Estrogens: Trophic and Protective Factors in the Adult Brain

The Physiology of Reproduction

1988 • 7,765 citations

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

1997 • 4,921 citations

Cloning of a novel receptor expressed in rat prostate and ovary.

1996 • 4,782 citations

Long-Term Potentiation--A Decade of Progress?

1999 • 2,701 citations

Hormone Therapy To Prevent Disease and Prolong Life in Postmenopausal Women

1992 • 2,379 citations

Dendritic spine changes associated with hippocampal long-term synaptic plasticity

1999 • 1,694 citations

Effect of oestrogen during menopause on risk and age at onset of Alzheimer's disease

1996 • 1,640 citations

Estrogen Actions in the Central Nervous System¹

1999 • 1,381 citations

Gonadal steroids regulate dendritic spine density in hippocampal pyramidal cells in adulthood

1990 • 1,352 citations

Postmenopausal Estrogen and Progestin Use and the Risk of Cardiovascular Disease

1996 • 1,323 citations

Estrogen and Coronary Heart Disease in Women

1991 • 1,237 citations

Postmenopausal Hormone Therapy and Mortality

1997 • 1,184 citations

Estradiol mediates fluctuation in hippocampal synapse density during the estrous cycle in the adult rat.

1992 • 1,178 citations

Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia

1994 • 1,106 citations

Naturally occurring fluctuation in dendritic spine density on adult hippocampal pyramidal neurons

1990 • 1,080 citations

Roles of estradiol and progesterone in regulation of hippocampal dendritic spine density during the estrous cycle in the rat

1993 • 1,066 citations

Cell Membrane and Nuclear Estrogen Receptors (ERs) Originate from a Single Transcript: Studies of ERα and ERβ Expressed in Chinese Hamster Ovary Cells

1999 • 1,046 citations

Estrogen Replacement Therapy for Treatment of Mild to Moderate Alzheimer Disease

2000 • 985 citations

A prospective study of estrogen replacement therapy and the risk of developing Alzheimer's disease

1997 • 965 citations

Tyrosine kinase/p21ras/MAP-kinase pathway activation by estradiol-receptor complex in MCF-7 cells.

1996 • 964 citations

Estradiol mediates fluctuation in hippocampal synapse density during the estrous cycle in the adult rat [published erratum appears in J Neurosci 1992 Oct;12(10):following table of contents]

1992 • 959 citations

Plasticity of Sensory and Motor Maps in Adult Mammals

1991 • 916 citations

Estrogen Deficiency and Risk of Alzheimer's Disease in Women

1994 • 843 citations

Estrogens Attenuate and Corticosterone Exacerbates Excitotoxicity, Oxidative Injury, and Amyloid β‐Peptide Toxicity in Hippocampal Neurons

1996 • 833 citations

Cardiovascular Health and Disease in Women

1993 • 803 citations

Neuroprotection against Oxidative Stress by Estrogens: Structure-Activity Relationship

1997 • 769 citations

Gender-Linked Brain Injury in Experimental Stroke

1998 • 730 citations

Prevention of Programmed Cell Death of Sympathetic Neurons by the bcl-2 Proto-Oncogene

1992 • 724 citations

Estrogen and/or androgen replacement therapy and cognitive functioning in surgically menopausal women

1988 • 708 citations

Estradiol regulates hippocampal dendritic spine density via an N-methyl- D-aspartate receptor-dependent mechanism

1994 • 679 citations

Estradiol Increases the Sensitivity of Hippocampal CA1 Pyramidal Cells to NMDA Receptor-Mediated Synaptic Input: Correlation with Dendritic Spine Density

1997 • 679 citations

Decreased Mortality in Users of Estrogen Replacement Therapy

1991 • 642 citations

The vascular protective effects of estrogen

1996 • 642 citations

Estradiol reduces calcium currents in rat neostriatal neurons via a membrane receptor

1996 • 638 citations

Postmenopausal Estrogen Use, Cigarette Smoking, and Cardiovascular Morbidity in Women over 50

1985 • 613 citations

17-β Estradiol Protects Neurons from Oxidative Stress-Induced Cell Death in Vitro

1995 • 612 citations

Prevention of hypoxia-induced cell death by Bcl-2 and Bcl-xL

1995 • 611 citations

Estrogen Replacement Therapy in Older Women

1994 • 596 citations

The Mitogen-Activated Protein Kinase Pathway Mediates Estrogen Neuroprotection after Glutamate Toxicity in Primary Cortical Neurons

1999 • 581 citations

Physiology of Reproduction

1972 • 577 citations

Estrogen for Alzheimer’s disease in women

2000 • 555 citations

Estradiol Protects against Ischemic Injury

1998 • 548 citations

Estrogen reduces neuronal generation of Alzheimer β-amyloid peptides

1998 • 545 citations

Effects of physiological levels of estrogen on coronary vasomotor function in postmenopausal women.

