Cellular pathophysiology and therapy of pulmonary hypertension

A Comparison of Continuous Intravenous Epoprostenol (Prostacyclin) with Conventional Therapy for Primary Pulmonary Hypertension

1996 • 2,590 citations

Expression of Endothelin-1 in the Lungs of Patients with Pulmonary Hypertension

1993 • 1,829 citations

The Effect of High Doses of Calcium-Channel Blockers on Survival in Primary Pulmonary Hypertension

1992 • 1,541 citations

Effects of the dual endothelin-receptor antagonist bosentan in patients with pulmonary hypertension: a randomised placebocontrolled study

2001 • 1,521 citations

Reduced Expression of Endothelial Nitric Oxide Synthase in the Lungs of Patients with Pulmonary Hypertension

1995 • 1,366 citations

Familial Primary Pulmonary Hypertension (Gene PPH1) Is Caused by Mutations in the Bone Morphogenetic Protein Receptor–II Gene

2000 • 1,184 citations

An Imbalance between the Excretion of Thromboxane and Prostacyclin Metabolites in Pulmonary Hypertension

1992 • 1,180 citations

Appetite-Suppressant Drugs and the Risk of Primary Pulmonary Hypertension

1996 • 1,131 citations

Primary pulmonary hypertension: natural history and the importance of thrombosis.

1984 • 1,077 citations

Inhaled nitric oxide as a cause of selective pulmonary vasodilatation in pulmonary hypertension

1991 • 1,062 citations

Continuous Intravenous Epoprostenol for Pulmonary Hypertension Due to the Scleroderma Spectrum of Disease

2000 • 1,051 citations

Plasma Brain Natriuretic Peptide as a Prognostic Indicator in Patients With Primary Pulmonary Hypertension

2000 • 881 citations

Prostacyclin Synthase Expression Is Decreased in Lungs from Patients with Severe Pulmonary Hypertension

1999 • 788 citations

Exuberant endothelial cell growth and elements of inflammation are present in plexiform lesions of pulmonary hypertension.

1994 • 769 citations

Sporadic primary pulmonary hypertension is associated with germline mutations of the gene encoding BMPR-II, a receptor member of the TGF-beta family

2000 • 725 citations

Reduction in Pulmonary Vascular Resistance with Long-Term Epoprostenol (Prostacyclin) Therapy in Primary Pulmonary Hypertension

1998 • 674 citations

Long-Term Treatment of Primary Pulmonary Hypertension with Aerosolized Iloprost, a Prostacyclin Analogue

2000 • 583 citations

Appetite-suppressant drugs and the risk of primary pulmonary hypertension

1997 • 582 citations

Survival in Primary Pulmonary Hypertension with Long-Term Continuous Intravenous Prostacyclin

1994 • 558 citations

Increased plasma serotonin in primary pulmonary hypertension

1995 • 551 citations

Long-Term Prostacyclin for Pulmonary Hypertension With Associated Congenital Heart Defects

1999 • 510 citations

Monoclonal endothelial cell proliferation is present in primary but not secondary pulmonary hypertension.

1998 • 432 citations

Vasodilator Therapy for Primary Pulmonary Hypertension in Children

1999 • 425 citations

Dysfunctional Voltage-Gated K ⁺ Channels in Pulmonary Artery Smooth Muscle Cells of Patients With Primary Pulmonary Hypertension

1998 • 411 citations

Inhaled Prostacyclin and Iloprost in Severe Pulmonary Hypertension Secondary to Lung Fibrosis

1999 • 399 citations

Aerosolized Prostacyclin and Iloprost in Severe Pulmonary Hypertension

1996 • 385 citations

Complete reversal of fatal pulmonary hypertension in rats by a serine elastase inhibitor

2000 • 373 citations

Hypoxia inhibits expression of eNOS via transcriptional and posttranscriptional mechanisms

1994 • 366 citations

Primary Pulmonary Hypertension

2000 • 361 citations

CELLULAR AND MOLECULAR MECHANISMS OF PULMONARY VASCULAR REMODELING

1997 • 358 citations

Direct comparison of inhaled nitric oxide and aerosolized prostacyclin in acute respiratory distress syndrome.

1996 • 328 citations

LONG-TERM TREATMENT OF PRIMARY PULMONARY HYPERTENSION WITH CONTINUOUS INTRAVENOUS EPOPROSTENOL (PROSTACYCLIN)

1984 • 319 citations

Prostacyclin-induced acute pulmonary vasodilation in primary pulmonary hypertension.

