Impaired Estrogen Sensitivity in Bone by Inhibiting Both Estrogen Receptor α and β Pathways

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

The nuclear receptor superfamily: The second decade

1995 • 6,929 citations

Efficient selection for high-expression transfectants with a novel eukaryotic vector

1991 • 5,120 citations

Cloning of a novel receptor expressed in rat prostate and ovary.

1996 • 4,782 citations

Estrogen Resistance Caused by a Mutation in the Estrogen-Receptor Gene in a Man

1994 • 2,443 citations

Estrogen Receptor Null Mice: What Have We Learned and Where Will They Lead Us?

1999 • 1,965 citations

Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene.

1993 • 1,836 citations

Increased bone formation in osteocalcin-deficient mice

1996 • 1,692 citations

Generation and reproductive phenotypes of mice lacking estrogen receptor β

1998 • 1,680 citations

Bone Marrow, Cytokines, and Bone Remodeling — Emerging Insights into the Pathophysiology of Osteoporosis

1995 • 1,661 citations

Increased Osteoclast Development After Estrogen Loss: Mediation by Interleukin-6

1992 • 1,437 citations

Stimulation of bone resorption and inhibition of bone formation in vitro by human tumour necrosis factors

1986 • 1,433 citations

Evidence of Estrogen Receptors in Normal Human Osteoblast-Like Cells

1988 • 1,246 citations

Nuclear receptors enhance our understanding of transcription regulation

1988 • 1,062 citations

LONG-TERM PREVENTION OF POSTMENOPAUSAL OSTEOPOROSIS BY ŒSTROGEN

1976 • 946 citations

Fulminant hypertension in transgenic rats harbouring the mouse Ren-2 gene

1990 • 913 citations

Mineralized bone nodules formedin vitro from enzymatically released rat calvaria cell populations

1986 • 855 citations

Estrogen Binding, Receptor mRNA, and Biologic Response in Osteoblast-Like Osteosarcoma Cells

1988 • 836 citations

OUTCOME FOR INFANTS OF VERY LOW BIRTHWEIGHT: SURVEY OF WORLD LITERATURE

1981 • 829 citations

Long-Term Estrogen Replacement Therapy Prevents Bone Loss and Fractures

1985 • 788 citations

Interleukin-6 deficient mice are protected from bone loss caused by estrogen depletion.

1994 • 738 citations

Estrogen, cytokines, and pathogenesis of postmenopausal osteoporosis

1996 • 730 citations

The Effect of Postmenopausal Estrogen Therapy on Bone Density in Elderly Women

1993 • 587 citations

Insights from the study of animals lacking functional estrogen receptor

1994 • 587 citations

Estrogen inhibits the vascular injury response in estrogen receptor α-deficient mice

1997 • 499 citations

Molecular cloning and charcterization of rat estrogen receptor cDNA

1987 • 488 citations

Molecular cloning and characterization of human estrogen receptor betacx: a potential inhibitor ofestrogen action in human

1998 • 452 citations

Expression vector system based on the chicken β-actin promoter directs efficient production of interleukin-5

1989 • 431 citations

Increased cortical bone mineral content but unchanged trabecular bone mineral density in female ERβ–/– mice

1999 • 412 citations

Ovarian steroid treatment blocks a postmenopausal increase in blood monocyte interleukin 1 release.

1989 • 381 citations

Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene

1993 • 315 citations

Differential Expression of Estrogen Receptors α and β mRNA During Differentiation of Human Osteoblast SV-HFO Cells

1997 • 306 citations

Transgenic mice expressing soluble tumor necrosis factor-receptor are protected against bone loss caused by estrogen deficiency.

1997 • 306 citations

Expression of Estrogen Receptor β in Rat Bone

1997 • 295 citations

Thyroid hormone resistance syndrome. Inhibition of normal receptor function by mutant thyroid hormone receptors.

1991 • 181 citations

Mice Lacking the Type I Interleukin-1 Receptor Do Not Lose Bone Mass after Ovariectomy

1998 • 180 citations

Expression of Estrogen Receptor in Rat Bone

1997 • 176 citations

Genomic binding-site cloning reveals an estrogen-responsive gene that encodes a RING finger protein.

1993 • 163 citations

Differential immunolocalization of estrogen receptor alpha and beta in rat ovary and uterus

1999 • 145 citations

Dominant Negative Transcriptional Regulation by a Mutant Thyroid Hormone Receptor-β in a Family with Generalized Resistance to Thyroid Hormone

1990 • 125 citations

Powerful dominant negative mutants of the human estrogen receptor

1993 • 119 citations

Differential Effects of Estrogen Metabolites on Bone and Reproductive Tissues of Ovariectomized Rats

1998 • 76 citations

Trans-activation of glutathione transferase P gene during chemical hepatocarcinogenesis of the rat.

1993 • 65 citations

Estrogen receptor β — Getting in on the action?

1997 • 48 citations

Estrogen binding and estrogenic responses in normal human osteoblast-like cells

1991 • 45 citations

Cross‐inhibition of both estrogen receptor α and β pathways by each dominant negative mutant

1998 • 39 citations

Rapid Fragmentation of Vimentin in Human Skin Fibroblasts Exposed to Tamoxifen: A Possible Involvement of Caspase-3

1998 • 37 citations

Tamoxifen Directly Stimulates the Mineralization of Human Osteoblast-Like Osteosarcoma Cells Through a Pathway Independent of Estrogen Response Element

1995 • 13 citations

Effect of Monoclonal Anti-Human GP130 Antibody (GPX7) on Bone Turnover in Normal and Ovariectomized Rats

1998 • 6 citations