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2

2004 • 4,416 citations

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

Molecular Mechanisms of Mammalian DNA Repair and the DNA Damage Checkpoints

2004 • 3,161 citations

Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain

1997 • 2,510 citations

Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53

1998 • 2,034 citations

The p53 pathway: positive and negative feedback loops

2005 • 1,899 citations

Enhanced Phosphorylation of p53 by ATM in Response to DNA Damage

1998 • 1,734 citations

The Ink4a Tumor Suppressor Gene Product, p19Arf, Interacts with MDM2 and Neutralizes MDM2's Inhibition of p53

1998 • 1,538 citations

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

1995 • 1,263 citations

DNA damage activates p53 through a phosphorylation–acetylation cascade

1998 • 1,194 citations

On the road to cancer: aneuploidy and the mitotic checkpoint

2005 • 1,162 citations

Post‐translational modifications and activation of p53 by genotoxic stresses

2001 • 1,076 citations

Mdm2 Is a RING Finger-dependent Ubiquitin Protein Ligase for Itself and p53

2000 • 1,026 citations

Regulation of p53 in response to DNA damage

1999 • 960 citations

Does the ribosome translate cancer?

2003 • 891 citations

UV irradiation stimulates levels of p53 cellular tumor antigen in nontransformed mouse cells.

1984 • 874 citations

PML regulates p53 acetylation and premature senescence induced by oncogenic Ras

2000 • 826 citations

Disruption of the nucleolus mediates stabilization of p53 in response to DNA damage and other stresses

2003 • 788 citations

Regulation of p53 activity through lysine methylation

2004 • 776 citations

Induction of nuclear accumulation of the tumor-suppressor protein p53 by DNA-damaging agents.

1993 • 770 citations

Pirh2, a p53-Induced Ubiquitin-Protein Ligase, Promotes p53 Degradation

2003 • 708 citations

Acetylation of p53 Activates Transcription through Recruitment of Coactivators/Histone Acetyltransferases

2001 • 704 citations

ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage

2001 • 681 citations

Recruitment of p300/CBP in p53-Dependent Signal Pathways

1997 • 671 citations

A Dynamic Role of HAUSP in the p53-Mdm2 Pathway

2004 • 644 citations

Regulation of p53 Translation and Induction after DNA Damage by Ribosomal Protein L26 and Nucleolin

2005 • 627 citations

MDM2–HDAC1-mediated deacetylation of p53 is required for its degradation

2002 • 554 citations

A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage.

1996 • 544 citations

Nucleophosmin regulates the stability and transcriptional activity of p53

2002 • 509 citations

ATM associates with and phosphorylates p53: mapping the region of interaction

1998 • 494 citations

BRCA1 physically associates with p53 and stimulates its transcriptional activity

1998 • 484 citations

Acetylation of p53 Inhibits Its Ubiquitination by Mdm2

2002 • 478 citations

ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins

1998 • 471 citations

Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage

1999 • 449 citations

Transcriptional Regulation by p53 through Intrinsic DNA/Chromatin Binding and Site-Directed Cofactor Recruitment

2001 • 437 citations

Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription

2002 • 430 citations

Phosphorylation of p53 Serine 15 Increases Interaction with CBP

1998 • 427 citations

The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults

2002 • 412 citations

Nucleolar protein NPM interacts with HDM2 and protects tumor suppressor protein p53 from HDM2-mediated degradation

2004 • 403 citations

Chk2 Is a Tumor Suppressor That Regulates Apoptosis in both an Ataxia Telangiectasia Mutated (ATM)-Dependent and an ATM-Independent Manner

2002 • 393 citations

The TP53 Colorectal Cancer International Collaborative Study on the Prognostic and Predictive Significance of p53 Mutation: Influence of Tumor Site, Type of Mutation, and Adjuvant Treatment

2005 • 364 citations

Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2

1999 • 362 citations

hnRNP K: An HDM2 Target and Transcriptional Coactivator of p53 in Response to DNA Damage

2005 • 323 citations

MDM2 interacts with MDMX through their RING finger domains

1999 • 319 citations

Hypoxia Links ATR and p53 through Replication Arrest

2002 • 309 citations

ATM Mediates Phosphorylation at Multiple p53 Sites, Including Ser46, in Response to Ionizing Radiation

2002 • 292 citations

Jun NH₂-Terminal Kinase Phosphorylation of p53 on Thr-81 Is Important for p53 Stabilization and Transcriptional Activities in Response to Stress

2001 • 290 citations

Mutual Dependence of MDM2 and MDMX in Their Functional Inactivation of p53

2002 • 260 citations

Ionizing radiation and UV induction of p53 protein by different pathways in ataxia-telangiectasia cells.

1993 • 253 citations

Phosphorylation Site Interdependence of Human p53 Post-translational Modifications in Response to Stress

2003 • 250 citations

ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage

2005 • 249 citations

Phosphorylation of p53 on Key Serines Is Dispensable for Transcriptional Activation and Apoptosis

2004 • 235 citations

p53-Mdm2--the affair that never ends

2002 • 230 citations

Mdmx stabilizes p53 and Mdm2 via two distinct mechanisms

2001 • 230 citations

Mdm-2 and ubiquitin-independent p53 proteasomal degradation regulated by NQO1

2002 • 217 citations

MdmX Protects p53 from Mdm2-Mediated Degradation

2000 • 212 citations

Why Is p53 Acetylated?