1994 • 543 citations

Identification of a putative estrogen response element in the gene encoding brain-derived neurotrophic factor.

1995 • 542 citations

Estrogen-related variations in human spatial and articulatory-motor skills

1990 • 534 citations

Estradiol increases choline acetyltransferase activity in specific basal forebrain nuclei and projection areas of female rats

1985 • 526 citations

Neuroprotective effects of estrogens: potential mechanisms of action

2000 • 515 citations

Estrogens may reduce mortality and ischemic damage caused by middle cerebral artery occlusion in the female rat

1997 • 512 citations

Estrogen Replacement Therapy and Risk of Alzheimer Disease

1996 • 504 citations

Sexual Differentiation of the Vertebrate Brain: Principles and Mechanisms

1998 • 500 citations

Estrogen inhibits the vascular injury response in estrogen receptor α-deficient mice

1997 • 499 citations

Ovarian steroid deprivation results in a reversible learning impairment and compromised cholinergic function in female Sprague-Dawley rats

1994 • 487 citations

Rapid Membrane Effects of Steroids in Neuroblastoma Cells: Effects of Estrogen on Mitogen Activated Protein Kinase Signalling Cascade and c-fos Immediate Early Gene Transcription

1997 • 478 citations

Androgens Prevent Normally Occurring Cell Death in a Sexually Dimorphic Spinal Nucleus

1985 • 470 citations

NGF and bFGF protect rat hippocampal and human cortical neurons against hypoglycemic damage by stabilizing calcium homeostasis

1991 • 462 citations

Estradiol Increases Dendritic Spine Density by Reducing GABA Neurotransmission in Hippocampal Neurons

1998 • 460 citations

Estradiol Modulates bcl-2 in Cerebral Ischemia: A Potential Role for Estrogen Receptors

1999 • 453 citations

Long-term and short-term electrophysiological effects of estrogen on the synaptic properties of hippocampal CA1 neurons

1992 • 449 citations

Sex and Handedness Differences in Cerebral Blood Flow During Rest and Cognitive Activity

1982 • 447 citations

Novel Mechanisms of Estrogen Action in the Brain: New Players in an Old Story

1999 • 434 citations

Estrogen receptors colocalize with low-affinity nerve growth factor receptors in cholinergic neurons of the basal forebrain.

1992 • 431 citations

LTP varies across the estrous cycle: enhanced synaptic plasticity in proestrus rats

1995 • 430 citations

Analysis of transcription and estrogen insensitivity in the female mouse after targeted disruption of the estrogen receptor gene.

1995 • 428 citations

Antioxidant effects of estradiol and 2-hydroxyestradiol on iron-induced lipid peroxidation of rat liver microsomes

1994 • 424 citations

The effect of ovariectomy and estradiol replacement on brain-derived neurotrophic factor messenger ribonucleic acid expression in cortical and hippocampal brain regions of female Sprague-Dawley rats.

1995 • 422 citations

Reduced Brain Edema and Infarction Volume in Mice Lacking the Neuronal Isoform of Nitric Oxide Synthase after Transient MCA Occlusion

1996 • 422 citations

Estrogen promotes chemotherapeutic drug resistance by a mechanism involving Bcl-2 proto-oncogene expression in human breast cancer cells.

