Phosphodiesterase inhibitors for persistent pulmonary hypertension of the newborn: A review

The Sequence of the Human Genome

2001 • 13,500 citations

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

Oral Sildenafil in the Treatment of Erectile Dysfunction

1998 • 2,097 citations

Inhaled nitric oxide in persistent pulmonary hypertension of the newborn

1992 • 865 citations

Low-dose inhalational nitric oxide in persistent pulmonary hypertension of the newborn

1992 • 731 citations

Studies on the Mechanism of Hormone Action

1972 • 682 citations

Oral Sildenafil in the Treatment of Erectile Dysfunction

1998 • 627 citations

Endogenous nitrogen oxides and bronchodilator S-nitrosothiols in human airways.

1993 • 616 citations

Oral Sildenafil Is an Effective and Specific Pulmonary Vasodilator in Patients With Pulmonary Arterial Hypertension

2002 • 589 citations

Persistent Pulmonary Hypertension of the Newborn in the Era Before Nitric Oxide: Practice Variation and Outcomes

2000 • 558 citations

Combination Therapy with Oral Sildenafil and Inhaled Iloprost for Severe Pulmonary Hypertension

2002 • 507 citations

Cyclic nucleotide phosphodiesterases

2001 • 500 citations

Use of Sildenafil (Viagra) in Patients With Cardiovascular Disease

1999 • 497 citations

Tailoring cAMP-signalling responses through isoform multiplicity

1997 • 437 citations

Inhalation of nitric oxide in acute lung injury: results of a European multicentre study

1999 • 420 citations

Isolation and characterization of a dual-substrate phosphodiesterase gene family: PDE10A

1999 • 369 citations

Inhaled Nitric Oxide for the Early Treatment of Persistent Pulmonary Hypertension of the Term Newborn: A Randomized, Double-Masked, Placebo-Controlled, Dose-Response, Multicenter Study

1998 • 355 citations

Sildenafil Ameliorates Effects of Inhaled Nitric Oxide Withdrawal

1999 • 344 citations

Identification and Characterization of a Novel Family of Cyclic Nucleotide Phosphodiesterases

1998 • 283 citations

Pulmonary vascular remodeling: a target for therapeutic intervention in pulmonary hypertension

2001 • 274 citations

Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase

1998 • 269 citations

Pharmacology of phosphodiesterase inhibitors

2005 • 267 citations

Cyclic nucleotide phosphodiesterases and their role in endocrine cell signaling

2002 • 256 citations

PHARMACOLOGY OF PHOSPHODIESTERASE‐5 INHIBITORS

2002 • 240 citations

Sildenafil for Male Erectile Dysfunction

2002 • 239 citations

Mechanisms of peroxynitrite-induced injury to pulmonary surfactants

1993 • 232 citations

Erectile dysfunction: comparison of efficacy and side effects of the PDE-5 inhibitors sildenafil, vardenafil and tadalafil--review of the literature.

2002 • 230 citations

Sildenafil Is a Pulmonary Vasodilator in Awake Lambs with Acute Pulmonary Hypertension

2000 • 221 citations

Identification of PDE isozymes in human pulmonary artery and effect of selective PDE inhibitors

1994 • 182 citations

Intravenous Sildenafil Lowers Pulmonary Vascular Resistance in a Model of Neonatal Pulmonary Hypertension

2002 • 175 citations

Nebulized sildenafil is a selective pulmonary vasodilator in lambs with acute pulmonary hypertension

2001 • 171 citations

Role for Endothelin-1–Induced Superoxide and Peroxynitrite Production in Rebound Pulmonary Hypertension Associated With Inhaled Nitric Oxide Therapy

2001 • 160 citations

New Treatments for Pulmonary Arterial Hypertension

2002 • 153 citations

Identification of the cytochrome P450 enzymes involved in the N‐demethylation of sildenafil

2001 • 152 citations

Neurodevelopmental and medical outcomes of persistent pulmonary hypertension in term newborns treated with nitric oxide

2002 • 142 citations

Cyclic nucleotide phosphodiesterase (PDE) inhibitors and immunomodulation

1999 • 125 citations

Four Patterns of Response to Inhaled Nitric Oxide for Persistent Pulmonary Hypertension of the Newborn

1996 • 123 citations

The cGMP phosphodiesterase inhibitor zaprinast enhances the effect of nitric oxide.