2001 • 211 citations

Radiosensitization of p53 mutant cells by PD0166285, a novel G(2) checkpoint abrogator.

2001 • 205 citations

Topors Functions as an E3 Ubiquitin Ligase with Specific E2 Enzymes and Ubiquitinates p53

2004 • 193 citations

mdmx is a negative regulator of p53 activity in vivo.

2002 • 188 citations

Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation

2004 • 186 citations

HAUSP is Required for p53 Destabilization

2004 • 185 citations

The p53 tumour suppressor gene

1998 • 185 citations

DNA damage-inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53

2001 • 184 citations

Role of p53 in Sensing Oxidative DNA Damage in Response to Reactive Oxygen Species-Generating Agents

2004 • 182 citations

The C-terminal lysines fine-tune P53 stress responses in a mouse model but are not required for stability control or transactivation

2005 • 181 citations

Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage

2005 • 181 citations

Analyzing the G2/M Checkpoint

2004 • 179 citations

ATM-Mediated Phosphorylations Inhibit Mdmx/Mdm2 Stabilization by HAUSP in Favor of p53 Activation

2005 • 164 citations

DNA damage induced p53 stabilization: no indication for an involvement of p53 phosphorylation

1999 • 152 citations

p53-Dependent accelerated senescence induced by ionizing radiation in breast tumour cells

2005 • 140 citations

Chk2 is dispensable for p53-mediated G₁arrest but is required for a latent p53-mediated apoptotic response

2002 • 140 citations

DNA Damage-Induced Phosphorylation of MdmX at Serine 367 Activates p53 by Targeting MdmX for Mdm2-Dependent Degradation

2005 • 130 citations

Poly(ADP-ribose) Polymerase-1 Is a Positive Regulator of the p53-mediated G1 Arrest Response following Ionizing Radiation

2003 • 108 citations

The p53 story: layers of complexity

2005 • 92 citations

p53 directly enhances rejoining of DNA double-strand breaks with cohesive ends in gamma-irradiated mouse fibroblasts.

1999 • 90 citations

Interferon Regulatory Factor 1 Binding to p300 Stimulates DNA-Dependent Acetylation of p53

2004 • 77 citations

The two edges of the ATM sword: Co-operation between repair and checkpoint functions

2005 • 76 citations

p53 Proteasomal Degradation: Poly-Ubiquitination is Not the Whole Story

2005 • 72 citations

Ataxia-telangiectasia: a multifaceted genetic disorder associated with defective signal transduction

1996 • 67 citations

HIPK2 neutralizes MDM2 inhibition rescuing p53 transcriptional activity and apoptotic function

2004 • 66 citations

Reactivation of mutant p53: a new strategy for cancer therapy

1998 • 62 citations

Overexpressed poly(ADP-ribose) polymerase delays the release of rat cells from p53-mediated G1 checkpoint

2000 • 62 citations

P53 and PML: new partners in tumor suppression

2001 • 62 citations

p53 in cancer: A paradigm for modern management of cancer

2005 • 60 citations

p53 phosphorylation mutants retain transcription activity.

1995 • 54 citations

DNA damage-induced phosphorylation of p53 at serine 20 correlates with p21 and Mdm-2 induction in vivo

2000 • 54 citations

Identification and Characterization of the IKKα Promoter

2004 • 52 citations

A new effector pathway links ATM kinase with the DNA damage response

2004 • 52 citations

Cell cycle control, DNA damage checkpoints and cancer

2003 • 49 citations

Delayed reactivation of p53 in the progeny of cells surviving ionizing radiation.

2003 • 47 citations

Poly(ADP-ribose) polymerase-1 regulates the stability of the wild-type p53 protein.

2001 • 43 citations

ATM-dependent CHK2 Activation Induced by Anticancer Agent, Irofulven

2004 • 43 citations

Prognostic value of p53 mutations in patients with locally advanced esophageal carcinoma treated with definitive chemoradiotherapy

2001 • 30 citations

Activation of p53 protein by telomeric (TTAGGG)n repeats

2001 • 29 citations

KeePin’ the p53 Family in Good Shape

2004 • 26 citations

Cooperation between BRCA1 and p53 in repair of cyclobutane pyrimidine dimers

2005 • 24 citations

Cleavage of poly(ADP-ribose) transferase during p53-independent apoptosis in rat liver after treatent withN-nitrosomorpholine and cyproterone acetate

1999 • 14 citations

Stabilization of alanine substituted p53 protein at Ser15, Thr18, and Ser20 in response to ionizing radiation

2004 • 10 citations

The p53 saga: the good, the bad, and the dead.

2003 • 9 citations

[Effects of hexamethylene bisacetamide on P53 protein expression of MEC-1 cell line and cell differentiation].

1999 • 1 citations