1995 • 422 citations

Fortnightly review: Hormone replacement therapy

1998 • 414 citations

Regulation of Dendritic Spine Density in Cultured Rat Hippocampal Neurons by Steroid Hormones

1996 • 402 citations

Estrogen Use and Verbal Memory in Healthy Postmenopausal Women

1994 • 397 citations

Estrogen Modulates Neuronal Bcl‐x_l Expression and β‐Amyloid‐Induced Apoptosis

1999 • 390 citations

Observations in a preliminary open trial of estradiol therapy for senile dementia-alzheimer's type

1986 • 384 citations

Estrogen Replacement Therapy and Cognitive Function in Older Women

1993 • 383 citations

Differential Regulation of NMDAR1 mRNA and Protein by Estradiol in the Rat Hippocampus

1996 • 376 citations

Nongenomic Actions of Steroid Hormones in Reproductive Tissues*

1998 • 375 citations

Estrogen regulates metabolism of Alzheimer amyloid beta precursor protein.

1994 • 365 citations

Estrogen actions in the central nervous system

1999 • 364 citations

Estrogen-Mediated Neuroprotection After Experimental Stroke in Male Rats

1998 • 362 citations

Estrogen differentially regulates estrogen and nerve growth factor receptor mRNAs in adult sensory neurons

1994 • 362 citations

17β-Estradiol Potentiates Kainate-Induced Currents via Activation of the cAMP Cascade

1996 • 347 citations

Estrogen protects primary cortical neurons from glutamate toxicity

1996 • 329 citations

Influence of Sex Hormones on Plasma Endothelin Levels

1993 • 328 citations

Brain-Derived Neurotrophic Factor Protects against Ischemic Cell Damage in Rat Hippocampus

1994 • 326 citations

Overexpression of the trk tyrosine kinase rapidly accelerates nerve growth factor-induced differentiation

1992 • 321 citations

Gender influences outcome of brain injury: progesterone plays a protective role

1993 • 320 citations

Estrogen and the blood vessel wall

1994 • 316 citations

Estrogen-induced uterine vasodilatation is antagonized by L-nitroarginine methyl ester, an inhibitor of nitric oxide synthesis

1992 • 312 citations

Overexpression of Bcl-2 with herpes simplex virus vectors protects CNS neurons against neurological insults in vitro and in vivo

1996 • 311 citations

Gene Expression Induced by Cerebral Ischemia: An Apoptotic Perspective

1997 • 305 citations

17β-Estradiol Reduces Stroke Injury in Estrogen-Deficient Female Animals

1999 • 303 citations

Postmenopausal Estrogen Replacement Therapy and the Risk of Alzheimer's Disease: A Population-based Case-Control Study

1994 • 300 citations

Postmenopausal estrogen replacement therapy and risk of AD

1999 • 293 citations

Estrogen effects on cognition in menopausal women

1997 • 292 citations

Differential expression of nerve growth factor receptors leads to altered binding affinity and neurotrophin responsiveness.

1993 • 292 citations

Morphological plasticity of dendritic spines in central neurons is mediated by activation of cAMP response element binding protein

1997 • 292 citations

Effects of estrogen on cognition, mood, and cerebral blood flow in AD

2000 • 292 citations

Estrogen rapidly induces the phosphorylation of the cAMP response element binding protein in rat brain.

1996 • 283 citations

17β-Estradiol protects against NMDA-induced excitotoxicity by direct inhibition of NMDA receptors

1997 • 278 citations

VEGF and flt

1996 • 276 citations

Role of astroglia in estrogen regulation of synaptic plasticity and brain repair

1999 • 266 citations

Estrogen and the developing mammalian brain

1999 • 263 citations

Neuronal colocalization of mRNAs for neurotrophins and their receptors in the developing central nervous system suggests a potential for autocrine interactions.

1993 • 261 citations

Levels of trkA and BDNF mRNA, but not NGF mRNA, fluctuate across the estrous cycle and increase in response to acute hormone replacement

1998 • 260 citations

17α-Estradiol Exerts Neuroprotective Effects on SK-N-SH Cells

1997 • 259 citations

Ethinylestradiol does not enhance the expression of nitric oxide synthase in bovine endothelial cells but increases the release of bioactive nitric oxide by inhibiting superoxide anion production.