1995 • 116 citations

Nitric oxide exposure inhibits endothelial NOS activity but not gene expression: a role for superoxide

1998 • 114 citations

Nitric oxide for respiratory failure in infants born at or near term

2001 • 110 citations

Sildenafil for primary and secondary pulmonary hypertension

2002 • 101 citations

Safety of Withdrawing Inhaled Nitric Oxide Therapy in Persistent Pulmonary Hypertension of the Newborn

1999 • 96 citations

Inhaled nitric oxide inhibits NOS activity in lambs: potential mechanism for rebound pulmonary hypertension

1999 • 91 citations

Low-level air pollution and hospital admissions for cardiac and cerebrovascular diseases in Helsinki.

1996 • 90 citations

Prolonged pulmonary vasodilator action of inhaled nitric oxide by Zaprinast in awake lambs

1995 • 89 citations

Sildenafil Modulates Hemodynamics and Pulmonary Gas Exchange

2001 • 89 citations

Cl- current activation in choroid plexus epithelial cells involves a G protein and protein kinase A

1994 • 87 citations

Hypoxic Induction of Cox-2 Regulates Proliferation of Human Pulmonary Artery Smooth Muscle Cells

2002 • 87 citations

Cloning and characterization of two splice variants of human phosphodiesterase 11A

2000 • 82 citations

Effect of inhaled nitric oxide on endothelin-1 and cyclic guanosine 5`-monophosphate plasma concentrations in newborn infants with persistent pulmonary hypertension

1997 • 81 citations

Inhaled nitric oxide increases endothelin-1 levels: A potential cause of rebound pulmonary hypertension

2002 • 78 citations

I-NO/PPHN Study Group. Neurodevelopmental and medical outcomes of persistent pulmonary hypertension in term newborns treated with nitric oxide

2002 • 77 citations

Selective Pulmonary Vasodilation Induced by Aerosolized Zaprinast

1998 • 77 citations

On the medical history of xanthines and other remedies for asthma: a tribute to HH Salter.

1985 • 74 citations

A maturational shift in pulmonary K⁺ channels, from Ca²⁺ sensitive to voltage dependent

1998 • 64 citations

Life‐threatening effects of discontinuing inhaled nitric oxide in children

1997 • 64 citations

Cellular pathophysiology and therapy of pulmonary hypertension

2001 • 61 citations

Physiologic basis for the treatment of pulmonary hypertension

2001 • 56 citations

Persistent pulmonary hypertension of the newborn. The black box revisited.

1993 • 52 citations

Persistent Pulmonary Hypertension of the Newborn

1993 • 52 citations

Sildenafil (viagra) facilitates weaning of inhaled nitric oxide following placement of a biventricular-assist device

2001 • 52 citations

Sildenafil-mediated reduction in retinal function in heterozygous mice lacking the gamma-subunit of phosphodiesterase.

2001 • 48 citations

Inhaled Nitric Oxide for Persistent Pulmonary Hypertension of the Newborn: The Physiology Matters

1995 • 48 citations

Inhaled Nitric Oxide Treatment for Stabilization and Emergency Medical Transport of Critically Ill Newborns and Infants

1995 • 46 citations

Nitric oxide therapy for the newborn infant

2000 • 44 citations

Nitric oxide and lung surfactant

1996 • 43 citations

Inhaled Nitric Oxide and Gentle Ventilation in the Treatment of Pulmonary Hypertension of the Newborn — a Single-Center, 5-Year Experience

