The p53 tumour suppressor gene

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

Mdm2 promotes the rapid degradation of p53

1997 • 4,336 citations

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

1990 • 3,896 citations

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms

1990 • 3,720 citations

Regulation of p53 stability by Mdm2

1997 • 3,238 citations

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1992 • 3,110 citations

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1993 • 2,969 citations

T antigen is bound to a host protein in SY40-transformed cells

1979 • 2,378 citations

Amplification of a gene encoding a p53-associated protein in human sarcomas

1992 • 1,959 citations

The multistep nature of cancer

1993 • 1,872 citations

Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells

1979 • 1,830 citations

The p53-mdm-2 autoregulatory feedback loop.

1993 • 1,795 citations

An Adenovirus Mutant That Replicates Selectively in p53- Deficient Human Tumor Cells

1996 • 1,735 citations

Sunburn and p53 in the onset of skin cancer

1994 • 1,501 citations

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

1995 • 1,401 citations

DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA

1976 • 1,290 citations

Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li–Fraumeni syndrome

1990 • 1,228 citations

A mutation in the RET proto-oncogene associated with multiple endocrine neoplasia type 2B and sporadic medullary thyroid carcinoma

1994 • 1,140 citations

Increased expression of mutant forms of p53 oncogene in primary lung cancer

1990 • 1,045 citations

p73 is a human p53-related protein that can induce apoptosis

1997 • 951 citations

ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents

1997 • 945 citations

Oncogenic forms of p53 inhibit p53-regulated gene expression

1992 • 933 citations

p53-Dependent apoptosis suppresses tumor growth and progression in vivo

1994 • 883 citations

Database of p53 gene somatic mutations in human tumors and cell lines.

1994 • 866 citations

p53-Dependent apoptosis in the absence of transcriptional activation of p53-target genes

1994 • 857 citations

DNA damage induces phosphorylation of the amino terminus of p53

1997 • 829 citations

Accumulation of p53 Tumor Suppressor Gene Protein: An Independent Marker of Prognosis in Breast Cancers

1992 • 757 citations

Specific P53 mutations are associated with de novo resistance to doxorubicin in breast cancer patients

1996 • 734 citations

The p53 Network

1998 • 731 citations

Retrovirus–mediated wild–type P53 gene transfer to tumors of patients with lung cancer.

1996 • 708 citations

High levels of p53 protein in UV-irradiated normal human skin.

1993 • 689 citations

MDMX: a novel p53-binding protein with some functional properties of MDM2.

1996 • 624 citations

A subset of p53-deficient embryos exhibit exencephaly

1995 • 577 citations

p53 mutations increase resistance to ionizing radiation.

1993 • 573 citations

Induction of apoptosis in HeLa cells by trans-activation-deficient p53.

1995 • 546 citations

An evaluation of six antibodies for immunohistochemistry of mutant p53 gene product in archival colorectal neoplasms

1994 • 513 citations

Disruption of p53 function sensitizes breast cancer MCF-7 cells to cisplatin and pentoxifylline.

1995 • 491 citations

High-frequency developmental abnormalities in p53-deficient mice

1995 • 464 citations

Small peptides activate the latent sequence-specific DNA binding function of p53

1995 • 444 citations

Association of p53 mutations with short survival in colorectal cancer

1994 • 357 citations

Oncogenic Forms of p53 Inhibit p53-Regulated Gene Expression

1992 • 333 citations

p53 expression and prognosis in gastric carcinoma

1992 • 333 citations

p53 protein stability in tumour cells is not determined by mutation but is dependent on Mdm2 binding

1997 • 315 citations

The candidate tumour suppressor p33ING1cooperates with p53 in cell growth control

1998 • 294 citations

A Mutant p53 That Discriminates between p53-Responsive Genes Cannot Induce Apoptosis

1996 • 283 citations

A novel protein with strong homology to the tumor suppressor p53

1997 • 282 citations

p53-dependent apoptosis suppresses radiation–induced teratogenesis

1996 • 250 citations

A teratologic suppressor role for p53 in benzo(a)pyrene–treated transgenic p53-deficient mice

1995 • 250 citations

Nucleotide sequences related to the transforming gene of avian sarcoma virus are present in DNA of uninfected vertebrates.

