Cardiovascular Effects of Raloxifene Hydrochloride

Randomized Trial of Estrogen Plus Progestin for Secondary Prevention of Coronary Heart Disease in Postmenopausal Women

1998 • 6,250 citations

Cloning of a novel receptor expressed in rat prostate and ovary.

1996 • 4,782 citations

Comparison of the Ligand Binding Specificity and Transcript Tissue Distribution of Estrogen Receptors α and β

1997 • 4,422 citations

Molecular basis of agonism and antagonism in the oestrogen receptor

1997 • 3,285 citations

Effects of Estrogen or Estrogen/ Progestin Regimens on Heart Disease Risk Factors in Postmenopausal Women

1995 • 2,281 citations

ERβ: Identification and characterization of a novel human estrogen receptor

1996 • 2,262 citations

Comparative distribution of estrogen receptor-? and -? mRNA in the rat central nervous system

1997 • 2,244 citations

Postmenopausal Estrogen Therapy and Cardiovascular Disease

1991 • 2,008 citations

Regulatory Functions of the Vascular Endothelium

1990 • 1,899 citations

Differential Ligand Activation of Estrogen Receptors ERα and ERβ at AP1 Sites

1997 • 1,808 citations

Effects of Raloxifene on Bone Mineral Density, Serum Cholesterol Concentrations, and Uterine Endometrium in Postmenopausal Women

1997 • 1,641 citations

Estrogen replacement therapy and coronary heart disease: A quantitative assessment of the epidemiologic evidence

1991 • 1,603 citations

The Use of Estrogens and Progestins and the Risk of Breast Cancer in Postmenopausal Women

1995 • 1,532 citations

Postmenopausal Estrogen and Progestin Use and the Risk of Cardiovascular Disease

1996 • 1,323 citations

Estrogen and Coronary Heart Disease in Women

1991 • 1,237 citations

Release of endothelin from the porcine aorta. Inhibition by endothelium-derived nitric oxide.

1990 • 1,066 citations

Estrogen Improves Endothelium-Dependent, Flow-Mediated Vasodilation in Postmenopausal Women

1994 • 708 citations

Effects of Raloxifene on Serum Lipids and Coagulation Factors in Healthy Postmenopausal Women

1998 • 702 citations

Endothelial Dysfunction: Does It Matter? Is It Reversible?

1997 • 680 citations

Cholesterol Reduction in Cardiovascular Disease — Clinical Benefits and Possible Mechanisms

1995 • 676 citations

Tamoxifen activation of the estrogen receptor/AP-1 pathway: potential origin for the cell-specific estrogen-like effects of antiestrogens.

1995 • 665 citations

Estrogen Receptor-Associated Proteins: Possible Mediators of Hormone-Induced Transcription

1994 • 645 citations

The vascular protective effects of estrogen

1996 • 642 citations

Raloxifene (LY139481 HCI) prevents bone loss and reduces serum cholesterol without causing uterine hypertrophy in ovariectomized rats.

1994 • 614 citations

Estrogen modulates responses of atherosclerotic coronary arteries.

1990 • 605 citations

Nitric oxide and its role in the cardiovascular system

1995 • 598 citations

Acute vascular effects of estrogen in postmenopausal women.

1994 • 557 citations

Effects of physiological levels of estrogen on coronary vasomotor function in postmenopausal women.

1994 • 543 citations

Ethinyl estradiol acutely attenuates abnormal coronary vasomotor responses to acetylcholine in postmenopausal women.

1994 • 540 citations

Tripartite steroid hormone receptor pharmacology: interaction with multiple effector sites as a basis for the cell- and promoter-specific action of these hormones.

1996 • 505 citations

Analysis of estrogen receptor function in vitro reveals three distinct classes of antiestrogens.

1995 • 502 citations

Chronic inhibition of nitric oxide production accelerates neointima formation and impairs endothelial function in hypercholesterolemic rabbits.

1994 • 501 citations

Activation of the ovalbumin gene by the estrogen receptor involves the Fos-Jun complex

1990 • 486 citations

Estrogen Promotes Angiogenic Activity in Human Umbilical Vein Endothelial Cells In Vitro and in a Murine Model

1995 • 458 citations

Identification of an Estrogen Response Element Activated by Metabolites of 17β-Estradiol and Raloxifene

1996 • 432 citations

Development of antiestrogens and their use in breast cancer: eighth Cain memorial award lecture.