1996 • 259 citations

Estrogen inhibits the vascular injury response in estrogen receptor β-deficient female mice

1999 • 254 citations

IGF-I and IGF-II protect cultured hippocampal and septal neurons against calcium-mediated hypoglycemic damage

1992 • 253 citations

Estradiol upregulates Bcl-2 expression in adult brain neurons

1998 • 253 citations

Sex Differences in Postischemic Neuronal Necrosis in Gerbils

1991 • 253 citations

Regulation of Brain-Derived Neurotrophic Factor Gene Expression after Transient Middle Cerebral Artery Occlusion with and without Brain Damage

1995 • 248 citations

Apoptosis-Suppressor Genebcl-2Expression after Traumatic Brain Injury in Rats

1997 • 244 citations

Brain-derived neurotrophic factor mediates estradiol-induced dendritic spine formation in hippocampal neurons

1998 • 242 citations

Phosphatidylinositol 3-kinase mediates neuroprotection by estrogen in cultured cortical neurons

2000 • 242 citations

Cognitive and neuroendocrine response to transdermal estrogen in postmenopausal women with Alzheimer’s disease: results of a placebo-controlled, double-blind, pilot study

1999 • 241 citations

17 beta-estradiol preserves endothelial vasodilator function and limits low-density lipoprotein oxidation in hypercholesterolemic swine.

1994 • 240 citations

Estradiol protects against β-amyloid (25–35)-induced toxicity in SK-N-SH human neuroblastoma cells

1996 • 238 citations

Decreased Risk of Stroke Among Postmenopausal Hormone Users

1993 • 237 citations

Estrogen facilitates induction of long term potentiation in the hippocampus of awake rats1First published on the World Wide Web on 4 November 1997.1

1997 • 234 citations

Rapid Action of 17β-Estradiol on Kainate-Induced Currents in Hippocampal Neurons Lacking Intracellular Estrogen Receptors*

1999 • 233 citations

Estradiol Exerts Neuroprotective Effects When Administered After Ischemic Insult

2000 • 233 citations

Effects of Estrogen Replacement on the Relative Levels of Choline Acetyltransferase, trkA, and Nerve Growth Factor Messenger RNAs in the Basal Forebrain and Hippocampal Formation of Adult Rats

1994 • 232 citations

Antioxidant potential of specific estrogens on lipid peroxidation.

1993 • 231 citations

Estrogen Replacement Therapy and Memory in Older Women

1994 • 230 citations

Electrical Activity During the Estrous Cycle of the Rat: Cyclic Changes in Limbic Structures

1968 • 227 citations

Sex Differences in Neurotransmitter Systems

1990 • 224 citations

Estrogen Supplementation Attenuates Glucocorticoid and Catecholamine Responses to Mental Stress in Perimenopausal Women1

1999 • 223 citations

Gonadal Steroids Promote Glial Differentiation and Alter Neuronal Morphology in the Developing Hypothalamus in a Regionally Specific Manner

1999 • 222 citations

Gonadal hormones down-regulate reactive gliosis and astrocyte proliferation after a penetrating brain injury

1993 • 221 citations

Free radicals in CNS injury.

1993 • 221 citations

Neuronal Damage and Plasticity Identified by Microtubule-Associated Protein 2, Growth-Associated Protein 43, and Cyclin D1 Immunoreactivity After Focal Cerebral Ischemia in Rats

1998 • 220 citations

Estradiol increases the frequency of multiple synapse boutons in the hippocampal CA1 region of the adult female rat

1996 • 219 citations

Estrogenic Effects on Memory in Women^a

1994 • 216 citations

Estrogen and Basal Forebrain Cholinergic Neurons: Implications for Brain Aging and Alzheimer's Disease-Related Cognitive Decline

1998 • 215 citations

Effects of gender and estradiol treatment on focal brain ischemia

1998 • 215 citations

Hormones, mood, and cognitive functioning in postmenopausal women

1996 • 214 citations

Estrogen Replacement Therapy In Older Women: A Neuropsychological And Brain MRI Study

1996 • 205 citations

Synaptic remodeling in the rat arcuate nucleus during the estrous cycle

1989 • 204 citations

Estrogen-enhanced neurite growth: evidence for a selective induction of Tau and stable microtubules

1991 • 202 citations

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyride Neurotoxicity Is Attenuated in Mice Overexpressing Bcl-2

1998 • 199 citations

Neuroprotective effects of estradiol in the adult rat hippocampus: Interaction with insulin-like growth factor-I signalling

1999 • 196 citations

Cognitive skills associated with estrogen replacement in women with Alzheimer's disease

