Antiestrogens Specifically Up-Regulate Bone Morphogenetic Protein-4 Promoter Activity in Human Osteoblastic Cells

Rapid detection of octamer binding proteins with ‘mini extracts’, prepared from a small number of cells

1989 • 4,279 citations

Novel Regulators of Bone Formation: Molecular Clones and Activities

1988 • 3,919 citations

Molecular basis of agonism and antagonism in the oestrogen receptor

1997 • 3,285 citations

ERβ: Identification and characterization of a novel human estrogen receptor

1996 • 2,262 citations

Bone morphogenetic proteins: multifunctional regulators of vertebrate development.

1996 • 1,959 citations

The Use of Estrogens and Progestins and the Risk of Breast Cancer in Postmenopausal Women

1995 • 1,532 citations

Sequence and Expression of Human Estrogen Receptor Complementary DNA

1986 • 1,321 citations

Evidence of Estrogen Receptors in Normal Human Osteoblast-Like Cells

1988 • 1,246 citations

Luciferase reporter gene vectors for analysis of promoters and enhancers.

1988 • 1,016 citations

Estrogen Binding, Receptor mRNA, and Biologic Response in Osteoblast-Like Osteosarcoma Cells

1988 • 836 citations

Estrogen Receptors α and β Form Heterodimers on DNA

1997 • 681 citations

Coactivator and Corepressor Regulation of the Agonist/Antagonist Activity of the Mixed Antiestrogen, 4-Hydroxytamoxifen

1997 • 640 citations

Bone Morphogenetic Protein and Bone Morphogenetic Protein Gene Family in Bone Formation and Repair

1998 • 628 citations

Raloxifene (LY139481 HCI) prevents bone loss and reduces serum cholesterol without causing uterine hypertrophy in ovariectomized rats.

1994 • 614 citations

Analysis of estrogen receptor function in vitro reveals three distinct classes of antiestrogens.

1995 • 502 citations

Stimulation of new bone formation by direct transfer of osteogenic plasmid genes.

1996 • 499 citations

Cytokines and Estrogen in Bone: Anti-Osteoporotic Effects

1993 • 466 citations

Development of a stably transfected estrogen receptor-mediated luciferase reporter gene assay in the human T47D breast cancer cell line

1999 • 436 citations

Identification of an Estrogen Response Element Activated by Metabolites of 17β-Estradiol and Raloxifene

1996 • 432 citations

The cloned human oestrogen receptor contains a mutation which alters its hormone binding properties.

1989 • 428 citations

Functional Synergy between the Transcription Factor Sp1 and the Estrogen Receptor

1997 • 399 citations

Immunolocalization and expression of bone morphogenetic proteins 2 and 4 in fracture healing

1995 • 374 citations

Transient and localized expression of bone morphogenetic protein 4 messenger RNA during fracture healing

1994 • 329 citations

Differential Expression of Estrogen Receptors α and β mRNA During Differentiation of Human Osteoblast SV-HFO Cells

1997 • 306 citations

Human Estrogen Receptor β Binds DNA in a Manner Similar to and Dimerizes with Estrogen Receptor α

1997 • 301 citations

Estrogen receptor-Sp1 complexes mediate estrogen-induced cathepsin D gene expression in MCF-7 human breast cancer cells.

1994 • 247 citations

Reporter constructs with low background activity utilizing the cat gene

1992 • 240 citations

Estrogen-Induced c-fos Protooncogene Expression in MCF-7 Human Breast Cancer Cells: Role of Estrogen Receptor Sp1 Complex Formation*

1998 • 190 citations

The quinone reductase gene: A unique estrogen receptor-regulated gene that is activated by antiestrogens

1997 • 166 citations

Regulation of Msx-1, Msx-2, Bmp-2 and Bmp-4 during foetal and postnatal mammary gland development

1996 • 164 citations

Time-dependent changes in biochemical bone markers and serum cholesterol in ovariectomized rats: Effects of raloxifene HCl, tamoxifen, estrogen, and alendronate

1996 • 142 citations

Estrogen Receptor Ligands Modulate Its Interaction with DNA

1997 • 123 citations

Regulation of estrogen receptor transcriptional enhancement by the cyclin A/Cdk2 complex

1997 • 95 citations

The Mouse Bone Morphogenetic Protein-4 Gene

1995 • 94 citations

Regulation of the transforming growth factor-β1 and -β3 promoters by transcription factor Spl

1993 • 87 citations

Effects of two classes of progestagens, pregnane and 19-nortestosterone derivatives, on cell growth of human breast tumor cells: I. MCF-7 cell lines

1995 • 85 citations

Bone morphogenetic proteins (BMPs): therapeutic potential in healing bony defects

1993 • 85 citations

Estrogen Induces Adenosine Deaminase Gene Expression in MCF-7 Human Breast Cancer Cells: Role of Estrogen Receptor-Sp1 Interactions**This work was supported by the National Institutes of Health (Grant CA-76636), the Welch Foundation, and the Texas Agricultural Experiment Station.

1999 • 82 citations

Genomic organization, coding sequence and functional expression of human 5-HT2 and 5-HT1A receptor genes

1992 • 57 citations

Expression of Bone Morphogenetic Proteins by Osteoinductive and Non-osteoinductive Human Osteosarcoma Cells

1996 • 47 citations

Analysis of the molecular pharmacology of estrogen receptor agonists and antagonists provides insights into the mechanism of action of estrogen in bone

1997 • 46 citations

Cross‐inhibition of both estrogen receptor α and β pathways by each dominant negative mutant

1998 • 39 citations

Genomic Organization of the Human Bone Morphogenetic Protein-4 Gene: Molecular Basis for Multiple Transcripts

1996 • 33 citations

Human endometrial epithelial cell lines for studying steroid and cytokine actions

1990 • 33 citations

Tissue-selective actions of estrogen analogs

1995 • 29 citations

Transcriptional Regulation of the mBMP-4 Gene through an E-Box in the 5′-Flanking Promoter Region Involving USF

1997 • 24 citations

Functional Characterization of Two Promoters in the Human Bone Morphogenetic Protein-4 Gene

1999 • 24 citations

Glucocorticoid and progestin receptors are differently involved in the cooperation with a structural element of the mouse mammary tumor virus promoter.

1996 • 24 citations

Analysis of human breast cancer nuclear proteins binding to the promoter elements of the c-myc gene

1996 • 23 citations

Osteoporosis: a bone morphogenetic protein auto-immune disorder.

1985 • 20 citations

Scientific Journals and Articles

1906 • 10 citations