1990 • 419 citations

Hormonal Treatment of Postmenopausal Women

1994 • 385 citations

Effects of Hormone-Replacement Therapy on Fibrinolysis in Postmenopausal Women

1997 • 379 citations

A controlled trial of raloxifene (LY139481) HCl: Impact on bone turnover and serum lipid profile in healthy postmenopausal women

1996 • 362 citations

Endothelin in Coronary Endothelial Dysfunction and Early Atherosclerosis in Humans

1995 • 358 citations

Antitumor actions of keoxifene and tamoxifen in the N-nitrosomethylurea-induced rat mammary carcinoma model.

1987 • 355 citations

Effects of Oral and Transdermal Estrogen/Progesterone Regimens on Blood Coagulation and Fibrinolysis in Postmenopausal Women

1997 • 353 citations

The Effects of Hormone Replacement Therapy and Raloxifene on C-Reactive Protein and Homocysteine in Healthy Postmenopausal Women: A Randomized, Controlled Trial1

2000 • 334 citations

Differential Expression of Estrogen Receptors α and β mRNA During Differentiation of Human Osteoblast SV-HFO Cells

1997 • 306 citations

Tripartite steroid hormone receptor pharmacology: interaction with multiple effector sites as a basis for the cell- and promoter-specific action of these hormones

1996 • 285 citations

Progestagen supplementation of exogenous oestrogens and risk of endometrial cancer

1991 • 276 citations

Tamoxifen activation of the estrogen receptor/AP-1 pathway: potential origin for the cell-specific estrogen-like effects of antiestrogens

1995 • 273 citations

Circulating Nitric Oxide (Nitrite/Nitrate) Levels in Postmenopausal Women Substituted With 17β-Estradiol and Norethisterone Acetate

1995 • 263 citations

Effects of hormone replacement therapy on reactivity of atherosclerotic coronary arteries in cynomolgus monkeys

1994 • 261 citations

Antagonism of estrogen action with a new benzothiophene derived antiestrogen

1983 • 244 citations

Endothelial Dysfunction in Atherosclerosis

1996 • 243 citations

Molecular determinants of tissue selectivity in estrogen receptor modulators

1997 • 240 citations

Antioxidant potential of specific estrogens on lipid peroxidation.

1993 • 231 citations

Expression of Estrogen Receptor-β in Human Breast Tumors

1997 • 214 citations

Analysis of estrogen receptor function in vitro reveals three distinct classes of antiestrogens

1995 • 206 citations

Randomized, Double-Blind, Placebo-Controlled Study on Effects of Raloxifene and Hormone Replacement Therapy on Plasma NO Concentrations, Endothelin-1 Levels, and Endothelium-Dependent Vasodilation in Postmenopausal Women

2001 • 183 citations

Phase II Evaluation of Lyl56758 in Metastatic Breast Cancer

1988 • 180 citations

Lack of Effect of Raloxifene on Coronary Artery Atherosclerosis of Postmenopausal Monkeys1

1998 • 176 citations

Structure−Activity Relationships of Selective Estrogen Receptor Modulators: Modifications to the 2-Arylbenzothiophene Core of Raloxifene

1997 • 172 citations

Chemoprevention of Mammary Carcinogenesis in the Rat: Combined Use of Raloxifene and 9-cis-Retinoic Acid

1996 • 172 citations

Raloxifene preserves bone strength and bone mass in ovariectomized rats.

1994 • 165 citations

Both Raloxifene and Estrogen Reduce Major Cardiovascular Risk Factors in Healthy Postmenopausal Women

1999 • 161 citations

Combined Hormone Replacement Therapy Does Not Protect Women Against the Age-Related Decline in Endothelium-Dependent Vasomotor Function

1998 • 159 citations

Effects of raloxifene hydrochloride on the endometrium of postmenopausal women

1997 • 149 citations

The Effects of Hormone Replacement Therapy and Raloxifene on C-Reactive Protein and Homocysteine in Healthy Postmenopausal Women: A Randomized, Controlled Trial

2000 • 141 citations

Raloxifene Inhibits Aortic Accumulation of Cholesterol in Ovariectomized, Cholesterol-Fed Rabbits

1997 • 135 citations

Long-term oral administration of L-arginine reduces intimal thickening and enhances neoendothelium-dependent acetylcholine-induced relaxation after arterial injury.

1994 • 133 citations

Raloxifene Acutely Relaxes Rabbit Coronary Arteries In Vitro by an Estrogen Receptor–Dependent and Nitric Oxide–Dependent Mechanism

1999 • 133 citations

Postmenopausal hormonal replacement decreases plasma levels of endothelin-1.

1995 • 129 citations

Effect of steroidal and nonsteroidal antiestrogens on the growth of a tamoxifen-stimulated human endometrial carcinoma (EnCa101) in athymic mice.