1982 • 314 citations

A comparison of the acute hemodynamic effects of inhaled nitric oxide and aerosolized iloprost in primary pulmonary hypertension

2000 • 309 citations

Thrombotic risk factors in pulmonary hypertension

2000 • 305 citations

Aerosolised prostacyclin in adult respiratory distress syndrome

1993 • 289 citations

Inhaled nitric oxide as a screening agent for safely identifying responders to oral calcium-channel blockers in primary pulmonary hypertension

1998 • 286 citations

Inhaled Iloprost To Treat Severe Pulmonary Hypertension: An Uncontrolled Trial

2000 • 281 citations

Hemodynamic, Renal, and Hormonal Effects of Adrenomedullin Infusion in Patients With Congestive Heart Failure

2000 • 263 citations

Distribution of Obstructive Intimal Lesions and Their Cellular Phenotypes in Chronic Pulmonary Hypertension

2000 • 261 citations

Inhaled nitric oxide in premature neonates with severe hypoxaemic respiratory failure: a randomised controlled trial

1999 • 261 citations

Abnormal Pulmonary Artery Pressure Response in Asymptomatic Carriers of Primary Pulmonary Hypertension Gene

2000 • 255 citations

Hypoxia inhibits gene expression of voltage-gated K+ channel alpha subunits in pulmonary artery smooth muscle cells.

1997 • 253 citations

Inhibitory Role of Plasminogen Activator Inhibitor-1 in Arterial Wound Healing and Neointima Formation

1997 • 250 citations

Pulmonary prostacyclin synthase overexpression in transgenic mice protects against development of hypoxic pulmonary hypertension

1999 • 226 citations

Elevated immunoreactive endothelin-1 levels in newborn infants with persistent pulmonary hypertension

1993 • 220 citations

Compassionate Use of Continuous Prostacyclin in the Management of Secondary Pulmonary Hypertension: A Case Series

1999 • 219 citations

Deleterious Effects of Hydralazine in Patients with Pulmonary Hypertension

1982 • 212 citations

Long term intravenous prostaglandin (epoprostenol or iloprost) for treatment of severe pulmonary hypertension

1998 • 211 citations

Effect of orally active prostacyclin analogue on survival of outpatients with primary pulmonary hypertension

1999 • 208 citations

Smooth Muscle Cells Isolated From Discrete Compartments of the Mature Vascular Media Exhibit Unique Phenotypes and Distinct Growth Capabilities

1997 • 208 citations

Pulsed Delivery of Inhaled Nitric Oxide to Patients With Primary Pulmonary Hypertension

1996 • 188 citations

Mortality in systemic sclerosis (scleroderma).

1992 • 169 citations

Continuous Infusion of Prostacyclin Normalizes Plasma Markers of Endothelial Cell Injury and Platelet Aggregation in Primary Pulmonary Hypertension

1997 • 166 citations

Circulating Immunoreactive Endothelin-1 in Children with Pulmonary Hypertension: Association with Acute Hypoxic Pulmonary Vasoreactivity

1993 • 158 citations

Adenoviral-mediated transfer of the human endothelial nitric oxide synthase gene reduces acute hypoxic pulmonary vasoconstriction in rats.

1996 • 152 citations

Activation of K⁺ channels induces apoptosis in vascular smooth muscle cells

2001 • 152 citations

Effects of Iloprost Inhalation on Exercise Capacity and Ventilatory Efficiency in Patients With Primary Pulmonary Hypertension

2000 • 129 citations

5-Lipoxygenase and 5-Lipoxygenase Activating Protein (FLAP) Immunoreactivity in Lungs from Patients with Primary Pulmonary Hypertension

1998 • 125 citations

Inhaled nitric oxide in primary pulmonary hypertension

1998 • 117 citations

Short-term and long-term epoprostenol (prostacyclin) therapy in pulmonary hypertension secondary to connective tissue diseases: results of a pilot study

1999 • 116 citations

Epoprostenol for Treatment of Pulmonary Hypertension in Patients With Systemic Lupus Erythematosus

2000 • 115 citations

Effects of aerosolized prostacyclin in severe pneumonia. Impact of fibrosis.