1996 • 192 citations

Neurogenesis of the sexually dimorphic nucleus of the preoptic area in the rat

1981 • 189 citations

Bcl‐2 Protects Isolated Plasma and Mitochondrial Membranes Against Lipid Peroxidation Induced by Hydrogen Peroxide and Amyloid β‐Peptide

1998 • 188 citations

Treatment with estrogen and progesterone affects relative levels of brain-derived neurotrophic factor mRNA and protein in different regions of the adult rat brain

1999 • 187 citations

Estrogen improves motor disability in parkinsonian postmenopausal women with motor fluctuations

2000 • 186 citations

Phenolic A ring requirement for the neuroprotective effects of steroids

1997 • 184 citations

17 beta-Estradiol enhances the outgrowth and survival of neocortical neurons in culture.

1997 • 184 citations

Neuroprotection by Estrogens in a Mouse Model of Focal Cerebral Ischemia and in Cultured Neurons: Evidence for a Receptor-Independent Antioxidative Mechanism

1999 • 183 citations

ESTROGENS AND ATHEROSCLEROSIS

1997 • 177 citations

Nuclear estrogen receptor-independent neuroprotection by estratrienes: a novel interaction with glutathione

1998 • 175 citations

The effects of ovariectomy and estrogen replacement on trkA and choline acetyltransferase mRNA expression in the basal forebrain of the adult female Sprague-Dawley rat

1996 • 173 citations

Modulation of Bcl-2 expression

1998 • 173 citations

Transcriptional Effects of Estrogen on Neuronal Neurotensin Gene Expression Involve cAMP/Protein Kinase A-Dependent Signaling Mechanisms

1998 • 171 citations

THE INFLUENCE OF OESTROGENS ON THE WELLBEING AND MENTAL PERFORMANCE IN CLIMACTERIC AND POSTMENOPAUSAL WOMEN

1977 • 170 citations

Destruction of Noradrenergic Neurons in Rabbit Brainstem Elevates Plasma Vasopressin, Causing Hypertension

1982 • 168 citations

Estrogen Provides Neuroprotection in Transient Forebrain Ischemia Through Perfusion-Independent Mechanisms in Rats

1999 • 166 citations

Estrogen increases intracellular p26Bcl-2 to p21Bax ratios and inhibits taxol-induced apoptosis of human breast cancer MCF-7 cells

1997 • 163 citations

17?-Estradiol attenuates oxidative impairment of synaptic Na+/K+-ATPase activity, glucose transport, and glutamate transport induced by amyloid ?-peptide and iron

1997 • 163 citations

Role of estrogen in postmenopausal depression

1997 • 161 citations

Estrogen: nontranscriptional signaling pathway.

1997 • 156 citations

Estrogen improves biochemical and neurologic outcome following traumatic brain injury in male rats, but not in females

1993 • 155 citations

Postischemic Cerebral Blood Flow Recovery in the Female: Effect of 17β-Estradiol

1995 • 151 citations

Effects of estrogen and fimbria/fornix transection on p75NGFR and ChAT expression in the medial septum and diagonal band of Broca

1992 • 149 citations

Cerebral vasodilating capacity during forebrain ischemia

1998 • 146 citations

Reciprocal regulation of estrogen and NGF receptors by their ligands in PC12 cells

1994 • 146 citations

Estrogen replacement therapy and stroke

1995 • 145 citations

Stroke in Estrogen Receptor-α–Deficient Mice

2000 • 144 citations

Hormone replacement therapy and risk of non-fatal stroke

1997 • 143 citations

Neurotransmitters and memory: Role of cholinergic, serotonergic, and noradrenergic systems.

1987 • 142 citations

Estrogens attenuate neuronal injury due to hemoglobin, chemical hypoxia, and excitatory amino acids in murine cortical cultures

1997 • 138 citations

The female sex hormone oestrogen as a neuroprotectant

1999 • 137 citations

Herpes Simplex Viral Vectors Expressing Bcl-2 Are Neuroprotective When Delivered After a Stroke

1997 • 135 citations

Gonadal Hormone Regulation of Insulin-Like Growth Factor-I Like Immunoreactivity in Hypothalamic Astroglia of Developing and Adult Rats

1994 • 135 citations

Low concentrations of estradiol reduce β-amyloid (25–35)-induced toxicity, lipid peroxidation and glucose utilization in human SK-N-SH neuroblastoma cells