1990 • 127 citations

Expression of Estrogen Receptor- in Human Breast Tumors

1997 • 127 citations

Estrogen Receptor Ligands Modulate Its Interaction with DNA

1997 • 123 citations

Suppression of spontaneous LH surges in estrogen-treated ovariectomized rats by microimplants of antiestrogens into the preoptic brain

1989 • 120 citations

Antioxidant potential of specific estrogens on lipid peroxidation

1993 • 111 citations

Non-steroidal antioestrogens—Receptor binding and biological response in rat uterus, rat mammary carcinoma and human breast cancer cells

1984 • 110 citations

Reproductive Endocrine and Endometrial Effects of Raloxifene Hydrochloride, a Selective Estrogen Receptor Modulator, in Women with Regular Menstrual Cycles1

1998 • 94 citations

Raloxifene is a Tissue‐Selective Agonist/Antagonist That Functions through the Estrogen Receptor

1995 • 88 citations

Alternative mechanisms of action of anti-oestrogens

1994 • 85 citations

Randomized, double-blind, placebo-controlled study of the effects of raloxifene and conjugated equine estrogen on plasma homocysteine levels in healthy postmenopausal women

1998 • 84 citations

Effect of 17β-Estradiol on Inhibition of Platelet Aggregation In Vitro Is Mediated by an Increase in NO Synthesis

1998 • 82 citations

Lack of Effect of Raloxifene on Coronary Artery Atherosclerosis of Postmenopausal Monkeys

1998 • 80 citations

Inhibition of estrogen-stimulated growth of uterine leiomyomas by selective estrogen receptor modulators

1996 • 79 citations

The Role of Endothelin in Coronary Atherosclerosis

1996 • 77 citations

Non-genomic effects of estrogens and antiestrogens

1988 • 70 citations

Advantages of raloxifene over alendronate or estrogen on nonreproductive and reproductive tissues in the long-term dosing of ovariectomized rats.

1996 • 68 citations

Estrogen and estrogen receptor antagonists stimulate transcription from the human retinoic acid receptor-alpha 1 promoter via a novel sequence.

1996 • 59 citations

Effect of conjugated estrogen on peripheral flow-mediated vasodilation in postmenopausal women

1998 • 55 citations

Vasodilator-derived nitric oxide inhibits fetal calf serum- and angiotensin-II-induced growth of renal arteriolar smooth muscle cells.

1994 • 54 citations

Evaluation of the major metabolites of raloxifene as modulators of tissue selectivity

1997 • 52 citations

Tissue selective action of tamoxifen methiodide, raloxifene and tamoxifen on creatine kinase B activity in vitro and in vivo

1996 • 50 citations

Raloxifene Lowers Serum Lipoprotein(A) in Healthy Postmenopausal Women

1999 • 48 citations

Endothelial dysfunction in coronary heart disease

1996 • 46 citations

Postmenopausal hormonal replacement decreases plasma levels of endothelin-1

1995 • 46 citations

Clinical Uses of Antiestrogens

1996 • 43 citations

Brzozowski, A M. et al. Molecular basis of agonism and antagonism in the estrogen receptor. Nature 389, 753-758

1997 • 43 citations

Reproductive Endocrine and Endometrial Effects of Raloxifene Hydrochloride, a Selective Estrogen Receptor Modulator, in Women with Regular Menstrual Cycles

1998 • 42 citations

Disposition and metabolism of a new benzothiophene antiestrogen in rats, dogs and monkeys

1984 • 42 citations

Antiestrogenic Properties of Raloxifene

1995 • 42 citations

Paradoxical influence of estrogenic hormones on platelet-endothelial cell interactions

1994 • 41 citations

Alternate antiestrogens and approaches to the prevention of breast cancer

1995 • 35 citations

Keoxifene shows pure antiestrogenic activity in pituitary gonadotrophs

1985 • 33 citations

Inhibitory Actions of Keoxifene on Luteinizing Hormone Secretion in Pituitary Gonadotrophs*

1988 • 29 citations

Estrogen and estrogen receptor antagonists stimulate transcription from the human retinoic acid receptor-alpha 1 promoter via a novel sequence

1996 • 27 citations

Tibolone as an alternative to estrogen for the prevention of postmenopausal osteoporosis in selected postmenopausal women [published erratum appears in J Clin Endocrinol Metab 1997 Jan;82(1):181]

1996 • 18 citations

Effects of Raloxifene in Postmenopausal Women

1998 • 15 citations

Raloxifene, Retinoids, and Lavender: "Me Too" Tamoxifen Alternatives Under Study

1996 • 13 citations

Keoxifene (LY 156758) inhibits follicle-stimulating hormone induced differentiation of cultured rat granulosa cells

1987 • 6 citations