1995 • 114 citations

Treatment of pulmonary hypertension with the continuous infusion of a prostacyclin analogue, iloprost

1998 • 105 citations

In Vivo Gene Transfer of Prepro-Calcitonin Gene–Related Peptide to the Lung Attenuates Chronic Hypoxia-Induced Pulmonary Hypertension in the Mouse

2000 • 101 citations

Imbalance between Platelet Vascular Endothelial Growth Factor and Platelet-derived Growth Factor in Pulmonary Hypertension

2000 • 99 citations

Elastase and the Pathobiology of Unexplained Pulmonary Hypertension

1998 • 97 citations

Effects of Dipyridamole and Inhaled Nitric Oxide in Pediatric Patients with Pulmonary Hypertension

1998 • 97 citations

Effects of Long-term Infusion of Prostacyclin on Exercise Performance in Patients With Primary Pulmonary Hypertension

1999 • 92 citations

Role of Hemodynamics in Pulmonary Vascular Remodeling

1999 • 91 citations

Increased plasma levels of adrenomedullin in patients with pulmonary hypertension

1999 • 89 citations

A comparison of continuous intravenous epoprostenol (prostacyclin) with conventional therapy for primary pulmonary hypertension

1997 • 88 citations

Iloprost Inhibits Neutrophil-induced Lung Injury and Neutrophil Adherence to Endothelial Monolayers

1990 • 84 citations

The influence of continuous intravenous prostacyclin therapy for primary pulmonary hypertension on the timing and outcome of transplantation.

1998 • 83 citations

A Survey of Diagnostic Practices and the Use of Epoprostenol In Patients With Primary Pulmonary Hypertension

1998 • 79 citations

Impairment of hypoxic pulmonary artery remodeling by heparin in mice.

1983 • 77 citations

Adventitial Fibroblasts

2000 • 71 citations

Aerosol Gene Transfer With Inducible Nitric Oxide Synthase Reduces Hypoxic Pulmonary Hypertension and Pulmonary Vascular Remodeling in Rats

2000 • 67 citations

Recovery from circulatory shock in severe primary pulmonary hypertension (PPH) with aerosolization of iloprost

1998 • 67 citations

Chronic Hypoxia Induces Exaggerated Growth Responses in Pulmonary Artery Adventitial Fibroblasts

2000 • 66 citations

Low-dose Systemic Phosphodiesterase Inhibitors Amplify the Pulmonary Vasodilatory Response to Inhaled Prostacyclin in Experimental Pulmonary Hypertension

1999 • 66 citations

Atrial natriuretic peptide in severe primary and nonprimary pulmonary hypertension

2001 • 55 citations

Subthreshold doses of specific phosphodiesterase type 3 and 4 inhibitors enhance the pulmonary vasodilatory response to nebulized prostacyclin with improvement in gas exchange.

2000 • 52 citations

Hypoxia inhibits expression of eNOS via transcriptional and posttranscriptional mechanisms

1995 • 51 citations

A Role for Potassium Channels in Smooth Muscle Cells and Platelets in the Etiology of Primary Pulmonary Hypertension

1998 • 50 citations

Increased plasma levels of adrenomedullin in patients with pulmonary hypertension

1999 • 49 citations

Soluble Guanylate Cyclase α ₁ and β ₁ Gene Transfer Increases NO Responsiveness and Reduces Neointima Formation After Balloon Injury in Rats via Antiproliferative and Antimigratory Effects

2001 • 47 citations

Improvement in Exercise Capacity With Nitric Oxide Inhalation in Patients With Precapillary Pulmonary Hypertension

2000 • 44 citations

Aerosolized Soluble Nitric Oxide Donor Improves Oxygenation and Pulmonary Hypertension in Acute Lung Injury

1998 • 42 citations

Atrial natriuretic peptide in primary pulmonary hypertension

1990 • 41 citations

Efficiency of aerosolized nitric oxide donor drugs to achieve sustained pulmonary vasodilation.

1997 • 40 citations

Acute Hemodynamic Responses to Inhaled Nitric Oxide in Patients With Limited Scleroderma and Isolated Pulmonary Hypertension

1996 • 40 citations

Prothrombotic mechanisms in primary pulmonary hypertension

1999 • 33 citations

Aerosolization of novel nitric oxide donors selectively reduce pulmonary hypertension

1998 • 32 citations

A Physical and Transcript Map Based upon Refinement of the Critical Interval for PPH1, a Gene for Familial Primary Pulmonary Hypertension

2000 • 30 citations

Severe pulmonary hypertensive diseases: a perspective

1999 • 28 citations

Pulmonary hypertension is a contraindication to β-blockade in patients with severe mitral stenosis

1993 • 20 citations

Inhibition of hypoxic pulmonary vasoconstriction by dipyridamole is not platelet mediated

1977 • 17 citations

Sustained improvement of performance and haemodynamics with long-term aerosolised prostacyclin therapy in severe pulmonary hypertension.

1999 • 16 citations

Effect of Aerosol Heparin on the Development of Hypoxic Pulmonary Hypertension in the Guinea Pig

1993 • 15 citations