1978 • 245 citations

Mdm-2 phosphorylation by DNA-dependent protein kinase prevents interaction with p53.

1997 • 243 citations

p53 as an Independent Prognostic Marker in Lymph Node-Negative Breast Cancer Patients

1993 • 243 citations

Coupling between gamma irradiation, p53 induction and the apoptotic response depends upon cell type in vivo

1995 • 240 citations

Therapeutic Effect of a Retroviral Wild-Type p53 Expression Vector in an Orthotopic Lung Cancer Model

1994 • 214 citations

Mutations of the p53 Gene as a Predictor of Poor Prognosis in Patients With Non-Small-Cell Lung Cancer

1993 • 213 citations

A functionally inactive p53 protein interatocarcinoma cells is activated by either DNA damage or cellular differentiation

1996 • 209 citations

The p53 response to ionising radiation in adult and developing murine tissues.

1996 • 206 citations

Regulation of the Sequence-specific DNA Binding Function of p53 by Protein Kinase C and Protein Phosphatases

1995 • 199 citations

Specific inhibition of K-ras expression and tumorigenicity of lung cancer cells by antisense RNA

1991 • 188 citations

Cytoplasmic Accumulation of p53 Protein: an Independent Prognostic Indicator in Colorectal Adenocarcinomas

1994 • 185 citations

Further characterisation of the p53 responsive element – identification of new candidate genes for trans-activation by p53

1997 • 160 citations

Increased p53 protein content of colorectal tumours correlates with poor survival

1992 • 147 citations

p53 in node-negative breast carcinoma: an immunohistochemical study of epidemiologic risk factors, histologic features, and prognosis.

1995 • 140 citations

MDM2-arbiter of p53's destruction

1997 • 127 citations

Clinical utility of the immunocytochemical detection of p53 protein in cytological specimens.

1994 • 112 citations

Thep53 gene is a potent determinant of chemosensitivity and radiosensitivity in gastric and colorectal cancers

1996 • 111 citations

Regulation of the Cryptic Sequence-specific DNA-binding Function of p53 by Protein Kinases

1994 • 106 citations

Tumour suppressors: A developing role for p53?

1997 • 104 citations

Induction of Mdm2 and enhancement of cell survival by bFGF

1997 • 103 citations

Mutations in the p53 gene in radiation-sensitive and -resistant human squamous carcinoma cells.

1992 • 98 citations

p53 accumulation in ovarian carcinomas and its prognostic implications

1993 • 97 citations

A direct effect of activated human p53 on nuclear DNA replication.

1995 • 87 citations

In vivo adenovirus-mediated p53 tumor suppressor gene therapy for colorectal cancer.

1996 • 86 citations

p53 and Rb1 protein expression: are they prognostically useful in colorectal cancer?

1997 • 77 citations

The human papilloma virus 16E6 gene sensitizes human mammary epithelial cells to apoptosis induced by DNA damage.

1995 • 73 citations

Novel combination therapy for human colon cancer with adenovirus-mediated wild-typep53 gene transfer and DNA-damaging chemotherapeutic agent

1997 • 67 citations

p53CP, a putative p53 competing protein that specifically binds to the consensus p53 DNA binding sites: A third member of the p53 family?

1997 • 58 citations

p53 derived from human tumour cell lines and containing distinct point mutations can be activated to bind its consensus target sequence.

1995 • 58 citations

Identification of RB18A, a 205 kDa new p53 regulatory protein which shares antigenic and functional properties with p53

1997 • 56 citations

Differences in perceived shape from shading correlate with activity in early visual areas

1997 • 56 citations

POTENTIAL FALSE‐POSITIVE RESULTS WITH ANTIGEN ENHANCEMENT FOR IMMUNOHISTOCHEMISTRY OF THE p53 GENE PRODUCT IN COLORECTAL NEOPLASMS

1996 • 45 citations

POTENTIAL FALSE-POSITIVE RESULTS WITH ANTIGEN ENHANCEMENT FOR IMMUNOHISTOCHEMISTRY OF THE p53 GENE PRODUCT IN COLORECTAL NEOPLASMS

1996 • 37 citations

Cancer and mutant DNA in blood plasma

1996 • 27 citations

Scientific American molecular oncology

1996 • 15 citations

Profile: Govindarajan Padmanaban

2003 • 5 citations