1997 • 133 citations

Estrogen Hormones Reduce Lipid Peroxidation in Cells and Tissues of the Central Nervous System

1999 • 132 citations

Estrogen use and depressive symptoms in postmenopausal women

1993 • 130 citations

HSV-1 vector-mediated gene transfer of the human nerve growth factor receptor p75hNGFR defines high-affinity NGF binding

1993 • 127 citations

Estradiol protects against injury-induced cell death in cortical explant cultures: a role for estrogen receptors

2000 • 126 citations

Oestrogen and progesterone inhibit the stimulated production of endothelin-1

1998 • 126 citations

Bcl‐2 Protects Neural Cells from Cyanide/Aglycemia‐Induced Lipid Oxidation, Mitochondrial Injury, and Loss of Viability

1995 • 126 citations

Functional Antagonism of Gonadal Steroids at the 5-Hydroxytryptamine Type 3 Receptor

1998 • 125 citations

Testosterone-induced plasticity of synaptic inputs to adult mammalian motoneurons

1987 • 123 citations

Estradiol induces plasticity of gabaergic synapses in the hypothalamus

1993 • 121 citations

p75 ^NTR : A Receptor After All

1996 • 120 citations

Neurotransmitters and memory: Role of cholinergic, serotonergic, and noradrenergic systems.

1987 • 118 citations

Interaction of insulin-like growth factor-I and estradiol signaling pathways on hypothalamic neuronal differentiation

1996 • 117 citations

Estrogen and Alzheimer??s Disease

2002 • 115 citations

Estrogen Increases Cerebral and Cerebellar Blood Flows in Postmenopausal Women

1995 • 112 citations

Comment

1995 • 105 citations

Trophic Effects of Estradiol on Fetal Rat Hypothalamic Neurons

1992 • 104 citations

Better postural balance in elderly women receiving estrogens

1997 • 102 citations

Ischemic Stroke and Use of Estrogen and Estrogen/Progestogen as Hormone Replacement Therapy

1998 • 102 citations

Amygdala neurons in vitro: Neurite growth and effects of estradiol

1992 • 100 citations

Estrogen and estrogen^progesterone treatments counteract the effect of scopolamine on reinforced T-maze alternation in female rats.

1994 • 100 citations

Insulin-like growth factor-I receptors and estrogen receptors interact in the promotion of neuronal survival and neuroprotection.

2000 • 97 citations

Interaction of human estrogen receptors α and β with the same naturally occurring estrogen response elements

1999 • 97 citations

Evidence for Sexual Differentiation of Glia in Rat Brain

1996 • 95 citations

Organotypic culture of the developing cerebral cortex and hypothalamus: Relevance to sexual differentiation

1991 • 94 citations

Estradiol — induced redistribution of glial fibrillary acidic protein immunoreactivity in the rat brain

1987 • 94 citations

CuZn-superoxide dismutase (CuZnSOD) transgenic mice show resistance to the lethal effects of methylenedioxyamphetamine (MDA) and of methylenedioxymethamphetamine (MDMA)

1994 • 93 citations

Non-genomic effects of estrogen and the vessel wall

1996 • 92 citations

Presumptive Estrogen Target Neurons Express mRNAs for both the Neurotrophins and Neurotrophin Receptors: A Basis for Potential Developmental Interactions of Estrogen with the Neurotrophins

1993 • 91 citations

Estrogen and estrogen-progesterone treatments counteract the effect of scopolamine on reinforced T-maze alternation in female rats.

1994 • 89 citations

Glutamate receptor requirement for neuronal death from anoxia-reoxygenation: an in Vitro model for assessment of the neuroprotective effects of estrogens.

1999 • 88 citations

Antagonism between estradiol and progestin on Bcl-2 expression in breast-cancer cells

1996 • 87 citations

Estrogen Induction of Cytochrome c Oxidase Subunit III in Rat Hippocampus

1992 • 84 citations

Time lapse study of neurite growth in hypothalamic dissociated neurons in culture: Sex differences and estrogen effects

1992 • 84 citations

Androgen Enhances Neuronal Degeneration in the Developing Preoptic Area: Apoptosis in the Anteroventral Periventricular Nucleus (AVPvN-POA)

1994 • 83 citations

Development and loss of early projections in a sexually dimorphic rat spinal nucleus

