Estrogen receptor α is a major mediator of 17β-estradiol’s atheroprotective effects on lesion size in Apoe–/– mice

The nuclear receptor superfamily: The second decade

1995 • 6,929 citations

Randomized Trial of Estrogen Plus Progestin for Secondary Prevention of Coronary Heart Disease in Postmenopausal Women

1998 • 6,250 citations

Cloning of a novel receptor expressed in rat prostate and ovary.

1996 • 4,782 citations

Comparison of the Ligand Binding Specificity and Transcript Tissue Distribution of Estrogen Receptors α and β

1997 • 4,422 citations

Spontaneous Hypercholesterolemia and Arterial Lesions in Mice Lacking Apolipoprotein E

1992 • 2,189 citations

Estrogen Receptor Null Mice: What Have We Learned and Where Will They Lead Us?

1999 • 1,965 citations

Differential Ligand Activation of Estrogen Receptors ERα and ERβ at AP1 Sites

1997 • 1,808 citations

Generation and reproductive phenotypes of mice lacking estrogen receptor β

1998 • 1,680 citations

The role of oxidized lipoproteins in atherogenesis

1996 • 1,382 citations

Estrogen and Coronary Heart Disease in Women

1991 • 1,237 citations

Cell Biology of Atherosclerosis

1995 • 982 citations

Cloning of the human estrogen receptor cDNA.

1985 • 720 citations

Inhibition of coronary artery atherosclerosis by 17-beta estradiol in ovariectomized monkeys. Lack of an effect of added progesterone.

1990 • 603 citations

Oestrogen and inhibition of oxidation of low-density lipoproteins in postmenopausal women

1994 • 534 citations

Tripartite steroid hormone receptor pharmacology: interaction with multiple effector sites as a basis for the cell- and promoter-specific action of these hormones.

1996 • 505 citations

Human vascular smooth muscle cells contain functional estrogen receptor.

1994 • 501 citations

Estrogen inhibits the vascular injury response in estrogen receptor α-deficient mice

1997 • 499 citations

Oxidants and antioxidants in the pathogenesis of atherosclerosis: implications for the oxidized low density lipoprotein hypothesis

1998 • 471 citations

Estrogen regulation of the insulin-like growth factor I gene transcription involves an AP-1 enhancer.

1994 • 390 citations

Effects of 17beta-estradiol on cytokine-induced endothelial cell adhesion molecule expression.

1996 • 351 citations

Estrogen and the blood vessel wall

1994 • 316 citations

Increased Expression of Estrogen Receptor-β mRNA in Male Blood Vessels After Vascular Injury

1998 • 303 citations

Vascular estrogen receptors and endothelium-derived nitric oxide production in the mouse aorta. Gender difference and effect of estrogen receptor gene disruption.

1997 • 269 citations

Estrogen Reduces Myointimal Proliferation After Balloon Injury of Rat Carotid Artery

1996 • 260 citations

Estrogen and progesterone replacement therapy reduces low density lipoprotein accumulation in the coronary arteries of surgically postmenopausal cynomolgus monkeys.

1991 • 256 citations

Estrogen inhibits the vascular injury response in estrogen receptor β-deficient female mice

1999 • 254 citations

Estrogen inhibits the response-to-injury in a mouse carotid artery model.

1995 • 252 citations

Estrogen reduces atherosclerotic lesion development in apolipoprotein E-deficient mice.

1996 • 248 citations

17 beta-estradiol preserves endothelial vasodilator function and limits low-density lipoprotein oxidation in hypercholesterolemic swine.

1994 • 240 citations

Estrogen monotherapy and combined estrogen-progestogen replacement therapy attenuate aortic accumulation of cholesterol in ovariectomized cholesterol-fed rabbits.

1991 • 204 citations

Estrogen Up-regulates Apolipoprotein E (ApoE) Gene Expression by Increasing ApoE mRNA in the Translating Pool via the Estrogen Receptor α-Mediated Pathway

1997 • 185 citations

Oestrogen Receptors in Macrophages

1990 • 183 citations

Estrogen modulation of JE/monocyte chemoattractant protein-1 mRNA expression in murine macrophages.

1995 • 180 citations

ESTROGENS AND ATHEROSCLEROSIS

1997 • 177 citations

Coronary artery and cultured aortic smooth muscle cells express mRNA for both the classical estrogen receptor and the newly described estrogen receptor beta

1998 • 147 citations

17β-Estradiol Prevents Fatty Streak Formation in Apolipoprotein E–Deficient Mice

1997 • 131 citations

Peripheral blood T cells and monocytes and B cell lines derived from patients with lupus express estrogen receptor transcripts similar to those of normal cells.

1998 • 124 citations

Estradiol inhibition of arterial neointimal hyperplasia after balloon injury

1994 • 117 citations

Estradiol as an antioxidant: incompatible with its physiological concentrations and function

1998 • 105 citations

Estrogen Restores Endothelial Cell Function in an Experimental Model of Vascular Injury

1997 • 92 citations

Accelerated atherosclerosis and premature calcified cartilaginous metaplasia in the aorta of diabetic male Apo E knockout mice can be prevented by chronic treatment with 17β-estradiol

1999 • 86 citations

17 -Estradiol inhibits proliferation and migration of human vascular smooth muscle cells: similar effects in cells from postmenopausal females and in males

1996 • 82 citations

Conjugated Equine Estrogens Alone, but Not in Combination With Medroxyprogesterone Acetate, Inhibit Aortic Connective Tissue Remodeling After Plasma Lipid Lowering in Female Monkeys

1998 • 81 citations

Protection against atherosclerosis by estrogen is independent of plasma cholesterol levels in LDL receptor-deficient mice

1999 • 81 citations

Calcifying Subpopulation of Bovine Aortic Smooth Muscle Cells Is Responsive to 17β-Estradiol

1997 • 80 citations

Estrogen reduces proliferation and agonist-induced calcium increase in coronary artery smooth muscle cells

1997 • 73 citations

Postmenopausal Hormone Replacement Therapy and Cardiovascular Disease

1997 • 62 citations

Estrogen suppression of connective tissue deposition in a murine model of peritoneal adhesion formation.

1996 • 52 citations

Estradiol-17β regulates the induction of VCAM-1 mRNA expression by interleukin-1β in human umbilical vein endothelial cells

1994 • 42 citations

Postmenopausal hormone replacement therapy and the vascular wall: Mechanisms of 17 β-estradio's effects on vascular biology

2009 • 39 citations

Targets of activated steroid hormone receptors: basal transcription factors and receptor interacting proteins

1998 • 35 citations

Antiatherogenic Effect of Estrogen Abolished by Balloon Catheter Injury in Cholesterol-Clamped Rabbits

1997 • 34 citations

Estrogen regulation of JE/MCP-1 mRNA expression in fibroblasts

1996 • 34 citations

Apolipoprotein E Deficiency Leads to Cutaneous Foam Cell Formation in Mice

1995 • 34 citations

Inhibition of cholesterylester accumulation by 17β-estradiol in macrophages through activation of neutral cholesterol esterase

1996 • 28 citations

Effects of estrogens on macrophage foam cells: a potential target for the protective effects of estrogens on atherosclerosis

1997 • 28 citations

Regulation of lipoprotein metabolism by estrogen in inbred strains of mice occurs primarily by posttranscriptional mechanisms.

1997 • 27 citations

Effects of estradiol on platelet aggregation in mouse mesenteric arterioles and ex vivo

1985 • 15 citations