2002 • 43 citations

Models of persistent pulmonary hypertension of the newborn (PPHN) and the role of cyclic guanosine monophosphate (GMP) in pulmonary vasorelaxation

1997 • 43 citations

Pulmonary and Systemic Effects of the Phosphodiesterase Inhibitor Dipyridamole in Newborn Lambs with Persistent Pulmonary Hypertension

1998 • 42 citations

The Clinical Safety of Viagra

2002 • 41 citations

Methaemoglobinaemia with high‐dose nitric oxide administration

1995 • 41 citations

Use of Inhaled Nitric Oxide During Interhospital Transport of Newborns With Hypoxemic Respiratory Failure

2002 • 39 citations

Sildenafil (Viagra) for male erectile dysfunction: a meta-analysis of clinical trial reports

2002 • 39 citations

Altered vasoreactivity in lungs isolated from rats exposed to nitric oxide gas

1996 • 38 citations

Sildenafil (Viagra) in childhood and neonatal pulmonary hypertension

2002 • 37 citations

Inhaled nitric oxide for respiratory failure in preterm infants

2001 • 37 citations

Recent advances in pulmonary vascular disease

2002 • 35 citations

The use of phosphodiesterase inhibitor (dipyridamole) to wean from inhaled nitric oxide

1996 • 35 citations

Combined therapy with zaprinast and inhaled nitric oxide abolishes hypoxic pulmonary hypertension

2000 • 32 citations

Inhaled diazeniumdiolates (NONOates) as selective pulmonary vasodilators

2002 • 31 citations

Altered Guanylyl-Cyclase Activity In Vitro of Pulmonary Arteries from Fetal Lambs with Congenital Diaphragmatic Hernia

2002 • 29 citations

Inhaled Nitric Oxide and Methemoglobin in Full-Term Infants with Persistent Pulmonary Hypertension of the Newborn

2002 • 26 citations

Nitric oxide in respiratory failure in the newborn infant

1997 • 25 citations

Hemodynamic Effects of Dipyridamole and Inhaled Nitric Oxide in Pediatric Patients With Pulmonary Hypertension

1998 • 24 citations

Dypiridamole, a cGMP phosphodiesterase inhibitor, transiently improves the response to inhaled nitric oxide in two newborns with congenital diaphragmatic hernia

1999 • 23 citations

Role of multiple cAMP-specific phosphodiesterase variants

1996 • 21 citations

The use of dipyridamole to wean from inhaled nitric oxide in congenital diaphragmatic hernia

2001 • 15 citations

Interaction of endogenous endothelin-1 and inhaled nitric oxide in term and preterm infants

2002 • 14 citations

Site-specific effect of guanosine 3′,5′-cyclic monophosphate phosphodiesterase inhibition in isolated lamb lungs

2000 • 14 citations

Physiologie und Pathophysiologie der pulmonalen Zirkulation

1999 • 12 citations

Intravenous Dipyridamole Enhances the Effects of Inhaled Nitric Oxide and Prevents Rebound Pulmonary Hypertension in Piglets

2002 • 12 citations

The use of F-arginine and phosphodiesterase inhibitor (dipyridamole) to wean from inhaled nitric oxide

2001 • 11 citations

Recovery from withdrawal of inhaled nitric oxide and kinetics of nitric oxide-induced inhibition of nitric oxide synthase activity in vitro

2000 • 11 citations

The pathophysiology of persistent pulmonary hypertension of the newborn

1997 • 10 citations

Patterning of rhythmical feeding behaviour by brainstem neurons and sensory afferents

1999 • 7 citations

Drug therapy in persistent pulmonary hypertension of the newborn

1997 • 7 citations

The use of nitric oxide therapy in the transport of newborns with persistent pulmonary hypertension

2001 • 6 citations

Efficacy and economy of inhaled nitric oxide in neonates accepted for extra‐corporeal membrane oxygenation

1999 • 5 citations

Dipyridamole in the treatment of a neonate with persistent pulmonary hypertension

2000 • 4 citations