1986 • 83 citations

Equilin, a Principal Component of the Estrogen Replacement Therapy Premarin, Increases the Growth of Cortical Neurons via an NMDA Receptor-Dependent Mechanism

1997 • 82 citations

Stable transfection of PC12 cells with estrogen receptor (ERα): Protective effects of estrogen on cell survival after serum deprivation

1999 • 81 citations

Estrogen and NGF synergistically protect terminally differentiated, ERα-transfected PC12 cells from apoptosis

1999 • 80 citations

Estrogens in the Pathogenesis and Treatment of Alzheimer's Disease in Postmenopausal Women

1994 • 79 citations

Molecular and Cellular Approaches to the Treatment of Neurological Disease

1993 • 78 citations

The role of gonadal hormones in neuromuscular synapse elimination in rats. I. Androgen delays the loss of multiple innervation in the levator ani muscle

1989 • 75 citations

Estrogen treatment enhances survival of cultured fetal rat amygdala neurons in a defined medium

1986 • 75 citations

Genetically modified fibroblasts producing NGF protect hippocampal neurons after ischemia in the rat

1995 • 72 citations

Hormonal Activation of the Striatum and the Nucleus Accumbens Modulates Paced Mating Behavior in the Female Rat

1997 • 72 citations

Lesion-induced neurite sprouting and synapse formation in hippocampal organotypic cultures

1993 • 71 citations

Estrogen Modulates the Growth-Associated Protein GAP-43 (Neuromodulin) mRNA in the Rat Preoptic Area and Basal Hypothalamus

1993 • 70 citations

A Revised Critical Period for the Sexual Differentiation of the Sexually Dimorphic Nucleus of the Preoptic Area in the Rat

1995 • 70 citations

Steroid Hormone Influences on Spatial Memory

1994 • 67 citations

Rapid effects of gonadal steroids upon hypothalamic neuronal membrane ultrastructure

1987 • 67 citations

Identification of Estrogen-Responsive Genes in Neuroblastoma SK-ER3 Cells

1997 • 65 citations

Molecular and cellular approaches to the treatment of neurological disease

1993 • 65 citations

Hormonal Control of the Anatomical Specificity of Motoneuron-to-Muscle Innervation in Rats

1985 • 59 citations

Neurotrophin-4/5 protects hippocampal and cortical neurons against energy deprivation- and excitatory amino acid-induced injury

1994 • 57 citations

17β-Estradiol Induction of Filopodial Growth in Cultured Hippocampal Neurons within Minutes of Exposure

1993 • 57 citations

Estrogen alleviates cognitive dysfunction following transient brain ischemia in ovariectomized gerbils

1997 • 49 citations

Hip Fracture

1994 • 47 citations

Potential neuronal mechanisms of estrogen actions in synaptogenesis and synaptic plasticity

1996 • 44 citations

Differentiation of rat hippocampal neurons induced by estrogen in vitro: Effects on neuritogenesis and Na,K‐ATPase activity

1990 • 41 citations

The European Stroke Prevention Study

1991 • 37 citations

Postnatal development of transmitter systems: Sexual differentiation of the gabaergic system and effects of muscimol

1986 • 34 citations

Investigation of peripeduncular-hypothalamic pathways involved in the control of Lordosis in the rat

1982 • 33 citations

Estradiol induces rapid remodelling of plasma membranes in developing rat cerebrocortical neurons in culture

1989 • 32 citations

Neurotrophin expression modulated by glucocorticoids and oestrogen in immortalized hippocampal neurons

1995 • 25 citations

Sex‐steroid actions on neurotransmission

1998 • 23 citations

Nitric Oxide and the Brain

1996 • 22 citations

Cholinergic and anticholinergic drug effects on survival during hypoxia: significant gender differences.

1993 • 21 citations

CONTRACTION STRESS TEST BY BREAST STIMULATION AS PART OF ANTEPARTUM MONITORING

1985 • 20 citations

Culture models for the study of estradiol-induced synaptic plasticity.

2000 • 18 citations

S42 Estrogen and memory in women

1996 • 9 citations

Expression of neurotrophin mRNAs in the postischemic phase.

1996 • 7 citations

ESTROGEN AND ALZHEIMERʼS DISEASE

1998 • 5 citations

Topics in neuroanesthesia

1996 • 1 citations